- |||||||||| Nplate (romiplostim) / Amgen, Kyowa Kirin, Abthrax (raxibacumab) / Emergent Biosolutions
Review, Journal: United States' regulatory approved pharmacotherapies for nuclear reactor explosions and anthrax-associated bioterrorism. (Pubmed Central) - Aug 18, 2023 For bioterrorism-associated anthrax, the FDA approved five antibiotics (doxycycline, penicillin-G, levofloxacin, moxifloxacin, and ciprofloxacin), two monoclonal antibodies (obiltoxaximab and raxibacumab), one polyclonal antitoxin (Anthrax Immune Globulin Intravenous) and two vaccines (Anthrax Vaccine Adsorbed and Anthrax Vaccine Adsorbed with an adjuvant)...Two potential mass public health disasters are aerosolized anthrax dissemination and radiological incidents. Five agents authorized for anthrax emergencies only have FDA approval for this indication, five antibiotics have FDA approvals as antibiotics for common infections and for bacillus anthrax, and four agents have regulatory approvals for supportive care for cancer and for radiological incidents.
- |||||||||| levofloxacin / Generic mfg.
Journal: Delphi Survey on the Current and Future Korean Guidelines for Isoniazid-Monoresistant Tuberculosis. (Pubmed Central) - Aug 17, 2023 Over 95.8% of experts recommended treating Hr-TB with a combination of rifampin, ethambutol, pyrazinamide, and levofloxacin for six months, without exceeding 12 months unless necessary...This Delphi survey enabled Korean tuberculosis experts to reach a consensus on diagnosing and treating Hr-TB. These findings will be valuable for developing the upcoming revised Korean guidelines for Hr-TB management.
- |||||||||| levofloxacin / Generic mfg.
Journal: Evaluation of drug-induced liver toxicity of trovafloxacin and levofloxacin in a human microphysiological liver model. (Pubmed Central) - Aug 16, 2023 Similar to in vivo, cytokine secretion was dependent on a multicellular immune response, highlighting the potential of the complex microphysiological liver model for reliably detecting drug-related cytotoxicity in preclinical testing. Moreover, hepatic glutathione depletion and mitochondrial ROS formation were elucidated as intrinsic toxicity mechanisms contributing to trovafloxacin toxicity.
- |||||||||| levofloxacin / Generic mfg., tigecycline / Generic mfg.
Preclinical, Journal: Exposure of Salmonella enterica serovar 1,4, [5],12:i:- to benzalkonium chloride leads to acquired resistance to this disinfectant and antibiotics. (Pubmed Central) - Aug 16, 2023 Moreover, hepatic glutathione depletion and mitochondrial ROS formation were elucidated as intrinsic toxicity mechanisms contributing to trovafloxacin toxicity. Repeated exposure to sublethal concentrations of BC could result in the emergence of BC- and antibiotic-resistant S. 1,4, [5],12: i:- strains.
- |||||||||| Secnizol DS (secnidazole) / Incepta Pharma
P4 data, Journal: Usefulness of medicine screening tools in the frame of pharmaceutical post-marketing surveillance. (Pubmed Central) - Aug 15, 2023 In this study, three screening tools were used on 292 samples of ciprofloxacin and metronidazole collected in Cameroon...Seven additional samples from the nitro-imidazole (secnidazole, ornidazole, tinidazole) and the fluoroquinolone (levofloxacin, ofloxacin, norfloxacin, moxifloxacin) families were analyzed to mimic falsified medicines...The advantages and drawbacks of each screening tool were highlighted. They are promising means in the frame of early detection of SF medicines and they can increase the speed of decision about SF medicines in the context of pharmaceutical post-marketing surveillance.
- |||||||||| levofloxacin / Generic mfg.
Journal: Biocompatible Gallium Nanodots against Drug-Resistant Bacterial Pneumonia and Liver Abscess. (Pubmed Central) - Aug 14, 2023 aeruginosa and ESBL E. coli) compared with clinically used antibacterial drugs, including penicillin and levofloxacin...Further, the Ga NDs demonstrated excellent biocompatibility and biosafety characteristics. Together, we believe that our gallium containing nanotherapeutics are expected to be developed into promising alternative therapies to combat drug-resistant bacterial infection.
- |||||||||| levofloxacin / Generic mfg.
Journal: A case of testicular seminoma with testicular abscess caused by Salmonella saintpaul. (Pubmed Central) - Aug 14, 2023 With the diagnosis of epididymitis, he was administered levofloxacin (LVFX) but the fever and painful enlargement persisted...Although testicular tumors are the most common differential diseases for testicular abscess, there are few reports of testicular abscess accompanying testicular tumors. Here, we report a case of testicular seminoma with testicular abscess caused by Salmonella saintpaul.
- |||||||||| Enhertu (fam-trastuzumab deruxtecan-nxki) / Daiichi Sankyo, AstraZeneca
Journal: Can You Establish the Cause of This Patient's Shortness of Breath? (Pubmed Central) - Aug 14, 2023 He received front-line leucovorin, 5-fluorouracil, and oxaliplatin (FOLFOX) and trastuzumab for 10 months before restaging imaging revealed progressive disease...He was discharged after an episode of pneumonia on a steroid taper with prophylactic trimethoprim/sulfamethoxazole...About a week later, wheezes were noticed on physical exam, and he was given a 5-day course of levofloxacin...He was discharged to an inpatient hospice facility where he passed away 2 weeks later. Drug-induced pneumonitis/ILD should be considered in all patients receiving trastuzumab deruxtecan who develop progressive shortness of breath or other respiratory complaints.
- |||||||||| levofloxacin / Generic mfg.
Journal: First Case of Meningoencephalitis and Bacteraemia with Flavobacterium Lindanitolerans. (Pubmed Central) - Aug 9, 2023 Therefore, it is important to use a combination of diagnostic methods to accurately assess antibiotic resistance in H. pylori infection. This is the first case of a meningoencephalitis and bacteraemia with Flavobacterium lindanitolerans.Levofloxacin can be given for 21 days as a treatment of F. lindanitolerans.
- |||||||||| Biomarker, Journal, Next-generation sequencing: Helicobacter pylori Antimicrobial Resistance Using Next-Generation Sequencing in stool samples in a pediatric population. (Pubmed Central) - Aug 7, 2023
Stool next-generation sequencing-based antimicrobial susceptibility analysis was highly concordant with agar dilution for no resistance (100% agreement), as well as clarithromycin, levofloxacin, and amoxicillin resistance (100%, 67%, and 100% agreement respectively) but not concordant for metronidazole in our cohort of patients. Future studies involving a larger number of patients and geographical regions are needed to further validate this analysis.
- |||||||||| Fetroja (cefiderocol) / Shionogi
Journal: Emerging infections in vulnerable hosts: stenotrophomonas maltophilia and Elizabethkingia anophelis. (Pubmed Central) - Aug 7, 2023 Immunocompromised patients are particularly vulnerable to infections caused by S. maltophilia and E. anophelis, but the optimal treatment strategy remains inconclusive. Further research is necessary to determine the most effective use of conventional and novel antimicrobial agents in combatting these multidrug-resistant pathogens.
- |||||||||| levofloxacin / Generic mfg.
Journal: Dual enzyme-mimicking carbon dots for enhanced antibacterial activity. (Pubmed Central) - Aug 7, 2023 The CDs were validated to have a broad-spectrum bactericidal effect against Gram-positive and -negative bacteria, compensating for the limitations of levofloxacin while also having enhanced sterilization ability. Importantly, the proposed Co-Lvx-CDs provide a new idea for the design of multifunctional CD-based nanozymes with preconceived outcomes.
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