levofloxacin / Generic mfg. 
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  • ||||||||||  levofloxacin / Generic mfg.
    Journal:  Efficient antibacterial AIEgens induced ROS for selective photodynamic treatment of bacterial keratitis. (Pubmed Central) -  Jan 24, 2023   
    Besides, TTVP manifested superior antibacterial efficacy than levofloxacin in acute BK, endowing its better vision salvage ability than conventional method. This research demonstrates the efficacy and advantages of TTVP as a photodynamic drug in the treatment of BK and represents its promise in clinical application of ocular infections.
  • ||||||||||  levofloxacin / Generic mfg.
    Journal:  Microbiome-Scale Analysis of Aerosol Facemask Contamination during Nebulization Therapy in the Hospital. (Pubmed Central) -  Jan 24, 2023   
    Sequencing-based microbiome-scale analysis is capable of providing comprehensive characterization of microbial contamination in aerosol facemasks. Insight gained from microbiome-scale analysis facilitates the development of effective strategies for the prevention and mitigation of nosocomial infection risks arising from exposure to microbial contamination of aerosol facemasks, such as targeted elimination of potential sources of contamination.
  • ||||||||||  Journal:  Antibiotic Resistance of Helicobacter pylori in Patients with Peptic Ulcer. (Pubmed Central) -  Jan 22, 2023   
    Therefore, continuous monitoring of antibiotic resistance of H. pylori in each population is very important. Having evidence helps clinicians to treat patients most effectively, reduce treatment costs, and limit the rate of antibiotic resistance.
  • ||||||||||  Journal:  Susceptibility and Virulence of Enterobacteriaceae Isolated from Urinary Tract Infections in Benin. (Pubmed Central) -  Jan 22, 2023   
    In regard to virulence genes, Sfa was the most detected (28.15%), followed by IronB (22.23%), iucD (21.36%), Cnf (15.53%), PapG (9.71%), FocG (8.74%), Sat (6.79%), FyuA (5.82%) and Hyl (2.91%). These data may help improve the diagnosis of uropathogenic strains of Enterobacteriaceae, but also in designing effective strategies and measures for the prevention and management of severe, recurrent, or complicated urinary tract infections in Benin.
  • ||||||||||  Takecab (vonoprazan) / Takeda, Phathom Pharma
    Review, Journal:  Management of Helicobacter pylori infection. (Pubmed Central) -  Jan 21, 2023   
    High-dose potent proton pump inhibitor or vonoprazan is recommended to achieve adequate acid suppression. Probiotics can be used as an adjuvant treatment to reduce the side effects of antibiotics and enhance eradication rate.
  • ||||||||||  levofloxacin / Generic mfg.
    Retrospective data, Journal:  Characteristics and impact of postoperative surgical site infection on increased antibiotic duration among patients with laryngocarcinoma: a retrospective cohort study. (Pubmed Central) -  Jan 17, 2023   
    Levofloxacin and cefoperazone-sulbactam were the most commonly used antibiotics for postoperative infection in both LRTI and SSI groups (P>0.05 for both), irrespective of antibiotic susceptibility tests or not...A multiple linear regression analysis including SSI, age, sex, diabetes, antibiotic susceptibility test and hypoalbuminemia showed that, SSI was independently associated with increased antibiotic duration with LRTI as the reference among LC patients diagnosed [regression coefficient β=3.02, 95% confidence interval (CI): 1.01-5.03, P=0.004], whereas antibiotic susceptibility test was not (P=0.467). SSI may be independently associated with increased postoperative antibiotic duration in patients with LC with or without antibiotic susceptibility test.
  • ||||||||||  levofloxacin / Generic mfg.
    Journal:  RNA-Targeting Carbon Dots for Live-Cell Imaging of Granule Dynamics. (Pubmed Central) -  Jan 17, 2023   
    Here we report the de novo design and microwave-assisted synthesis of a novel RNA-targeting, red-emissive carbon dots (named as M-CDs) by choosing neutral red and levofloxacin as precursors...More interestingly, such an RNA-targeting, red-emissive M-CDs can be fast internalized into cells within 5 seconds and thus used for real-time imaging the dynamic process of intracellular stress granules under oxidative stress, revealing some characteristics of granules that have not been identified by previously reported RNA and protein biomarkers. Our research paves a new pathway for visualizing bulk RNA dynamics and studying phase separation behaviors in living cells by rational design of the fluorescent carbon dots in terms of structure and functionality for the first time.
  • ||||||||||  levofloxacin / Generic mfg., rifampicin / Generic mfg.
    Journal:  Dual antituberculosis drugs-loaded gelatin hydrogel bioimplant for treating spinal tuberculosis. (Pubmed Central) -  Jan 16, 2023   
    Besides, loading of LEV and RIF in the implants declined the presence of the giant macrophages clusters as compared to control groups. All the obtained results support the potential use of the developed vertebral hydrogel bioimplant as a scaffold with good mechanical and biocompatible properties along with a good ability to eradicate the TB pathogen.
  • ||||||||||  levofloxacin / Generic mfg.
    PK/PD data, Journal:  PHARMACOKINETICS OF RECTALLY AND ORALLY ADMINISTERED LEVOFLOXACIN IN ASIAN ELEPHANTS (ELEPHAS MAXIMUS). (Pubmed Central) -  Jan 15, 2023   
    Based on these findings, levofloxacin may be a consideration for administration orally (5 mg/kg) and rectally (15 mg/kg) in Asian elephants. Antimicrobial stewardship principles, culture and susceptibility of suspected pathogens, and blood level monitoring should be used to tailor administration of levofloxacin in this species.
  • ||||||||||  levofloxacin / Generic mfg., cefuroxime / Generic mfg., ceftazidime / Generic mfg.
    Journal:  Antibiotic Sensitivity of Proteus mirabilis Urinary Tract Infection in Patients with Urinary Calculi. (Pubmed Central) -  Jan 12, 2023   
    Seasonal variation in antibiotic sensitivity was confirmed, with significantly higher rates in the winter for cefuroxime (p = 0.002) and sulfamethoxazole (p = 0.002)...Highly effective antibiotics such as cefoxitin and ceftazidime should be used empirically by considering antibiotic sensitivity changes by sex, season, and year. Regional studies should be conducted frequently.
  • ||||||||||  Orapenem (tebipenem pivoxil) / Meiji Seika, GSK
    Preclinical, Journal:  Contemporary Evaluation of Tebipenem In Vitro Activity against Enterobacterales Clinical Isolates Causing Urinary Tract Infections in US Medical Centers (2019-2020). (Pubmed Central) -  Jan 11, 2023   
    Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis with an MIC of ≥2 μg/mL for ceftazidime, ceftriaxone, and/or aztreonam were designated ESBL...Tebipenem, meropenem, and ertapenem had MIC against Enterobacterales of 0.06 μg/mL, 0.06 μg/mL and 0.03 μg/mL, respectively...Oral agents, such as amoxicillin-clavulanate, levofloxacin, and trimethoprim-sulfamethoxazole, showed elevated nonsusceptibility rates in the Middle Atlantic region (26, 45, 47, and 41%, respectively)...IMPORTANCE The occurrence of urinary-tract Enterobacterales pathogens producing ESBL enzymes in community and nosocomial settings continues to increase, as does the coresistance to fluoroquinolones, trimethoprim-sulfamethoxazole and nitrofurantoin often exhibited by these pathogens...In addition, the interregional variability of susceptibility results of US UTI pathogens provides a less predictable susceptibility pattern to inform empirical treatment decisions. This study evaluated the in vitro activity of tebipenem against contemporary uropathogens, including those resistant to currently available oral options.
  • ||||||||||  Primaxin (cilastatin/imipenem) / Abbott
    Journal, Surgery:  Temporal Changes in Extended Spectrum β-Lactamase Producing Organisms in Acute Care Surgery. (Pubmed Central) -  Jan 10, 2023   
    Pathogenic Escherichia coli causing diarrhea in calves contain abundant virulence genes and antibiotic resistance genes. The incidence of ESBL-producing organisms continues to increase at an alarming rate, which mandates strict antibiotic stewardship and amendments to local guidelines.
  • ||||||||||  levofloxacin / Generic mfg.
    Journal:  Fabrication of Z-scheme BiOI/g-CN heterojunction modified by carbon quantum dots for synchronous photocatalytic removal of Cr (Ⅵ) and organic pollutants. (Pubmed Central) -  Jan 8, 2023   
    A series of BiOI/g-CN (BOI/CN) composites modified by lignin-derived carbon quantum dots (CQDs) were fabricated by hydrothermal method and applied for synchronous photocatalytic removal of Cr (Ⅵ) and levofloxacin (LEV)...The intermediates of LEV were determined by LC-MS and the possible degradation pathway was speculated in combination with density functional theory calculation, involving defluorination, decarboxylation, quinolone rings opening, and piperazine moieties oxidation reactions. This work provides an advanced strategy for the fabrication of high-efficiency CQDs-based Z-scheme photocatalysts for environmental remediation.
  • ||||||||||  Comirnaty (tozinameran) / Pfizer, Fosun Pharma, BioNTech, Vaxzevria (ChAdOx1-S recombinant) / Oxford Biomedica, Emergent Biosolutions, Jenner Institute, Vaccitech, AstraZeneca, University of Oxford, Spikevax (elasomeran) / Moderna
    Journal:  Drug-induced radiation recall reactions and non-anticancer drugs: A descriptive analysis from VigiBase®. (Pubmed Central) -  Jan 7, 2023   
    Our study first describes the occurrence of radiation recall reactions during non-anticancer treatment. It also highlights a potential safety signal with COVID-19 vaccines.
  • ||||||||||  apixaban / Generic mfg.
    APIXABAN INDUCED ANAPHYLACTIC REACTION (Poster Hall_Hall F) -  Jan 4, 2023 - Abstract #ACCWCC2023ACC_WCC_5813;    
    It is crucial to recognize Apixaban as a potential cause of anaphylaxis. Even though it is rare, clinicians should be aware of and keep this in mind while explaining possible adverse effects to the patient.
  • ||||||||||  levofloxacin / Generic mfg., amiodarone / Generic mfg., methylprednisolone sodium succinate / Generic mfg.
    LEGIONELLA MYOCARDITIS MASQUERADING AS DUAL CHAMBER CARDIAC ARRHYTHMIA (Poster Hall_Hall F) -  Jan 4, 2023 - Abstract #ACCWCC2023ACC_WCC_153;    
    There was good correlation between LGE inflammation/scar location and origin of VT, as well as active inflammation demonstrated by FDG PET imaging. The patient was successfully treated with antibiotics, steroids and anti-arrhythmic drugs.
  • ||||||||||  Journal:  Distribution and Characteristics of Bacteria Isolated from Cystic Fibrosis Patients with Pulmonary Exacerbation. (Pubmed Central) -  Jan 4, 2023   
    The highest rate of resistance for S. aureus was observed to azithromycin and erythromycin (80%), ciprofloxacin (52.3%), clindamycin (44.6%) and tetracycline (43%)...For P. aeruginosa isolates the highest resistance was to cefepime (38.3%) and levofloxacin (33.3%) and 20% showed MDR phenotype...We found S. aureus to be more prevalent in younger patients, whereas mucoid P. aeruginosa showed a shift in prevalence toward older ages. Molecular typing methods showed great diversity between isolates.
  • ||||||||||  levofloxacin / Generic mfg.
    Journal:  Case report: One human Streptococcus suis occurred in Shandong Province, China. (Pubmed Central) -  Jan 4, 2023   
    Molecular typing methods showed great diversity between isolates. Although human S suis infection generally presents as a sporadic disease, its high burden highlights the importance of epidemiological surveillance and health education regarding human S suis infection.
  • ||||||||||  levofloxacin / Generic mfg., cefotaxime / Generic mfg., nitrofurantoin / Generic mfg.
    Journal:  Identification and antibiotic susceptibility of microorganisms isolated from diabetic foot ulcers: A pathological aspect. (Pubmed Central) -  Jan 3, 2023   
    Penicillin resistance was significantly higher among the gram-negative bacteria (P=0.019). Staphylococcus aureus and Escherichia coli were the predominant gram-positive and gram-negative bacteria isolated and levofloxacin and nitrofurantoin were the most effective antibiotics among the gram-positive and gram-negative bacterial isolates, respectively.