levofloxacin / Generic mfg. 
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  • ||||||||||  Preclinical, Journal:  In vitro analysis of synergistic combination of polymyxin B with 12 other antibiotics against MDR Acinetobacter baumannii isolated from a Chinese tertiary hospital. (Pubmed Central) -  Oct 30, 2022   
    The results suggest that, for polymyxin B-based combination therapy against MDR A. baumannii as characterized in this hospital, cefperazone-sulbactam may be the best partner, since it has the highest synergistic rate and the best synergistic effect with polymyxin B. Minocycline, imipenem, meropenem, ceftazidime, cefepime, amikacin and sulfamethoxazole also have some synergistic effects with polymyxin B, but piperacillin-tazobactam, ciprofloxacin, levofloxacin and tobramycin show no synergism. None of these 12 antibiotics has an antagonistic effect when combined with polymyxin B.
  • ||||||||||  Nuvocid (oritavancin) / Melinta Therap, Cubicin (daptomycin) / Merck (MSD)
    Journal:  Eradication of Staphylococcus aureus Biofilm Infection by Persister Drug Combination. (Pubmed Central) -  Oct 29, 2022   
    Our study demonstrates an important treatment principle, the Yin-Yang model, for persistent infections by targeting both growing and non-growing heterogeneous bacterial populations, utilizing persister drugs for the more effective eradication of persistent and biofilm infections. Our findings have implications for the improved treatment of other persistent and biofilm infections in general.
  • ||||||||||  Journal:  Molecular Characterization and Antibiotic Susceptibility of Non-PCV13 Pneumococcal Serotypes among Vaccinated Children in Cape Coast, Ghana. (Pubmed Central) -  Oct 28, 2022   
    As such, 20 (21.5%), 49 (48.4%), and 70 (74.3%) isolates were non-susceptible to penicillin, tetracycline, and cotrimoxazole, respectively...However, non-susceptibility to ceftriaxone and erythromycin was low and all isolates were fully susceptible to levofloxacin, linezolid, and vancomycin...In conclusion, non-PCV13 serotype 23B was the most prevalent, with characteristics of rapid clonal expansion of ST172 and ST15111, which are related to international clones of the pneumococcus. Continuous monitoring of NVTs in Ghana is, therefore, essential, as they have the potential to cause invasive disease, show high antibiotic resistance, and attenuate the effects of PCV vaccination.
  • ||||||||||  Deltyba  (delamanid) / Otsuka
    Review, Journal:  Preventive Therapy for Contacts of Drug-Resistant Tuberculosis. (Pubmed Central) -  Oct 28, 2022   
    Additional evidence is also needed, regarding TPT treatment in fluoroquinolone-resistant-TB contacts, patient and health care worker perceptions on DR-TB preventive therapy for contacts, and the service delivery models to increase DR-TPT access. This state-of-the-art review presents the current literature on TPT for contacts of DR-TB cases, focusing on the available evidence and international guidelines.
  • ||||||||||  ciprofloxacin oral / Generic mfg., levofloxacin / Generic mfg.
    Journal:  Fluoroquinolone Derivatives in the Treatment of Mycobacterium tuberculosis Infection. (Pubmed Central) -  Oct 28, 2022   
    This might lead to new compounds that are efficient against resistant strains. This idea that the compounds may act by a different mechanism of action was further supported by a brief computer investigation that demonstrated the potential lack of selectivity of the esters to the fluoroquinolone target.
  • ||||||||||  Journal:  Achyranthes aspera Extracts as Adjuvants for the Redressal of Antibiotic Resistance. (Pubmed Central) -  Oct 28, 2022   
    For Methicillin-resistant Staphylococcus aureus Cefoxitin, Penicillin, and Co-trimoxazole were resistant out of seven antibiotics...For Enterococcus faecalis, Ciprofloxacin, Levofloxacin, Penicillin, Amoxicillin, Imipenem, and Vancomycin were resistant after treatment with the plant extracts, and the Ciprofloxacin, Levofloxacin, Imipenem, and Vancomycin zones of inhibition were from the resistant to the sensitive range...For Acinetobacter baumannii, Ciprofloxacin, Levofloxacin, Ceftriaxone, Ceftazidime, and Imipenem were resistant...No zone of inhibition was observed for Pseudomonas aeruginosa before or after using plant extracts against any antibiotic. This study suggests that the Achyranthes aspera seed and leaf extracts can reverse antibiotic resistance without any side effects on the human body, and that they can reverse antibiotic resistance naturally.
  • ||||||||||  ciprofloxacin oral / Generic mfg., levofloxacin / Generic mfg.
    Preclinical, Journal:  The Combination of Salmonella Phage ST-3 and Antibiotics to Prevent Salmonella Typhimurium In Vitro. (Pubmed Central) -  Oct 28, 2022   
    The phage ST-3 combined with 0.5 µg/mL levofloxacin hydrochloride resulted in the largest decrease in biofilm biomass at 54%. The phage ST-3 could be a potential agent to control Salmonella Typhimurium growth and provide instruction for use it and antibiotics together.
  • ||||||||||  Journal:  Genotypic Detection of qnrA and qnrC Genes in Citrobacter koseri Isolated from Patients with Urinary Tract Infection. (Pubmed Central) -  Oct 27, 2022   
    Whereas Gentamicin showed a moderate rate of resistance (4 isolates, 57.14%), and Amikacin resistance was found in 5 isolates, accounting for 28.57%...However, the recorded data demonstrated that there is no isolate carrying the qnrC gene. Among all pathogenic bacteria, C. koseri was the lowest causative agent of UTI in this study and was highly resistant to most antimicrobials except Imipenem, which was a good antibiotic with 100% sensitivity.
  • ||||||||||  Preclinical, Journal:  Influence of Antibiotics on Functionality and Viability of Liver Cells In Vitro. (Pubmed Central) -  Oct 27, 2022   
    Rifampicin and cefuroxime showed significantly negative effects on the viability of test cells. (4) Further in vitro studies and global pharmacovigilance reports should be conducted to reveal underlying mechanism of the hepatotoxic action of vancomycin, rifampicin, tigecycline, and cefuroxime, as well as the clinical relevance of these findings.
  • ||||||||||  Voquezna (vonoprazan) / Takeda, Phathom Pharma
    Trial completion, Trial primary completion date:  The Study on the Selection of Time for Retreatment of Helicobacter Pylori After Eradication Failure (clinicaltrials.gov) -  Oct 27, 2022   
    P=N/A,  N=820, Completed, 
    (4) Further in vitro studies and global pharmacovigilance reports should be conducted to reveal underlying mechanism of the hepatotoxic action of vancomycin, rifampicin, tigecycline, and cefuroxime, as well as the clinical relevance of these findings. Recruiting --> Completed | Trial primary completion date: Dec 2021 --> Jun 2022
  • ||||||||||  levofloxacin / Generic mfg., rifampicin / Generic mfg.
    Retrospective data, Journal:  Factors influencing treatment outcomes in patients with isoniazid-resistant pulmonary TB. (Pubmed Central) -  Oct 26, 2022   
    A levofloxacin-based regimen offers a treatment success rate of 82% in patients with pulmonary INH TB. Sex-specific strategies, interventions to address smoking and alcohol use, focus on HIV-reactive patients and optimising treatment regimens based on drug susceptibility should be considered for improving treatment outcomes.
  • ||||||||||  ciprofloxacin oral / Generic mfg., levofloxacin / Generic mfg., moxifloxacin intravenous / Generic mfg.
    Journal:  A Sensor Array Based on Molecularly Imprinted Polymers and Machine Learning for the Analysis of Fluoroquinolone Antibiotics. (Pubmed Central) -  Oct 26, 2022   
    1 μM, and a wide detection range up to 300 μM for the three FQs. Lastly, the developed ET presents satisfactory agreement between the expected and obtained values when used for the simultaneous determination of mixtures of the three FQs (R ≥0.960, testing subset), which was also applied to the analysis of FQs in commercial pharmaceuticals and spiked human urine samples.
  • ||||||||||  Omnicef  (cefdinir) / Abbott
    Retrospective data, Journal:  Assessment of nationally recommended antibiotics for treatment of UTI in U.S.-Mexico border emergency departments. (Pubmed Central) -  Oct 25, 2022   
    Although not listed as first line agents per current IDSA recommendations, 2nd and 3rd generation cephalosporins, and amoxicillin/clavulanate would be acceptable options given resistance patterns demonstrated in accordance with IDSA allowance for tailoring selection to local resistance. Nitrofurantoin appears to be consistent with recommendations and demonstrates a favorable resistance profile for treatment of outpatient UTI within this region.
  • ||||||||||  clarithromycin / Generic mfg., azithromycin / Generic mfg.
    Journal:  Determination of the Postexposure Prophylactic Benefit of Oral Azithromycin and Clarithromycin Against Inhalation Anthrax in Cynomolgus Macaques. (Pubmed Central) -  Oct 25, 2022   
    The efficacy of clarithromycin prophylaxis was statistically significant compared with placebo, while azithromycin prophylaxis was indistinguishable from placebo. Given the low plasma concentrations of azithromycin achieved in the study, it is not surprising that half the animals succumbed to anthrax during the dosing period; the animals that survived beyond the time during which placebo control animals succumbed survived to the end of the observation period.
  • ||||||||||  ciprofloxacin oral / Generic mfg., levofloxacin / Generic mfg.
    Trial completion date, Trial primary completion date:  Ciprofloxacin Versus Levofloxacin in Stem Cell Transplant (clinicaltrials.gov) -  Oct 25, 2022   
    P2,  N=308, Recruiting, 
    The phenotypic susceptibility was consistent with the genotypic characteristic without non-synonymous mutations associated with drug resistance. Trial completion date: Aug 2022 --> Aug 2024 | Trial primary completion date: Aug 2022 --> Aug 2023
  • ||||||||||  Prevalence of Polymicrobial Urinary Tract Infections: Molecular Diagnostic Approach () -  Oct 24, 2022 - Abstract #AMP2022AMP_448;    
    The identification of polymicrobial infections along with antimicrobial sensitivity data will assist clinicians providing personalized treatment resulting in better patient outcomes. Widespread adoption of this approach should improve antibiotic stewardship.
  • ||||||||||  ciprofloxacin oral / Generic mfg., levofloxacin / Generic mfg.
    Journal:  Effect of Ciprofloxacin, Levofloxacin, and Ofloxacin on Pseudomonas aeruginosa: A case control study with time kill curve analysis. (Pubmed Central) -  Oct 22, 2022   
    Statistical analysis showed there were significant differences in the number of colonies p < 0.001 in the second, fourth, sixth, and eighth hour between the three isolates, p < 0.001 in the sixth and second 4 h between 1MIC and 4MIC, p = 0.012 in the second 4 h between levofloxacin and ofloxacin antibiotics. Levofloxacin has shown to have better bactericidal activity than ciprofloxacin, and ciprofloxacin has almost the same bactericidal activity as ofloxacin in vitro tests seen from the time-kill curve.
  • ||||||||||  Preclinical, Journal:  Investigation of the effects of three different generations of fluoroquinolone derivatives on antioxidant and immunotoxic enzyme levels in different rat tissues. (Pubmed Central) -  Oct 21, 2022   
    Fluoroquinolones (FQs) are synthetic and broad-spectrum antimicrobial drugs derived from nalidixic acid...The present study investigated the effect of 1-,7-,14-day treatments of three different FQ derivatives; ciprofloxacin (CIP) 80 mg/kg/day, levofloxacin (LVX) 40 mg/kg/day, and moxifloxacin (MXF) 40 mg/kg/day, on biochemical parameters, lipid peroxidation, antioxidant enzymes, and immunotoxicity...It has been concluded that FQ derivatives used in this experiment did not display any correlation in terms of the efficacies in the different time points and tissues. Thus, it is recommended to use such FQ derivatives considering the duration of use and target tissue.
  • ||||||||||  levofloxacin / Generic mfg., tetracycline / Generic mfg.
    Journal:  Dye-encapsulated Zr-based MOFs composites as a sensitive platform for ratiometric luminescent sensing of antibiotics in water. (Pubmed Central) -  Oct 20, 2022   
    Interestingly, these two peak intensities were switched anisotropically by levofloxacin (LEV), in which the signal at 515 nm was enhanced...In addition, TET and LEV were also successfully detected by FS@UIO66 in water from real water environment. The results indicate that FS@UIO66 composites are favorable for TET and LEV detection, presenting a great sensing platform for antibiotic detection.
  • ||||||||||  Timcynis (ticarcillin and clavulanic acid) / Emcure Pharma
    Journal:  Analysis of drug resistance genes of integrons in clinical isolates of Escherichia coli from elderly bloodstream infections. (Pubmed Central) -  Oct 20, 2022   
    The resistance rate of 230 strains of E. coli to meropenem, minocycline, amikacin, gentamicin and cefoxitin was less than 20%...ESBLs-producing genotyping-positive bacteria were detected with more than 50% of type I integrated genes. It was concluded that type I integrated genes in ESBLs-producing E. coli isolated from elderly patients carried resistance genes such as CTX-M-9 and CTX-M-2 aggravating multi-drug resistance in bacteria.
  • ||||||||||  ciprofloxacin oral / Generic mfg., levofloxacin / Generic mfg.
    Journal:  Human health risk estimation of antibiotics transferred from wastewater and soil to crops. (Pubmed Central) -  Oct 19, 2022   
    Risk quotient of both LEV and CIP in current study is found to be in between 0.018 and 0.557 and shows a medium risk (0.1 to 1) to human health due the discharge of untreated wastewater into the fields. However, our study reports that both antibiotics do accumulate in the edible plant parts; therefore, it poses potential risks to human health.