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- | Journal: The Impact of an Antimicrobial Stewardship Clinical Pharmacy Specialist on Antimicrobial Days of Therapy through Education Driven Policies, Procedures, and Interventions. (Pubmed Central) - Sep 22, 2023
Pharmacists performed 75 interventions pre-intervention and 102 interventions post-intervention (p = 0.0092). The implementation of a dedicated antimicrobial stewardship clinical pharmacy specialist responsible for developing policies, procedures, and education successfully reduced antimicrobial days of therapy and documented interventions.
- | levofloxacin / Generic mfg., enoxaparin sodium / Generic mfg.
New trial: D2 Versus D3 Dissection in Laparoscopic Right Hemicolectomy (clinicaltrials.gov) - Sep 22, 2023
P=N/A, N=80, Not yet recruiting, Sponsor: General Committee of Teaching Hospitals and Institutes, Egypt
- | New P4 trial: A Comparative Study Between Concomitant Versus Load Therapy in Eradication of Helicobacter Pylori Infection (clinicaltrials.gov) - Sep 22, 2023
P4, N=200, Completed, Sponsor: Helwan University
- | levofloxacin / Generic mfg.
Journal: A novel electrochemical sensing platform based on double-active-center polyimide covalent organic frameworks for sensitive analysis of levofloxacin. (Pubmed Central) - Sep 21, 2023
The implementation of a dedicated antimicrobial stewardship clinical pharmacy specialist responsible for developing policies, procedures, and education successfully reduced antimicrobial days of therapy and documented interventions. The linear range of LVF was 0.6-1000
- | Retrospective data, Journal: Phenotype and genotype analysis for Helicobacter pylori antibiotic resistance in outpatients: a retrospective study. (Pubmed Central) - Sep 21, 2023
We found a higher resistance rate to metronidazole (MTZ) , clarithromycin (CLR), and levofloxacin (LEV), and the genotype could be used to predict the phenotypic H. pylori resistance to CLR and LEV. This study provides information on H. pylori infection and also provides guidance for clinical doctors' drug treatment.
- | Fetroja (cefiderocol) / Shionogi
Journal, Gram negative: What is the clinical significance of 'heteroresistance' in non-fermenting Gram-negative strains? (Pubmed Central) - Sep 20, 2023
Although in-vitro detection of heteroresistance in non-fermenting GNB has not been associated with in-vivo treatment failure, its presence may suggest to prefer combination regimens instead monotherapy when treating infections by nonfermenters. Further studies are needed to clarify the clinical significance of heteroresistance.
- | ciprofloxacin oral / Generic mfg., levofloxacin / Generic mfg.
Journal: Predicting ciprofloxacin and levofloxacin decomposition utilizing ozone micro-nano bubbles through the central composite design method. (Pubmed Central) - Sep 20, 2023
The order of influence of various factors on CIPR and LEVO decomposition were obtained and the interactions between the main factors were also investigated. At the last stage of the research, the efficiency of OzMNBs in the removal of total organic carbon and mineralization of the solutions containing CIPR and LEVO under optimum conditions was examined.
- | levofloxacin / Generic mfg., rifampicin / Generic mfg., moxifloxacin intravenous / Generic mfg.
Journal: Fluoroquinolone resistance mutations among Mycobacterium tuberculosis and their interconnection with treatment outcome. (Pubmed Central) - Sep 18, 2023
The most common hetero-resistance mutation pattern observed in GyrA gene was wild type plus Asp94Gly mutation in 24.6% of isolates. GyrA MUT3C hybridization corresponding to single-point mutation of aspartic acid to glycine at codon 94 constitutes the most common mutation in GyrA gene locus in M. tuberculosis with significant association with treatment outcome as died compared to those with treatment outcome as cured.
- | Journal: Characteristics of Biofilm-Forming Ability and Antibiotic Resistance of Cutibacterium acnes and Staphylococcus epidermidis from Acne Vulgaris Patients. (Pubmed Central) - Sep 18, 2023
Furthermore, although statistically not significant, some resistances were observed against clindamycin, erythromycin, and azithromycin. Consequently, the use of these three antibiotics should be judiciously regulated.
- | levofloxacin / Generic mfg.
Journal: Degradation of levofloxacin from antibiotic wastewater by pulse electrochemical oxidation with BDD electrode. (Pubmed Central) - Sep 18, 2023
Ten aromatic intermediates were formed during the degradation of LFXN, which were further degraded to F, NH, NO, CO and HO. This study provides a promising approach for efficiently treating LFXN antibiotic wastewater by pulsed electrochemical oxidation with a BDD electrode without adding HO.
- | levofloxacin / Generic mfg.
Journal: Responses of Phragmites communis and its rhizosphere bacteria to different exposure sequences of molybdenum disulfide and levofloxacin. (Pubmed Central) - Sep 18, 2023
Potential functional profiling of bacterial community indicated the addition of MoS contributed to relieve the reduction in functional genes associated with amino acid metabolism and the debilitation of gram_negative and aerobic phenotypic traits caused by LVF stress. This finding reveals the effect of different exposure sequences of MoS nanoparticles and antibiotic for plant-soil systems.
- | ciprofloxacin oral / Generic mfg., levofloxacin / Generic mfg.
Enrollment closed, Trial completion date, Trial primary completion date: Ciprofloxacin Versus Levofloxacin in Stem Cell Transplant (clinicaltrials.gov) - Sep 18, 2023
P2, N=308, Active, not recruiting, Sponsor: Henry Ford Health System
This finding reveals the effect of different exposure sequences of MoS nanoparticles and antibiotic for plant-soil systems. Recruiting --> Active, not recruiting | Trial completion date: Aug 2024 --> Apr 2024 | Trial primary completion date: Aug 2023 --> Apr 2024
- | FML, FML Forte (fluorometholone ophthalmic suspension) / AbbVie
Journal: Lately Diagnosed Acanthamoeba Keratitis Manifesting as an Intrastromal Corneal Abscess: A Case Report. (Pubmed Central) - Sep 15, 2023
After 3 weeks of worsening symptoms, she was diagnosed with bacterial corneal ulcer and treated with levofloxacin eye drops every 2 hr...The patient received polyhexamethylene biguanide 0.02% every 2 hr and oral ketoconazole 200 mg twice a day, which resulted in improvement in her signs and symptoms within 10 days...At the 9-month follow-up visit, the best-corrected visual acuity was 5/10 with a superficial central stromal scar at slitlamp examination. Acanthamoeba infection should be considered in contact lens wearers who present with intrastromal corneal abscess.
- | levofloxacin / Generic mfg.
Enrollment open: Safety and Efficacy of Levofloxacin for Acute Ischemic Stroke (clinicaltrials.gov) - Sep 15, 2023
P=N/A, N=100, Recruiting, Sponsor: Yi Yang
Acanthamoeba infection should be considered in contact lens wearers who present with intrastromal corneal abscess. Not yet recruiting --> Recruiting
- | levofloxacin / Generic mfg.
Enrollment open: Safety and Efficacy of Levofloxacin Combined With Intravenous Thrombolysis for Acute Ischemic Stroke (clinicaltrials.gov) - Sep 15, 2023
P=N/A, N=100, Recruiting, Sponsor: Yi Yang
Not yet recruiting --> Recruiting Not yet recruiting --> Recruiting
- Cubicin (daptomycin) / Merck (MSD)
Near Fatal Anaphylaxis in a Patient with Multiple Drug Intolerance Syndrome (MDIS) (Monitor 02) - Sep 14, 2023 - Abstract #ACAAI2023ACAAI_733;
Due to wound cultures positive for MRSA and Pseudomonas, levofloxacin was changed to meropenem, which she previously tolerated...She required cardiopulmonary resuscitation, including two doses of 1 mg IV epinephrine and intubation prior to return of spontaneous circulation...Her cellulitis was subsequently treated with daptomycin, metronidazole, and aztreonam...Her baseline tryptase > 8 ng/mL raises the possibility of underlying HAT. Further research is necessary to enhance our understanding of carbapenem anaphylaxis.
- levofloxacin / Generic mfg.
Pneumocystis Jirovecii Presenting As Pulmonary Mass In Patient With Common Variable Immunodeficiency And Hematologic Malignancy (Monitor 06) - Sep 14, 2023 - Abstract #ACAAI2023ACAAI_644;
He was prescribed a course of levofloxacin with temporary improvement of symptoms, but shortly thereafter the cough worsened and he began to experience hemoptysis...Chest CT obtained at 4 months showed near complete resolution of mass with linear scarring as we continue to follow this patient closely. Discussion To our knowledge, we present the first reported case of a patient with CVID with concurrent B-cell lymphoma and PJP infection in the setting of normal CD4+ counts.
- | Xerava (eravacycline) / SOM Biotech, Ewha Womans University, PAION, Innoviva
Preclinical, Journal: In vitro Antimicrobial Activity and Dose Optimization of Eravacycline and Other Tetracycline Derivatives Against Levofloxacin-Non-Susceptible and/or Trimethoprim-Sulfamethoxazole-Resistant Stenotrophomonas maltophilia. (Pubmed Central) - Sep 14, 2023
In contrast, the CFR of tigecycline was less than 40%, even at a dose of 100 mg q12 h. For pneumonia, minocycline is better for S. maltophilia that is non-susceptible to LVFX; for TMP-SMZ-resistant strains and strains that are not susceptible to either LVFX or TMP-SMZ, the efficiency of eravacycline requires further evaluation. Eravacycline may be a better choice for extremely resistant S. maltophilia strains that are non-susceptible to LVFX, TMP-SMZ, and minocycline.
- | Journal: Efficacy and safety of a 14-day modified concomitant therapy for refractory Helicobacter pylori infection: a pilot study. (Pubmed Central) - Sep 13, 2023
The 14-day modified concomitant therapy appears to be appropriate for refractory H.?pylori infection and is particularly promising for the Chinese population. A randomized controlled trial is warranted to verify its efficacy, especially in the current environment of increasing antibiotic resistance.
- | levofloxacin / Generic mfg., meropenem / Generic mfg.
Journal: Microbiological patterns of bacterial infections in tracheostomized children: Reducing uncertainty in continuous care. (Pubmed Central) - Sep 13, 2023
The risk of multidrug resistance increased with longer hospital stays, especially for E. coli and K. pneumoniae. Recent isolation of P. aeruginosa may justify empirical coverage.
- | Invanz (ertapenem) / Merck (MSD)
Journal: Patterns of Drug Resistance and Bacterial Pathogen Distribution in Patients with Urinary Tract Infections in the Jiaxing Region from 2020 to 2022. (Pubmed Central) - Sep 13, 2023
As far as antibiotic resistance was concerned, Escherichia coli had a greater than 50% resistance rate to ampicillin (76.1%), ciprofloxacin (58.6%), and levofloxacin (51.2%)...Low levels of resistance were seen to ertapenem (0.1%), imipenem (0.7%), meropenem (0.7%), piperacillin/tazobactam (0.7%), and nitrofurantoin (1.8%)...The resistance rates to nitrofurantoin, ceftriaxone, and ciprofloxacin were 37.4%, 37.1%, and 35.1%, respectively...Two species of enterococci were highly sensitive to tigecycline and linezolid (100%), and a small number of norvancomycin-resistant strains (0.2%/two strains) were found...The isolated pathogens showed different sensitivity patterns. Antibiotics should be selected reasonably according to the sensitivity mode of pathogenic bacteria to effectively treat and prevent urinary tract infections.
- | levofloxacin / Generic mfg., fosfomycin tromethamine / Generic mfg.
Journal: Daily fosfomycin versus levofloxacin for complicated urinary tract infections. (Pubmed Central) - Sep 12, 2023
P4
Fosfomycin is a drug that is routinely used for the treatment of uncomplicated cystitis. This study shows that fosfomycin could be an oral alternative as step-down therapy for the treatment of complicated urinary tract infections, with a clinical cure rate comparable to levofloxacin but a lower microbiological success rate 3 weeks from start of antibiotics.
- | cefepime hydrochloride / Generic mfg., ciprofloxacin oral / Generic mfg., gentamicin sulfate / Generic mfg.
Journal: Synergistic Effects of Gentamicin, Cefepime, and Ciprofloxacin on Biofilm of Pseudomonas aeruginosa. (Pubmed Central) - Sep 11, 2023
We further confirm inhibitory effects of ciprofloxacin, levofloxacin, and cefepime on P. aeruginosa biofilms. Hence, combination therapy can be more effective against biofilm-associated infections.
- | levofloxacin / Generic mfg., acarbose / Generic mfg.
Journal: Exploring Kinnow mandarin's hidden potential: Nature's key to antimicrobial and antidiabetic gold nanoparticles (K-AuNPs). (Pubmed Central) - Sep 11, 2023
Furthermore, the anti-diabetic efficacy was evaluated through ?-amylase and ?-glucosidase experiments, comparing K-AuNPs to pure KAPE and the standard inhibitor acarbose...To sum up, the process of producing K-AuNPs utilizing Kinnow mandarin peel extracts demonstrates a powerful antibacterial and antidiabetic remedy sourced from previously discarded materials. These findings signify a significant leap forward in the domain of natural product exploration, with the potential to fundamentally reshape modern healthcare approaches.
- | levofloxacin / Generic mfg., trimethoprim/sulfamethoxazole / Generic mfg., minocycline / Generic mfg.
Journal: The Relationship between the Biofilm Genes and Antibiotic Resistance in Stenotrophomonas maltophilia. (Pubmed Central) - Sep 11, 2023
Moreover, smf-1, rmlA, and spgM genes were presented in all strong biofilm producers. Although the overall resistance rate to the evaluated antibiotics was high, there was no statistically significant relation between antibiotic resistance and the type of biofilm.
- | tamsulosin / Generic mfg., levofloxacin / Generic mfg.
Journal: Transcutaneous electrical nerve stimulation combined with levofloxacin and tamsulosin for patients with chronic prostatitis: clinical efficacy and changes in serum factors. (Pubmed Central) - Sep 11, 2023
Compared to medication alone (levofloxacin and tamsulosin), the combination of TENS with levofloxacin and tamsulosin can reduce the levels of inflammatory and pain-causing factors in patients, and improve the efficacy. Importantly, it has been observed that this combination therapy does not lead to an increase in adverse reactions and is considered to be safe for patients.
- | Journal: Staphylococcus epidermidis induced toxic shock syndrome (TSS) secondary to influenza infection. (Pubmed Central) - Sep 11, 2023
To our knowledge, this is the first adult case with TSS induced by CoNS (MRSE) secondary to an influenza type B infection, who had favorable progression and outcome. Further research is warranted to determine how TSS is induced by the CoNS infections.
- | levofloxacin / Generic mfg., gentamicin sulfate / Generic mfg., moxifloxacin intravenous / Generic mfg.
Preclinical, Journal: High antipersister activity of a promising new quinolone drug candidate in eradicating uropathogenic Escherichia coli persisters and persistent infection in mice. (Pubmed Central) - Sep 11, 2023
Further research is warranted to determine how TSS is induced by the CoNS infections. QDF has high antipersister activity and its drug combinations proved highly effective against biofilm bacteria in vitro and persistent UTIs in mice, which may have implications for treating rUTIs.
- | levofloxacin / Generic mfg.
Journal: Degradation of Levofloxacin by a green zero-valent iron-loaded carbon composite activating peroxydisulfate system: Reactivity, products and mechanism. (Pubmed Central) - Sep 11, 2023
The potential toxicity of LEX and its oxidation products decreased significantly after treatment. This study provides a promising strategy of water treatment for the antibiotics-containing wastewater.
- | levofloxacin / Generic mfg.
Journal: Enhanced generation of reactive radicals and electrocatalytic oxidation of levofloxacin using a trimetallic CuFeV layered double hydroxide-containing electrode. (Pubmed Central) - Sep 11, 2023
Additionally, GC-MS analyses revealed the degradation of intermediate compounds, which include cyclic and aliphatic compounds. This study provides significant insights into the synergistic effects of trimetallic LDHs, contributing to the development of high-performance cathodes.
- Outcomes after Stenotrophomonas maltophilia bloodstream infection. (Hall B + C) - Sep 11, 2023 - Abstract #IDWeek2023IDWeek_3378;
- | Journal: Analysis of the Influence of Diabetic Nephropathy in Patients with Diabetic Foot Osteomyelitis. (Pubmed Central) - Sep 9, 2023
The most frequently prescribed oral antibiotic was amoxicillin/clavulanate (43.89%), followed by levofloxacin (28.4%), and trimethoprim/sulfamethoxazole (14.7%). This study shows that DN does not have a significant influence on the healing prognosis of patients with DFO after conservative surgery.
- || Takecab (vonoprazan) / Takeda, Phathom Pharma
Review, Journal: Update on the second-line treatment of Helicobacter pylori infection: a narrative review. (Pubmed Central) - Sep 8, 2023
In conclusion, the eradication rate of levofloxacin-amoxicillin triple therapy is suboptimal in the second-line treatment of H. pylori infection now. Currently, a standard bismuth quadruple therapy (tetracycline-metronidazole quadruple therapy), a tetracycline-levofloxacin quadruple therapy, an amoxicillin-levofloxacin quadruple therapy, a levofloxacin-based sequential quadruple therapy or a high-dose PPI-amoxicillin dual therapy is recommended for the second-line treatment of H. pylori infection.
- | ciprofloxacin oral / Generic mfg.
Journal: Upcycling of waste EPS beads to immobilized codoped TiO photocatalysts for ciprofloxacin degradation and E. coli disinfection under sunlight. (Pubmed Central) - Sep 8, 2023
Also, the effectiveness of BCeTiO/EPS film in real water samples indicates its potential in large-scale and real-world applications. Thus, these BCeTiO/EPS films can be effectively employed for both degradation of ciprofloxacin and the disinfection of E. coli under solar light to solve the increasing problem of antimicrobial resistance.
- | levofloxacin / Generic mfg.
Preclinical, Journal: In vitro and ex vivo antibacterial activity of levofloxacin against Pasteurella multocida and Escherichia coli isolated from rabbits (Oryctolagus cuniculus) - A preliminary study. (Pubmed Central) - Sep 7, 2023
Considering the increasing importance of antimicrobial stewardship, antimicrobials from a lower importance category that are active against the isolate of interest should be used in preference to fluoroquinolones. Fluoroquinolone use in veterinary medicine should be based on antimicrobial susceptibility testing in order to mitigate the risk to public health and prevent the spread of bacterial resistance.
- Evaluation of a Weighted-Incidence Syndromic Combination Antibiogram (WISCA) to guide empiric therapy in pneumonia cases (Hall B + C) - Sep 6, 2023 - Abstract #IDWeek2023IDWeek_3290;
- Antimicrobial Photodynamic Therapy (aPDT) Is Highly Effective Against Multidrug-Resistant HA- and CA- S. aureus Strains (Hall B + C) - Sep 6, 2023 - Abstract #IDWeek2023IDWeek_3281;
- Fetroja (cefiderocol) / Shionogi
Activity of Cefiderocol and Comparator Agents Against Achromobacter and Burkholderia Isolates, Collected During 2020-2022 as Part of SENTRY Antimicrobial Surveillance Program (Hall B + C) - Sep 6, 2023 - Abstract #IDWeek2023IDWeek_3245;
- Vabomere (meropenem/vaborbactam) / Melinta Therap
Activity of meropenem-vaborbactam tested against Burkholderia species isolates (Hall B + C) - Sep 6, 2023 - Abstract #IDWeek2023IDWeek_3241;
- Baxdela (delafloxacin) / Menarini, Melinta Therap
Delafloxacin and Comparator Fluoroquinolone In Vitro Resistance Trends in Isolates from Skin and Skin Structure Infections in the USA (2017 (Hall B + C) - Sep 6, 2023 - Abstract #IDWeek2023IDWeek_3238;
- Fetroja (cefiderocol) / Shionogi
Cefiderocol Use in Treating Patients with Confirmed Stenotrophomonas maltophilia Infections in US Hospitals During January 2020 - June 2022 (Hall B + C) - Sep 6, 2023 - Abstract #IDWeek2023IDWeek_3235;
- Nuzyra (omadacycline) / Paratek
Comparing Omadacycline with Existing Antibiotics in the treatment of Acute Bacterial Infections: A Systematic Review (Hall B + C) - Sep 6, 2023 - Abstract #IDWeek2023IDWeek_3120;
- sulopenem (CP-70429) / Iterum
Pharmacokinetic-Pharmacodynamic Evaluation of Sulopenem Using a Five-Day Hollow-Fiber In Vitro Infection Model (Hall B + C) - Sep 6, 2023 - Abstract #IDWeek2023IDWeek_3105;
- Stenotrophomonas maltophilia Infection in a Neonatal Intensive Care Unit (NICU): A Retrospective Study of Risk Factors and Outcomes in an Inner-City Hospital (Hall B + C) - Sep 6, 2023 - Abstract #IDWeek2023IDWeek_3048;
- The DOOR is open: A Web-based Application for Analyzing the Desirability of Outcome Ranking (Hall B + C) - Sep 6, 2023 - Abstract #IDWeek2023IDWeek_2570;
- Impact of CLSI Breakpoint Changes on Unit-Specific Combination Antibiograms for Gram-Negative Respiratory Isolates (Hall B + C) - Sep 6, 2023 - Abstract #IDWeek2023IDWeek_2559;
- Comparing Alternative Treatment Options for Stenotrophomonas maltophilia bacteremia (Hall B + C) - Sep 6, 2023 - Abstract #IDWeek2023IDWeek_2472;
- The increased frequency and clinical characteristics of Streptococcus agalactiae serotype VIII from blood isolates at two tertiary care hospital in South Korea over 14 years. (Hall B + C) - Sep 6, 2023 - Abstract #IDWeek2023IDWeek_2441;
- Game of Trophs: Stenotrophomonas maltophilia Management 2.0: Before and After an Antimicrobial Stewardship Intervention (Hall B + C) - Sep 6, 2023 - Abstract #IDWeek2023IDWeek_2381;
- imipenem/relebactam / Merck (MSD)
Activity of Imipenem/Relebactam Against Carbapenem-Resistant Non-Morganellaceae Enterobacterales (NME) in the United States (Hall B + C) - Sep 6, 2023 - Abstract #IDWeek2023IDWeek_2331;