levofloxacin / Generic mfg. 
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  • ||||||||||  Clinical Correlation and Antibiotic Sensitivity Profile of Clinical Strains of Novel Species Stenotrophomonas Sepilia (Exhibit and Poster Hall) -  May 21, 2022 - Abstract #ASMMicrobe2022ASM_Microbe_1982;    
    S. sepilia has significant clinical correlation with bloodstream infections and warrants serious measuresfor the management of infected patients. Microbiologists and clinicians should be aware of thisemerging pathogenic species of genus Stenotrophomonas for its rapid identification and to provide adirected antibiotic therapy and avoid unnecessary antibiotic usage and in turn the emergence ofresistance.
  • ||||||||||  levofloxacin / Generic mfg., trimethoprim/sulfamethoxazole / Generic mfg., minocycline / Generic mfg.
    Stenotrophomonas Maltophilia from Patients with and without Cf (Exhibit and Poster Hall) -  May 21, 2022 - Abstract #ASMMicrobe2022ASM_Microbe_1816;    
    These differences could be due to the adaptation of Sm to the selective pressure of the CF lungs and would contribute to its persistence. The detection of 27.6% of CF isolates resistant to TMS is clinically relevant since it is the drug of choice for Sm treatment.
  • ||||||||||  levofloxacin / Generic mfg.
    Topical Antibiotic Treatment Prevented Amputation of a Leg Injury Caused by Pseudomonas Aeruginosa and Staphylococcus Aureus (Exhibit and Poster Hall) -  May 21, 2022 - Abstract #ASMMicrobe2022ASM_Microbe_1713;    
    The detection of 27.6% of CF isolates resistant to TMS is clinically relevant since it is the drug of choice for Sm treatment. Initial and follow-ups of culture and AST are necessary in open wounds to find out which precise antibiotic treatment would be given. The use of an appropriate topical antibiotic applied in the injury, and oral, intravenous or intramuscular doses, if needed, are recommended.  That would prevent harmful effects caused by just performing one-time AST and definitely try not do empiric therapy.  A precise antibiotic treatment tends to improve the quality of life in patients.  It also decreases dosage of any unnecessary antibiotic treatments, as well as the frequency and duration of patients’ conditions due to open wounds.  It also has the advantages of reducing health complications and of avoiding bacterial resistance in patients.  Besides that, there would be less absenteeism at work, decreased emotional stress in patients and fewer monetary expenses as a result of shorter hospital stays.
  • ||||||||||  Antimicrobial Susceptibilities and Mechanisms of Resistance of Commensal and Invasive Mycoplasma Salivarium Isolates (Exhibit and Poster Hall) -  May 21, 2022 - Abstract #ASMMicrobe2022ASM_Microbe_1523;    
    All isolates were resistant to erythromycin (MIC ≥ 4 mg/L) due to the presence of 2057A (Escherichia coli numbering) in 23S rRNA gene...Multi-drug resistance was observed in five (14.3%) isolates. This study demonstrates the frequent occurrence of antimicrobial resistance in M. salivarium, emphasizing the need for culture and susceptibility testing to guide antimicrobial therapy.
  • ||||||||||  sulbactam-durlobactam (ETX2514SUL) / Entasis Therap, ZAI Lab
    In Vitro Activity of Sulbactam-Durlobactam Against Acinetobacter Baumannii Clinical Isolates Collected in 2020 from China (Exhibit and Poster Hall) -  May 21, 2022 - Abstract #ASMMicrobe2022ASM_Microbe_1457;    
    SUL-DUR demonstrated potent antibacterial activity against recent clinical isolates of A. baumannii collected in China. These data support the potential utility of SUL-DUR, if approved, for the treatment of antibiotic-resistant infections caused by Acinetobacter baumannii-calcoaceticus complex organisms from China.
  • ||||||||||  Bacteriological Evaluation of Street Vended ''Suya'' in Akoko, Ondo State, Nigeria (Exhibit and Poster Hall) -  May 21, 2022 - Abstract #ASMMicrobe2022ASM_Microbe_1100;    
    A 31% resistant to Streptomycin, 26% resistant to Ciprofloxacin and Erythromycin respectively, 5.2% resistant to Levofloxacin and 10% resistant to Gentamicin...The findings revealed contamination of "suya" meat by potential pathogenic bacteria. Therefore, environmental sanitation, regular hand washing, routine inspection and clean equipment should be encouraged among ''suya'' sellers within the study area.i
  • ||||||||||  Clinical guideline:  V Spanish Consensus Conference on Helicobacter pylori infection treatment. (Pubmed Central) -  May 20, 2022   
    A non-bismuth quadruple concomitant regimen (proton pump inhibitor, clarithromycin, amoxicillin, and metronidazole) or a quadruple bismuth-based combination (proton pump inhibitor, bismuth, tetracycline, and metronidazole), are recommended as first-line regimens. Rescue therapies after eradication failure and management of H. pylori infection in peptic ulcer disease were also reviewed.
  • ||||||||||  quetiapine / Generic mfg.
    Journal:  The Atypical Antipsychotic Quetiapine Promotes Multiple Antibiotic Resistance in Escherichia coli. (Pubmed Central) -  May 20, 2022   
    Investigation of mutations in the marR gene, which encodes a repressor for the multiple antibiotic resistance (mar) operon, reveals a potential mechanism that increases the fitness of E. coli in the presence of quetiapine. Our findings establish a link between the use of AAPs and AMR development in bacteria.
  • ||||||||||  Thymoglobulin (anti-thymocyte globulin (rabbit)) / Sanofi, Soliris (eculizumab) / AstraZeneca
    Early Outcomes of Single Dose Eculizumab for Abo-Incompatible Living Donor Renal Transplantation (Board No. D186) -  May 20, 2022 - Abstract #ATC2022ATC_1635;    
    Early outcomes following a single dose of ECU 900 mg for ABOi LDRT showed excellent allograft function and patient outcomes without the need for PLEX and anti-ABO titer monitoring. Infectious complications were mild in most cases.
  • ||||||||||  levofloxacin / Generic mfg.
    TUBERCULOUS PLEURISY BY ISONIAZID RESISTANT M. TUBERCULOSIS IN A FEMALE ADOLESCENT () -  May 19, 2022 - Abstract #ESPID2022ESPID_1104;    
    ADA represents a useful diagnostic biomarker, however in the early stages of disease sensitivity may be low. Further studies are needed to determine the clinical significance of isoniazid resistance mutations (esp.katG), in Hr-Tb patients receiving the newer, levofloxacin containing, WHO/CDC regimens.
  • ||||||||||  levofloxacin / Generic mfg., clindamycin phosphate / Generic mfg., moxifloxacin intravenous / Generic mfg.
    A CASE OF BIOFILM INFECTION ASSOCIATED WITH ORTHOPEDIC IMPLANTS () -  May 19, 2022 - Abstract #ESPID2022ESPID_1038;    
    At follow up visit after 1.5 month her wound was fully healed. Learning Points/ Biofilm infections are mostly caused by S. aureus and are the most common complication associated with placement of orthopedic implants.
  • ||||||||||  SPLENIC ABSCESS IN A CHILD: A CASE REPORT () -  May 19, 2022 - Abstract #ESPID2022ESPID_1020;    
    She was treated with injection of ceftriaxone (8 days), cefoperazone-sulbactam (19 days), levofloxacin (14 days), Metronidazole (14 days) and ampicillin (14 days)...Learning Points/ Spleen abscess has non specific signs and symptoms, thus radiological investigation is needed for diagnosis. Treatment with antibiotics and surgical intervention can give a good result.
  • ||||||||||  Lamprene (clofazimine) / Novartis
    CHALLENGES IN DIAGNOSIS, MANAGEMENT AND TREATMENT OF ISONIAZID-INDUCED DRESS SYNDROME () -  May 19, 2022 - Abstract #ESPID2022ESPID_821;    
    DRESS symptoms progressively disappeared and a second line treatment with levofloxacin, linezolid, clofazimine and streptomycin was started seven days later for 2 months...The LTT is highly useful in the diagnosis of severe drug reactions minimizing treatment interruption, without compromising efficacy. Strengthening screening for infectious diseases among newly arrived migrants is key to start prompt treatment.
  • ||||||||||  Invanz (ertapenem) / Merck (MSD)
    Clinical, Journal:  Pott's puffy tumor in a 23-month-old: Youngest known case of a rare disease. (Pubmed Central) -  May 17, 2022   
    The presence of a developed frontal sinus in a 23-month-old is an unexpected radiologic finding. This case represents the youngest patient reported in the literature to develop this rare complication of frontal sinusitis.
  • ||||||||||  vancomycin / Generic mfg., levofloxacin / Generic mfg.
    Journal:  Microbiologic Analysis of Removed Silicone Punctal Plugs in Dry Eye Patients. (Pubmed Central) -  May 15, 2022   
    Among the patients who complained of discomfort after insertion of silicone punctal plugs, approximately 42% had a positive result in bacterial culture. Therefore, when removing punctal plugs in such patients, a microbiological examination may be needed for the appropriate selection of antibiotics.
  • ||||||||||  levofloxacin / Generic mfg.
    Clinical data, Journal:  Evaluation of a carbapenem antimicrobial stewardship program and clinical outcomes in a Japanese hospital. (Pubmed Central) -  May 15, 2022   
    Therefore, when removing punctal plugs in such patients, a microbiological examination may be needed for the appropriate selection of antibiotics. The implementation of the Appropriate Use of Carbapenems Program was effective in reducing the use of broad-spectrum antibiotics and maintaining the antibiotic susceptibility of P. aeruginosa.
  • ||||||||||  Mycobutin (rifabutin) / Pfizer, Lupin, mosedipimod (EC-18) / Enzychem Lifesci, Sirturo (bedaquiline) / J&J, Pharmstandard
    Journal:  Development, validation and clinical use of a LC-MS/MS method for the simultaneous determination of the nine main antituberculosis drugs in human plasma. (Pubmed Central) -  May 12, 2022   
    We developed a LC-MS/MS method allowing the simultaneous quantification of the four first-line drugs (isoniazid, rifampicin, pyrazinamide and ethambutol), a metabolite of isoniazid (acetylisoniazid) and the five main second-line drugs (rifabutin, levofloxacin, moxifloxacin, linezolid and bedaquiline)...The protein precipitation was performed with acetonitrile and the separation was carried out using an EC-18 column and a gradient elution...Preliminary data were obtained for 12 patients. The results showed that 38% of the patients had infra-therapeutic levels for both rifampicin and isoniazid, that the leading cause of an impaired oral absorption seemed to be malabsorption and that the effective concentrations for rifampicin were in the lower range of the therapeutic interval.
  • ||||||||||  Clinical, Journal:  Comparison of Methods for Determining the Antibiotic Susceptibility of Aerococcus Species in a Clinical Setting. (Pubmed Central) -  May 11, 2022   
    Nasal carriage of S. aureus and MRSA in students, coincided with the general population and sensitive-methicillin strains showed clonal diversity and high antimicrobial susceptibility except for penicillin. Overall, the alternate AST method with the highest agreement with broth microdilution was the Etest on Mueller-Hinton agar with 5% sheep blood and may be an optimal alternative to broth microdilution.
  • ||||||||||  Retrospective data, Journal:  Important rise in antibiotic resistance rates inHelicobacter pyloriin the Netherlands (Pubmed Central) -  May 9, 2022   
    Treatment of H. pylori should be based on the individual antibiotic resistance profile and be in concordance with the principles of antibiotic stewardship. Guidelines for treatment of H. pylori in the Netherlands should be adapted and have a better correlation with International guidelines and best practices.