levofloxacin / Generic mfg. 
Welcome,         Profile    Billing    Logout  
 0 Diseases   137 Trials   137 Trials   5343 News 


«12...2324252627282930313233...9091»
  • ||||||||||  levofloxacin / Generic mfg., rosiglitazone / Generic mfg.
    Journal:  Mechanistic Understanding of Idiosyncratic Drug-Induced Hepatotoxicity Using Co-Cultures of Hepatocytes and Macrophages. (Pubmed Central) -  Jul 29, 2023   
    Then, mono-cultures and co-cultures were treated with model iDILI compounds (trovafloxacin, troglitazone) and their parent non-iDILI compounds (levofloxacin, rosiglitazone), and the effects on viability and the mechanisms implicated (i.e., oxidative stress induction) were analyzed. Our results show that co-culture systems including hepatocytes (HepG2) and other cell types (THP-1-derived macrophages) help to enhance the mechanistic understanding of iDILI, providing better hepatotoxicity predictions.
  • ||||||||||  levofloxacin / Generic mfg.
    Journal:  OP-4?Development of novel human-derived hybrid host defense peptides for infectious keratitis. (Pubmed Central) -  Jul 26, 2023   
    In addition, an increase in P. aeruginosa resistance to beta-lactams, quinolones, carbapenems, and cephalosporins was observed during the COVID-19 pandemic compared with the period before the pandemic, especially in ICUs. Rational hybridisation of HDPs, with guidance from MD simulations, has enabled the development of a novel HDP-based therapy for IK.
  • ||||||||||  levofloxacin / Generic mfg.
    Journal:  Atomic hydrogen-mediated enhanced electrocatalytic hydrodehalogenation on Pd@MXene electrodes. (Pubmed Central) -  Jul 24, 2023   
    Furthermore, the high activity of Pd@MX/CC was also observed in the ECH of other halogenated organic pollutants (levofloxacin, tetrabromobisphenol A, and diatrizoate). Density functional theory (DFT) calculations revealed that electronic configuration modulation of the Pd@MXene catalyst optimized binging energies to H*
  • ||||||||||  levofloxacin / Generic mfg.
    Journal:  Atomic-Scale Resolution Insights into Structural and Dynamic Differences between Ofloxacin and Levofloxacin. (Pubmed Central) -  Jul 10, 2023   
    Additionally, the study employs the H-C frequency-switched Lee-Goldburg heteronuclear correlation (FSLGHETCOR) experiment to identify the presence of heteronuclear correlations between specific nuclei (C15 and H7 nuclei and C13 and H12 nuclei) in ofloxacin but not in levofloxacin. These observations offer insights into the link between bioavailability and nuclear spin dynamics, underscoring the significance of NMR crystallography approaches in advanced drug design.
  • ||||||||||  Zavicefta (ceftazidime/avibactam) / Pfizer, AbbVie
    Preclinical, Journal:  In vitro activities of antimicrobial combinations against planktonic and biofilm forms of Stenotrophomonas maltophilia. (Pubmed Central) -  Jul 6, 2023   
    The susceptibility rates of levofloxacin (LVX), fosfomycin (FOS), tigecycline (TGC) and sulfamethoxazole-trimethoprim (SXT) against 32 S. maltophilia isolates were 56.3, 71.9, 71.9 and 90.6%, respectively...Antibiotic combinations, including aztreonam-clavulanic (ATM-CLA) with LVX, ceftazidime-avibactam (CZA) with LVX and SXT with TGC, exhibited potent inhibitory activity against these isolates with strong biofilm formation...maltophilia remained resistant to most antibiotics, including LVX and ?-lactam/?-lactamases; however, TGC, FOS and SXT still exhibited potent activity. Although all tested S. maltophilia isolates exhibited moderate-to-strong biofilm formation, combination therapies, especially ATM-CLA with LVX, CZA with LVX and SXT with TGC, exhibited a higher inhibitory activity for these isolates.
  • ||||||||||  levofloxacin / Generic mfg.
    Atypical Papular Tuberculid- Uncommon manifestation of a common disease () -  Jul 3, 2023 - Abstract #WCD2023WCD_7381;    
    Patient was started on HRLE (Isoniazid, Rifampicin, Levofloxacin and Ethambutol) regimen as she developed Hepatitis...KEY MESSAGE: In India, with high prevalence of Tuberculosis, the existence of cutaneous tuberculosis is likely and focus of infection may not be found in majority of cases. It is essential for clinicians to suspect Tuberculid in a patient with recurrent eruption that heal with scarring in an endemic area
  • ||||||||||  amoxycillin/clavulanate / Generic mfg.
    Sweet Syndrome Induced By Amoxicillin-Clavulanate () -  Jul 3, 2023 - Abstract #WCD2023WCD_5281;    
    One case of histiocytoid SS has been reported induced by Levofloxacin and AC. A case of SS have been reported associated with upper respiratory infection and amoxicillin use but no case of SS have been reported induced by AC.
  • ||||||||||  Facial atypical mycobacteriosis by M. abscesus due to cosmetic filler: case report () -  Jul 3, 2023 - Abstract #WCD2023WCD_4372;    
    One month later began with skin redness and mild pain when pressure in application sites and was attended by a doctor who suspected foreign body type granuloma and applied intralesional corticosteroids, colchicine and non specified antibiotics with partial response...Treatment started with clarithromycin 500 mg BID, Levofloxacin 500 mg OD and Trimetroprim-Sulfametoxazole 800/160 mg BID for one month an then only clarithromycin + Levofloxacin continued for 8 months...(5) Macrolid like clarithromycin and a quinolone like moxifloxacin or ciprofloxacin are adequate empiric treatment, awaiting and tempered by the sensitivity report. (2) This clinical case illustrates the risk of late complications due to filler material, particularly hyaluronic acid, and possible contamination due to inappropriate aseptic technique
  • ||||||||||  Journal:  Profiling of Antimicrobial Resistance Genes and Integron from Escherichia coli Isolates Using Whole Genome Sequencing. (Pubmed Central) -  Jul 2, 2023   
    The E. coli isolates were 100% sensitive to amikacin, followed by chloramphenicol, cefixime, cefoperazone, and cephalothin...The different classes of antibiotics included aminoglycoside, sulphonamide, tetracycline, trimethoprim, quinolone, fosfomycin, phenicol, macrolide, colistin, fosmidomycin, and multidrug efflux. The class 1 integrons were detected in 6/8 (75.00%) isolates with 14 different gene cassettes.
  • ||||||||||  Journal:  Current Prevalence of Antimicrobial Resistance in Okayama from a National Database between 2018 and 2021. (Pubmed Central) -  Jun 30, 2023   
    The average isolated proportions of the seven AMR pathogens were higher in Okayama compared to other prefectures: the worst (19.9%) was meropenem-resistant P. aeruginosa, the sixth worst (57.2%) was methicillin-resistant S. aureus, the eighth worst (3.3%) was vancomycin-resistant E. faecium, the second (37.8%) and fifth worst (17.6%) were cefotaxime-resistant E. coli and K. pneumoniae, respectively, and the fourth (49.9%) and third worst (8.7%) were levofloxacin-resistant E. coli and K. pneumoniae, respectively. Our study highlights the notably high prevalences of representative AMR pathogens in Okayama, suggesting the need for fundamental infection prevention and control by healthcare professionals, promoting antimicrobial stewardship, and educating undergraduates and postgraduates in Okayama.
  • ||||||||||  ciprofloxacin oral / Generic mfg., levofloxacin / Generic mfg.
    Journal:  Oral Fluoroquinolones and Risk of Aortic Aneurysm or Dissection: A Nationwide Population-Based Propensity Score Matched Cohort Study. (Pubmed Central) -  Jun 29, 2023   
    Our study highlights the notably high prevalences of representative AMR pathogens in Okayama, suggesting the need for fundamental infection prevention and control by healthcare professionals, promoting antimicrobial stewardship, and educating undergraduates and postgraduates in Okayama. Fluoroquinolone use was associated with a 34% increased risk of aortic aneurysm or dissection compared to macrolide use among a general US population.
  • ||||||||||  levofloxacin / Generic mfg.
    Journal:  Preparation of Co-Amorphous Levofloxacin Systems for Pulmonary Application. (Pubmed Central) -  Jun 28, 2023   
    Fluoroquinolone use was associated with a 34% increased risk of aortic aneurysm or dissection compared to macrolide use among a general US population. With a mass median aerodynamic diameter of just over 2
  • ||||||||||  ceftriaxone / Generic mfg., levofloxacin / Generic mfg., meropenem / Generic mfg.
    Journal:  Cyclodextrins and Their Polymers Affect Human Serum Albumin's Interaction with Drugs Used in the Treatment of Pulmonary Infections. (Pubmed Central) -  Jun 28, 2023   
    The drug's encapsulation in CD carriers leads to a decrease in the degree of change in the protein's secondary structure. The drug-CD carrier-HSA complexes demonstrate satisfying antibacterial activity in vitro, and even a high binding affinity does not decrease the drug's microbiological properties after 24 h. The proposed carriers are promising for a drug form with a prolonged drug release.