levofloxacin / Generic mfg. 
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  • ||||||||||  Priligy (dapoxetine) / AbbVie
    Retrospective data, Review, Journal:  Oral pharmacological treatments for chronic prostatitis/chronic pelvic pain syndrome: A systematic review and network meta-analysis of randomised controlled trials. (Pubmed Central) -  Jun 22, 2022   
    Low and very low quality evidence suggested that combination treatment including doxazosin, ibuprofen, and thiocolchicoside (odds ratios [OR], 3.2, CrI, 0.5 to 19.3) and the tamsulosin and dapoxetine combination (OR, 6.0, CrI, 0.7 to 67.3) caused more adverse events...There was also high heterogeneity in NIH-CPSI urine scores for the combination of tamsulosin and ciprofloxacin versus tamsulosin (I  = 66.8%), tamsulosin and levofloxacin versus tamsulosin (I  = 93.3%), and tamsulosin versus placebo (I  = 83%)...Future studies could personalise therapy for individuals according to specific symptoms and identify non-pharmacological targets for CP/CPPS. Dr Jiani Wu received funding for this project from the China Association for Science and Technology (2017QNRC001), the China Academy of Chinese Medical Sciences (ZZ13-YQ-027), and the National Natural Science Foundation of China (82105037).
  • ||||||||||  Invanz (ertapenem) / Merck (MSD)
    Retrospective data, Journal:  Clinical Laboratory Features of Microbes That Cause Neonatal Sepsis: An 8-Year Retrospective Study. (Pubmed Central) -  Jun 22, 2022   
    With regard to the trends in resistance among important pathogens, the rates of resistance to rifampicin, ciprofloxacin, levofloxacin, moxifloxacin and clindamycin by Staphylococcus epidermidis significantly decreased (p<0.05) during the study period...coli strains exhibited a significant increase in ceftriaxone resistance during the study period (p<0.05)...The bacterial isolates showed varying levels of resistance to the antimicrobial drugs tested. Thus, periodic surveillance in hospital settings to monitor changes in pathogens and antibiotic resistance is important.
  • ||||||||||  Gatiflox (gatifloxacin) / Orient Europharma
    Journal:  Ten-Year Analysis of Pathogenic Factors and Etiological Characteristics of Endophthalmitis from a Tertiary Eye Center in North China. (Pubmed Central) -  Jun 22, 2022   
    The high susceptibility of bacteria to vancomycin (77.78%~98.33%) supported its continued use as empirical treatment...Fungal susceptibilities to voriconazole and amphotericin B were 90.16% and 70.31% respectively...Gram-positive cocci were the most common pathogens of traumatic and postoperative endophthalmitis, while suppurative keratitis-associated endophthalmitis often resulted from fungal pathogens. Levofloxacin as the preferred antibiotic in the perioperative period and cephalosporin as the first-line drug for the treatment of empiric endophthalmitis need to be vigilant.
  • ||||||||||  Journal:  Molecular Characterization of Predominant Serotypes, Drug Resistance, and Virulence Genes of Streptococcus pneumoniae Isolates From East China. (Pubmed Central) -  Jun 22, 2022   
    Of the nine detected virulence genes, the lytA, ply, hysA, and nanA were the most common with 95-100% positive rates in the 309 pneumococcal isolates, while the pavA and psaA genes displayed a significant correlation with pneumococcal bacteremia and meningitis (p < 0.05). Overall, our data suggested that the predominant serotypes, drug resistance, and virulence genes of the S. pneumoniae isolates prevailing in East China are distinct from those observed in other areas of China and adjacent countries.
  • ||||||||||  Journal:  Antibiotic resistance of Helicobacter pylori isolated from children in Chongqing, China. (Pubmed Central) -  Jun 19, 2022   
    The A2143G and A2142G mutations in 23S rRNA gene, which are related to clarithromycin resistance, and Asn87 and Asp91 mutations in gyrA gene, which are related to levofloxacin resistance, were investigated in 102 strains...No resistance to amoxicillin, tetracycline, and furazolidone was observed...What is New: • High resistance rates to single and multiple antibiotics in children of Chongqing, a city located in southwest China, were observed. • Molecular assays showed good conformance with susceptibility test results to direct antibiotic resistance of H. pylori.
  • ||||||||||  Review, Journal:  Are Antibiotics Appropriately Dosed in Critically Ill Patients with Augmented Renal Clearance? A Narrative Review. (Pubmed Central) -  Jun 19, 2022   
    PK properties of antibiotics including lipophilicity or hydrophilicity, protein binding, the volume of distribution, and elimination rate that affect drug concentration should be considered along with PD parameters for drug dosing in critically ill patients with ARC. This review recommends a dosing protocol for some antibiotics to help the appropriate dosing of antibiotics in ARC and decrease the risk of subtherapeutic exposure that may be observed while receiving conventional dosing regimens in critically ill patients with ARC.
  • ||||||||||  Xifaxan (rifaximin) / Alfa Wassermann, Bausch Health, Norgine, ASKA Pharma
    Journal:  Kinetics of bactericidal potency with synergistic combination of allicin and selected antibiotics. (Pubmed Central) -  Jun 15, 2022   
    Moreover, the average inhibition potential to protein denaturation by the synergistic combination group was significantly higher (3.4 fold) than the sole antibiotic's group manifests reduction in the dose-related toxicity. The potential of synergism between antibiotics and allicin combination demonstrated greater killing efficiency at significantly lower concentration compared to monotherapy with increased kill rates in all cases.
  • ||||||||||  Journal:  Antibiotic resistance pattern and pathological features of avian pathogenic Escherichia coli O78:K80 in chickens. (Pubmed Central) -  Jun 15, 2022   
    Histopathological examination depicted hepatocellular degeneration, myocardial necrosis, interstitial nephritis, intestinal hemorrhages and lymphopenia in the spleen. This study is the first evidence to assess the antibiotic resistance profile linked with virulence genes and clinicopathological potential of APEC O78:K80 in chickens in Pakistan, which could be a useful and rapid approach to prevent and control the disease by developing the control strategies.
  • ||||||||||  Journal:  Phenotyping and genotyping studies on extended-spectrum β-lactamase-producing Escherichia coli isolates from mastitic cows on dairy farms in Egypt. (Pubmed Central) -  Jun 15, 2022   
    Results also revealed that 51.25%, 52.5%, 66.25%, 77.5% and 60% of ESBL-producing E. coli isolates were responsive to ciprofloxacin, ofloxacin, norfloxacin, levofloxacin, and gentamycin, respectively...Regular and thorough surveillance of ESBL-producing E. coli and subsequent preventive actions are essential for preventing the spread of these resistance genes in the future, which could pose serious and catastrophic health risks. Authorities should cling to the concept of One Health to minimize the risk of new varieties.
  • ||||||||||  Gatiflox (gatifloxacin) / Orient Europharma
    Journal:  Etiological analysis of infectious keratitis in children from 2007 to 2016 (Pubmed Central) -  Jun 14, 2022   
    Gram-positive cocci were sensitive to vancomycin...Gatifloxacin had the highest sensitivity, while the difference between gatifloxacin and moxifloxacin, levofloxacin, ofloxacin were not statistically significant (χ²=0.836,0.358, 1.490; P=0.361,0.550,0.222)...Fusarium showed a relatively high sensitivity to terbinafine, but it was not sensitive to fluconazole and itraconazole...Candida had high sensitivities to amphotericin, fluconazole, itraconazole and voriconazole...Streptococcus pneumoniae is the most common in children aged 7 and below, and Staphylococcus epidermidis is the most common in children aged 8-14. Fungal infection was significantly lower than that of bacteria, mainly Fusarium, Aspergillus and Candida.
  • ||||||||||  levofloxacin / Generic mfg.
    Journal:  Levofloxacin Use in Patients with Suspected Tuberculosis in a Community Hospital, Thailand: A Pilot Study. (Pubmed Central) -  Jun 14, 2022   
    The results from this study indicated high usage of levofloxacin despite no evidence of drug-resistant TB or negative AFB results in a community hospital in Thailand. The results from this study will be further used for the investigation of the prevalence of antibiotic resistance and clinical outcomes of using second-line regimens for TB treatment.
  • ||||||||||  Zavicefta (ceftazidime/avibactam) / Pfizer, AbbVie
    Preclinical, Journal:  In Vitro Activity of MRX-8 and Comparators Against Clinical Isolated Gram-Negative Bacilli in China. (Pubmed Central) -  Jun 11, 2022   
    and Haemophilus spp., MIC was 1/4 mg/L and 0.25/0.5 mg/L. MRX-8 was more effective against most clinically isolated gram-negative isolates, including carbapenem-resistant E. coli, K. pneumoniae, P. aeruginosa and A. baumannii, highlighting its potential as valuable therapeutics.
  • ||||||||||  levofloxacin / Generic mfg., rifampicin / Generic mfg.
    Journal:  Extrapulmonary Tuberculosis in Cirrhosis: Too Familiar-Too Much Unknown. (Pubmed Central) -  Jun 10, 2022   
    Burkillanthusmalaccensis (Ridl.) Swingle can be a potential source of natural products with antibiotic-potentiating activity and that are anti-SARS-CoV-2. No abstract available
  • ||||||||||  cefepime hydrochloride / Generic mfg., levofloxacin / Generic mfg.
    Journal:  Periprosthetic knee joint infection caused by Sneathia sanguinegens. (Pubmed Central) -  Jun 9, 2022   
    The antimicrobial therapy with cefepime was given for 19 days and, thereafter, changed with oral levofloxacin. Although the patient showed full recovery after administration of levofloxacin for 100 days, an in vitro study conducted later revealed that levofloxacin was inactive to the isolated organism.
  • ||||||||||  levofloxacin / Generic mfg., trimethoprim/sulfamethoxazole / Generic mfg.
    Preclinical, Journal:  In vitro activity of ceragenins against Burkholderia cepacia complex. (Pubmed Central) -  Jun 9, 2022   
    The findings of this study demonstrate that combinations of ceragenins with currently marketed antibiotics could be synergistic in vitro against Bcc isolates. These results suggest that combination therapy with conventional antibiotics could be an alternative approach for treating Bcc infections in the future.
  • ||||||||||  levofloxacin / Generic mfg., amikacin sulfate / Generic mfg.
    Biomarker, Journal, Next-generation sequencing:  Exploratory study on detection of drug resistance of Mycobacterium tuberculosis in sputum specimens by next-generation sequencing (Pubmed Central) -  Jun 8, 2022   
    With the accuracy of the NGS method for detecting strains as a reference, there was no statistically significant difference in the accuracy of all drug resistance detected between strains and sputum specimens. This study showed that the NGS technology was effective in predicting the resistance of isoniazid, rifampicin, and second-line injectable drugs (capreomycin, kanamycin and amikacin) by detecting sputum samples and strain genotypes, suggesting the feasibility and potential of direct detection of sputum samples by the NGS method as an early detection method for drug resistance.