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137 Trials |
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137 Trials |  |
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- | levofloxacin / Generic mfg., clarithromycin / Generic mfg.
Journal, Polymerase Chain Reaction: Quantitative Polymerase Chain Reaction (qPCR)-Based Rapid Diagnosis of Helicobacter pylori Infection and Antibiotic Resistance. (Pubmed Central) - Aug 18, 2023
Specifically, we used qPCR to detect rea for H. pylori infection and mutations in the 23S rRNA and gyrA genes, which encode resistance against clarithromycin and levofloxacin, respectively. Compared to routinely used culturing techniques, this protocol provides a noninvasive, low-cost, and time-saving technique to detect H. pylori infection and determine its antibiotic resistance using qPCR.
- || Nplate (romiplostim) / Amgen, Kyowa Kirin, Abthrax (raxibacumab) / Emergent Biosolutions
Review, Journal: United States' regulatory approved pharmacotherapies for nuclear reactor explosions and anthrax-associated bioterrorism. (Pubmed Central) - Aug 18, 2023
For bioterrorism-associated anthrax, the FDA approved five antibiotics (doxycycline, penicillin-G, levofloxacin, moxifloxacin, and ciprofloxacin), two monoclonal antibodies (obiltoxaximab and raxibacumab), one polyclonal antitoxin (Anthrax Immune Globulin Intravenous) and two vaccines (Anthrax Vaccine Adsorbed and Anthrax Vaccine Adsorbed with an adjuvant)...Two potential mass public health disasters are aerosolized anthrax dissemination and radiological incidents. Five agents authorized for anthrax emergencies only have FDA approval for this indication, five antibiotics have FDA approvals as antibiotics for common infections and for bacillus anthrax, and four agents have regulatory approvals for supportive care for cancer and for radiological incidents.
- | Journal: A Multicenter Evaluation of Overall Susceptibility and Antimicrobial Resistance Among Streptococcus pneumoniae Isolates. (Pubmed Central) - Aug 18, 2023
An increase in resistance to penicillin and macrolides among S. pneumoniae isolates was observed in the Indian population. Addressing the elevating rates of S. pneumoniae resistance may require pneumococcal conjugate vaccines (PCVs) with expanded serotype coverage and targeted antimicrobial stewardship efforts.
- | levofloxacin / Generic mfg.
Journal: Delphi Survey on the Current and Future Korean Guidelines for Isoniazid-Monoresistant Tuberculosis. (Pubmed Central) - Aug 17, 2023
Over 95.8% of experts recommended treating Hr-TB with a combination of rifampin, ethambutol, pyrazinamide, and levofloxacin for six months, without exceeding 12 months unless necessary...This Delphi survey enabled Korean tuberculosis experts to reach a consensus on diagnosing and treating Hr-TB. These findings will be valuable for developing the upcoming revised Korean guidelines for Hr-TB management.
- | levofloxacin / Generic mfg.
Journal: Evaluation of drug-induced liver toxicity of trovafloxacin and levofloxacin in a human microphysiological liver model. (Pubmed Central) - Aug 16, 2023
Similar to in vivo, cytokine secretion was dependent on a multicellular immune response, highlighting the potential of the complex microphysiological liver model for reliably detecting drug-related cytotoxicity in preclinical testing. Moreover, hepatic glutathione depletion and mitochondrial ROS formation were elucidated as intrinsic toxicity mechanisms contributing to trovafloxacin toxicity.
- | levofloxacin / Generic mfg., tigecycline / Generic mfg.
Preclinical, Journal: Exposure of Salmonella enterica serovar 1,4, [5],12:i:- to benzalkonium chloride leads to acquired resistance to this disinfectant and antibiotics. (Pubmed Central) - Aug 16, 2023
Moreover, hepatic glutathione depletion and mitochondrial ROS formation were elucidated as intrinsic toxicity mechanisms contributing to trovafloxacin toxicity. Repeated exposure to sublethal concentrations of BC could result in the emergence of BC- and antibiotic-resistant S. 1,4, [5],12: i:- strains.
- || Secnizol DS (secnidazole) / Incepta Pharma
P4 data, Journal: Usefulness of medicine screening tools in the frame of pharmaceutical post-marketing surveillance. (Pubmed Central) - Aug 15, 2023
In this study, three screening tools were used on 292 samples of ciprofloxacin and metronidazole collected in Cameroon...Seven additional samples from the nitro-imidazole (secnidazole, ornidazole, tinidazole) and the fluoroquinolone (levofloxacin, ofloxacin, norfloxacin, moxifloxacin) families were analyzed to mimic falsified medicines...The advantages and drawbacks of each screening tool were highlighted. They are promising means in the frame of early detection of SF medicines and they can increase the speed of decision about SF medicines in the context of pharmaceutical post-marketing surveillance.
- || Clinical data, Retrospective data, Journal: The Activities of Antimicrobials Against Stenotrophomonas maltophilia Isolates and Evaluation of Clinical Outcomes Among Treatment Regimens in Patients with Stenotrophomonas maltophilia Infections: A Retrospective Multicenter Cohort Study. (Pubmed Central) - Aug 15, 2023
However, we also report the susceptibility of minocycline and tigecycline in some clinical S. maltophilia strains (n = 149) and determined by MIC with E-test method...The predictive factors for an unfavourable outcome were severity of illness, septic shock, and non-use of TMP-SMX. Therefore, a TMP-SMX-based regimen is recommended for the treatment of S. maltophilia infections.
- | levofloxacin / Generic mfg.
Journal: Biocompatible Gallium Nanodots against Drug-Resistant Bacterial Pneumonia and Liver Abscess. (Pubmed Central) - Aug 14, 2023
aeruginosa and ESBL E. coli) compared with clinically used antibacterial drugs, including penicillin and levofloxacin...Further, the Ga NDs demonstrated excellent biocompatibility and biosafety characteristics. Together, we believe that our gallium containing nanotherapeutics are expected to be developed into promising alternative therapies to combat drug-resistant bacterial infection.
- | Observational data, Journal: Assessment of antibacterial drug utilization patterns and antibiogram in infectious diseases: a prospective cross-sectional study. (Pubmed Central) - Aug 14, 2023
The current study showed that in the antibiogram pattern, Escherichia coli and coagulase-negative Staphylococci contributed significantly as causative organisms for infectious disease cases. The present study highlighted demographic distribution, infectious diseases with their antibacterial drug utilization patterns and antibiogram assessment in the admitted patients.
- | levofloxacin / Generic mfg.
Journal: A case of testicular seminoma with testicular abscess caused by Salmonella saintpaul. (Pubmed Central) - Aug 14, 2023
With the diagnosis of epididymitis, he was administered levofloxacin (LVFX) but the fever and painful enlargement persisted...Although testicular tumors are the most common differential diseases for testicular abscess, there are few reports of testicular abscess accompanying testicular tumors. Here, we report a case of testicular seminoma with testicular abscess caused by Salmonella saintpaul.
- | Journal: Phenotypic diagnosis and genotypic identification of Bacillus cereus causing subclinical mastitis in cows. (Pubmed Central) - Aug 14, 2023
These results highlight the need to promote awareness regarding B. cereus, the most common pathogen causing mastitis in Egyptian dairy cows. We also emphasized that antibiotic misuse during mastitis is a potential public health threat.
- | Enhertu (fam-trastuzumab deruxtecan-nxki) / Daiichi Sankyo, AstraZeneca
Journal: Can You Establish the Cause of This Patient's Shortness of Breath? (Pubmed Central) - Aug 14, 2023
He received front-line leucovorin, 5-fluorouracil, and oxaliplatin (FOLFOX) and trastuzumab for 10 months before restaging imaging revealed progressive disease...He was discharged after an episode of pneumonia on a steroid taper with prophylactic trimethoprim/sulfamethoxazole...About a week later, wheezes were noticed on physical exam, and he was given a 5-day course of levofloxacin...He was discharged to an inpatient hospice facility where he passed away 2 weeks later. Drug-induced pneumonitis/ILD should be considered in all patients receiving trastuzumab deruxtecan who develop progressive shortness of breath or other respiratory complaints.
- | Lamprene (clofazimine) / Novartis, Sirturo (bedaquiline) / J&J, Pharmstandard
Trial completion: TRUNCATE-TB: Two-month Regimens Using Novel Combinations to Augment Treatment Effectiveness for Drug-sensitive Tuberculosis (clinicaltrials.gov) - Aug 14, 2023
P2/3, N=675, Completed, Sponsor: University College, London
Drug-induced pneumonitis/ILD should be considered in all patients receiving trastuzumab deruxtecan who develop progressive shortness of breath or other respiratory complaints. Unknown status --> Completed
- | levofloxacin / Generic mfg.
Journal: Expression of concern: 'Two-day versus seven-day course of levofloxacin in acute COPD exacerbation: a randomized controlled trial'. (Pubmed Central) - Aug 12, 2023
Unknown status --> Completed No abstract available
- | levofloxacin / Generic mfg.
Preclinical, Journal: Spanlastic-laden in situ gel as a promising approach for ocular delivery of Levofloxacin: In-vitro characterization, microbiological assessment, corneal permeability and in-vivo study. (Pubmed Central) - Aug 10, 2023
No abstract available The apparent permeation coefficient was (14.7
- | levofloxacin / Generic mfg.
Journal: Ultrasensitive levofloxacin electrochemical biosensor based on semiconducting covalent organic framework/poly-L-cysteine/triangular Ag nanoplates modified glassy carbon electrode. (Pubmed Central) - Aug 9, 2023
The prepared sensor also realized sensitive and accurate determination of LEV in human serum and urine samples by standard addition method, with satisfactory recoveries (97.1 to 104%) and a low relative standard deviation of less than 4.6%. These results indicated that the novel ternary system has a promising application in the development of electrochemical signal probe and electrochemical biosensing platform.
- | levofloxacin / Generic mfg., clarithromycin / Generic mfg.
Journal: Prevalence of Helicobacter pylori Antibiotic Resistance in Patients Enrolled in Guangzhou, China. (Pubmed Central) - Aug 9, 2023
The DOB value is not a direct indicator of antibiotic resistance to CLA and LEV. Therefore, it is important to use a combination of diagnostic methods to accurately assess antibiotic resistance in H. pylori infection.
- | levofloxacin / Generic mfg.
Journal: First Case of Meningoencephalitis and Bacteraemia with Flavobacterium Lindanitolerans. (Pubmed Central) - Aug 9, 2023
Therefore, it is important to use a combination of diagnostic methods to accurately assess antibiotic resistance in H. pylori infection. This is the first case of a meningoencephalitis and bacteraemia with Flavobacterium lindanitolerans.Levofloxacin can be given for 21 days as a treatment of F. lindanitolerans.
- || levofloxacin / Generic mfg.
Journal, Adverse drug reaction: An association study of HLA with levofloxacin-induced severe cutaneous adverse drug reactions in Han Chinese. (Pubmed Central) - Aug 9, 2023
Mass spectrometry revealed that nonapeptides bound to HLA-B?13:02 shifted at several positions after exposure to levofloxacin. Prospective screening for serotype B13 (sensitivity: 83%, specificity: 78%) and alternative drug treatment for carriers may significantly decrease the incidence of LEV-SCARs.
- | levofloxacin / Generic mfg.
Journal: Serotype replacement and an increase in non-encapsulated isolates among community-acquired infections of Streptococcus pneumoniae during post-vaccine era in Japan. (Pubmed Central) - Aug 9, 2023
The progression of serotype replacement in non-invasive pneumococcal infections has occurred during the post-vaccine era in Japan, and non-encapsulated isolates, such as NCC, have increased. Antimicrobial susceptibility is not worsened.
- | Biomarker, Journal, Next-generation sequencing: Helicobacter pylori Antimicrobial Resistance Using Next-Generation Sequencing in stool samples in a pediatric population. (Pubmed Central) - Aug 7, 2023
Stool next-generation sequencing-based antimicrobial susceptibility analysis was highly concordant with agar dilution for no resistance (100% agreement), as well as clarithromycin, levofloxacin, and amoxicillin resistance (100%, 67%, and 100% agreement respectively) but not concordant for metronidazole in our cohort of patients. Future studies involving a larger number of patients and geographical regions are needed to further validate this analysis.
- | Fetroja (cefiderocol) / Shionogi
Journal: Emerging infections in vulnerable hosts: stenotrophomonas maltophilia and Elizabethkingia anophelis. (Pubmed Central) - Aug 7, 2023
Immunocompromised patients are particularly vulnerable to infections caused by S. maltophilia and E. anophelis, but the optimal treatment strategy remains inconclusive. Further research is necessary to determine the most effective use of conventional and novel antimicrobial agents in combatting these multidrug-resistant pathogens.
- | levofloxacin / Generic mfg., tetracycline / Generic mfg.
Journal: Levofloxacin+Tetracycline Quadruple Regimen for Eradication of Helicobacter pylori: A Multicenter Multinational Randomized Controlled Trial. (Pubmed Central) - Aug 7, 2023
Overall, the combination of tetracycline+levofloxacin is more efficient for HP eradication in comparison with clarithromycin+amoxicillin despite more complication rate. In areas with a high rate of resistance to clarithromycin, this therapeutic regimen could be an ideal choice for HP eradication, especially among those who were diagnosed with PUD.
- | levofloxacin / Generic mfg.
Journal: Dual enzyme-mimicking carbon dots for enhanced antibacterial activity. (Pubmed Central) - Aug 7, 2023
The CDs were validated to have a broad-spectrum bactericidal effect against Gram-positive and -negative bacteria, compensating for the limitations of levofloxacin while also having enhanced sterilization ability. Importantly, the proposed Co-Lvx-CDs provide a new idea for the design of multifunctional CD-based nanozymes with preconceived outcomes.
- | New P4 trial: COPAT: Comparing Oral Versus Parenteral Antimicrobial Therapy (clinicaltrials.gov) - Aug 7, 2023
P4, N=135, Not yet recruiting, Sponsor: West Virginia University
- CONCOMITANT MYCOBACTERIUM AVIUM INTRACELLULARE PLEURITIS AND PLEUROPULMONARY KAPOSI'S SARCOMA IN AN AIDS PATIENT (Convention Center Exhibit Hall - Rapid Area 3A) - Aug 4, 2023 - Abstract #CHEST2023CHEST_5493;
- BENIGN METASTASIZING LEIOMYOMA IN A MORBIDLY OBESE WOMAN (Convention Center Exhibit Hall - Rapid Area 3C) - Aug 4, 2023 - Abstract #CHEST2023CHEST_5434;
- PULMONARY NOCARDIOSIS MASQUERADING AS AN ASTHMA-ASSOCIATED CHRONIC COUGH IN AN IMMUNOCOMPETENT HOST (Convention Center Exhibit Hall) - Aug 4, 2023 - Abstract #CHEST2023CHEST_5080;
- DOWNWARD SPIRAL AND DRAMATIC RESCUE: A CASE OF LEGIONELLA PNEUMONIA COMPLICATED BY DIFFUSE ALVEOLAR HEMORRHAGE AND REFRACTORY ACUTE RESPIRATORY DISTRESS SYNDROME (Convention Center Exhibit Hall) - Aug 4, 2023 - Abstract #CHEST2023CHEST_5078;
- MULTIORGAN CAVITARY LESIONS FROM FUSOBACTERIUM NUCLEATUM: A DIAGNOSTIC DILEMMA (Convention Center Exhibit Hall) - Aug 4, 2023 - Abstract #CHEST2023CHEST_5062;
- CONCURRENT COMPLICATIONS OF ASPERGILLUS FUMIGATUS IN A PATIENT WITH CYSTIC FIBROSIS (Convention Center Exhibit Hall) - Aug 4, 2023 - Abstract #CHEST2023CHEST_5059;
- SEVERE ARDS AND IMMUNE RECONSTITUTION SYNDROME IN A RARE CASE OF MULTIDRUG-RESISTANT TUBERCULOSIS: A CASE REPORT AND REVIEW (Convention Center Exhibit Hall) - Aug 4, 2023 - Abstract #CHEST2023CHEST_5045;
- HYPERAMMONEMIA IN A POST-LUNG TRANSPLANT PATIENT (Convention Center Exhibit Hall) - Aug 4, 2023 - Abstract #CHEST2023CHEST_3557;
- CAVITARY LUNG LESION: A RARE PRESENTATION OF PRIMARY PULMONARY HODGKIN'S LYMPHOMA (Convention Center Exhibit Hall) - Aug 4, 2023 - Abstract #CHEST2023CHEST_3414;
- THE EYES AS A WINDOW TO THE HEART: A CASE OF INFECTIVE ENDOCARDITIS PRESENTING WITH ENDOPHTHALMITIS (Convention Center Exhibit Hall) - Aug 4, 2023 - Abstract #CHEST2023CHEST_3090;
- CHRONIC CAVITARY LESION AND BACTERIAL SUPERINFECTION WITH ASPERGILLOSIS IN AN IMMUNOCOMPETENT PATIENT (Convention Center Exhibit Hall) - Aug 4, 2023 - Abstract #CHEST2023CHEST_2965;
- LEGIONELLA PNEUMOPHILA CAUSING PLEURAL EMPYEMA: CLINICAL PRESENTATION AND MANAGEMENT STRATEGY (Convention Center Exhibit Hall) - Aug 4, 2023 - Abstract #CHEST2023CHEST_2960;
- A CASE OF AEROMONAS HYDROPHILIA PNEUMONIA IN A PATIENT WITH NEWLY DIAGNOSED TUBERCULOSIS (Convention Center Exhibit Hall) - Aug 4, 2023 - Abstract #CHEST2023CHEST_2959;
- A CASE OF MOTILE BACTERIA TUNNELING THROUGH THE HEART: INFECTIVE ENDOCARDITIS WITH AORTO-ATRIAL FISTULA BY SERRATIA MARCESCENS (Convention Center Exhibit Hall) - Aug 4, 2023 - Abstract #CHEST2023CHEST_2936;
- EOSINOPHILIC ASTHMA-MASKING PULMONARY TOXOCARIASIS: A DIAGNOSTIC DILEMMA (Convention Center Exhibit Hall) - Aug 4, 2023 - Abstract #CHEST2023CHEST_2927;
- A CASE OF NON-RESOLVING PNEUMONIA (Convention Center Exhibit Hall) - Aug 4, 2023 - Abstract #CHEST2023CHEST_2920;
- COVID 19 PNEUMONIA AS A TRIGGER FOR PATHOGENICITY OF AN USUAL ORAL COMMENSAL LEADING TO EMPYEMA (Convention Center Exhibit Hall) - Aug 4, 2023 - Abstract #CHEST2023CHEST_2913;
- THE GREAT MIMICKER IN CALIFORNIA -- A RARE AND MISLEADING PRESENTATION OF DISSEMINATED COCCIDIOIDOMYCOSIS WITH EXTENSIVE ENDOBRONCHIAL INVOLVEMENT MASQUERADING LUNG CANCER (Convention Center Exhibit Hall - Rapid Area 2C) - Aug 4, 2023 - Abstract #CHEST2023CHEST_2900;
- OCHROBACTRUM ANTHROPI MASQUERADING AS RECURRENT LUNG NODULES: A MEDICAL CONUNDRUM (Convention Center Exhibit Hall - Rapid Area 2C) - Aug 4, 2023 - Abstract #CHEST2023CHEST_2895;
- A CASE OF HYPERAMMONEMIA AFTER LUNG AND KIDNEY TRANSPLANTATION ASSOCIATED WITH MYCOPLASMA SPP (Convention Center Exhibit Hall - Rapid Area 4D) - Aug 4, 2023 - Abstract #CHEST2023CHEST_2888;
- HEMOTHORAX AND CARDIAC ARREST AFTER CHEST TUBE REMOVAL (Convention Center 317B) - Aug 4, 2023 - Abstract #CHEST2023CHEST_2794;
- A RARE CASE OF IMMUNOSUPPRESSION-INDUCED PULMONARY ALVEOLAR PROTEINOSIS YEARS AFTER HEMATOPOIETIC STEM CELL TRANSPLANT (Convention Center 323A) - Aug 4, 2023 - Abstract #CHEST2023CHEST_2772;
- MULTI-DRUG-RESISTANT (MDR) TUBERCULOSIS (TB) COMPLICATED WITH EMPYEMA NECESSITANS (EN) (Convention Center Exhibit Hall - Rapid Area 3D) - Aug 4, 2023 - Abstract #CHEST2023CHEST_2455;
- levofloxacin / Generic mfg.
AN UNUSUAL CAUSE OF MYASTHENIC CRISIS: LEVOFLOXACIN (Convention Center Exhibit Hall) - Aug 4, 2023 - Abstract #CHEST2023CHEST_2049;