levofloxacin / Generic mfg. 
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 0 Diseases   137 Trials   137 Trials   5343 News 


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  • ||||||||||  Zeven (dalbavancin) / RaQualia, AbbVie
    Journal:  Molecular Epidemiology and Characterization of Multidrug-Resistant MRSA ST398 and ST239 in Himachal Pradesh, India. (Pubmed Central) -  May 1, 2023   
    All isolates were sensitive to linezolid, quinupristin-dulfopristin, dalbavancin, and cefazoline...The MRSA isolates produced staphylokinase and ?-hemolysis but were negative for bovine plasma coagulation tests. The predominant MRSA clones in Himachal Pradesh, India, were hospital-associated multi-drug resistant-MRSA ST239 with PVL and community-associated MRSA ST398.
  • ||||||||||  levofloxacin / Generic mfg.
    Journal:  Levofloxacin-induced acute rhabdomyolysis: A case report. (Pubmed Central) -  Apr 28, 2023   
    Her symptoms resolved after discontinuation of levofloxacin. This case report highlights the need for monitoring of blood biochemistry in patients taking levofloxacin to enable early diagnosis and treatment of potentially life-threatening myositis.
  • ||||||||||  levofloxacin / Generic mfg.
    Journal:  Levofloxacin HCl-Incorporated Zein-Based Solvent Removal Phase Inversion In Situ Forming Gel for Periodontitis Treatment. (Pubmed Central) -  Apr 28, 2023   
    Lv-loaded 20% zein ISG using GF as a solvent exhibited appropriate viscosity, Newtonian flow, acceptable gel formation and injectability, and prolonged Lv release over 7 days with efficient antimicrobial activities against various test microbes; thus, it is the potential ISG formulation for periodontitis treatment. Consequently, the Lv-loaded solvent removal zein-based ISGs proposed in this investigation offer promising potential as an efficacious drug delivery system for periodontitis treatment by local injection.
  • ||||||||||  levofloxacin / Generic mfg.
    Journal:  Controlled Drug Delivery Device for Cornea Treatment and Novel Method for Its Testing. (Pubmed Central) -  Apr 28, 2023   
    A contact lens-shaped collagen drug carrier was created and loaded by Levofloxacin and Tetracaine with a riboflavin crosslinked surface layer, thus impeding diffusion...The experimental setup with simple geometry revealed that the prepared drug delivery device can provide the prolonged release profile of the pseudo-first-order for up to 72 h. The efficiency of the drug delivery was further demonstrated using a dead porcine cornea as a drug recipient, without the need to use live animals for testing. Our drug delivery system significantly surpasses the efficiency of antibiotic and anesthetic eyedrops that would have to be applied approximately 30 times per hour to achieve the same dose as that delivered continuously by our device.
  • ||||||||||  Mycobutin (rifabutin) / Pfizer, Lupin, Gracevit (sitafloxacin) / Daiichi Sankyo, Takecab (vonoprazan) / Takeda, Phathom Pharma
    Review, Journal:  Treatment of Helicobacter pylori Infection in Patients with Penicillin Allergy. (Pubmed Central) -  Apr 28, 2023   
    In patients with true allergy, Vonoprazan-Clarithromycin-Metronidazole and bismuth quadruple therapy have demonstrated excellent eradication and high adherence rates...Levofloxacin or sitafloxacin-based regimens achieve a moderately high eradication rate...Cephalosporins such as cefuroxime have been used as an alternative to amoxicillin...PPI-Clarithromycin-Rifabutin should not be used because of low eradication rate and frequent adverse reactions. The choice of the most effective antibiotic regimen can enhance clinical outcomes in patients with H. pylori infection and penicillin allergy.
  • ||||||||||  ciprofloxacin oral / Generic mfg., levofloxacin / Generic mfg., ampicillin / Generic mfg.
    Journal:  Occurrence and Treatment of Antibiotic-Resistant Bacteria Present in Surface Water. (Pubmed Central) -  Apr 27, 2023   
    The hybrid treatment proposed is a promising approach to use as point-of-use treatment by isolated populations or when conventional systems and electricity fail due to natural disasters or war. Furthermore, the effective treatment obtained when the combined system was used with UV-A light sources indicates that the process may be a promising approach to guarantee water disinfection using natural sunlight.
  • ||||||||||  levofloxacin / Generic mfg., cefuroxime / Generic mfg.
    Journal:  Dietary 5-demethylnobiletin prevents antibiotic-associated dysbiosis of gut microbiota and damage to the colonic barrier. (Pubmed Central) -  Apr 25, 2023   
    Moreover, PMFs increased the contents of isobutyric acid and butyric acid, which were almost eliminated by antibiotic exposure. In conclusion, 5DN could alleviate antibiotic-related imbalance of intestinal oxidative stress, barrier function damage, intestinal flora disorders and the reduction of short-chain fatty acids (SCFAs), which lays a foundation for exploring safer and more effective ways to prevent or mitigate antibiotic-associated intestinal damage.
  • ||||||||||  rifampicin/isoniazid/pyrazinamide / Generic mfg., levofloxacin / Generic mfg., aspirin / Generic mfg.
    BASELINE CLINICAL CHARACTERISTICS OF CHILDREN AND ADOLESCENTS WITH TUBERCULOUS MENINGITIS IN THE SURE TRIAL (ISRCTN40829906) (STATION 5) -  Apr 21, 2023 - Abstract #ESPID2023ESPID_721;    
    Methods SURE is a factorial phase III RCT evaluating the non-inferiority for mortality of shorter intensive 6-month (high-dose rifampicin/isoniazid, pyrazinamide, levofloxacin) vs standard 12- month antituberculosis treatment and superiority of aspirin vs placebo on neurological disability. Between 3 March 2021 and 31 December 2022 , 157 children (females [45%], median age 4.0 years [IQR 1.0
  • ||||||||||  STAPHYLOCOCCUS NECROTIZING PNEUMONIA IN A CHILD WITH COVID-19 (E-Poster Area) -  Apr 21, 2023 - Abstract #ESPID2023ESPID_658;    
    Case Presentation Summary: An eleven-year-old boy was referred from previous hospital due to pneumonia and fever which not improved after 10 days of intravenous Levofloxacin and Gentamycin...Treatment given were Vancomycin for 20 days, enoxaparine, anemia and hypoalbuminemia correction...Other common causes was Streptococcus pneumonia. Vancomycin should be considered as the treatment of choice in MRSA infections, especially if clinical improvements were not observed after adequate treatment with sensitive antibiotics.
  • ||||||||||  levofloxacin / Generic mfg.
    THE FUNCTION OF THE UNIVERSITY EXTENSION IN PROSTATE CANCER SCREENING, A RIGHT FOR EVERYONE () -  Apr 18, 2023 - Abstract #ICUC2023ICUC_494;    
    There was an expansion of access to information by the population, and the formation of a link between extension, research and teaching. Finally, it allowed the screening of prostate and penile cancer among rural men, favoring early diagnosis, a fact that guarantees a greater chance of a good prognosis for patients.
  • ||||||||||  aztreonam/avibactam (PF-06947387) / Pfizer, AbbVie, imipenem/relebactam / Merck (MSD), Zavicefta (ceftazidime/avibactam) / Pfizer, AbbVie
    Journal:  Chimeric Tobramycin-Based Adjuvant TOB-TOB-CIP Potentiates Fluoroquinolone and ?-Lactam Antibiotics against Multidrug-Resistant Pseudomonas aeruginosa. (Pubmed Central) -  Apr 17, 2023   
    Moreover, the susceptibility breakpoints of ceftazidime, aztreonam, and imipenem were reached using the triple combination of chimera 4 with ceftazidime/avibactam, aztreonam/avibactam, and imipenem/relebactam, respectively, against ?-lactamase-harboring P. aeruginosa. Our findings demonstrate that tobramycin-based chimeras form a novel class of antibiotic potentiators capable of restoring the activity of antibiotics against P. aeruginosa.
  • ||||||||||  levofloxacin / Generic mfg., amikacin sulfate / Generic mfg.
    Enrollment closed, Phase classification, Trial completion date, Trial primary completion date:  TB-TRUST: Refining MDR-TB Treatment (T) Regimens (R) for Ultra(U) Short(S) Therapy(T) (clinicaltrials.gov) -  Apr 7, 2023   
    P4,  N=354, Active, not recruiting, 
    To the best of our knowledge, this is the first study in the region that studies the association between ESKAPE pathogens and UTIs. Recruiting --> Active, not recruiting | Phase classification: PN/A --> P4 | Trial completion date: Dec 2022 --> Nov 2023 | Trial primary completion date: Dec 2021 --> May 2023
  • ||||||||||  vancomycin / Generic mfg.
    Vancomycin Induced Agranulocytosis: An Uncommon Adverse Drug Reaction () -  Apr 6, 2023 - Abstract #AFMRSER2023AFMR_SER_19;    
    Case DescriptionA 42-year-old female with a history of chronic pain on narcotics was admitted to the hospital for acute hypoxic respiratory failure with multifocal pneumonia, streptococcus pneumonia bacteremia, and acute kidney injury.The patient reported an allergy to Ceftriaxone that manifested as lip swelling, and she was empirically started on Vancomycin and Meropenem on hospital day one, then the bacteremia resolved...Vancomycin and levofloxacin were discontinued while Meropenem was restarted given concern for drug side effect...The incidences are irrespective of dose, and treatment is discontinuing the drug. After discontinuation, neutrophils typically recover spontaneously and G-CSF can be given for support if they do not recover.Ultimately, vancomycin induced agranulocytosis is uncommon, but it should always be considered in the differential for neutropenia when the patient is on vancomycin for more than 7 days.
  • ||||||||||  pretomanid (PA-824) / Global Alliance for TB Drug Development, Sirturo (bedaquiline) / J&J, Pharmstandard
    Increasing Fluoroquinolone Resistance In Drug Resistant TB () -  Apr 6, 2023 - Abstract #AFMRSER2023AFMR_SER_6;    
    This is concerning as these agents are essential in first-line regimens for the treatment of DRTB. If the MICs continue to uptrend at a similar pace, we anticipate that more strains will surpass the breakpoint of 1 mg/L leading to potential ineffectiveness of both levofloxacin and moxifloxacin in the treatment of tuberculosis.
  • ||||||||||  Journal:  Role of AlgC and GalU in the Intrinsic Antibiotic Resistance of Helicobacter pylori. (Pubmed Central) -  Apr 5, 2023   
    UDP-glucose may play an important role in increasing drug resistance to AMO, MNZ, CLA, LEV, TET, and RIF by maintaining the lipid A-core structure and decreasing membrane permeability. AlgC and GalU may serve as potential drug targets for decreasing antibiotic resistance in clinical isolates.
  • ||||||||||  Baxdela (delafloxacin) / Menarini, Melinta Therap
    In vitro (C / 06) -  Apr 2, 2023 - Abstract #ECCMID2023ECCMID_5797;    
  • ||||||||||  levofloxacin / Generic mfg.
    Trial completion date, Trial initiation date, Trial suspension, Trial primary completion date, Surgery:  A Study of Levofloxacin Ocular Implant in Patients Undergoing Routine Bilateral Cataract Surgery (clinicaltrials.gov) -  Mar 29, 2023   
    P1,  N=12, Suspended, 
    Consumption of oral azithromycin was higher in 2021 than 2020. Trial completion date: Mar 2023 --> Mar 2024 | Initiation date: Oct 2022 --> Jun 2023 | Not yet recruiting --> Suspended | Trial primary completion date: Dec 2022 --> Dec 2023
  • ||||||||||  levofloxacin / Generic mfg., tetracycline / Generic mfg.
    Journal:  Antibiotic induced changes in nitrogen metabolism and antioxidative enzymes in mung bean (Vigna radiata). (Pubmed Central) -  Mar 28, 2023   
    However, significantly higher malondialdehyde (MDA) concentrations at higher doses (20?mg?L and above) than the control showed that plants' tolerance against oxidative stress was conceded with increasing antibiotic concentrations. The toxicity trend was levofloxacin?>?mixture?>?oxytetracycline.