- |||||||||| Xalkori (crizotinib) / Pfizer
Journal: Crizotinib Associated Renal Abscess --A Case Report- (Pubmed Central) - Dec 5, 2024
Pathology of the left kidney revealed a renal abscess, but there was no sign of malignancy. Crizotinib has been reported to cause rare adverse effects, such as polycystic renal lesions or renal abscesses.
- |||||||||| Journal: Etiological characteristics of Brucella melitensis in Henan Province, 2013-2022 (Pubmed Central) - Dec 5, 2024
Human Brucella melitensis strains isolated from surveillance sentinels in Henan from 2013 to 2022 carried multiple virulence and antibiotic resistance genes and had different drug resistance phenotypes. Single nucleotide polymorphism analysis and phylogenetic tree analysis showed significant differences in phylogenetic relationships among different strains.
- |||||||||| Journal: Streptococcus suis-Associated Meningitis in a Southern Region of Vietnam. (Pubmed Central) - Dec 4, 2024
Occupational exposure to pigs and the consumption of contaminated food have been identified as primary risk factors associated with this zoonosis, and our study found no significant changes in epidemiological factors compared with past data. The Mekong Delta continues to be the most affected region for S. suis meningitis in southern Vietnam, with S. suis serotype 2 remaining the most relevant agent.
- |||||||||| levofloxacin / Generic mfg.
Journal: Fusobacterium nucleatum-Induced Empyema Masquerading as Lung Cancer: A Diagnostic Challenge. (Pubmed Central) - Dec 4, 2024
He was discharged with a course of oral antibiotics, levofloxacin, and scheduled for a two-week follow-up on the lung cancer pathway...Surgical intervention was not pursued because of the patient's comorbidities and clinical and biochemical resolution of the infection. This case highlights the importance of considering rare pathogens, such as Fusobacterium nucleatum, in pleural infections, particularly when linked to oral sources.
- |||||||||| Mycobutin (rifabutin) / Pfizer, Lupin
Clinical guideline, Journal: ACG Clinical Guideline: Treatment of Helicobacter pylori Infection. (Pubmed Central) - Dec 3, 2024
The CPG also addresses who to test, the need for universal post-treatment test-of-cure, and the current evidence regarding antibiotic susceptibility testing and its role in guiding the choice of initial and salvage treatment. The CPG concludes with a discussion of proposed research priorities to address knowledge gaps and inform future management recommendations in patients with H. pylori infection from North America.
- |||||||||| ciprofloxacin oral / Generic mfg., levofloxacin / Generic mfg., tetracycline / Generic mfg.
Journal: Risk assessment of antibiotic residues in raw cow's milk in Bangladesh. (Pubmed Central) - Dec 3, 2024
About 30% of the oxytetracycline-positive samples exceeded the MRL, while none surpassed the MRL for enrofloxacin and ciprofloxacin. Calculated human health risks appeared to be low, but children might face potential risks due to prolonged exposure.
- |||||||||| Journal: Phenotypic and genotypic detection of multi drug resistant coagulase-positive Staphylococcus spp. isolates from canine pyoderma. (Pubmed Central) - Dec 3, 2024
A higher percentage of antibiotic resistance was observed against penicillin-G (46.27%), followed by amoxiclav (38.81%), enrofloxacin (32.84%), cefpodoxime, oxytetracycline (28.36% each), levofloxacin (26.86%), and co-trimoxazole (22.39%)...pseudintermedius) revealed low-level mupirocin resistance in the E-test...coagulans (MRSS) and one (50%) methicillin-resistant S. aureus (MRSA) were reported using PCR. This study helps to understand the increased level and pattern of resistance in coagulase-positive staphylococci isolated from different types of canine pyoderma cases.
- |||||||||| Preclinical, Journal: Monitoring and controlling bacteria in cleanrooms of pharmaceutical plant model: an in vitro study. (Pubmed Central) - Dec 2, 2024
One hundred percent of collected Gram-positive and Gram-negative isolates of bacteria were sensitive to Levofloxacin...The five Gram-positive MDR bacterial isolates were resistant to Tobramycin, Gentamicin, Piperacillin, Cefaclor, and Amikacin while the one Gram-negative MDR bacterial isolate was resistant to Ceftazidime, Cefotaxime, Tobramycin, Gentamicin, Piperacillin, Cefoperazone/Sulbactam, Ofloxacin, and Polymixin b. The existence of multidrug-resistant bacteria inside cleanrooms of pharmaceutical plants signifies a life-threatening danger on human through generating contaminated drugs and/or vaccines that undoubtedly harm the consumer's healthiness...Klericide and Dettol mixture showed more anti adhesion and invasion effects against Staphylococcus gallinarum strain NM2009 and strain MN1812 and Pseudomonas putida compared to using Klericide alone. Ethanol and Klericide had the least contact time (30
- |||||||||| Gatiflox (gatifloxacin) / Orient Europharma
Review, Journal: Thelaziasis in an urban woman in Beijing: a case report and literature review. (Pubmed Central) - Nov 29, 2024
This case highlights the thelaziasis in urban settings, emphasizing the need for ophthalmologists to consider parasitic infections in differential diagnosis even in well-maintained environments. Then, we provided an overview of human thelaziasis in China by mining publicly available databases from 2014 to 2023, suggesting a difference in regional distribution that warrants further epidemiological studies.
- |||||||||| levofloxacin / Generic mfg.
Journal: Clinical characteristics associated with peripartum maternal bloodstream infection. (Pubmed Central) - Nov 28, 2024
Approximately 31.2% of E. coli were resistant to levofloxacin, and 38.6% were extended-spectrum ?-lactamase-producing bacteria...Maternal BSI is a potentially life-threatening disease associated with PROM and the timing and severity of fever. Early identification and surveillance of pathogen composition and antimicrobial resistance can help prevent adverse outcomes.
- |||||||||| Invanz (ertapenem) / Merck (MSD), ceftriaxone / Generic mfg., levofloxacin / Generic mfg.
Journal: Influence of Kidney Environment Parameters on Antibiotic Efficacy Against Uropathogenic Escherichia coli. (Pubmed Central) - Nov 27, 2024
Further research is needed to evaluate a broader range of antibiotics and additional environmental parameters, to develop a more comprehensive understanding of how the kidney environment affects antimicrobial activity. This knowledge will be vital in optimizing treatment strategies for pyelonephritis, ultimately improving patient outcomes.
- |||||||||| Review, Journal: Fluoroquinolone Resistance in Escherichia coli Causing Community-Acquired Urinary Tract Infections: A Systematic Review. (Pubmed Central) - Nov 27, 2024
Several studies have addressed the prevalence of uropathogens producing ESBLs, but only a few have focused on fluoroquinolone resistance, and, to our knowledge, none have addressed the prevalence of phylotypes or genes responsible for antimicrobial resistance to fluoroquinolones. The focus of the present review was to analyze recently published papers that described the E. coli phylotype causing community-acquired UTIs in association with fluoroquinolone resistance.
- |||||||||| levofloxacin / Generic mfg., rifampicin / Generic mfg., doxycycline / Generic mfg.
Review, Journal: Coxiella burnetii caused lumbar infection: A case report and literature review. (Pubmed Central) - Nov 24, 2024
This case highlights mNGS as a valuable tool for diagnosing rare infections, especially in patients with a history of animal exposure. It underscores the importance of considering zoonotic infections and the need for combined antibiotic and surgical management in suspected cases.
- |||||||||| Bestron (cefmenoxime) / Senju
Journal: Combination effect of levofloxacin and cefmenoxime against ocular isolates of Pseudomonas aeruginosa. (Pubmed Central) - Nov 21, 2024
Sex, age, prior therapy, and proton pump inhibitors (PPIs) or potassium-competitive acid blockers (P-CABs) use were not significantly associated with an increased risk of eradication failure in AST-guided therapy. The combination of LVFX with CMX may have beneficial interactions which increase antibacterial activity against P. aeruginosa isolates and may be a feasible option for addressing the issue of bacteria resistant to each antibiotic.
- |||||||||| levofloxacin / Generic mfg.
Journal: Streptococcus pneumoniae as a Potential Cause of Pyogenic Parotitis in a Patient with Poor Oral Hygiene and Vitamin D Deficiency. (Pubmed Central) - Nov 19, 2024
The patient was successfully treated with levofloxacin, guided by culture sensitivity, along with parotid massage and hydration...It emphasises the role of comprehensive diagnostics, including imaging and microbiology, in managing recurrent parotitis, especially when typical treatments fail. The case also highlights the potential interplay between oral hygiene, vitamin D status, and susceptibility to unusual pathogens in parotid infections.
- |||||||||| levofloxacin / Generic mfg.
Review, Journal: LC enantioseparation of active pharmaceutical ingredients using rationally synthesized CDRs and chiral molecules with high molar absorptivity. (Pubmed Central) - Nov 17, 2024
Besides, the application of (i) certain enantiomerically pure amines, either directly or by incorporating each of them as chiral auxiliary in difluorodinitrobenzene or cyanuric chloride moieties to construct the CDR, (ii) (S)-ketoprofen and (S)-levofloxacin as chiral platforms, and (iii) a few isothiocyanates, have been suitably included...The methods can be easily used to determine and control enantiomeric purity with advantages over a variety of commercial chiral phases. This comprehensive review not only highlights innovative methodologies for enantioseparation but also underscores their practical applications in controlling and ensuring the enantiomeric purity of pharmaceutical compounds.
- |||||||||| Cubicin (daptomycin) / Merck (MSD)
Journal: Antimicrobial susceptibility testing of Dermabacter hominis. (Pubmed Central) - Nov 17, 2024
Due to limited variances in both MIC values and inhibition zone diameters, no disk diffusion breakpoint could be deduced for gentamicin and benzylpenicillin in our dataset...In addition to that, we created a current overview of resistance rates from the existing literature. Our data provide deeper insight into resistance rates and antimicrobial susceptibility testing of this specific pathogen.
- |||||||||| Journal, Real-world evidence, Real-world: Drug risks associated with sarcopenia: a real-world and GWAS study. (Pubmed Central) - Nov 15, 2024
We find that metformin, aspirin, and acetaminophen are specifically noted for their potential to induce sarcopenia based on the analyses conducted. We perform signal mining for drug-associated sarcopenia events based on real-world data and provides certain guidance for the safe use of medications to prevent sarcopenia.
- |||||||||| Journal: Bacteriuria Among Type 2 Diabetes Mellitus Patients Attending Ejisu Government Hospital in the Ashanti Region, Ghana. (Pubmed Central) - Nov 15, 2024
However, 60% of the E. coli isolates and 25% of the Klebsiella isolates were multidrug resistant (MDR; resistant to at least one antibiotic agent in three or more antimicrobial categories). The study shows that T2DM patients have bacteria in their urine which are resistant to most common antibiotics, even among those with no history of UTIs; hence, routine bacterial culture and antibiotic sensitivity testing among T2DM patients is recommended for better patient management to reduce the co-morbidities of UTIs.
- |||||||||| Journal: The catalogue of Mycobacterium tuberculosis mutations associated with drug resistance to 12 (Pubmed Central) - Nov 13, 2024
These findings highlight a significant public health and food safety risk associated with raw milk due to the presence of S. aureus strains with toxigenic genes and high antimicrobial resistance. Our analysis reflects the complexity of drug resistance mutations in China and suggests that indel mutations, efflux pump genes, protein structure, and MICs should be fully considered in the WHO catalogue, especially in countries with a high tuberculosis burden.
- |||||||||| ciprofloxacin oral / Generic mfg., levofloxacin / Generic mfg.
Journal: Cu-MoOx-based nanozyme with enhanced peroxidase like activity for quinolone antibiotics detection. (Pubmed Central) - Nov 13, 2024
Our analysis reflects the complexity of drug resistance mutations in China and suggests that indel mutations, efflux pump genes, protein structure, and MICs should be fully considered in the WHO catalogue, especially in countries with a high tuberculosis burden. Based on this phenomenon, a colorimetric method for detecting quinolone antibiotics was established with a good linear relationship ranging from 1
- |||||||||| levofloxacin / Generic mfg., amikacin sulfate / Generic mfg.
Trial completion, Trial completion date, Trial primary completion date: TB-TRUST: Refining MDR-TB Treatment (T) Regimens (R) for Ultra(U) Short(S) Therapy(T) (clinicaltrials.gov) - Nov 12, 2024
P4, N=354, Completed,
However, further enhancements are required to optimize its performance. Trial completion date: Nov 2023 --> Aug 2024 | Trial primary completion date: May 2023 --> Aug 2024 | Active, not recruiting --> Completed
- |||||||||| levofloxacin / Generic mfg.
New P3 trial, Combination therapy: The Role of Butirprost (clinicaltrials.gov) - Nov 11, 2024
P3, N=60, Completed,
- |||||||||| Humira (adalimumab) / AbbVie
TB or not TB... That is the question! () - Nov 8, 2024 - Abstract #BSRCBC2024BSR_CBC_87;
Unfortunately he could not tolerate high doses of sulfasalazine and hydroxychloroquine was introduced, which again he could not tolerate...Incidentally, it picked up tree-in-bud changes in the lower lungs in keeping with possible chest infection, treated with two weeks of levofloxacin...He was on 17.5 mg of oral prednisolone, which was incrementally increased to 80 mg in light of rifampicin effect...Lastly, this case report represents a case of GCA occurring in a patient already on adalimumab and methotrexate (a steroid-sparing agent for GCA)...This case is complex, demonstrating an unusual presentation of GCA in the context of a patient already on immunosuppression, who subsequently developed military TB despite a negative pre-immunosuppression screen and no risk factors for TB. It contributes to the ongoing discussion about the need for TB screening in all DMARD-naive patients.
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