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137 Trials |  |
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- | Journal: Antimicrobial susceptibility testing of invasive isolates of Streptococcus pneumoniae from Canadian patients: the SAVE study, 2011-2020. (Pubmed Central) - May 2, 2023
Invasive pneumococcal isolates collected in Canada from 2011 to 2020 generally exhibited consistent in vitro susceptibility to commonly tested antimicrobial agents.
- | Journal: Prevalence of Some Group A Beta-Lactamase Genes among Uropathogenic Escherichia coli isolated from Women with Cystitis. (Pubmed Central) - May 2, 2023
The study concludes the high spreading of coexistence of more than one gene of Group A ?-lactamase genes among uropathogenic Escherichia coli causes them to resist many antibiotics. This makes the treatment regimen unusual or hard to be achieved.
- || levofloxacin / Generic mfg.
Review, Journal: Enzyme-linked immunospot assay and metagenomic sequencing of Mycobacterium tuberculosis, coagulopathy symptoms, and pancytopenia testing for characterization of pulmonary tuberculosis: case report and literature review. (Pubmed Central) - May 2, 2023
So ati-TB was initiated with HRftELfx (isoniazid, 0.3 g qd; rifapentine, 0.45 g biw; ethambutol, 0.75 g qd; and levofloxacin, 0.5 g qd) regimen. Eventually, the patient's clinical symptoms improved significantly, the pulmonary lesions were absorbed, and the coagulation function and blood cell count returned to normal, which achieved a satisfactory treatment effect.
- | levofloxacin / Generic mfg., trimethoprim/sulfamethoxazole / Generic mfg.
Retrospective data, Journal: Association between minimum inhibitory concentration values and mortality risk in patients with Stenotrophomonas maltophilia infections: a retrospective cohort study of electronic health records from 148 US hospitals. (Pubmed Central) - May 1, 2023
Only 9/645 trimethoprim/sulfamethoxazole-treated patients had trimethoprim/sulfamethoxazole MIC of exactly 2/38?mg/L precluding informative models for this agent. In this retrospective study of real-world patients with S. maltophilia infection, risk-adjusted survival data do not appear to stratify patients clinically within current susceptible-range MIC breakpoint for levofloxacin (?2?mg/L) by mortality.
- | Journal: Molecular characterization and antimicrobial susceptibility of human Brucella in Northeast China. (Pubmed Central) - May 1, 2023
Brucellosis is usually treated with antibiotics for several months, which can easily lead to the emergence of antibiotic resistance. To ensure the effectiveness and safety of antibiotics for treatment of brucellosis, continuous surveillance of antibiotic susceptibility is especially important.
- | Zeven (dalbavancin) / RaQualia, AbbVie
Journal: Molecular Epidemiology and Characterization of Multidrug-Resistant MRSA ST398 and ST239 in Himachal Pradesh, India. (Pubmed Central) - May 1, 2023
All isolates were sensitive to linezolid, quinupristin-dulfopristin, dalbavancin, and cefazoline...The MRSA isolates produced staphylokinase and ?-hemolysis but were negative for bovine plasma coagulation tests. The predominant MRSA clones in Himachal Pradesh, India, were hospital-associated multi-drug resistant-MRSA ST239 with PVL and community-associated MRSA ST398.
- | levofloxacin / Generic mfg.
Journal: Scalable and Chromatography-Free Synthesis of Efflux Pump Inhibitor Phenylalanine Arginine ?-Naphthylamide for its Validation in Wild-Type Bacterial Strains. (Pubmed Central) - May 1, 2023
While most analogues were less active than the broadly utilized L,L-PA?N itself, we identified that its enantiomer, D,D-PA?N, also provided 8- to 16-fold potentiation of the antibiotic levofloxacin at 40 to 50 ?g/mL concentrations of EPI in various wild-type Pseudomonas aeruginosa strains. Additionally, D,D-PA?N was shown to be significantly more hydrolytically stable than L,L-PA?N, indicating that it may be a useful, and now readily synthesized, tool compound facilitating future EPI research.
- | Pneumosil (10-valent pneumococcal conjugate vaccine) / Serum Institute of India
Journal: Prevalence, capsular types, antimicrobial resistance and risk factors associated with pneumococcal carriage among children after long-term 10-valent pneumococcal conjugate vaccine use in Brazil. (Pubmed Central) - May 1, 2023
Long-term universal childhood use of PCV10 has nearly eliminated carriage with PCV10 serotypes, but the high frequency of MDR isolates, especially associated with serotype 6C/D, remains a concern. Replacing PCV10 with PCV13 should reduce the proportion of ERY-R isolates and PNSP by at least 14% and 18%, respectively.
- | Journal: QT-Prolonging Antibiotics, Serum-to-Dialysate Potassium Gradient, and Risk of Sudden Cardiac Death Among Patients Receiving Maintenance Hemodialysis. (Pubmed Central) - Apr 28, 2023
Although treatment with azithromycin and, separately, respiratory fluoroquinolones were each associated with a heightened risk of sudden cardiac death, this risk was augmented in the setting of larger serum-to-dialysate potassium gradients. Minimizing the potassium gradient may be an approach to reduce the cardiac risk of these antibiotics.
- | levofloxacin / Generic mfg.
Journal: Levofloxacin-induced acute rhabdomyolysis: A case report. (Pubmed Central) - Apr 28, 2023
Her symptoms resolved after discontinuation of levofloxacin. This case report highlights the need for monitoring of blood biochemistry in patients taking levofloxacin to enable early diagnosis and treatment of potentially life-threatening myositis.
- ||| pretomanid (PA-824) / Global Alliance for TB Drug Development, Lamprene (clofazimine) / Novartis, Sirturo (bedaquiline) / J&J, Pharmstandard
Review, Journal, Adverse events: Infant Exposure to Antituberculosis Drugs via Breast Milk and Assessment of Potential Adverse Effects in Breastfed Infants: Critical Review of Data. (Pubmed Central) - Apr 28, 2023
Concerns for potential adverse effects in breastfed infants could be ruled out for bedaquiline, cycloserine/terizidone, linezolid and pyrazinamide. Adequate studies should be performed covering the scenario in treated mothers, breast milk and infants.
- | levofloxacin / Generic mfg.
Journal: Levofloxacin HCl-Incorporated Zein-Based Solvent Removal Phase Inversion In Situ Forming Gel for Periodontitis Treatment. (Pubmed Central) - Apr 28, 2023
Lv-loaded 20% zein ISG using GF as a solvent exhibited appropriate viscosity, Newtonian flow, acceptable gel formation and injectability, and prolonged Lv release over 7 days with efficient antimicrobial activities against various test microbes; thus, it is the potential ISG formulation for periodontitis treatment. Consequently, the Lv-loaded solvent removal zein-based ISGs proposed in this investigation offer promising potential as an efficacious drug delivery system for periodontitis treatment by local injection.
- | levofloxacin / Generic mfg.
Journal: Controlled Drug Delivery Device for Cornea Treatment and Novel Method for Its Testing. (Pubmed Central) - Apr 28, 2023
A contact lens-shaped collagen drug carrier was created and loaded by Levofloxacin and Tetracaine with a riboflavin crosslinked surface layer, thus impeding diffusion...The experimental setup with simple geometry revealed that the prepared drug delivery device can provide the prolonged release profile of the pseudo-first-order for up to 72 h. The efficiency of the drug delivery was further demonstrated using a dead porcine cornea as a drug recipient, without the need to use live animals for testing. Our drug delivery system significantly surpasses the efficiency of antibiotic and anesthetic eyedrops that would have to be applied approximately 30 times per hour to achieve the same dose as that delivered continuously by our device.
- | Journal: Evidence of Bacterial Community Coalescence between Freshwater and Discharged tpm-Harboring Bacterial Taxa from Hospital and Domestic Wastewater Treatment Plants among Epilithic Biofilms. (Pubmed Central) - Apr 28, 2023
Higher contributions of TWW taxa among epilithic biofilms were recorded closer to the WWTP outlet. These analyses demonstrated a coalescence of WWTP sewer communities with river freshwater taxa among epilithic biofilms developing downstream of a WWTP outlet.
- | Journal: Phenotypic and Molecular Characteristics of Carbapenem-Resistant Acinetobacter baumannii Isolates from Bulgarian Intensive Care Unit Patients. (Pubmed Central) - Apr 28, 2023
The isolates belonged to the widespread high-risk sequence types ST2 (n = 2) and ST636 (n = 1) (Pasteur scheme). Our results show the presence of XDR-AB isolates, carrying a variety of ARGs, in Bulgarian ICU settings, which highlights the crucial need for nationwide surveillance, especially in the conditions of extensive antibiotic usage during COVID-19.
- | Journal: Phenotypic and Genotypic Characteristics of Antimicrobial Resistance in Citrobacter freundii Isolated from Domestic Ducks (Anas platyrhynchos domesticus) in Bangladesh. (Pubmed Central) - Apr 28, 2023
To the best of our knowledge, this is the first study in Bangladesh to detect MDR C. freundii with their associated resistance genes from duck samples. We suggest addressing the burden of diseases in ducks and humans and associated AMR issues using the One Health approach.
- || Mycobutin (rifabutin) / Pfizer, Lupin, Gracevit (sitafloxacin) / Daiichi Sankyo, Takecab (vonoprazan) / Takeda, Phathom Pharma
Review, Journal: Treatment of Helicobacter pylori Infection in Patients with Penicillin Allergy. (Pubmed Central) - Apr 28, 2023
In patients with true allergy, Vonoprazan-Clarithromycin-Metronidazole and bismuth quadruple therapy have demonstrated excellent eradication and high adherence rates...Levofloxacin or sitafloxacin-based regimens achieve a moderately high eradication rate...Cephalosporins such as cefuroxime have been used as an alternative to amoxicillin...PPI-Clarithromycin-Rifabutin should not be used because of low eradication rate and frequent adverse reactions. The choice of the most effective antibiotic regimen can enhance clinical outcomes in patients with H. pylori infection and penicillin allergy.
- | ciprofloxacin oral / Generic mfg., levofloxacin / Generic mfg., rifampicin / Generic mfg.
Journal: Comparing the Synergistic and Antagonistic Interactions of Ciprofloxacin and Levofloxacin Combined with Rifampin against Drug-Resistant Staphylococcus aureus: A Time-Kill Assay. (Pubmed Central) - Apr 28, 2023
High MICs of fluoroquinolones were found to predict synergism. Our results suggest that ciprofloxacin may be a more effective choice than levofloxacin for combination therapy with rifampin in the treatment of MRSA infections.
- | ciprofloxacin oral / Generic mfg., levofloxacin / Generic mfg., ampicillin / Generic mfg.
Journal: Occurrence and Treatment of Antibiotic-Resistant Bacteria Present in Surface Water. (Pubmed Central) - Apr 27, 2023
The hybrid treatment proposed is a promising approach to use as point-of-use treatment by isolated populations or when conventional systems and electricity fail due to natural disasters or war. Furthermore, the effective treatment obtained when the combined system was used with UV-A light sources indicates that the process may be a promising approach to guarantee water disinfection using natural sunlight.
- | Journal: Pathogenic Role and Antibiotic Resistance of Methicillin-Resistant Staphylococcus aureus (MRSA) Strains Causing Severe Community-Acquired Pneumonia in Vietnamese Children. (Pubmed Central) - Apr 27, 2023
MRSA strains were completely non-susceptible to penicillin (100%), more resistant to clindamycin and erythromycin, less sensitive to ciprofloxacin and levofloxacin, and fully susceptible to vancomycin and linezolid, with a 32-fold decreased MIC for vancomycin (0.5 mg/L) and a 2-fold decreased MIC for linezolid (4 mg/L). Therefore, vancomycin and linezolid may be appropriate options for severe CAP identified by MRSA.
- doxycycline / Generic mfg.
Addition of doxycycline to fluoroquinolones for bacterial prophylaxis in autologous stem cell transplantation for multiple myeloma. () - Apr 26, 2023 - Abstract #ASCO2023ASCO_5935;
This finding does not support the addition of doxy to FQ ppx at our institution and a future randomized controlled trial investigating appropriate ppx for ASCT is warranted. >
- | levofloxacin / Generic mfg., meropenem / Generic mfg.
Biomarker, Journal, Next-generation sequencing: Application of next-generation sequencing on diagnosis of bloodstream infection caused by Mycoplasma hominis in a patient with ANCA-associated vasculitis. (Pubmed Central) - Apr 26, 2023
> This successful application of next generation sequencing assisted the rapid diagnosis of Mycoplasma hominis bloodstream infection, provided a new perspective in the clinical approach and highlighted the potential of this technique in rapid etiological diagnosis.
- | levofloxacin / Generic mfg., cefuroxime / Generic mfg.
Journal: Dietary 5-demethylnobiletin prevents antibiotic-associated dysbiosis of gut microbiota and damage to the colonic barrier. (Pubmed Central) - Apr 25, 2023
Moreover, PMFs increased the contents of isobutyric acid and butyric acid, which were almost eliminated by antibiotic exposure. In conclusion, 5DN could alleviate antibiotic-related imbalance of intestinal oxidative stress, barrier function damage, intestinal flora disorders and the reduction of short-chain fatty acids (SCFAs), which lays a foundation for exploring safer and more effective ways to prevent or mitigate antibiotic-associated intestinal damage.
- rifampicin/isoniazid/pyrazinamide / Generic mfg., levofloxacin / Generic mfg., aspirin / Generic mfg.
BASELINE CLINICAL CHARACTERISTICS OF CHILDREN AND ADOLESCENTS WITH TUBERCULOUS MENINGITIS IN THE SURE TRIAL (ISRCTN40829906) (STATION 5) - Apr 21, 2023 - Abstract #ESPID2023ESPID_721;
Methods SURE is a factorial phase III RCT evaluating the non-inferiority for mortality of shorter intensive 6-month (high-dose rifampicin/isoniazid, pyrazinamide, levofloxacin) vs standard 12- month antituberculosis treatment and superiority of aspirin vs placebo on neurological disability. Between 3 March 2021 and 31 December 2022 , 157 children (females [45%], median age 4.0 years [IQR 1.0
- STAPHYLOCOCCUS NECROTIZING PNEUMONIA IN A CHILD WITH COVID-19 (E-Poster Area) - Apr 21, 2023 - Abstract #ESPID2023ESPID_658;
Case Presentation Summary: An eleven-year-old boy was referred from previous hospital due to pneumonia and fever which not improved after 10 days of intravenous Levofloxacin and Gentamycin...Treatment given were Vancomycin for 20 days, enoxaparine, anemia and hypoalbuminemia correction...Other common causes was Streptococcus pneumonia. Vancomycin should be considered as the treatment of choice in MRSA infections, especially if clinical improvements were not observed after adequate treatment with sensitive antibiotics.
- levofloxacin / Generic mfg.
THE FUNCTION OF THE UNIVERSITY EXTENSION IN PROSTATE CANCER SCREENING, A RIGHT FOR EVERYONE () - Apr 18, 2023 - Abstract #ICUC2023ICUC_494;
There was an expansion of access to information by the population, and the formation of a link between extension, research and teaching. Finally, it allowed the screening of prostate and penile cancer among rural men, favoring early diagnosis, a fact that guarantees a greater chance of a good prognosis for patients.
- | aztreonam/avibactam (PF-06947387) / Pfizer, AbbVie, imipenem/relebactam / Merck (MSD), Zavicefta (ceftazidime/avibactam) / Pfizer, AbbVie
Journal: Chimeric Tobramycin-Based Adjuvant TOB-TOB-CIP Potentiates Fluoroquinolone and ?-Lactam Antibiotics against Multidrug-Resistant Pseudomonas aeruginosa. (Pubmed Central) - Apr 17, 2023
Moreover, the susceptibility breakpoints of ceftazidime, aztreonam, and imipenem were reached using the triple combination of chimera 4 with ceftazidime/avibactam, aztreonam/avibactam, and imipenem/relebactam, respectively, against ?-lactamase-harboring P. aeruginosa. Our findings demonstrate that tobramycin-based chimeras form a novel class of antibiotic potentiators capable of restoring the activity of antibiotics against P. aeruginosa.
- || levofloxacin / Generic mfg.
That’s exactly right, everyone receives levofloxacin prophylaxis and the difference in resistance to fluoroquinolones between HCT and the general population is more pronounced than with other antimicrobials. Not a coincidence. (Twitter) - Apr 15, 2023
- || ethambutol / Generic mfg., levofloxacin / Generic mfg.
Initially with ALT 200 we would use linezolid, levofloxacin and ethambutol only. When ALT about 100, rechallenge rif for 3 days if ALT holds rechallenge INH. If ALT rises on either drug we abandon it and construct a regimen with alternative drugs. We do the A LOT in South Africa (Twitter) - Apr 15, 2023
- || levofloxacin / Generic mfg.
I wouldn't use an AG at all. Linezolid, levofloxacin would be good drugs. If you end up stopping RIF you could use bedaqualine. (Twitter) - Apr 15, 2023
- | levofloxacin / Generic mfg.
Journal: Mn-MOF derived manganese sulfide as peroxymonosulfate activator for levofloxacin degradation: An electron-transfer dominated and radical/nonradical coupling process. (Pubmed Central) - Apr 14, 2023
Finally, six possible pathways of LVF oxidation in the system were proposed based on the identified byproducts and their ecotoxicity was evaluated with ECOSAR method. This work promotes the fundamental understanding of PMS activation by ?-MnS and provides useful information for practical application of manganese sulfide in water treatment.
- | Retrospective data, Journal: Characteristics of phenotypic antibiotic resistance of Helicobacter pylori and its correlation with genotypic antibiotic resistance: A retrospective study in Ningxia. (Pubmed Central) - Apr 12, 2023
This work promotes the fundamental understanding of PMS activation by ?-MnS and provides useful information for practical application of manganese sulfide in water treatment. H.
- | Retrospective data, Journal: Characterization of ESKAPE pathogens in urinary tract infections among Jordanian patients. (Pubmed Central) - Apr 11, 2023
This research work has shown that patients with UTI-associated ESKAPE pathogens in Jordan are at high risk of antibiotic resistance. To the best of our knowledge, this is the first study in the region that studies the association between ESKAPE pathogens and UTIs.
- || ciprofloxacin oral / Generic mfg., levofloxacin / Generic mfg.
Why ciprofloxacin rather than levofloxacin for oral Rx? This is not logical to me. (Twitter) - Apr 9, 2023
- | levofloxacin / Generic mfg., amikacin sulfate / Generic mfg.
Enrollment closed, Phase classification, Trial completion date, Trial primary completion date: TB-TRUST: Refining MDR-TB Treatment (T) Regimens (R) for Ultra(U) Short(S) Therapy(T) (clinicaltrials.gov) - Apr 7, 2023
P4, N=354, Active, not recruiting, Sponsor: Huashan Hospital
To the best of our knowledge, this is the first study in the region that studies the association between ESKAPE pathogens and UTIs. Recruiting --> Active, not recruiting | Phase classification: PN/A --> P4 | Trial completion date: Dec 2022 --> Nov 2023 | Trial primary completion date: Dec 2021 --> May 2023
- vancomycin / Generic mfg.
Vancomycin Induced Agranulocytosis: An Uncommon Adverse Drug Reaction () - Apr 6, 2023 - Abstract #AFMRSER2023AFMR_SER_19;
Case DescriptionA 42-year-old female with a history of chronic pain on narcotics was admitted to the hospital for acute hypoxic respiratory failure with multifocal pneumonia, streptococcus pneumonia bacteremia, and acute kidney injury.The patient reported an allergy to Ceftriaxone that manifested as lip swelling, and she was empirically started on Vancomycin and Meropenem on hospital day one, then the bacteremia resolved...Vancomycin and levofloxacin were discontinued while Meropenem was restarted given concern for drug side effect...The incidences are irrespective of dose, and treatment is discontinuing the drug. After discontinuation, neutrophils typically recover spontaneously and G-CSF can be given for support if they do not recover.Ultimately, vancomycin induced agranulocytosis is uncommon, but it should always be considered in the differential for neutropenia when the patient is on vancomycin for more than 7 days.
- pretomanid (PA-824) / Global Alliance for TB Drug Development, Sirturo (bedaquiline) / J&J, Pharmstandard
Increasing Fluoroquinolone Resistance In Drug Resistant TB () - Apr 6, 2023 - Abstract #AFMRSER2023AFMR_SER_6;
This is concerning as these agents are essential in first-line regimens for the treatment of DRTB. If the MICs continue to uptrend at a similar pace, we anticipate that more strains will surpass the breakpoint of 1 mg/L leading to potential ineffectiveness of both levofloxacin and moxifloxacin in the treatment of tuberculosis.
- | Journal: Role of AlgC and GalU in the Intrinsic Antibiotic Resistance of Helicobacter pylori. (Pubmed Central) - Apr 5, 2023
UDP-glucose may play an important role in increasing drug resistance to AMO, MNZ, CLA, LEV, TET, and RIF by maintaining the lipid A-core structure and decreasing membrane permeability. AlgC and GalU may serve as potential drug targets for decreasing antibiotic resistance in clinical isolates.
- | levofloxacin / Generic mfg.
New trial: Safety and Efficacy of Levofloxacin for Acute Ischemic Stroke (clinicaltrials.gov) - Apr 5, 2023
P=N/A, N=100, Not yet recruiting, Sponsor: Yi Yang
- rifampicin / Generic mfg.
Multi-year cryptic transmission of multidrug-resistant tuberculosis with rifampicin resistance not detectable by Xpert MTB/RIF in Botswana: case study and phylogenetic analysis (D / 05) - Apr 2, 2023 - Abstract #ECCMID2023ECCMID_5856;
- Baxdela (delafloxacin) / Menarini, Melinta Therap
In vitro (C / 06) - Apr 2, 2023 - Abstract #ECCMID2023ECCMID_5797;
- | Journal: Phenotypic and genotypic characteristics of Escherichia coli causing bloodstream and abdominal co-infection (Pubmed Central) - Mar 30, 2023
No genotype with obvious advantages was found. Although the strain has a high resistance rate to some antibacterial drugs, the proportion of carrying resistant genes is low, and it has a high sensitivity to some first-line antibacterial drugs.
- | Journal: Investigation of antimicrobial resistance patterns and molecular typing of Pseudomonas aeruginosa isolates among Coronavirus disease-19 patients. (Pubmed Central) - Mar 30, 2023
Although the strain has a high resistance rate to some antibacterial drugs, the proportion of carrying resistant genes is low, and it has a high sensitivity to some first-line antibacterial drugs. Due to the high rate of antimicrobial resistance, as well as the genetic diversity of Pseudomonas aeruginosa isolates from COVID-19 patients, it is indispensable to monitor the antimicrobial resistance pattern and epidemiology of the isolates on a regular basis.
- | levofloxacin / Generic mfg., meropenem / Generic mfg., colistin sulphate / Generic mfg.
Journal: Genome Analysis of Pseudomonas aeruginosa Strains from Chronically Infected Patients with High Levels of Persister Formation. (Pubmed Central) - Mar 30, 2023
Conclusively, the persister isolates in our study are MDR and form a highly strong biofilm. WGS revealed a smaller genome that belongs to a distinct clade.
- | levofloxacin / Generic mfg., clarithromycin / Generic mfg.
Observational data, Journal: Antimicrobial Resistance Molecular Mechanisms of Helicobacter pylori in Jordanian Children: A Cross-Sectional Observational Study. (Pubmed Central) - Mar 29, 2023
pylori resistance was documented for Metronidazole and Clarithromycin. RT-PCR for H. pylori identification and microbial resistance determination are valuable alternatives for cultures in determining antimicrobial susceptibility.
- || murepavadin (POL7080) / Spexis
Review, Journal: Current and Emerging Inhaled Antibiotics for Chronic Pulmonary Pseudomonas aeruginosa and Staphylococcus aureus Infections in Cystic Fibrosis. (Pubmed Central) - Mar 29, 2023
Additionally, inhaled liposomal amikacin and murepavadin are also in development...The mechanism of action, efficacy and safety, current status, and indications of corresponding inhaled antibiotics will be summarized. Combination therapy and the strategies to select an optimal inhaled antibiotic protocol will also be discussed.
- | Journal: Antimicrobial Consumption from 2017 to 2021 in East Trinidad and Tobago: A Study in the English-Speaking Caribbean. (Pubmed Central) - Mar 29, 2023
The consumption of 'Watch' group antibiotics increased from 2017 to 2021, with a drop in consumption of 'Access' antibiotics and at the onset of COVID-19. Consumption of oral azithromycin was higher in 2021 than 2020.
- ||| levofloxacin / Generic mfg.
Trial completion date, Trial initiation date, Trial suspension, Trial primary completion date, Surgery: A Study of Levofloxacin Ocular Implant in Patients Undergoing Routine Bilateral Cataract Surgery (clinicaltrials.gov) - Mar 29, 2023
P1, N=12, Suspended, Sponsor: PolyActiva Pty Ltd
Consumption of oral azithromycin was higher in 2021 than 2020. Trial completion date: Mar 2023 --> Mar 2024 | Initiation date: Oct 2022 --> Jun 2023 | Not yet recruiting --> Suspended | Trial primary completion date: Dec 2022 --> Dec 2023
- | levofloxacin / Generic mfg., tetracycline / Generic mfg.
Journal: Antibiotic induced changes in nitrogen metabolism and antioxidative enzymes in mung bean (Vigna radiata). (Pubmed Central) - Mar 28, 2023
However, significantly higher malondialdehyde (MDA) concentrations at higher doses (20?mg?L and above) than the control showed that plants' tolerance against oxidative stress was conceded with increasing antibiotic concentrations. The toxicity trend was levofloxacin?>?mixture?>?oxytetracycline.
- | levofloxacin / Generic mfg.
Journal: Safety of levofloxacin as an antibiotic prophylaxis in the induction phase of children newly diagnosed with acute lymphoblastic leukemia: an interim analysis of a randomized, open-label trial in Brazil. (Pubmed Central) - Mar 28, 2023
The use of this medication did not increase the rate of colonization by CPE nor the rate of diarrhea by C. difficile. All adverse reactions were mild and remitted either spontaneously or after switching medicine administration from oral to intravenous route.