levofloxacin / Generic mfg. 
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  • ||||||||||  levofloxacin / Generic mfg.
    Journal:  Prediction and mechanism of combined toxicity of surfactants and antibiotics in aquatic environment based on in silico method. (Pubmed Central) -  Feb 2, 2025   
    The results shown that synergistic toxicity effects were observed in the binary mixture of levofloxacin (LEV) and octylphenol ethoxylate (Triton X-100)...Further analysis revealed that the electrostatic potential of different target chemicals and their binding ability with enzymes affected the activity of AChE of Daphnia magna, resulting in different toxicity. Specifically, in the AChE?+?Triton X-100?+?LEV system, the second pollutant enhances the ability of the overall system to bind pollutants, which exhibit a synergistic effect during the binding process.
  • ||||||||||  Retrospective data, Journal:  Use of Machine Learning to Assess the Management of Uncomplicated Urinary Tract Infection. (Pubmed Central) -  Jan 31, 2025   
    In this cohort study of patients with uncomplicated UTI derived from a large regional claims dataset, national treatment guidelines published almost 14 years ago continue to recommend optimal treatments. These results also provide proof-of-principle that automated feature extraction methods for OMOP formatted data can emulate manually curated models, thereby promoting reproducibility and generalizability.
  • ||||||||||  Clinical, Journal:  Oral Regimens for Rifampin-Resistant, Fluoroquinolone-Susceptible Tuberculosis. (Pubmed Central) -  Jan 29, 2025   
    P3
    Consistent results across all the analyses support the noninferior efficacy of three all-oral shortened regimens for the treatment of rifampin-resistant tuberculosis. (Funded by Unitaid and others; endTB ClinicalTrials.gov number, NCT02754765.).
  • ||||||||||  cefepime hydrochloride / Generic mfg., levofloxacin / Generic mfg., trimethoprim/sulfamethoxazole / Generic mfg.
    Journal:  A case of W. chitiniclastica bacteremia in a 38-year-old homeless male originating from a maggot-infested amputated foot. (Pubmed Central) -  Jan 29, 2025   
    This case underscores the intersection of infectious diseases and social inequalities, highlighting the need for clinicians to consider W. chitiniclastica in patients with poor hygiene, alcoholism, peripheral vascular disease, and open wounds. It also emphasizes the dual role of maggots in wound care, capable of both cleaning necrotic tissue and introducing pathogenic bacteria.
  • ||||||||||  levofloxacin / Generic mfg.
    Journal:  Necrotizing Fasciitis-Induced Septic Shock due to Aeromonas hydrophila: A Case Report. (Pubmed Central) -  Jan 28, 2025   
    In the present case, the patient's successful recovery was achieved through the administration of a combination of cefoperazone/sulbactam and levofloxacin, as determined by sensitivity testing. This case study underscores the critical importance of considering A. hydrophila infection in patients with septic shock who present with necrotizing fasciitis.
  • ||||||||||  Journal:  Case report: co-infection of Scedosporium and Mycobacterium in lungs. (Pubmed Central) -  Jan 27, 2025   
    Therefore, combined treatment with voriconazole, ethambutol, azithromycin, and levofloxacin were given to the S. boydii and MAC for 1 week, and then patient's condition improved and discharged. mNGS, a non-targeted sequencing technology, could improve the efficiency of clinical diagnosis for mixed infection of rare or atypical pathogens, bring new ideas for clinical pathogen diagnosis, and improve patient prognosis.
  • ||||||||||  tobramycin inhalation / Generic mfg.
    Calcineurin Inhibitors Not Always to Blame: Case of Inhaled Tobramycin Nephrotoxicity in Lung Transplant (Poster Hall) -  Jan 19, 2025 - Abstract #ISHLT2025ISHLT_1276;    
    mNGS, a non-targeted sequencing technology, could improve the efficiency of clinical diagnosis for mixed infection of rare or atypical pathogens, bring new ideas for clinical pathogen diagnosis, and improve patient prognosis. Bronchoscopy cultures grew Serratia marcescens on POD 16 which was treated with intravenous (IV) cefepime and meropenem...However, with increased congestion and cough, oral levofloxacin started POD 170...A serum tobramycin trough level was elevated at 4.1
  • ||||||||||  Burkholderia-Induced Neck Abscess in a Lung Transplant Recipient without Cystic Fibrosis (Poster Hall) -  Jan 19, 2025 - Abstract #ISHLT2025ISHLT_458;    
    The patient was started on empiric steroids, vancomycin and ampicillin-sulbactam...The patient was discharged on levofloxacin and doxycycline and clinically improved.Summary Burkholderia cepacia is a group of highly virulent organisms classically associated with colonization and acute exacerbations in cystic fibrosis (CF) patients(1)...Burkholderia is not a common organism found in neck abscesses in both immunocompetent and immunocompromised patients. A wide differential of possible organisms should be considered in patients with extrapulmonary infections after lung transplant.
  • ||||||||||  levofloxacin / Generic mfg.
    Journal:  NIR-Activated Hydrogel with Dual-Enhanced Antibiotic Effectiveness for Thorough Elimination of Antibiotic-Resistant Bacteria. (Pubmed Central) -  Jan 16, 2025   
    Here, we have developed a dual-antibiotic hydrogel delivery system (PDA-Ag@Levo/CMCS), which can achieve controlled release of clinical antibiotics levofloxacin (Levo) and classic nanoscale antibiotic silver nanoparticles (AgNPs), effectively eliminating drug-resistant P. aeruginosa...Mechanism studies have shown that PDA-Ag@Levo might eliminate drug-resistant P. aeruginosa by disrupting biofilm formation and protein synthesis, and inhibit the resistance mutation of P. aeruginosa by promoting the expression of related genes, such as rpoS, dinB, and mutS. Collectively, the synergistic effect of this dual-antibiotic hydrogel combined with PTT provides a creative strategy for eliminating drug-resistant bacteria in chronic infection wounds.
  • ||||||||||  levofloxacin / Generic mfg.
    Journal:  Two Cases of Iatrogenic Levofloxacin-Resistant Pre-XDR Tuberculosis in Japan. (Pubmed Central) -  Jan 15, 2025   
    However, by the time these patients were transferred to our hospital and began MDR-TB treatment, they had already developed resistance to levofloxacin, escalating their condition to pre-XDR TB. These cases underscore the importance of rapid access to comprehensive DST upon the identification of rifampicin resistance and adherence to established clinical guidelines.
  • ||||||||||  levofloxacin / Generic mfg.
    Preclinical, Journal:  Computational assessment and in (Pubmed Central) -  Jan 15, 2025   
    These cases underscore the importance of rapid access to comprehensive DST upon the identification of rifampicin resistance and adherence to established clinical guidelines. Compound 8 exhibited AcrB inhibition activity in
  • ||||||||||  Journal:  Antimicrobial agents in agricultural fertilizers produced from sewage sludge - A cause for concern? (Pubmed Central) -  Jan 12, 2025   
    Our results suggest the role of guinea pigs as a zoonotic reservoir for occupational exposure to respiratory pathogens in the Andean region of South America, where guinea pig farming is an important industry. Several AAs were successfully removed during the sludge treatment process (sulfasalazine, sulfapyridine, isoniazid, isonicotinic acid, erythromycin, clarithromycin, erythromycin N-desmethyl, clarithromycin N-desmethyl, azithromycin N-desmethyl, emtricitabine, ANP) with reduction ranging from 34
  • ||||||||||  levofloxacin / Generic mfg., warfarin / Generic mfg.
    Journal:  A 51-Year-Old Man With Dyspnea and a Pulmonary Nodule. (Pubmed Central) -  Jan 12, 2025   
    Several AAs were successfully removed during the sludge treatment process (sulfasalazine, sulfapyridine, isoniazid, isonicotinic acid, erythromycin, clarithromycin, erythromycin N-desmethyl, clarithromycin N-desmethyl, azithromycin N-desmethyl, emtricitabine, ANP) with reduction ranging from 34 He was diagnosed as having pulmonary infection and treated with levofloxacin for 12
  • ||||||||||  Preclinical, Journal:  Increased in vitro antimicrobial resistance of Mycoplasma pneumoniae isolates obtained from children in Beijing, China, in 2023. (Pubmed Central) -  Jan 12, 2025   
    The resistance rates of M. pneumoniae isolates against erythromycin and azithromycin were both 100% (62/62)...No resistance to tetracycline and levofloxacin was observed...Our study showed that macrolide-resistant M. pneumoniae (MRMP) with high in vitro antimicrobial resistance level may be the causative factor of the M. pneumoniae epidemic in late 2023 in Beijing, China. It is urgent to pay more attention to MRMP and the antibiotics choose.
  • ||||||||||  levofloxacin / Generic mfg., Gracevit (sitafloxacin) / Daiichi Sankyo
    Journal:  Early bactericidal activity of sitafloxacin against pulmonary tuberculosis. (Pubmed Central) -  Jan 8, 2025   
    In addition, this novel fluoroquinolone has a good safety profile. Our study data highlights the potential of sitafloxacin in the clinical management of drug-susceptible tuberculosis, as well as drug-resistant tuberculosis.
  • ||||||||||  Trial completion:  Treatment Shortening of MDR-TB Using Existing and New Drugs (clinicaltrials.gov) -  Jan 3, 2025   
    P2,  N=214, Completed, 
    Our study data highlights the potential of sitafloxacin in the clinical management of drug-susceptible tuberculosis, as well as drug-resistant tuberculosis. Unknown status --> Completed