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137 Trials |
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137 Trials |  |
5343 News |  |
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- || Cayston (aztreonam lysine) / Gilead
Review, Journal: Inhaled anti-pseudomonal antibiotics for long-term therapy in cystic fibrosis. (Pubmed Central) - Nov 15, 2022
More evidence from trials measuring similar outcomes in the same way is needed to determine a better measure of benefit. Longer-term trials are needed to look at the effect of inhaled antibiotics on quality of life, survival and nutritional outcomes.
- Xifaxan (rifaximin) / Alfa Wassermann, Bausch Health, Norgine, ASKA Pharma
Efficacy of Rifaximin add-on Levofloxacin Regimen as Third-line Rescue Therapy of Helicobacter pylori Eradication (Room 4) - Nov 12, 2022 - Abstract #KDDW2022KDDW_412;
- Tubo-ovarian Abscess in a Non-sexually Active Adolescent Female: an Uncommon Diagnosis (Anaheim Convention Center, Hall A, Board # 186) - Nov 10, 2022 - Abstract #AAPNCE2022AAP_NCE_2156;
This case highlights that early recognition is key to diagnosis and appropriate management of TOA in a non-sexually active adolescent female. A multi-disciplinary approach is critical to optimize therapeutic options including antibiotics, surgery, and IR drainage.
- vancomycin / Generic mfg., levofloxacin / Generic mfg.
Elizabethkingia Miricola: A First Report of bacteremia in an At-risk Pediatric Patient (Anaheim Convention Center, Hall A, Board # 166) - Nov 10, 2022 - Abstract #AAPNCE2022AAP_NCE_2136;
E. miricola is a rare opportunistic gram-negative bacillus that has the ability to cause invasive infections in susceptible hosts.
- | Journal: Occurrence and significance of fluoroquinolone-resistant and ESBL-producing Escherichia coli and Klebsiella pneumoniae complex of the rectal flora in Ghanaian patients undergoing prostate biopsy. (Pubmed Central) - Nov 10, 2022
Amikacin and meropenem were the most effective antibiotics against the MDR rectal E. coli and K. pneumoniae complex (78.7% and 84.3%, respectively)...Rectal colonization by ESBL-positive E. coli and K. pneumoniae complex comprised an independent risk factor for post-biopsy infectious complications. The findings suggest that a change in prophylactic antibiotics to a more targeted regimen may be warranted in our institution.
- || Review, Journal: Fluoroquinolone antibiotics: Occurrence, mode of action, resistance, environmental detection, and remediation - A comprehensive review. (Pubmed Central) - Nov 10, 2022
This review provides a detailed overview of the classification, occurrence, distribution, and ecotoxicological effects of Fluoroquinolones. Their modes of action, resistance mechanism, detection and analysis methods, and remediation strategies have also been discussed in detail.
- | AzaSite (1% azithromycin ophthalmic solution) / Sun Pharma, Akorn, Nicox
Trial completion, Trial completion date, Trial primary completion date: Healthy Patients & Effect of Antibiotics (clinicaltrials.gov) - Nov 10, 2022
P=N/A, N=20, Completed, Sponsor: Washington University School of Medicine
Their modes of action, resistance mechanism, detection and analysis methods, and remediation strategies have also been discussed in detail. Active, not recruiting --> Completed | Trial completion date: Dec 2022 --> Aug 2022 | Trial primary completion date: Dec 2022 --> Aug 2022
- || levofloxacin / Generic mfg.
Clinical data, Journal: Correlation of Vitek 2 and Agar dilution for levofloxacin susceptibility testing and clinical outcomes of Enterobacterales bacteremia with 2019 CLSI breakpoints. (Pubmed Central) - Nov 9, 2022
In conclusion, Vitek 2 performance for levofloxacin susceptibility testing of Enterobacterales declined according to the 2019 CLSI criteria compared with the pre-2019 criteria. Although discrepant results were obtained, the MICs measured by Vitek 2 could still predict treatment outcomes.
- | Journal: A battery of tandem mass spectrometry assays with stable isotope-dilution for the quantification of 15 anti-tuberculosis drugs and two metabolites in patients with susceptible-, multidrug-resistant- and extensively drug-resistant tuberculosis. (Pubmed Central) - Nov 9, 2022
Although discrepant results were obtained, the MICs measured by Vitek 2 could still predict treatment outcomes. Such convenient extraction methods and the use of stable isotope-labelled drugs as internal standards provide an accurate and precise quantification of plasma concentrations of all major clinically-used antiTB drugs regimens and is optimally suited for clinically efficient TDM against tuberculosis.
- ||| levofloxacin / Generic mfg.
Retrospective data: I am not quite sure whether levofloxacin or combo therapy are better, most studies are retrospective. To the best of my knowledge there is no prospective study/RTC (Twitter) - Nov 9, 2022
- || levofloxacin / Generic mfg., azithromycin / Generic mfg.
https://t.co/HuWBLxQ78q it seems azithromycin and levofloxacin are equally effective (Twitter) - Nov 9, 2022
- ||| levofloxacin / Generic mfg., doxycycline / Generic mfg.
Combination therapy: Why not doxycycline in combination with levofloxacin? (Twitter) - Nov 9, 2022
- |||| levofloxacin / Generic mfg., tigecycline / Generic mfg.
Combination therapy: Any thoughts on tigecycline in combination with levofloxacin as salvage therapy for severe Legionella pneumonia? #IDTwitter #TwitteRx @BradSpellberg @DrToddLee @jpogue1 @IdVilchez @ABsteward (Twitter) - Nov 9, 2022
- | levofloxacin / Generic mfg., rifampicin / Generic mfg., minocycline / Generic mfg.
Journal: Leprosy chemoprophylaxis of household contacts: A survey of Canadian infectious disease and tropical medicine specialists. (Pubmed Central) - Nov 8, 2022
Such convenient extraction methods and the use of stable isotope-labelled drugs as internal standards provide an accurate and precise quantification of plasma concentrations of all major clinically-used antiTB drugs regimens and is optimally suited for clinically efficient TDM against tuberculosis. Consensus among Canadian infectious diseases specialists is lacking regarding leprosy PEP and screening of household contacts.
- | levofloxacin / Generic mfg., erythromycin / Generic mfg.
Journal: Clinical and molecular epidemiology of invasive group B Streptococcus infections in adults in a referral center in Korea. (Pubmed Central) - Nov 8, 2022
Serotypes Ib, III, and V were most common among adults, which is inconsistent with recent reports in Korea where III, V, and Ia were predominant in infants. The difference in the serotype distribution between adults and children may be associated with the selective pressure imparted by antibiotics.
- || Gracevit (sitafloxacin) / Daiichi Sankyo
PK/PD data, Preclinical, Journal: Sitafloxacin pharmacokinetics/pharmacodynamics against multidrug-resistant bacteria in a dynamic urinary tract infection in vitro model. (Pubmed Central) - Nov 5, 2022
The difference in the serotype distribution between adults and children may be associated with the selective pressure imparted by antibiotics. Sitafloxacin fumarate injection is an alternative therapeutic agent for the treatment of UTIs caused by MDR isolates.
- | Journal: The Clinical Features and Management of Empyema Caused by Streptococcus constellatus. (Pubmed Central) - Nov 5, 2022
constellatus were sensitive to penicillin G, linezolid, levofloxacin, vancomycin, ceftriaxone, and chloramphenicol, resistant to erythromycin, tetracycline, and clindamycin...constellatus often co-isolated with anaerobes in empyema. Antibiotics should cover simultaneously both S. constellatus and anaerobes.
- ||| levofloxacin / Generic mfg.
Interesting paper looking at (predominantly observational) studies of Levofloxacin to prevent infection in kids with leukemia. (Twitter) - Nov 4, 2022
- Campath (alemtuzumab) / Sanofi
Infectious Disease Antimicrobial Prophylaxis Strategies in Children with Severe or Very Severe Aplastic Anemia: A North American Pediatric Aplastic Anemia Consortium (NAPAAC) Study (ENMCC - Hall D) - Nov 4, 2022 - Abstract #ASH2022ASH_6683;
Interestingly, the majority of centers do not have written ID prophylaxis guidelines in place and in centers with a prophylaxis CPG for this population, practice variability persists regarding type of prophylaxis, preferred agents, and criteria to start and stop prophylaxis. This study underscores the need for sAA/vsAA-specific data to inform national guidelines regarding optimal antimicrobial prophylaxis strategies in these high-risk children.
- levofloxacin / Generic mfg.
Improvement of Platelet Count after Helicobacter Pylori Screening and Eradication in Immune Thrombocytopenia Patients: A Randomized Open-Label Study (ENMCC - 220-222) - Nov 4, 2022 - Abstract #ASH2022ASH_5320;
The prevalence of HP infection in adult Thai ITP patients was 47.9%. HP screening is effective in the improvement of platelet count and quality of life at 6 months in adult ITP patients with platelet count below 150 x 109/L.
- IV Antibiotic Use during Autologous Hematopoietic Stem Cell Transplantation Is Associated with Inferior Survival in Patients with Multiple Myeloma (ENMCC - Hall D) - Nov 4, 2022 - Abstract #ASH2022ASH_4823;
Two hundred thirty-seven subjects received IV antibiotics including cefepime or piperacillin/tazobactam and vancomycin predominantly to treat neutropenic fever...This finding supports a growing body of literature describing adverse long-term clinical impact of antibiotic exposure and on outcomes in cellular therapy, which we hypothesize is related to deleterious effects of antibiotic exposure on the gut microbiome. Larger prospective studies are necessary to further examine this relationship on myeloma outcomes.
- cyclophosphamide / Generic mfg.
Viridans Group Streptococcal Bacteremia after Allogeneic Stem Cell Transplant with Post-Transplant Cyclophosphamide (ENMCC - Hall D) - Nov 4, 2022 - Abstract #ASH2022ASH_4762;
A similar rate of VGS bacteremia has been reported in a cohort of alloHSCTs, but most cases were CBT, with prolonged post-HSCT neutropenia. Similarly, PTCy may increase the risk of VGS bacteremia by prolongation of neutropenia.
- ciprofloxacin oral / Generic mfg., levofloxacin / Generic mfg., amoxycillin/clavulanate / Generic mfg.
Efficacy of Levofloxacin Versus Amoxicillin/Clavulanate and Ciprofloxacin in the Outpatient Management of Low-Risk Febrile Neutropenia in Children with Cancer; A Randomised Control Study (ENMCC - Hall D) - Nov 4, 2022 - Abstract #ASH2022ASH_4373;
Levofloxacin was tolerable in all patients with no significant side effects apart from insomnia reported by the parents in 1 patient, while patients in the double agent arm; 4 had diarrhoea, 2 nausea and 2 complained of bad drug taste. Conclusions Levofloxacin has better efficacy and can be administered safely in children with low-risk FN, however close follow-up for long-term side effects and monitoring of possible emerging bacterial resistance is warranted.
- Prevymis (letermovir) / Merck (MSD)
Impact of Ptcy-Based Prophylaxis on Early Infectious Complications in Adults Undergoing Peripheral Blood Allo-HCT (ENMCC - Hall D) - Nov 4, 2022 - Abstract #ASH2022ASH_2935;
Lastly, despite the low mortality rate directly attributed to BK HC, the presence of this complication increased the probability of mortality at 1 year. Based on these results, further refinements will be done focussed on preventing HC after PTCY administration.
- | Journal: A successful management algorithm for vulvar abscess: A tertiary hospital experience. (Pubmed Central) - Nov 4, 2022
This is the first study in the literature to present a successful algorithm for the treatment and management of vulvar abscess. Our treatment methods shed light on the treatment and management of vulvar abscess.
- | Journal: An Initial Survey on the Prevalence of Group B Streptococcus (GBS) among Yemeni Pregnant Women in Sana'a City. (Pubmed Central) - Nov 4, 2022
Beta-lactam antibiotics remain the drug of choice to treat and prevent GBS infections. A prenatal screening policy is urgently needed for Yemeni pregnant women.
- | levofloxacin / Generic mfg., trimethoprim/sulfamethoxazole / Generic mfg., minocycline / Generic mfg.
Journal: Trends in Stenotrophomonas maltophilia antibiotic resistance rates in the United States Veterans Affairs Health System. (Pubmed Central) - Nov 4, 2022
Resistance to SMX/TMP decreased over the study period in VA hospitals and now more closely reflects previously reported resistance rates worldwide (0-10 %). MDR S. maltophilia remained stable and low in the national VA Healthcare System.
- | levofloxacin / Generic mfg.
Journal: Fractionation of levofloxacin and ofloxacin during their transport in NOM-goethite: Batch and column studies. (Pubmed Central) - Nov 4, 2022
The EF values in the effluent increased with retention time and reached the largest values (0.59-0.72) at around 1.5 pore volume (PV), and then decreased again, reaching a stable value at 5.0-30.0 PV. Both batch and column experiments showed that, fractionation of LEV and OFL occurred during adsorption and transport in the presence of NOM-goethite complexes, which would eventually affect their environmental fate.
- || Clinical, Review, Journal: Antimicrobial resistance in patients with odontogenic infections: A systematic scoping review of prospective and experimental studies. (Pubmed Central) - Nov 3, 2022
Streptococcus had resistance to metronidazole, clindamycin, doxycycline, penicillin, and amoxicillin...Gram-negative microorganisms had resistance to tetracycline, ciprofloxacin, azithromycin, amoxicillin, erythromycin, and penicillin...exhibited resistance to penicillin, erythromycin, and gentamicin...showed resistance to penicillin, amoxicillin, erythromycin, clindamycin, levofloxacin, and imipenem...displayed resistance to ampicillin, amoxicillin, moxifloxacin, and cefalexin...A preponderance of anaerobic microorganisms over aerobic ones was observed. Key words:Antibiotic resistance, odontogenic infections, efficacy, microorganisms, scoping review.
- | levofloxacin / Generic mfg.
Journal: Synergies in antimicrobial treatment by a levofloxacin-loaded halloysite and gold nanoparticles with a conjugation to a cell-penetrating peptide. (Pubmed Central) - Nov 3, 2022
Concisely, the structure of the designed nano-cargo has been investigated by various methods, and the in vitro cellular experiments (zone of inhibition and colony-counting) have disclosed that the antimicrobial activity of the lvx is significantly enhanced through incorporation into the HNT/Au-CPP delivery system (drug content: 16 wt%), in comparison with the individual lvx with the same dosage. Hence, it can be stated that the bacterial resistance against antibiotics and the toxic effects of the chemical medications are reduced through the application of the presented strategy.
- | Journal: The Antimicrobial Effect Against Multi-Drug Resistant Bacteria of The SK4 Peptide: a Novel Hybrid Peptide of Cecropin-A and BMAP-27. (Pubmed Central) - Nov 3, 2022
Hence, it can be stated that the bacterial resistance against antibiotics and the toxic effects of the chemical medications are reduced through the application of the presented strategy. The SK4 peptide showed better activity, selectivity, and safety profile than the parent peptides, making it a novel potential treatment for MDR bacterial infections.
- || levofloxacin / Generic mfg.
Clinical, Journal: Randomized Clinical Trial of High Dose Rifampicin with or without Levofloxacin versus Standard of Care for Paediatric Tuberculous Meningitis: The TBM-KIDS Trial. (Pubmed Central) - Nov 2, 2022
P1/2
In a pediatric TBM trial, functional outcomes were excellent overall. The trend toward higher frequency of adverse events but better neurocognitive outcomes in children receiving high-dose rifampicin requires confirmation in a larger trial.
- | Journal: Phenotypic and genotypic antimicrobial susceptibility patterns of the emerging human respiratory pathogen Mycoplasma amphoriforme isolated from the UK and Denmark. (Pubmed Central) - Nov 2, 2022
To the best of our knowledge, this is the first time where phenotypic and genotypic resistance data have been paired for M. amphoriforme confirming a correlation between the two. These data suggest the need for focused testing and resistance determination of isolates from high-risk patients given the backdrop of a high prevalence of antimicrobial resistance.
- | levofloxacin / Generic mfg.
Journal: Clonal dissemination and resistance genes among Stenotrophomonas maltophilia in a Greek University Hospital during a four-year period. (Pubmed Central) - Nov 2, 2022
Two isolates (3%) were resistant to SXT and three (5%) to levofloxacin...Resistance of S. maltophilia was low and was not associated with sul1 or smqnr carriage. Although high degree of genetic diversity was identified (29 pulsotypes), 22/62 (35.5%) strains were classified into four clones; clone b was associated with bacteraemias.
- | levofloxacin / Generic mfg., meropenem / Generic mfg., amoxycillin/clavulanate / Generic mfg.
Trial initiation date: FRANCiS-NF: Fast-track Blood Test for Suspected Fever by Deficiency of a Kind of White Blood Cells As Main Defense Against Infection (clinicaltrials.gov) - Nov 2, 2022
P4, N=344, Recruiting, Sponsor: The University of Hong Kong
Although high degree of genetic diversity was identified (29 pulsotypes), 22/62 (35.5%) strains were classified into four clones; clone b was associated with bacteraemias. Initiation date: Jun 2022 --> Oct 2022
- | Journal: Impact of a pilot multimodal intervention to decrease antibiotic use for respiratory infections in a geriatric clinic. (Pubmed Central) - Nov 1, 2022
Low-cost interventions were initially successful in changing patterns of antibiotic use and decreasing overall antibiotic prescribing among older patients in the outpatient setting. Long-term follow-up studies are needed to determine the sustainability and clinical impact of these interventions.
- | Journal: Helicobacter pylori Antibiotic Resistance in Egypt: A Single-Center Study. (Pubmed Central) - Nov 1, 2022
In Egyptian patients, H. pylori had >90% resistance to metronidazole and amoxicillin; modest resistance to erythromycin, azithromycin, and clarithromycin; and low resistance to moxifloxacin, and levofloxacin (≤20%). Dual resistance was high for amoxicillin/clarithromycin and amoxicillin/metronidazole, which prefers using quinolones rather than clarithromycin or metronidazole for first-line treatment of H. pylori in Egypt.
- || Retrospective data, Review, Journal: Prevalence of ESBL-Producing Enterobacter Species Resistant to Carbapenems in Iran: A Systematic Review and Meta-Analysis. (Pubmed Central) - Nov 1, 2022
However, the resistance rate to carbapenems was relatively low, and these drugs can still be considered as drugs of choice for the treatment of Enterobacter infections in Iran. Nevertheless, continuous monitoring of drug resistance along with antibiotic therapy based on the local data and evaluation of the therapeutic efficacy of new antibiotics or combination therapeutic strategies, such as ceftazidime/avibactam, meropenem/vaborbactam, plazomicin, and eravacycline, is recommended.
- | Journal: Antimicrobial susceptibility profiles and tentative epidemiological cutoff values of Legionella pneumophila from environmental water and soil sources in China. (Pubmed Central) - Nov 1, 2022
Based on the big MIC data obtained in the present study, the same defense strategies, particularly against both CLA and RIF, may exist in L. pneumophila. The results determined in our study will guide further research on antimicrobial resistance mechanisms of L. pneumophila and could be used as a reference for setting clinical breakpoints and discovering antimicrobial-resistant isolates in the clinic, contributing to the antibiotic choice in the treatment of LD.
- | Journal: First report of Klebsiella pneumoniae co-producing OXA-181, CTX-M-55, and MCR-8 isolated from the patient with bacteremia. (Pubmed Central) - Nov 1, 2022
In this case, colistin is often used to treat the infection caused by CRE...Antimicrobial susceptibility testing showed that K. pneumoniae 5589 was resistant to aztreonam, imipenem, meropenem, ceftriaxone, cefotaxime, ceftazidime, levofloxacin, ciprofloxacin, gentamicin, piperacillin-tazobactam, cefepime, and polymyxin B, but sensitive to amikacin...The in vitro conjugation experiments and plasmid sequence probe indicated that the plasmid p5589-OXA-181 and the p5589-mcr-8 were conjugative, which may contribute to the propagation of ARGs. Relevant detection and investigation measures should be taken to control the prevalence of pathogens coharboring bla , bla and mcr-8.
- | Preclinical, Journal: Validation of risk-stratification method for the chronic atrioventricular block cynomolgus monkey model and its mechanistic interpretation using 6 drugs with pharmacologically-distinct profile. (Pubmed Central) - Nov 1, 2022
The magnitude of risk was intermediate for astemizole and haloperidol, and low/no risk for the others. The pre-specified, risk-stratification method for the monkey model may solve the issue existing between non-clinical models and patients with labile repolarization, which can reinforce the regulatory decision-making and labelling at time of marketing application of non-double-negative drug candidate (hERG assay positive and/or in vivo QT study positive).
- | ciprofloxacin oral / Generic mfg., levofloxacin / Generic mfg.
Journal: A preventable, life-altering case of fluoroquinolone-associated tendonitis. (Pubmed Central) - Nov 1, 2022
These drugs should not be used for uncomplicated infections unless no other antimicrobial treatment is feasible. This article describes a patient who experienced life-altering disability from a fluoroquinolone, reviews the adverse reactions of this drug class, and discusses recommended treatment for acute uncomplicated cystitis and asymptomatic bacteriuria.
- | levofloxacin / Generic mfg., tetracycline / Generic mfg., amoxicillin / Generic mfg.
Journal: A Complete Method for Evaluating the Performance of Photocatalysts for the Degradation of Antibiotics in Environmental Remediation. (Pubmed Central) - Nov 1, 2022
The stability of silver phosphate samples was further tested by a five-cycle experiment. This paper provides a complete process for evaluating the catalytic performance of semiconductor catalysts in the laboratory for the development of semiconductor catalysts with potential for practical applications.
- | levofloxacin / Generic mfg.
Journal: Pyrvinium pamoate potentiates levofloxacin against levofloxacin-resistant Staphylococcus aureus. (Pubmed Central) - Nov 1, 2022
PP synergized with levofloxacin both in vitro and in vivo, resulting in ∼1.5 and ∼0.5 log CFU/g reduction against susceptible and resistant S. aureus infections, respectively, as compared with untreated control. Pyrvinium potentiates levofloxacin against levofloxacin-resistant S. aureus.
- | Nuzyra (omadacycline) / Paratek
Preclinical, Journal: Omadacycline Is Highly Active In Vitro against Mycoplasma genitalium. (Pubmed Central) - Nov 1, 2022
We studied 10 isolates and determined that the new semisynthetic aminomethylcycline omadacycline is active against isolates that are resistant to tetracyclines, macrolides, and quinolones. These data suggest that clinical studies should be performed in order to see if omadacycline may be useful to treat urogenital infections caused by M. genitalium.
- | Cubicin (daptomycin) / Merck (MSD)
Enrollment status, Trial completion date, Trial initiation date, Trial primary completion date, Surgery: Postoperative Antibiotic Management Duration Following Surgery for Intravenous Drug Abuse (IVDA) Endocarditis (OPTIMAL) (clinicaltrials.gov) - Nov 1, 2022
P4, N=20, Enrolling by invitation, Sponsor: Vinay Badhwar
These data suggest that clinical studies should be performed in order to see if omadacycline may be useful to treat urogenital infections caused by M. genitalium. Recruiting --> Enrolling by invitation | Trial completion date: May 2023 --> Oct 2024 | Initiation date: Feb 2021 --> Mar 2022 | Trial primary completion date: May 2023 --> Oct 2024
- | Journal: Alarming antibiotics resistance of Helicobacter pylori from children in Southeast China over 6 years. (Pubmed Central) - Oct 30, 2022
The antibiotic resistance rates of H. pylori were high in a large pediatric population in southeast China from 2015 to 2020. Individual treatment based on susceptibility test is imperative and optimal regimens should be chosen in H. pylori eradication therapy.
- | Journal: In silico evaluation of WHO-endorsed molecular methods to detect drug resistant tuberculosis. (Pubmed Central) - Oct 30, 2022
PCR-based diagnostic tests were most sensitive for drugs where mechanisms of resistance are well established and localised to small genetic regions or a few prevalent mutations. Approaches using sequencing technologies can provide advantages for drugs where our knowledge of resistance is limited, or where complex resistance signatures exist.
- | Preclinical, Journal: In vitro analysis of synergistic combination of polymyxin B with 12 other antibiotics against MDR Acinetobacter baumannii isolated from a Chinese tertiary hospital. (Pubmed Central) - Oct 30, 2022
The results suggest that, for polymyxin B-based combination therapy against MDR A. baumannii as characterized in this hospital, cefperazone-sulbactam may be the best partner, since it has the highest synergistic rate and the best synergistic effect with polymyxin B. Minocycline, imipenem, meropenem, ceftazidime, cefepime, amikacin and sulfamethoxazole also have some synergistic effects with polymyxin B, but piperacillin-tazobactam, ciprofloxacin, levofloxacin and tobramycin show no synergism. None of these 12 antibiotics has an antagonistic effect when combined with polymyxin B.