- |||||||||| ciprofloxacin oral / Generic mfg., levofloxacin / Generic mfg.
Journal: Using Targeted Nano-Antibiotics to Improve Antibiotic Efficacy against Staphylococcus aureus Infections. (Pubmed Central) - Jun 28, 2023
In comparison to the free-form antibiotic, the targeted nano-antibiotic exhibited enhanced antimicrobial activity against both the planktonic and biofilm forms of S. aureus. Furthermore, our data suggested that the efficacy of a targeted nano-antibiotic treatment can be influenced by its antibiotic release profile.
- |||||||||| vancomycin / Generic mfg., levofloxacin / Generic mfg., cefuroxime / Generic mfg.
Journal: Clinical Features, Antibiotic Susceptibilities, and Outcomes of Endophthalmitis Caused by Streptococcal Infection: Children vs. Adults. (Pubmed Central) - Jun 28, 2023
The commonly used antibiotics, vancomycin, cefuroxime, and fluoroquinolone, showed higher antibiotic susceptibility. After prompt treatment, visual outcomes improved.
- |||||||||| levofloxacin / Generic mfg.
Journal: Ultrasonic-assisted photocatalytic degradation of various organic contaminants using ZnO supported on a natural polymer of sporopollenin. (Pubmed Central) - Jun 23, 2023
Here, sporopollenin/zinc oxide (SP/ZnO) was used as an environmentally friendly and durable catalyst for sonophotocatalytic treatment of three organic compounds: direct blue 25 (DB 25), levofloxacin (LEV), and dimethylphtalate (DMPh)...Moreover, gas chromatography-mass spectrometry (GC-MS) analyses indicated that the contaminants were initially converted into cyclic compounds and then into aliphatic compounds, including carboxylic acids and animated products. Thus, this study synthesized an environmentally friendly and reusable SP/ZnO composite for the degradation of various organic pollutants using a sonophotocatalytic process.
- |||||||||| levofloxacin / Generic mfg., doxycycline / Generic mfg.
Journal, Pleural effusion: Pleural effusion-related Nocardia otitidiscaviarum, Anaplasma platys and Ehrlichia canis coinfection in a dog. (Pubmed Central) - Jun 23, 2023
Therapy of N. otitidiscaviarum isolate using levofloxacin (supported by a previous in vitro susceptibility testing) and doxycycline for E. canis and A. platys resulted in complete resolution of the clinical picture. Here, we report for the first time a triple coinfection by Nocardia otitidiscaviarum, A. platys, and E. canis in a dog with pleural effusion, where debilitating or immunosuppressive conditions induced by A. platys and E. canis coinfection probably contributed to the opportunistic behavior of N. otitidiscaviarum.
- |||||||||| levofloxacin / Generic mfg., cyclophosphamide / Generic mfg.
Journal: Role of fluoroquinolone prophylaxis in allogeneic hematopoietic cell transplantation in regions with a high prevalence of fluoroquinolone resistance. (Pubmed Central) - Jun 22, 2023
Allo-HCT recipients until 2016 were administered FQ prophylaxis (levofloxacin)...The no-antibiotic prophylaxis cohort had a higher proportion of malignant diagnoses (80% vs. 58%, p = 0.01), haploidentical transplants (46% vs. 14%, p = 0.004), and posttransplant cyclophosphamide exposure (46% vs. 14%, p = 0.003) than did the FQ cohort...The 1-year OS was similar between the two cohorts (66% vs. 67%, p = 0.6). This study shows that FQ prophylaxis did not affect the incidence of GNB bacteremia, parenteral antibiotic use, hospitalization duration, acute GVHD, and OS post-allo-HCT.
- |||||||||| Journal: Susceptibility-guided sequential strategy versus empirical (Pubmed Central) - Jun 20, 2023
P=N/A
It should implement a health education strategy and hygiene measures to prevent the spread of wound infection-causing organisms in the community. This randomised controlled trial will provide objective and valid evidence about the value of polymerase chain reaction-based molecular methods for antibiotic susceptibility testing in guiding H. pylori eradication.
- |||||||||| levofloxacin / Generic mfg.
PK/PD data, Journal: Pharmacokinetic/Pharmacodynamic Comparison between Generic and Brand-name Levofloxacin based on Monte Carlo Simulation. (Pubmed Central) - Jun 20, 2023
This randomised controlled trial will provide objective and valid evidence about the value of polymerase chain reaction-based molecular methods for antibiotic susceptibility testing in guiding H. pylori eradication. Our results indicated that PK or PD equivalence did not imply therapeutic equivalence; thus, we suggest including PK/PD analysis in the bioequivalence evaluation system, which benefits prediction of clinical outcome with high application value.
- |||||||||| ciprofloxacin oral / Generic mfg., levofloxacin / Generic mfg., moxifloxacin intravenous / Generic mfg.
Clinical, Journal: In-Class Cross-Reactivity among Hospitalized Patients with Hypersensitivity Reactions to Fluoroquinolones. (Pubmed Central) - Jun 19, 2023
This was a study of patients with a ciprofloxacin, moxifloxacin, or levofloxacin hypersensitivity reaction and a documented electronic medical record administration of a different fluoroquinolone. Numerically, the most common reaction risk occurred with a challenge to moxifloxacin (2/19; 9.5%), followed by ciprofloxacin (6/89; 6.3%), and levofloxacin (1/44; 2.2%).
- |||||||||| Cubicin (daptomycin) / Merck (MSD)
Journal: Eradication of Staphylococcus epidermidis within Biofilms: Comparison of Systemic versus Supratherapeutic Concentrations of Antibiotics. (Pubmed Central) - Jun 19, 2023
Vancomycin, daptomycin, levofloxacin, and minocycline were used alone and combined with rifampin to evaluate the effect of biofilm eradication...Simulated humanized systemic doses of a lipoglycopeptide (daptomycin), a fluoroquinolone (levofloxacin), a tetracycline (minocycline), and a glycopeptide (vancomycin) alone failed to eradicate a formed S. epidermidis biofilm...Supratherapeutic daptomycin dosing may be effective at the site of action to eradicate biofilms. Further studies are needed.
- |||||||||| Journal: Long-Read- and Short-Read-Based Whole-Genome Sequencing Reveals the Antibiotic Resistance Pattern of Helicobacter pylori. (Pubmed Central) - Jun 19, 2023
However, a relatively higher error rate of sequencing reads was also found. In this study, we compared Nanopore sequencing and Illumina sequencing for revealing single nucleotide variations in the 23S rRNA gene, which determines clarithromycin resistance, and we found that although there were a few false discoveries, Nanopore sequencing showed good consistency with Illumina sequencing, indicating that it is a potential tool for predicting clarithromycin resistance.
- |||||||||| Journal: Whole-Genome Sequencing and Comparative Genomics Analysis of a Newly Emerged Multidrug-Resistant Klebsiella pneumoniae Isolate of ST967. (Pubmed Central) - Jun 19, 2023
Multilevel comparative analysis revealed that ARM01 (an isolate belonging to a newly emerged K. pneumoniae ST967 lineage) was genetically similar to two isolates recovered from Qatar. ARM01 was resistant to a wide range of antibiotics, reflecting the unregulated usage of antibiotics (in most LMICs, antibiotic use is typically unregulated.) Understanding the genetic makeup of these newly emerging lineages will aid in optimizing antibiotic use for patient treatment and contribute to the worldwide efforts of pathogen and AMR surveillance and implementation of more effective infection prevention and control strategies.
- |||||||||| Retrospective data, Review, Journal: Epidemiology of pathogens and antimicrobial resistance of nosocomial urinary tract infections in patients with spinal cord injuries in China: A systematic review and meta-analysis. (Pubmed Central) - Jun 19, 2023
coli was more likely to be resistant to Levofloxacin, Amikacin, sulfonamides, 4th-generation cephalosporins and Nitrofurantoin before 2012 (81.8% vs. 62.9%, 32.0% vs. 7.6%, 81.3% vs. 61.6%, 81.8% vs. 24.1%, 33.5% vs. 5.1%), whereas E. coli was more frequently resistant to Inhibitor-resistant ?-lactamas after 2012 (56.3% vs. 34.0%)...pneumoniae was more likely to be resistant to Aztreonam, Amikacin before 2012 (80.0% vs. 39.8%, 48.1% vs. 19.0%)...UTI in patients with SCI in China were mainly caused by gram-negative bacteria. We observed a remarkable modification in resistance profiles of pathogen distribution before 2012 and after 2012, which suggests reasonable control of the use of antibiotics has a positive effectiveness on resistance profiles.
- |||||||||| levofloxacin / Generic mfg.
Clinical, P3 data, Journal: Efficacy and safety of 1.5% levofloxacin otic solution for the treatment of otitis media in a multicenter, randomized, double-blind, parallel-group, placebo-controlled, phase III study. (Pubmed Central) - Jun 19, 2023
No deaths or serious treatment-related AEs were observed. The study provided confirmation that 1.5% LVFX otic solution is a safe, well-tolerated, and effective treatment for CSOM and AOM.
- |||||||||| Journal: Antibiotics Associated With Clostridium difficile Infection. (Pubmed Central) - Jun 16, 2023
Conclusion The antibiotics associated with C. difficile infection are piperacillin/tazobactam, meropenem, vancomycin, ciprofloxacin, ceftriaxone, and levofloxacin. Other risk factors for CDI are proton pump inhibitor use, prior hospital admission, solid organ malignancy, neutropenia, diabetes mellitus (DM), and chronic kidney disease (CKD).
- |||||||||| levofloxacin / Generic mfg.
Preclinical, Journal: Glutamate Transporters GltS, GltP and GltI Are Involved in Escherichia coli Tolerance In Vitro and Pathogenicity in Mouse Urinary Tract Infections. (Pubmed Central) - Jun 16, 2023
Furthermore, deletion of gltS, gltP, and gltI genes in E. coli BW25113 results in decreased tolerance to antibiotics (levofloxacin and ofloxacin) and stressors (acid pH, hyperosmosis, and heat), and loss of gltS, gltP, and gltI in uropathogenic E. coli UTI89 caused attenuated adhesion and invasion in human bladder epithelial cells and markedly reduced survival in mice. The results showed the important roles of the glutamate transporter genes gltI, gltP, and gltS in E. coli tolerance to antibiotics (levofloxacin and ofloxacin) and stressors (acid pH, hyperosmosis, and heat) in vitro and in pathogenicity in mouse urinary tracts and human bladder epithelial cells, as shown by reduced survival and colonization, which improves our understanding of the molecular mechanisms of bacterial tolerance and pathogenicity.
- |||||||||| ciprofloxacin oral / Generic mfg., levofloxacin / Generic mfg., norfloxacin / Generic mfg.
Journal, Machine learning: Magnetic FeO@COF@Ag SERS substrate combined with machine learning algorithms for detection of three quinolone antibiotics: Ciprofloxacin, norfloxacin and levofloxacin. (Pubmed Central) - Jun 16, 2023
The results showed the important roles of the glutamate transporter genes gltI, gltP, and gltS in E. coli tolerance to antibiotics (levofloxacin and ofloxacin) and stressors (acid pH, hyperosmosis, and heat) in vitro and in pathogenicity in mouse urinary tracts and human bladder epithelial cells, as shown by reduced survival and colonization, which improves our understanding of the molecular mechanisms of bacterial tolerance and pathogenicity. The classification accuracy of the spectral dataset could reach 100% and the results of LOD calculation were: CIP: 5.61
- |||||||||| ciprofloxacin oral / Generic mfg., piperacillin sodium/tazobactam sodium / Generic mfg., levofloxacin / Generic mfg.
Journal: Evaluation of Antimicrobial Susceptibility Testing Performance of DL 96 System for Enterobacterales. (Pubmed Central) - Jun 13, 2023
A total of 103 carbapenem-resistant Enterobacterales were evaluated; DL 96E miss identified 22 isolates, including six carbapenemase-producing Enterobacteriaceae. DL 96E must adjust the Minimum Inhibitory Concentration (MIC) ranges of ciprofloxacin, levofloxacin, and piperacillin-tazobactam to cover Clinical and Laboratory Standards Institute (CLSI) breakpoints, adjust the formulation of some antimicrobial, such as imipenem, and increase the MIC detection range to cover the Quality control (QC) strains' MIC range.
- |||||||||| levofloxacin / Generic mfg., rifampicin / Generic mfg.
Journal: Comparison of Staphylococcus aureus tolerance between antimicrobial blue light, levofloxacin, and rifampin. (Pubmed Central) - Jun 12, 2023
We determined that phenotype is an important characteristic to consider when determining aBL parameters for treating OI implant infections. Future research would benefit from expanding these findings against clinical S. aureus isolates and other bacterial strains, as well as the safety of long aBL exposures on human cells.
- |||||||||| simvastatin / Generic mfg., levofloxacin / Generic mfg., rifampicin / Generic mfg.
Journal: 3D-bioimplants mimicking the structure and function of spine units for the treatment of spinal tuberculosis. (Pubmed Central) - Jun 12, 2023
The IVD scaffold incorporates a gelatin hydrogel loaded with regenerative platelet-rich plasma and anti-inflammatory simvastatin-loaded mixed nanomicelles...Moreover, the custom-designed replacements have achieved the expected prolonged release of antibiotics up to 60 days. Given the promising study findings, the utilization of the developed drug-eluting scaffold system can be extrapolated to treat not only spinal TB but also to resolve diverse backbone/spine problems that need a critical surgical process including degenerative IVD and its consequences like atherosclerosis, sliding or spondylolisthesis and severe traumatic bone fracture.
- |||||||||| levofloxacin / Generic mfg., clarithromycin / Generic mfg.
Review, Journal: Diagnosis and Treatment of Helicobacter pylori Infection in Real Practice-New Role of Primary Care Services in Antibiotic Resistance Era. (Pubmed Central) - Jun 10, 2023
Both gastroenterologists and mainly primary care physicians (PCPs), who currently routinely manage this infection, perform suboptimal management of the diagnosis and treatment of H. pylori infection by not following the current consensus recommendations. In order to improve H. pylori infection management and to increase PCPs' compliance with guidelines, some strategies have been evaluated with satisfactory results, but it is still necessary to design and evaluate new different approaches.
- |||||||||| levofloxacin / Generic mfg.
Journal: OP-4?Development of novel human-derived hybrid host defense peptides for infectious keratitis. (Pubmed Central) - Jun 10, 2023
Our results supported the administration of thioridazine, as an efflux pump inhibitor, in fluoroquinolone-resistant E. faecium infections due to its synergistic effect with CIP. Rational hybridisation of HDPs, with guidance from MD simulations, has enabled the development of a novel HDP-based therapy for IK.
- |||||||||| Journal: The Distribution, Drug Susceptibility, and Dynamic Trends of Pseudomonas aeruginosa Infection in a Tertiary Hospital in China During 2016?2022. (Pubmed Central) - Jun 9, 2023
The P. aeruginosa infections demonstrated a greater sensitivity to amikacin (AMK, 91.82%), tobramycin (TOB, 82.79%), and gentamycin (GEN, 82.01%); however, P. aeruginosa infection demonstrated greater resistance to ticarcillin (22.57%), levofloxacin (21.63%), and ciprofloxacin (18.00%). The P. aeruginosa infections were commonly observed in the Neurosurgery, Emergency, and Critical Care Medicine departments and demonstrated greater sensitivity to AMK, TOB, and GEN than the other drugs.
- |||||||||| levofloxacin / Generic mfg., trimethoprim/sulfamethoxazole / Generic mfg., cefadroxil / Generic mfg.
New trial, Gram negative: BALANCE+ Vanguard Phase (clinicaltrials.gov) - Jun 7, 2023
P=N/A, N=72, Not yet recruiting,
|
