levofloxacin / Generic mfg. 
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  • ||||||||||  PSEUDOTUMOR OR PSEUDOMONAS? (Convention Center Exhibit Hall - Rapid Area 2C) -  Aug 4, 2023 - Abstract #CHEST2023CHEST_800;    
  • ||||||||||  levofloxacin / Generic mfg.
    Journal, IO biomarker:  Meticulously Designed Carbon Dots as Photo-Triggered RNA-Destroyer for Evoking Pyroptosis. (Pubmed Central) -  Aug 3, 2023   
    = 38.85%) and superior RNA selectivity...This work represents the meticulously designed CDs with high ROS generation and utilization efficiency via good organization of the photosensitive and targeting modularity. Moreover, it is the first CDs-based pyroptosis inducer to the best of our knowledge.
  • ||||||||||  Cubicin (daptomycin) / Merck (MSD)
    Journal:  Nasal Carriage of Methicillin-Resistant Staphylococcus Sciuri Group by Residents of an Urban Informal Settlement in Kenya. (Pubmed Central) -  Aug 2, 2023   
    Resistance was observed to clindamycin (63%), tetracycline (56%), erythromycin (56%), sulfamethoxazole/trimethoprim (25%), daptomycin (19%), rifampicin (13%), doxycycline, linezolid, and vancomycin (each 6%)...Our study scope precluded identifying other molecular determinants for all the observed resistance phenotypes. Larger studies that address the prevalence and risk factors for colonization with S. sciuri group and adopt a one health approach can complement the surveillance efforts.
  • ||||||||||  ciprofloxacin oral / Generic mfg., levofloxacin / Generic mfg.
    Journal:  Genomic alterations involved in fluoroquinolone resistance development in Staphylococcus aureus. (Pubmed Central) -  Jul 30, 2023   
    Therefore, it is essential to incorporate basic hygiene measures into the cycle of meat production to ensure food safety. The emergence of MDR S. aureus was associated with the mutations in the FQ-target sequences and the overexpression of efflux pump systems and their regulators.
  • ||||||||||  Carafate (sucralfate) / AbbVie
    Reliance on Clinical Judgment to Target Immunohistochemical Stain Use for Diagnosis of HSV Esophagitis (Exhibit Hall) -  Jul 29, 2023 - Abstract #ACG2023ACG_3812;    
    As part of her IVF, the patient had completed a 10-day course of dexamethasone 2mg daily six weeks prior to presentation...The patient was started on a proton pump inhibitor and sucralfate...The patient was started on a 10-day course of valacyclovir with eventual resolution of symptoms following treatment...Compared with routine hematoxylin and eosin (H&E) staining, IHC is more sensitive and can identify more infected cells. IHC stains should primarily be employed in cases where histopathologic findings are ambiguous and clinical suspicion remains high.
  • ||||||||||  Mycobutin (rifabutin) / Pfizer, Lupin, Talicia (amoxicillin/omeprazole/rifabutin) / RedHill
    Treatment Resistant Helicobacter pylori in a Patient with Tuberculosis (Exhibit Hall) -  Jul 29, 2023 - Abstract #ACG2023ACG_3264;    
    Due to documented local resistance to triple therapy, he started quadruple therapy with bismuth subsalicylate, pantoprazole, metronidazole and tetracycline...Following completion of his tuberculosis treatment he started on omeprazole, rifabutin and amoxicillin for H pylori salvage therapy...If the first regimen fails, the second line is using an antibiotic not used in the initial treatment such as, a bismuth quadruple therapy, levofloxacin or clarithromycin containing therapy...There are currently no studies proving an acquired resistance to rifabutin with prior exposure. In this patient despite prior exposure to rifampin, he was successfully treated with a rifabutin based therapy.
  • ||||||||||  The Hidden Peril of Multiple Drug Exposure: A Fatal Case of Acute Liver Injury (Exhibit Hall) -  Jul 29, 2023 - Abstract #ACG2023ACG_3016;    
    Complications arose, leading to brain/scalp abscess, requiring treatment with vancomycin and cefepime...The antibiotic regimen was exchanged for levofloxacin; however, the patient subsequently developed new-onset jaundice, anorexia, abdominal pain, and pruritus...Despite switching the antibiotic therapy to trimethoprim/sulfamethoxazole, the patient's condition rapidly deteriorated, resulting in acute liver failure and eventual death...It underscores the critical need for diligent monitoring, prompt identification, and cessation of the offending drug, as it offers the possibility of complete recovery, and improves patient outcomes. Advancements in diagnostic approaches, such as incorporating genetic and metabolic factors, hold promise in identifying the responsible drug and enhancing the management of drug-induced hepatotoxicity.
  • ||||||||||  Mycamine (micafungin) / Astellas
    I (Eye) Spot a Fungus Ball in the Heart: Opportunistic Pathogens in Primary Sclerosing Cholangitis (Exhibit Hall) -  Jul 29, 2023 - Abstract #ACG2023ACG_2022;    
    She was given intravenous (IV) ceftriaxone and octreotide for suspected variceal hemorrhage...Post-endoscopy, she was discharged with oral levofloxacin...The cultured mass confirmed Candida albicans, which later led to septic emboli and endophthalmitis, treated with IV micafungin and intravitreous voriconazole...Figure: Figure 1: Apical four-chamber view of a transthoracic echocardiogram demonstrating mobile right atrial thrombus consistent with intracardiac fungus ball. RA: Right Atrium; LA: Left Atrium; LV: Left Ventricle; RV: Right Ventricle.
  • ||||||||||  Remicade (infliximab) / Merck (MSD), Mitsubishi Tanabe, J&J, Entyvio (vedolizumab) / Takeda
    A Discerning Eye for Nontuberculous Mycobacterium: A Case Series (Exhibit Hall) -  Jul 29, 2023 - Abstract #ACG2023ACG_1288;    
    Figure b, c, and d- showing Terminal Ileum ulcer, cecal ulcer, and Transverse colon ulcer respectively. Case Description/ Our first patient is a 45 year-old female with non-stricturing, non-penetrating Crohn
  • ||||||||||  levofloxacin / Generic mfg.
    Underdiagnosed Medical Condition: Auto-Brewery Syndrome (Exhibit Hall) -  Jul 29, 2023 - Abstract #ACG2023ACG_1018;    
    About 6 weeks after he completed a round of levofloxacin for acute prostatitis he started complaining of intermittent encephalopathy after eating associated with significant abdominal distention and bloating...Antifungals have been implicated in their treatment. They should also carry breathalyzers with them to avoid driving when inebriated.
  • ||||||||||  piperacillin sodium/tazobactam sodium / Generic mfg., levofloxacin / Generic mfg.
    An Unusual Case of Streptococcus bovis Subspecies (S. lutetiensis) Bacteremia Associated With a Colon Ulcer (Exhibit Hall) -  Jul 29, 2023 - Abstract #ACG2023ACG_705;    
    Blood cultures grew Streptococcus lutetiensis , and the patient was treated with piperacillin-tazobactam...The patient improved and was discharged with levofloxacin...2014;20(5):405-409. Figure: 10cm deep linear ulceration in the sigmoid colon spanning 30-40cm from the anal verge (A,B) I have no tables to add
  • ||||||||||  levofloxacin / Generic mfg.
    Abdominal Cutaneous Drainage: A Rare Presentation of Recurrent Pyogenic Cholangitis (Exhibit Hall) -  Jul 29, 2023 - Abstract #ACG2023ACG_599;    
    Infectious disease was consulted for antibiotic recommendations given the extensive infection burden and recommended levofloxacin and metronidazole for 2 weeks...For optimal patient care, multidisciplinary collaboration involving gastroenterologists, radiologists, infectious disease, and surgeons is crucial. Figure: A. Coronal view of biliary anatomy B. Coronal view of hepatic fluid collection in left lobe C. Sagittal view displaying ventral abdominal soft tissue fluid collection
  • ||||||||||  Journal:  The Gut Microbiota Contributes to Systemic Responses and Liver Injury in Gut-Derived Sepsis. (Pubmed Central) -  Jul 29, 2023   
    The results of the RNA sequencing and the fecal suspension intraperitoneal injection sepsis model indicated that the amoxicillin-associated enterotype provoked acute hepatic immune responses and led to more significant metabolic compensation in the event of sepsis. Collectively, we concluded that the gut microbiota was one crucial factor for heterogeneity in sepsis, where the modulated gut microbiota likely prevented or reduced the serious consequences of sepsis, at least in gut-derived sepsis.
  • ||||||||||  Journal:  The Prevalence of the Virulence Genes of Staphylococcus aureus in Sickle Cell Disease Patients at KSUMC, Riyadh, Saudi Arabia. (Pubmed Central) -  Jul 29, 2023   
    As for the antibiotic (ampicillin, penicillin, amoxicillin, cefazolin, imipenem, oxacillin, erythromycin, tetracycline, azithromycin, ciprofloxacin, moxifloxacin, and levofloxacin) resistance of the S. aureus strains isolated from the SCD patients compared with non-SCD patients (control group), the prevalence percentages were as follows: (100% vs. 100%), (97.9% vs. 100%), (72.3% vs. 25%), (68.1% vs. 37.5%), (68.1% vs. 25%), (66% vs. 25%), (36.2% vs. 18.8%), (23.4% vs. 12.5%), (19.1% vs. 12.5%), (17% vs. 12.5%), (14.9% vs. 25%), and (10.6% vs. 18.7%). This study concluded that several virulence genes were present in the S. aureus strains recovered from the SCD patients at KSUMC, with all the isolates containing the finbB, sdrC, sdrD, icaA, coa, nuc, hlg, and hla genes.
  • ||||||||||  levofloxacin / Generic mfg., norfloxacin / Generic mfg., sulphadiazine / Generic mfg.
    Journal:  Analysis, Occurrence and Exposure Evaluation of Antibiotic and Anthelmintic Residues in Whole Cow Milk from China. (Pubmed Central) -  Jul 29, 2023   
    Satisfactory recoveries were obtained using the modified QuEChERS method, with recoveries of the antibiotics ranging from 79.7 to 117.2%, with the exception of norfloxacin, which was at 53.4%, while those for anthelmintics were in the range of 73.1-105.1%...Fenbendazole, febantel, enrofloxacin, levofloxacin, sulfadiazine, and sulfamethoxazole were the predominant drug residues in the whole cow milk samples...Based on the current study, exposure to antibiotics and anthelmintics through whole cow milk consumption are lower than the acceptable daily intake values suggested by the China Institute of Veterinary Drug Control. However, long-term exposure to low doses of antibiotics and anthelmintics still needs attention and merits further study.