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137 Trials |
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137 Trials |  |
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- Venclexta (venetoclax) / Roche, AbbVie, Walter and Eliza Hall Institute, Vyxeos (cytarabine/daunorubicin liposomal formulation) / Jazz, Nippon Shinyaku
Shotgun Sequencing of Multi-Site Oral and Colonic Microbiota in Patients with AML: Site-Specific Patterns and Microbiota Decompartmentalization (SDCC - Halls G-H) - Nov 3, 2023 - Abstract #ASH2023ASH_2717;
The 3 most frequently used antibacterial antibiotics were cefepime (n=14), IV vancomycin (n=12), and levofloxacin (n=11)...Future mechanistic studies of plaque biofilms may reveal community-protective mechanisms that sustain oral plaque microbial diversity and contribute oral flora to the gut. Mitigating gut dysbiosis in AML patients by manipulating plaque biofilms could be a novel approach to improve patient outcomes.
- Neupogen (filgrastim) / Kyowa Kirin, Amgen
Fluoroquinolone-Resistant Enterobacteriaceae Prevalence for Patients Undergoing Autologous Hematopoietic Stem Cell Transplantation (aHSCT) in the Treatment of Multiple Myeloma (MM) (SDCC - Halls G-H) - Nov 3, 2023 - Abstract #ASH2023ASH_2663;
Mitigating gut dysbiosis in AML patients by manipulating plaque biofilms could be a novel approach to improve patient outcomes. This prospective study aims to determine the prevalence of FRE in defined pt populations in two metropolitan areas treated with dose-intense melphalan with autologous peripheral blood stem cell (PBSC) transplantation, and to determine the possible clinical effects of FRE in the host microbiome on transplant outcomes...Bacterial cultures from perirectal swabs (fresh or frozen for shipping) were purified on CHROMagar
- cyclophosphamide / Generic mfg.
Post-Transplant Cyclophosphamide-Based Prophylaxis and Its Impact on the Immune Reconstitution and the Incidence of Infectious Complications (SDCC - Halls G-H) - Nov 3, 2023 - Abstract #ASH2023ASH_2638;
No patient received letermovir...Conclusions Patients undergoing allo-HCT with PTCY-based prophylaxis have a relevant infectious density rate during the peri-engraftment phase with no differences according to donor type. Infectious complications decreased 6 months after allo-HCT, and in parallel with discontinuation of immunosuppression and immune reconstitution with no differences according to donor type.
- | levofloxacin / Generic mfg.
New trial: Study comparing anti-tuberculosis drug levels in saliva, plasma, and urine in patients (EUDRACT) - Nov 2, 2023
P=N/A, N=30, Not yet recruiting, Sponsor: Western Sydney Local Health District
- | Trial completion date, Trial primary completion date: INSPIRE-CODA: Innovating Shorter, All- Oral, Precised, Individualized Treatment Regimen for Rifampicin Resistant Tuberculosis?Contezolid, Delamanid and Bedaquiline Cohort (clinicaltrials.gov) - Oct 31, 2023
P3, N=186, Not yet recruiting, Sponsor: Beijing Chest Hospital
Infectious complications decreased 6 months after allo-HCT, and in parallel with discontinuation of immunosuppression and immune reconstitution with no differences according to donor type. Trial completion date: Aug 2026 --> Dec 2026 | Trial primary completion date: May 2026 --> Oct 2026
- | Journal: Pasteurella multocida Pneumonia with Hemoptysis in an Immunocompetent Case (Pubmed Central) - Oct 31, 2023
Although Pasteurella multocida pneumonia is not commonly observed, the presence of underlying bronchiectasis in this patient facilitated the establishment of the bacteria. In order not to miss the diagnosis of pneumonia due to P.multocida, microbiological evaluation and molecular typing should be performed in the samples taken from the respiratory tract in patients with chronic respiratory diseases such as bronchiectasis.
- | Journal: The Change in Antimicrobial Resistance During the COVID-19 Pandemic in T (Pubmed Central) - Oct 31, 2023
While cefotaxime and ceftazidime susceptibility rates in E.coli strains increased during the pandemic period compared to previous period (p= 0.04, p= 0.001, respectively); nitrofurantoin sensitivity (p= 0.02) and extended-spectrum beta-lactamase (ESBL) ratios (p< 0.001) were found to be decreased...It was observed that the susceptibility to ciprofloxacin (p= 0.0001), levofloxacin (p= 0.003), and gentamicin (p= 0.005) in S.aureus strains increased during the pandemic period...The decrease in the susceptibility rate of K.pneumoniae isolates to antibiotics and the increase in the ESBL rate may be due to inappropriate and excessive use of antibiotics during the pandemic period. However, we believe that these data should be supported by studies to be conducted nowadays when all the rules and measures are back as if the pandemic has ended.
- | Journal: Phenotypic and genomic characterization of Pseudomonas aeruginosa isolates recovered from catheter-associated urinary tract infections in an Egyptian hospital. (Pubmed Central) - Oct 30, 2023
Genotypic analysis of resistance determinants predicted all isolates to encode a range of AMR genes, including those conferring resistance to aminoglycosides, ?-lactamases, fluoroquinolones, fosfomycin, sulfonamides, tetracyclines and chloramphenicol...All isolates were able to form biofilms and were predicted to encode virulence genes associated with adherence, antimicrobial activity, anti-phagocytosis, phospholipase enzymes, iron uptake, proteases, secretion systems and toxins. The present study shows how phenotypic analysis alongside genomic analysis may help us understand the AMR and virulence profiles of P. aeruginosa contributing to CAUTIs in Egypt.
- | levofloxacin / Generic mfg.
Observational data, Journal: Nephroprotective effect of vitamin D Against Levofloxacin-induced renal injury: an observational study. (Pubmed Central) - Oct 30, 2023
Urea, creatinine, and malondialdehyde levels were significantly (p<0.05) higher in rats administered LFX 50mg and 100mg compared to rats given (LFX + vitamin D). The main findings of this study show that vitamin D reduces renal dysfunction, suggesting that vitamin D has antioxidant properties and may be used to prevent renal injury.
- | Journal: Clinical and etiological characteristics of infectious vulvovaginitis in children in Zhejiang province from 2009 to 2019 (Pubmed Central) - Oct 29, 2023
For H.influenzae, 32.5% (161/496) produced ?-elactamase, and all strains were sensitive to meropenem (489/489, 100.0%) and levofloxacin (388/388, 100.0%), while 40.5% (202/499) were resistant to ampicillin...All methicillin-sensitive Staphylococcus aureus (MSSA) strains were sensitive to oxacillin (114/114, 100.0%), linezolid (94/94, 100.0%), vancomycin (114/114, 100.0%), and tigecycline (84/84, 100.0%); it's resistance rates to penicillin G, erythromycin and clindamycin were 78.1% (89/114), 59.7% (68/114) and 46.5% (53/114), respectively...Third generation cephalosporins can be used as the first choice of empirical anti-infection drugs. However, the results of drug susceptibility should be considered for targeted treatment.
- | levofloxacin / Generic mfg.
Journal: Prophylactic Use Of Levofloxacin During Induction Of Acute Lymphoblastic Leukaemia In Children-Experience From Pakistan. (Pubmed Central) - Oct 29, 2023
No significant difference in induction mortality was seen between the two groups (p?0.14). Levofloxacin prophylaxis reduced the rate of febrile neutropenia episodes among patients, but it did not affect the infection related mortality.
- | levofloxacin / Generic mfg., tetracycline / Generic mfg.
Journal: Assisted assembling of BiWO/rGO composites: A 3D/2D Hierarchical nanostructures for enhanced photocatalytic water remediation and photo-(electro)catalytic water splitting proficiency. (Pubmed Central) - Oct 29, 2023
Furthermore, photo-electrochemical measurements showed the lowest onset potential and better charge transfer for efficient splitting of water. The photocatalytic water splitting was performed in the presence of sacrificial agents and in the absence of sacrificial agents, where BWO/15% rGO exhibited maximum H evolution.
- | levofloxacin / Generic mfg.
Journal: Numerical Mechanistic Modelling of Drug Release from Solvent-Removal Zein-Based In Situ Gel. (Pubmed Central) - Oct 28, 2023
This research focuses on the mathematical modeling of levofloxacin HCl (Lv) release from zein-based ISG using the cup method, aiming to mimic the environment of a periodontal pocket...The imaging results offered valuable insights into the matrix formation kinetics, controlled drug release mechanisms, and the influence of solvent properties on drug diffusion. The combination of mathematical modeling and experimental visualization provides a comprehensive understanding of drug release from zein-based ISGs and offers a foundation for tailored drug delivery strategies.
- | Preclinical, Journal: Impact of Solidago virgaurea Extract on Biofilm Formation for ESBL-Pseudomonas aeruginosa: An In Vitro Model Study. (Pubmed Central) - Oct 28, 2023
0.01 against ESBL production and biofilm formation in P. aeruginosa. The S. virgaurea extract exhibited effectiveness in inhibiting biofilm formation and combating P. aeruginosa strains that produce extended-spectrum ?-lactamases (ESBLs).
- | ciprofloxacin oral / Generic mfg., fosfomycin tromethamine / Generic mfg.
Journal: FOVOCIP study: a multicenter randomized trial of fosfomycin versus ciprofloxacin for febrile neutropenia in hematologic patients-efficacy and microbiologic safety. (Pubmed Central) - Oct 28, 2023
P3
The battery of planned microbiological studies will allow us to evaluate prospectively the microbiological safety of both pharmacological strategies in terms of the selection of MRGNB occurring in each arm. In addition, valuable information on the way in which each drug changes the fecal microbiome of the patients throughout the treatment will be generated.
- | tetracycline / Generic mfg.
Journal: Antimicrobial Susceptibility to 27 Drugs and the Molecular Mechanisms of Macrolide, Tetracycline, and Quinolone Resistance in Gemella sp. (Pubmed Central) - Oct 27, 2023
No strain was resistant to beta-lactams and vancomycin...The MIC of minocycline and the ratios of tetM-positive strains varied across the different species-G...The mechanisms of resistance to erythromycin and clindamycin differed across Gemella species. In addition, the rate of susceptibility to levofloxacin differed across Gemella sp., and the quinolone resistance mechanism was caused by mutations in GyrA alone.
- | Journal: Antibiogram Profile and Detection of Resistance Genes in Pseudomonas aeruginosa Recovered from Hospital Wastewater Effluent. (Pubmed Central) - Oct 27, 2023
Meanwhile, a low susceptibility was recorded for amikacin and ceftazidime...Only one non-?-lactamase gene (qnrA) was detected, with a prevalence of 4.9%. The findings of this study revealed a high prevalence of multidrug-resistant P. aeruginosa and resistance determinants potentially posing environmental health risks.
- | NN1213 / Novo Nordisk
Trial completion: Personalized Treatment for Refractory H Pylori Infection (clinicaltrials.gov) - Oct 26, 2023
P=N/A, N=126, Completed, Sponsor: Kaohsiung Veterans General Hospital.
The findings of this study revealed a high prevalence of multidrug-resistant P. aeruginosa and resistance determinants potentially posing environmental health risks. Unknown status --> Completed
- | levofloxacin / Generic mfg., rifampicin / Generic mfg., moxifloxacin intravenous / Generic mfg.
Journal: Incidence and Patterns of Drug Resistance in Patients with Spinal Tuberculosis: a Prospective, Single-Center Study from a Tuberculosis-Endemic Country. (Pubmed Central) - Oct 26, 2023
Isolated RIF (Rifampicin) resistance and XDR pattern were not observed...Among second-line drugs, FQ resistance was more than SLID resistance and within FQ, levofloxacin resistance was more frequent than moxifloxacin...However, in the presence of insufficient tissue sample histology and CBNAAT can ascertain etiological diagnosis in 100% cases. INH resistance is more than RIF with isolated RIF resistance unreported.
- | levofloxacin / Generic mfg., tetracycline / Generic mfg.
Trial completion: Comparing the Efficacy of Hybrid, High-dose Dual and Bismuth Quadruple Therapies (clinicaltrials.gov) - Oct 26, 2023
P3, N=918, Completed, Sponsor: Kaohsiung Veterans General Hospital.
INH resistance is more than RIF with isolated RIF resistance unreported. Recruiting --> Completed
- | Trial completion, Enrollment change: Efficacies of Two Bismuth Quadruple Therapies in the Second-line Treatment of H Pylori Infection (clinicaltrials.gov) - Oct 26, 2023
P=N/A, N=112, Completed, Sponsor: Ping-I (William) Hsu, M.D.
Recruiting --> Completed Unknown status --> Completed | N=184 --> 112
- | Voquezna (vonoprazan) / Takeda, Phathom Pharma
New P3 trial: P-CABs: Potassium Copetitive Acid Blockers Efficacy in H.Pylori Eradication (clinicaltrials.gov) - Oct 25, 2023
P3, N=232, Completed, Sponsor: Ain Shams University
- | levofloxacin / Generic mfg.
Preclinical, Journal: Comparing the Therapeutic Potency of Camel Milk and Whey Protein Against Toxicity-Induced by Levofloxacin in Male Albino Rats. (Pubmed Central) - Oct 24, 2023
BIL creatinine), hepatic and renal MDA than the treatment with CWP did. <b></b> The use of CWP after LFX-treatment showed greater therapeutic potency than the use of CM.
- | levofloxacin / Generic mfg.
Journal: Characteristics and outcome of infectious complications after autologous hematopoietic cell transplantation in multiple myeloma patients. (Pubmed Central) - Oct 22, 2023
The majority of such patients lack clinical localization and microbiological proof of infection. There was no significant difference in the spectrum of infections and their outcomes in patients with and without levofloxacin prophylaxis.
- | levofloxacin / Generic mfg.
Journal: The phosphotransferase system gene ptsH affects persister formation in Klebsiella pneumoniae by regulating cAMP levels. (Pubmed Central) - Oct 22, 2023
In this study, we treated K. pneumoniae with a lethal concentration of levofloxacin...To the best of our knowledge, this is the first study to report that ptsH plays a vital role in forming K. pneumoniae persisters. This study provided important insights to further explore the mechanism underlying the formation of K. pneumoniae persisters and provided a potential target for treating infection with K. pneumoniae persisters.
- | Journal: Methicillin-Resistant Staphylococcus aureus and Coagulase-Negative Staphylococcus from School Dining Rooms in Argentina. (Pubmed Central) - Oct 19, 2023
In particular, it was detected that the handlers were the source of MRSA, VRSA, MR-CoNS (methicillin-resistant coagulase-negative Staphylococcus), and MDR isolates. The results obtained indicate that the vigilance of this pathogen in school dining rooms should be extreme.
- | levofloxacin / Generic mfg., clindamycin phosphate / Generic mfg., amoxycillin/clavulanate / Generic mfg.
Trial completion date, Trial initiation date, Trial primary completion date, Head-to-Head: Efficacy of Oral vs IV Antibiotics in the Treatment of Orofacial Osteomyelitis (clinicaltrials.gov) - Oct 19, 2023
P=N/A, N=100, Not yet recruiting, Sponsor: University of Louisville
The results obtained indicate that the vigilance of this pathogen in school dining rooms should be extreme. Trial completion date: Dec 2024 --> Dec 2025 | Initiation date: May 2023 --> Nov 2023 | Trial primary completion date: Jul 2024 --> Nov 2025
- | levofloxacin / Generic mfg., esomeprazole / Generic mfg.
New P4 trial: Efficacy of Amoxicillin-Esomeprazole HDDT Compared to Levofloxacin Triple Therapy for H. Pylori Eradication: A RCT (clinicaltrials.gov) - Oct 17, 2023
P4, N=70, Recruiting, Sponsor: Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
- | Cubicin (daptomycin) / Merck (MSD)
Retrospective data, Journal: The distribution and the antimicrobial susceptibility features of microorganisms isolated from the burn wounds; a ten-year retrospective analysis. (Pubmed Central) - Oct 17, 2023
The highest resistance rates were observed against levofloxacin (64%), tobramycin (64%), pip/tazobactam (63%), imipenem (63%), and the lowest against colistin (5%) and ceftazidime (29%), among Pseudomonas spp. The most common causative agents in burn wound infections and their current antimicrobial susceptibility features should be well identified, in order for prevention of serious complications and optimal management the condition to occur.
- | tamsulosin / Generic mfg., levofloxacin / Generic mfg.
Journal, Surgery: Effect of bird-induced anus-lifting surgery combined with oral Relinqing Granules on LUTS/CP with damp heat syndrome: Evaluation by infrared thermal imaging (Pubmed Central) - Oct 17, 2023
The most common causative agents in burn wound infections and their current antimicrobial susceptibility features should be well identified, in order for prevention of serious complications and optimal management the condition to occur. Bird-induced anus-lifting surgery combined with oral Relinqing Granules can safely and significantly improve infrared thermal imaging indicators and NIH-CPSI scores in LUTS/CP patients with damp-heat syndrome.
- | New P3 trial: INSPIRE-CODA: Innovating Shorter, All- Oral, Precised, Individualized Treatment Regimen for Rifampicin Resistant Tuberculosis?Contezolid, Delamanid and Bedaquiline Cohort (clinicaltrials.gov) - Oct 13, 2023
P3, N=198, Not yet recruiting, Sponsor: Beijing Chest Hospital
- | Journal: The Resistance and Virulence Characteristics of Salmonella Enteritidis Strain Isolated from Patients with Food Poisoning Based on the Whole-Genome Sequencing and Quantitative Proteomic Analysis. (Pubmed Central) - Oct 12, 2023
This study comprehensively analyzed the drug resistance and virulence phenotypes of S. Enteritidis 27A using genomic and proteomic approaches. These helps reveal the drug resistance and virulence mechanisms of S. Enteritidis, and provides important information for the source tracing and the prevention of related diseases, which lays a foundation for research on food safety, public health monitoring, and the drug resistance and pathogenicity of S. Enteritidis.
- | levofloxacin / Generic mfg.
Journal: Prevalence, risk factors and treatment outcomes of fluoroquinolones-associated tendinopathy in tuberculosis patients at university hospital, Thailand. (Pubmed Central) - Oct 9, 2023
The risk factors that were associated with fluoroquinolones-associated tendinopathy were younger age (180 days) (OR 2.61; 95%CI 1.12-6.08)...Conservative treatment, reducing the dose or discontinuation of fluoroquinolones successfully improved the symptoms of tendinopathy. Fluoroquinolones-associated tendinopathy did not affect the treatment of TB.
- | Journal: Assessing prescription of antibiotics after vaccination against pneumococcal pneumonia; using Prescription Sequence Symmetry Analysis. (Pubmed Central) - Oct 7, 2023
The lower prescription rate of antibiotics for CAP after vaccination could be attributed to a protective effect of PCV13. This novel application of PSSA can be used to compare the real-world impact of other vaccines on drug consumption.
- | levofloxacin / Generic mfg.
Journal: Enhanced photocatalytic degradation of levofloxacin over heterostructured CN/NbO system under visible light. (Pubmed Central) - Oct 6, 2023
The process is mainly photo-driven, and the trapping experiments reveal superoxide radicals as key species responsible for the degradation. Additionally, the adsorption behaviour, reformation of the degraded pollutant and reusability factors are evaluated to assess the practical feasibility of the photocatalytic system.
- | ceftriaxone / Generic mfg., levofloxacin / Generic mfg.
Journal: Antimicrobial effects of Medicines for Malaria Venture Pathogen Box compounds on strains of Neisseria gonorrhoeae. (Pubmed Central) - Oct 4, 2023
Additionally, the adsorption behaviour, reformation of the degraded pollutant and reusability factors are evaluated to assess the practical feasibility of the photocatalytic system. A checkerboard assay was used to determine synergy between the active compounds and in conjunction with ceftriaxone...The Pathogen Box compounds: MMV676501, MMV002817, MMV688327, MMV688508, MMV024937, MMV687798 (levofloxacin), MMV021013, and MMV688978 (auranofin) showed potent activity against resistant strains of N. gonorrhoeae at an MIC and MBC of ?10
- | levofloxacin / Generic mfg.
Journal: Zwitterionic silver nanoparticle based antibacterial eye drops for efficient therapy of bacterial keratitis. (Pubmed Central) - Oct 4, 2023
Importantly, in vivo BK rabbit models showed that the ZP@Ag-drops effectively inhibited corneal infection and prevented ocular tissue damage, surpassing the therapeutic effect of commercial levofloxacin eye drops (LEV-drops). Overall, this study presents a promising alternative option for the effective treatment of BK using antibacterial eye drops.
- | Geninax (garenoxacin) / BMS, Fujifilm Holdings, Gracevit (sitafloxacin) / Daiichi Sankyo
Preclinical, Journal: The Drug-Specific Propensity Regarding the Acquisition of Fluoroquinolone Resistance in Escherichia coli: An in vitro Challenge and DNA Mutation Analysis. (Pubmed Central) - Oct 4, 2023
However, resistance acquisition was detected frequently after 15- to 25-days of exposure. Among fluoroquinolones, lascufloxacn had the least impact on the resistance acquisition in E. coli.
- | levofloxacin / Generic mfg.
New P4 trial: Levofloxacin Concomitant Versus Levofloxacin Sequential (clinicaltrials.gov) - Oct 3, 2023
P4, N=150, Not yet recruiting, Sponsor: Damascus Hospital
- | Lamprene (clofazimine) / Novartis, Sirturo (bedaquiline) / J&J, Pharmstandard, NN1213 / Novo Nordisk
Trial completion: STREAM: The Evaluation of a Standard Treatment Regimen of Anti-tuberculosis Drugs for Patients With MDR-TB (clinicaltrials.gov) - Sep 28, 2023
P3, N=588, Completed, Sponsor: IUATLD, Inc
Among fluoroquinolones, lascufloxacn had the least impact on the resistance acquisition in E. coli. Active, not recruiting --> Completed
- | levofloxacin / Generic mfg.
Journal: Mucosal Adhesive Chitosan Nanogel Formulations of Antibiotics and Adjuvants (Terpenoids, Flavonoids, etc.) and Their Potential for the Treatment of Infectious Diseases of the Gastrointestinal Tract. (Pubmed Central) - Sep 28, 2023
It has been shown that levofloxacin (LF) in combination with zephirol demonstrate synergistic effects against E. coli (cell viability decreased by about 50%) and, surprisingly, a much weaker effect against Lactobacilli...In vivo experiments (on sturgeon fish) showed the effective action of antibacterial formulations developed based on LF in chitosan nanogels for up to 11 days. Thus, chitosan nanogels loaded with a combination of drugs and adjuvants can be considered as a new strategy for the treatment of infectious diseases of the gastrointestinal tract.
- | Zavicefta (ceftazidime/avibactam) / Pfizer, AbbVie
Preclinical, Journal: In Vitro Susceptibility to Ceftazidime-Avibactam and Comparator Antimicrobial Agents of Carbapenem-Resistant Enterobacterales Isolates. (Pubmed Central) - Sep 28, 2023
CZA was the most active ?-lactam agent against 68.9% of the studied isolates, while amikacin was the most active agent among all comparator antibiotics (80% susceptibility)...CZA is a promising addition to our limited armamentarium against CRE infections, given the reasonably high susceptibility rates against these CRE isolates. Careful stewardship and rational dosing regimens are required to preserve CZA's utility against CRE infections.
- | levofloxacin / Generic mfg.
Journal: Viscosity Measurement of CO-Solvent Mixtures for the Study of the Morphology and Size of Crystalline Particles Obtained Using Supercritical Antisolvent Precipitation. (Pubmed Central) - Sep 28, 2023
The viscosity values of CO-dimethylphormamide, chloroform, methanol, isopropanol, ethyl acetate, acetone, and dimethyl sulfoxide mixtures were measured at a pressure of 150 bar and a temperature of 313 K. The correlation of the mean size of levofloxacin hydrochloride and malonic acid particles precipitated using the SAS method with the viscosity of the used CO-solvent mixtures is shown...Therefore, crystallization occurs at large fractions of the solvent, and as a consequence at a lower supersaturation. This causes the formation of larger particles when using more viscous solvents in SAS.
- | Journal: Impact of Continuous Kidney Replacement Therapy and Hemoadsorption with CytoSorb on Antimicrobial Drug Removal in Critically Ill Children with Septic Shock: A Single-Center Prospective Study on a Pediatric Cohort. (Pubmed Central) - Sep 28, 2023
Higher MR and clearance were observed with CKRT compared to CS. To the best of our knowledge, this is the first report regarding pharmacokinetic dynamics in critically ill children treated with CKRT and CS for septic shock.
- | levofloxacin / Generic mfg.
Journal: A DNA Origami-based Bactericide for Efficient Healing of Infected Wounds. (Pubmed Central) - Sep 27, 2023
With the incorporation of DNA aptamer targeting bacterial peptidoglycan, the DNA origami-based bactericide can achieve targeted and combined antibacterial therapy for efficiently promoting the healing of infected wounds. This tailored DNA origami-based nanoplatform provides a new strategy for the treatment of infectious diseases in vivo.
- | levofloxacin / Generic mfg.
Journal: Polyurethane Degradable Hydrogels Based on Cyclodextrin-Oligocaprolactone Derivatives. (Pubmed Central) - Sep 27, 2023
Further, thermal water swelling and hydrolytic degradation in basic conditions revealed the connectivity of the polymer network and the particular influence of the cyclodextrin amount in the crosslinking reaction feed on the material properties. Also, levofloxacin was employed as a model drug to investigate the drug loading and release capacity of the prepared hydrogels.
- | Journal: Drug Resistance in Osteoarticular Tuberculosis: A Study From an Endemic Zone. (Pubmed Central) - Sep 27, 2023
Also, levofloxacin was employed as a model drug to investigate the drug loading and release capacity of the prepared hydrogels. The pus/tissue was subjected to acid-fast bacilli (AFB) staining and liquid culture, sensitivity to 13 anti-tubercular drugs (Isoniazid (INH), rifampicin (RIF), kanamycin (KAN), amikacin (AMK,) capreomycin (CAP), ethionamide (ETH), levofloxacin (LEV), moxifloxacin (MOX), linezolid (LNZ), para-amino-salicylic acid (PAS), bedaquiline (BDQ), delamanid (DLM), and clofazimine (CFO)) were checked, and histopathological/cytopathological examination and molecular tests were performed.?
- | ciprofloxacin oral / Generic mfg., levofloxacin / Generic mfg.
Journal: Molecular characterization and differential effects of levofloxacin and ciprofloxacin on the potential for developing quinolone resistance among clinical Pseudomonas aeruginosa isolates. (Pubmed Central) - Sep 25, 2023
Whole genome sequencing results showed that resistance to ciprofloxacin and levofloxacin in sequenced mutants were mainly associated with alterations in gyrA, gyrB and parC genes. Understanding resistance patterns and risk factors associated with infections is crucial to decrease the emerging threat of antimicrobial resistance.
- | sulbactam-durlobactam (ETX2514SUL) / Entasis Therap, ZAI Lab
Journal: Physical compatibility of sulbactam/durlobactam with select intravenous drugs during simulated Y-site administration. (Pubmed Central) - Sep 23, 2023
The Y-site compatibility of sulbactam/durlobactam with 95 IV drugs was described. These compatibility data will assist pharmacists and nurses to safely coordinate administration of IV medications with sulbactam/durlobactam.
- | Journal: Invasion of HeLa Cells by Shigella Species Clinical Isolates Recovered from Pediatric Diarrhea. (Pubmed Central) - Sep 22, 2023
isolates recovered from pediatric patients were able to invade HeLa cells, but the total number and average size of plaques were different between the isolates. The higher invasion ability of S. flexneri isolates in HeLa cells compared to S. sonnei isolates was attributed to the presence of particular virulence genes; however, the role of each of these virulence factors remains to be determined.