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0 Diseases |  |
137 Trials |
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137 Trials |  |
5343 News |  |
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- prednisone / Generic mfg., levofloxacin / Generic mfg.
PROGRESSIVE PULMONARY FIBROSIS: USE OF TRANSBRONCHIAL BIOPSY TO DIFFERENTIATE SILICOSIS FROM SARCOIDOSIS (Convention Center Exhibit Hall: Rapid Area 4D) - Sep 11, 2022 - Abstract #CHEST2022CHEST_3806;
Even though lung biopsy is not required for the diagnosis of silicosis, it is a beneficial tool in ruling out competing diagnoses. This patient's occupational history and imaging findings fit the diagnosis of silicosis; however, his biopsy revealed non-necrotizing granulomas; thus, leading to the diagnosis of sarcoidosis.
- levofloxacin / Generic mfg.
A RARE CAUSE OF COMMUNITY-ACQUIRED BACTERIAL PNEUMONIA IN A PATIENT WITH POORLY CONTROLLED DIABETES (Convention Center Exhibit Hall: Rapid Area 4A) - Sep 11, 2022 - Abstract #CHEST2022CHEST_3801;
She completed 12 days of antimicrobial therapy with levofloxacin and was discharged home... NTS pneumonia should be suspected in salmonellosis with bacteremia, and the cause of DKA needs always to be investigated.
- ceftriaxone / Generic mfg., levofloxacin / Generic mfg., amoxycillin/clavulanate / Generic mfg.
PULMONARY ABSCESS DEVELOPING AFTER FAILED TREATMENT FOR COMMUNITY-ACQUIRED PNEUMONIA (Convention Center Exhibit Hall: Rapid Area 2B) - Sep 11, 2022 - Abstract #CHEST2022CHEST_3781;
Therefore, any patient with an unresolved respiratory infection not responding to empirical antibiotic therapy, lobar consolidation on repeated radiological imaging, S. anginosus empyema should be in differentials. To ensure resolution, aggressive management with antibiotics, drainage, and, if necessary, surgical debridement should be done.
- DEEP IN THE LUNGS: A CASE OF AN ATYPICAL LUNG ABSCESS CAUSED BY STREPTOCOCCUS CONSTELLATUS AND GRANULICATELLA ADIACENS (Convention Center Exhibit Hall: Rapid Area 4B) - Sep 11, 2022 - Abstract #CHEST2022CHEST_3685;
He was prescribed Amoxicillin-Clavulanate and a repeat bronchoscopy was performed...He was started on IV Vancomycin but, due to recurrent PICC line associated DVT, was switched to oral Levofloxacin and completed 6 weeks of antibiotics... It is important for clinicians to be aware of serious infections caused by these commensals to provide timely diagnosis and management with appropriate antibiotics.
- levofloxacin / Generic mfg.
ATYPICAL PRESENTATION OF FAT EMBOLISM SYNDROME IN AN IMMUNOCOMPROMISED PATIENT (Convention Center Exhibit Hall: Rapid Area 4C) - Sep 11, 2022 - Abstract #CHEST2022CHEST_3589;
The diagnosis of fat embolism syndrome condition should still be suspected despite a delay from the initial surgery. Diagnosis in immunocompromised patients requires a detailed workup to rule out other etiologies.
- Humira (adalimumab) / Eisai, AbbVie
DISSEMINATED PULMONARY HISTOPLASMOSIS PRESENTING AS MILIARY PATTERN ON IMAGING (Convention Center Exhibit Hall: Rapid Area 1C) - Sep 11, 2022 - Abstract #CHEST2022CHEST_3581;
Histoplasmosis can present as severe pulmonary disease or disseminated infections in immunocompromised patients. In such patients in endemic areas, imaging findings of a miliary pattern of diffuse pulmonary nodules should prompt early evaluation for histoplasmosis infection with consideration for empiric treatment.
- ethambutol / Generic mfg., levofloxacin / Generic mfg.
FLUID IN THE FISSURE: DIAGNOSTIC CHALLENGE WITH A RARE CASE OF EXTRAPULMONARY TB (Convention Center Exhibit Hall: Rapid Area 1D) - Sep 11, 2022 - Abstract #CHEST2022CHEST_3489;
Although active TB was unconfirmed, given high clinical suspicion, the decision was made to empirically treat with rifampin, ethambutol, and levofloxacin. Despite pragmatic challenges in diagnostic workup, empiric treatment for extrapulmonary TB through prioritized differential diagnosis can improve clinical outcome.
- prednisone / Generic mfg., levofloxacin / Generic mfg., trimethoprim/sulfamethoxazole / Generic mfg.
ORGANIZING PNEUMONIA WITH FOREIGN BODY REACTION AS A RESULT OF SODIUM HYDROXIDE AND AMMONIUM SALT VAPOR EXPOSURE (Convention Center Exhibit Hall: Rapid Area 2D) - Sep 11, 2022 - Abstract #CHEST2022CHEST_3477;
High suspicion for occult pneumonitis should exist when patients present with prolonged exposure to cleaning/noxious chemical vapors exist. Respiratory protection should be emphasized as a public health policy to prevent lung damage among any type of cleaner use including high-skilled (HVAC) cleaners.
- levofloxacin / Generic mfg.
A CASE OF DIFFUSE ALVEOLAR HEMORRHAGE SECONDARY TO LEGIONELLA PNEUMONIA IN A YOUNG IMMUNOCOMPETENT PATIENT (Convention Center Exhibit Hall: Rapid Area 2D) - Sep 11, 2022 - Abstract #CHEST2022CHEST_3475;
Clinicians should be aware of this rare association in critically ill patients. We encourage the development of higher-quality evidence to determine early severity indicators and the role of corticosteroid therapy in survival.
- TRIPLE WHAMMY IS NO LAUGHING MATTER: A CASE OF STAGE IV SARCOIDOSIS, SEVERE BRONCHIECTASIS, AND PULMONARY EMBOLISM (Convention Center Exhibit Hall: Rapid Area 2C) - Sep 11, 2022 - Abstract #CHEST2022CHEST_3407;
His respiratory status slowly improved, and he was discharged with supplemental oxygen, and apixaban... Our patient's rare combination of bronchiectasis, pneumonia, and pulmonary embolism may be linked to chronic low-grade sarcoidosis-related inflammation.
- Mycobutin (rifabutin) / Pfizer, Lupin
MYCOBACTERIUM SHIMOIDEI: A RARE NONTUBERCULOUS INFECTION IN A US PATIENT (Convention Center Exhibit Hall: Rapid Area 3A) - Sep 11, 2022 - Abstract #CHEST2022CHEST_3390;
Pyrazinamide was switched to levofloxacin 750mg daily and rifabutin 150mg daily due hepatotoxicity... Due to the rarity of M. Shimodeii, cases need to be reported in order to determine pathogenicity, predisposing risk factors and treatment of choice.
- levofloxacin / Generic mfg., amikacin sulfate / Generic mfg.
TB OR NOT TB: AN UNUSUAL TALE OF BACK PAIN AND CUTANEOUS TB (Convention Center Exhibit Hall: Rapid Area 4C) - Sep 11, 2022 - Abstract #CHEST2022CHEST_3342;
This is more important now than ever given social disparities in healthcare, the ease of international travel and the challenges we face with the emergence of resistance patterns. Early recognition and treatment can prevent complications and transmission of the disease.
- levofloxacin / Generic mfg., azithromycin / Generic mfg.
IGG4-RELATED DISEASE: A RARE ETIOLOGY OF CAVITARY LUNG DISEASE (Convention Center Exhibit Hall: Rapid Area 4B) - Sep 11, 2022 - Abstract #CHEST2022CHEST_3276;
Her initial chest X-ray done 3 weeks prior showed a left lower lobe (LLL) opacity concerning for a bacterial pneumonia and she was treated with azithromycin, levofloxacin, and metronidazole. IgG4-RD is a rare cause of cavitary lung mass that should be considered if the routine workup for infectious and malignant etiologies is unrevealing.
- Biktarvy (bictegravir/emtricitabine/tenofovir alafenamide) / Gilead
A TALE OF TWO CONDITIONS: HUMAN HERPESVIRUS (HHV) TYPE 8 MANIFESTED AS KAPOSI SARCOMA AND PRIMARY EFFUSION LYMPHOMA IN RECENTLY DIAGNOSED PATIENTS WITH HIV/AIDS (Convention Center Exhibit Hall: Poster Area) - Sep 11, 2022 - Abstract #CHEST2022CHEST_3110;
He was discharged with a Pleurx catheter following the development of recurrent pleural effusions; started on bictegravir, emtricitabine, and tenofovir alafenamide for AIDS infection; levofloxacin for empyema; and sulfamethoxazole-trimethoprim for Pneumocystis Jirovecii prophylaxis. This case highlights the significance of thorough diagnostic workup in immunocompromised patients particularly when accounting for life prolonging treatments.
- levofloxacin / Generic mfg.
ASEPTIC LOCULATED EMPYEMA WITH FAILED DECORTICATION CONVERTED TO A THORACOPLASTY WITH LATISSIMUS DORSI AND SERRATUS ANTERIOR MUSCLE FLAP (Convention Center Exhibit Hall: Poster Area) - Sep 11, 2022 - Abstract #CHEST2022CHEST_3106;
He was given levofloxacin and transferred to a tertiary care center... When chronic inflammation and persistent empyema are not appropriately targeted with decortication, a limited thoracoplasty may be pursued to reduce the thoracic cavity.
- | ciprofloxacin oral / Generic mfg., levofloxacin / Generic mfg., amoxicillin / Generic mfg.
Journal: Changes in antibiotic consumption patterns after the implementation of the National Action Plan according to the AWaRe (Access, Watch, Reserve) classification system. (Pubmed Central) - Sep 10, 2022
After the implementation of the NAP in South Korea, antibiotic use in terms of total antibiotics and fluoroquinolone in the watch and reserve groups decreased. Further policies to improve the use of antibiotics in the watch and reserve groups are needed.
- | Invanz (ertapenem) / Merck (MSD)
Journal: Clonal and Horizontal Transmission of bla among Klebsiella pneumoniae in Children's Intensive Care Units. (Pubmed Central) - Sep 10, 2022
In addition, our findings provided recommendations for pediatric clinicians to use antibiotics to treat NDM-KP infections. Our current large-scale epidemiological survey would support further infection intervention strategies of NDM-KP in NICU/PICU of children's hospitals.
- || levofloxacin / Generic mfg.
Clinical, Retrospective data, Review: Safety of Quinolones in Children: A Systematic Review and Meta-Analysis. (Pubmed Central) - Sep 10, 2022
Our current large-scale epidemiological survey would support further infection intervention strategies of NDM-KP in NICU/PICU of children's hospitals. Although the existing evidence shows that quinolone-induced musculoskeletal ADEs seem to be only short-term and reversible, and no serious skeletal and muscular system damage cases have been reported in children, quinolones should be avoided unless necessary in children because the incidence rate of quinolone-related ADEs is not low and they are broad-spectrum antibiotics that will induce the emergence of resistant strains if used frequently.
- | ciprofloxacin oral / Generic mfg., levofloxacin / Generic mfg.
Journal: Exploration of fluoroquinolone-induced retinal pigment epithelium layer changes in the pathogenesis of macular degeneration. (Pubmed Central) - Sep 10, 2022
This study evaluated the association between the administration of oral fluoroquinolone and the onset of acute retinal degeneration. Preliminary results of this study showed that use of oral fluoroquinolone had no detectable impact on retinal degeneration at acute phase.
- || levofloxacin / Generic mfg.
PK/PD data, Journal: Pharmacokinetics and Safety of WHO-recommended Dosage and Higher Dosage of Levofloxacin for Tuberculosis Treatment in Children: A pilot study. (Pubmed Central) - Sep 10, 2022
Preliminary results of this study showed that use of oral fluoroquinolone had no detectable impact on retinal degeneration at acute phase. Levofloxacin at a higher dose of 20-30 mg/kg/day could achieve the fAUC/MIC target in children.
- | Baxdela (delafloxacin) / Menarini, Melinta Therap
Journal: Activity of Delafloxacin and Levofloxacin against Stenotrophomonas maltophilia at Simulated Plasma and Intrapulmonary pH Values. (Pubmed Central) - Sep 10, 2022
Therefore, the purpose of this study was to investigate whether one drug might be better than the other in this setting by testing each agent's ability to kill S. maltophilia at pH 7.3 and pH 6.5. These findings could then be used to design confirmatory studies that may ultimately impact which drug is given to patients with lung infections due to S. maltophilia.
- | Journal: Emergence and Evolution of Unique Plasmids Harboring bla and bla in Multidrug-Resistant Providencia rettgeri. (Pubmed Central) - Sep 10, 2022
This strain is resistant to β-lactams, amikacin, levofloxacin, and colistin...IMPORTANCE Although Providencia rettgeri is an opportunistic pathogen, its intrinsic resistance to colistin and tigecycline makes the treatment of carbapenem-resistant P. rettgeri challenging...We show that bla, bla, and bla are present on unique plasmids and that they have high similarities to the plasmid of another IMP-70-producing P. rettgeri isolate that was identified as being from the same location. The evolution of plasmids through mutations and recombination may play a role in the development and spread of multidrug resistance.
- | levofloxacin / Generic mfg., amikacin sulfate / Generic mfg.
Observational data, Journal: Investigating resistance in clinical Mycobacterium tuberculosis complex isolates with genomic and phenotypic antimicrobial susceptibility testing: a multicentre observational study. (Pubmed Central) - Sep 10, 2022
The combined analysis of mutations and quantitative phenotypes shows the potential of WGS to produce a refined interpretation of resistance, which is needed for individualised therapy, and eventually could allow differential drug dosing. However, variability of MIC data for some M tuberculosis complex isolates carrying identical mutations also reveals limitations of our understanding of the genotype and phenotype relationships (eg, including epistasis and strain genetic background).
- | ciprofloxacin oral / Generic mfg., levofloxacin / Generic mfg., ceftazidime / Generic mfg.
Journal: Description of a Rare Pyomelanin-Producing Carbapenem-Resistant Acinetobacter baumannii Strain Coharboring Chromosomal OXA-23 and NDM-1. (Pubmed Central) - Sep 10, 2022
Our study provides important insights into the new rare ST164 A. baumannii strain with high level carbapenem resistance, which is of great threat for patients. These findings will provide important insights into the resistance gene transfer via transposition events and further spread in the clinic.
- | Mycobutin (rifabutin) / Pfizer, Lupin, Lamprene (clofazimine) / Novartis
Journal: Arabinosyltransferase C Mediates Multiple Drugs Intrinsic Resistance by Altering Cell Envelope Permeability in Mycobacterium abscessus. (Pubmed Central) - Sep 10, 2022
Here, we selected and confirmed an M. abscessus transposon mutant that is hypersensitive to multiple drugs including rifampin, rifabutin, vancomycin, clofazimine, linezolid, imipenem, levofloxacin, cefoxitin, and clarithromycin...Importantly, treatment of M. abscessus with ethambutol, a first-line antituberculosis drug targeting arabinosyltransferases of M. tuberculosis, largely sensitized M. abscessus to multiple antibiotics in vitro...Knockout of MAB_0189c made M. abscessus become susceptible to 3 drugs in mice. These findings indicated that potential powerful M. abscessus EmbC inhibitor might be used to reverse the intrinsic resistance of M. abscessus to multiple drugs.
- || Retrospective data, Review, Journal: Prevalence of antibiotic heteroresistance associated with Helicobacter pylori infection: A systematic review and meta-analysis. (Pubmed Central) - Sep 10, 2022
Considering the role of heteroresistance H. pylori infection in treatment failure, it is very important for gastroenterologists to improve their knowledge about this fact. Regardingly, new guidelines should be developed and designed for the management and treatment of heteroresistance H. pylori infection.
- | ciprofloxacin oral / Generic mfg., levofloxacin / Generic mfg., norfloxacin / Generic mfg.
Journal: Loosely Sandwich-Structured Membranes Decorated with UiO-66-NH for Efficient Antibiotic Separation and Organic Solvent Resistance. (Pubmed Central) - Sep 10, 2022
Moreover, organic solvent resistance testing confirms that the sandwich-structured membrane maintained stable solvent flux and better recovery rates in ethanol, acetone, isopropanol, and N,N-dimethylformamide. Detailed nanofiltration mechanism studies revealed that these outstanding performances are based on the joint effect of the TA-PEI interlayer and PA-MOF selective layer, proposing a new perspective to break through the bottleneck of nanofiltration application in a complex environment.
- | Pneumosil (10-valent pneumococcal conjugate vaccine) / Serum Institute of India
Journal: Serotype Distribution and Antimicrobial Resistance of Streptococcus pneumoniae Causing Invasive Pneumococcal Disease in Korea Between 2017 and 2019 After Introduction of the 13-Valent Pneumococcal Conjugate Vaccine. (Pubmed Central) - Sep 10, 2022
Resistance rates to penicillin, ceftriaxone, erythromycin, and levofloxacin were 13.1%, 9.2%, 80.3%, and 4.1%, respectively...Differences in antimicrobial resistance were found according to the specific serotype. Continuous monitoring of serotypes and antimicrobial resistance is necessary for the appropriate management of S. pneumoniae infections.
- Hospital COVID-19 Burden Impact on Inpatient Antibiotic Use Rates (147 AB) - Sep 8, 2022 - Abstract #IDWeek2022IDWEEK_2567;
- levofloxacin / Generic mfg.
Relevance of Levofloxacin-Resistant MRSA and hVISA when utilizing directed antibiotic locks to treat stage 4 biofilm bone and joint infections (Hall B + C) - Sep 8, 2022 - Abstract #IDWeek2022IDWEEK_2309;
- In vitro activity of cefiderocol against difficult-to-treat resistance European Gram-negative bacterial pathogens from the multi-national sentinel surveillance study, SENTRY in 2020 and 2021 (Hall B + C) - Sep 8, 2022 - Abstract #IDWeek2022IDWEEK_2298;
- minocycline / Generic mfg.
Trends in the Susceptibility of US Acinetobacter baumannii-calcoaceticus Species Complex and Stenotrophomonas maltophilia Isolates to Minocycline, 2014-2021 (Hall B + C) - Sep 8, 2022 - Abstract #IDWeek2022IDWEEK_2283;
- Vabomere (meropenem/vaborbactam) / Melinta Therap
Activity of Meropenem-Vaborbactam and Comparators Against Isolates from Patients in Hematology/Oncology and Transplant Units in the United States (Hall B + C) - Sep 8, 2022 - Abstract #IDWeek2022IDWEEK_2282;
- gepotidacin (GSK2140944) / GSK
Activity of Gepotidacin Tested Against Molecularly Characterized Escherichia coli Isolates Resistant to Commonly Used Oral Therapies for UTI in the US (2019-2020) (Hall B + C) - Sep 8, 2022 - Abstract #IDWeek2022IDWEEK_2279;
- Baxdela (delafloxacin) / Menarini, Melinta Therap
In Vitro Evaluation of Delafloxacin Activity Against Contemporary US Isolates from Cystic Fibrosis Patients Hospitalized with Pneumonia: Results from the SENTRY Antimicrobial Surveillance Program (2019-2021) (Hall B + C) - Sep 8, 2022 - Abstract #IDWeek2022IDWEEK_2181;
- The Impact of a Clinical Practice Guideline and Educational Interventions on the Management of Children Hospitalized with Uncomplicated Community Acquired Pneumonia (Virtual) - Sep 8, 2022 - Abstract #IDWeek2022IDWEEK_2019;
- levofloxacin / Generic mfg.
Evaluation of Antimicrobial Susceptibility Patterns Following Implementation of Levofloxacin Prophylaxis in those with Cancer and Blood Disorders (Virtual) - Sep 8, 2022 - Abstract #IDWeek2022IDWEEK_2009;
- Discharge Antibiotic Prescribing at Children’s Hospitals with Established Antimicrobial Stewardship Programs (Hall B + C) - Sep 8, 2022 - Abstract #IDWeek2022IDWEEK_2007;
- Analysis of Staphylococcus aureus resistance patterns and antibiotic prescribing practices in a single tertiary pediatric center in South Florida (Virtual) - Sep 8, 2022 - Abstract #IDWeek2022IDWEEK_2003;
- levofloxacin / Generic mfg.
A randomized control trial on the effect of oral calcium carbonate to fecal levofloxacin concentration and microbiota diversity in healthy volunteers taking oral levofloxacin (Hall B + C) - Sep 8, 2022 - Abstract #IDWeek2022IDWEEK_1961;
- Evaluation of Electrocardiogram (ECG) Monitoring Practice in Newly Initiated Azole Antifungal Therapy (Hall B + C) - Sep 8, 2022 - Abstract #IDWeek2022IDWEEK_1927;
- Zinplava (bezlotoxumab) / Merck (MSD)
Evaluation of Bezlotoxumab for the Prevention of Recurrent Clostridioides difficile Infection in Patients Living With Cancer at a Large Comprehensive Cancer Center (Hall B + C) - Sep 8, 2022 - Abstract #IDWeek2022IDWEEK_1852;
- Bacterial Infections in the Setting of Late Neutropenia Following CD19 Chimeric Antigen Receptor T-Cell (CAR-T) Therapy for Non-Hodgkin Lymphoma (NHL) (Hall B + C) - Sep 8, 2022 - Abstract #IDWeek2022IDWEEK_1842;
- Dual VIM-producing Proteus mirabilis, Including a Novel VIM-75, Among Elderly Patients in a Medical Center from Hungary: Report from the 2020 SENTRY Antimicrobial Surveillance Program (Hall B + C) - Sep 8, 2022 - Abstract #IDWeek2022IDWEEK_1716;
- Trends in Hospital-onset Escherichia coli Infections Resistant to Fluoroquinolones and Extended-spectrum Cephalosporins, 2012-2020 (Hall B + C) - Sep 8, 2022 - Abstract #IDWeek2022IDWEEK_1681;
- Benchmarking the Use of New β-lactams Utilizing a Novel Metric of Microbiological Burden (Hall B + C) - Sep 8, 2022 - Abstract #IDWeek2022IDWEEK_1664;
- Serotype Prevalence and Antimicrobial Resistance Patterns of Streptococcus pneumoniae in Ecuador (Virtual) - Sep 8, 2022 - Abstract #IDWeek2022IDWEEK_1590;
- Clinical significance and antimicrobial susceptibilities of Roseomonas species infections (Hall B + C) - Sep 8, 2022 - Abstract #IDWeek2022IDWEEK_1114;
- Epidemiology, risk factors for mortality and resistance associated with Stenotrophomonas maltophilia bacteremia at a tertiary care hospital in Korea over 7 years (Hall B + C) - Sep 8, 2022 - Abstract #IDWeek2022IDWEEK_1041;
- Characterizing Treatment Duration of Viridans Group Streptococci Bacteremia in Neutropenic Cancer Patients: Is 14 Days Necessary? (Hall B + C) - Sep 8, 2022 - Abstract #IDWeek2022IDWEEK_1028;