levofloxacin / Generic mfg. 
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  • ||||||||||  levofloxacin / Generic mfg.
    Journal:  A case of Legionella pneumophila serogroup 13 pneumonia based on the detection of serogroup-specific genes in culture-negative sputum. (Pubmed Central) -  Nov 30, 2023   
    Based on the presentation and clinical course (fever, muscle pain, disturbance of consciousness, high C-reactive protein titer, rhabdomyolysis, hypophosphatemia, and symptomatic improvement with levofloxacin treatment) in combination with the detection of L. pneumophila SG-specific genes, we suspected L. pneumophila SG13 pneumonia...pneumophila non-SG1 pneumonia is thought to be underestimated due to of its difficult laboratory diagnosis. The modified multiplex PCR system for lower respiratory tract specimens shown in this study is likely to increase the diagnosis of Legionnaires' disease caused by L. pneumophila SG13 and other SGs.
  • ||||||||||  vincristine / Generic mfg.
    Journal:  Delayed presentation of vincristine extravasation. (Pubmed Central) -  Nov 30, 2023   
    Identifying the correct pathogens and their antibiotic sensitivity patterns can help plan treatment strategies for the effective management of recurrent AT. Due to the ineffectiveness of antidote therapy for the management of delayed extravasation of vincristine and beneficial effect of our clinical approach, it could consider for the management of similar cases with delayed extravasation following vincristine administration.
  • ||||||||||  Journal:  Detection of Enterobacteriaceae in cerebrospinal fluid fluid of neonates with meningitis from tertiary care hospitals. (Pubmed Central) -  Nov 27, 2023   
    Overall, this study provides comprehensive insights into the degradation mechanism of micropollutants, involving hydroxyl radical (OH?), Fe(IV), and Fe(III)-LVF complexes, providing an efficient and green strategy for contaminant removal during wastewater treatment. CSF culture revealed that Gram-negative bacteria, specifically Pseudomonas spp., were the predominant pathogens in this family based on Pakistani data.
  • ||||||||||  Journal:  Evaluated gene expressions of Metallo beta lactamase genes (Pubmed Central) -  Nov 27, 2023   
    The carbapenem VIM and GIM, SPM (class B) genes are essential for resistance in P. aeruginosa induced by chromosomal changes that modify membrane permeability efflux pump overexpression for genes. As a result, many studies require for discovering new strategies to reduce the threat to public health through preventing the spread of these isolates via tight infections, control measures, and the reduction of the danger to public health.
  • ||||||||||  levofloxacin / Generic mfg.
    Journal:  Nanoparticles of the Perovskite-Structure CaTiO System: The Synthesis, Characterization, and Evaluation of Its Photocatalytic Capacity to Degrade Emerging Pollutants. (Pubmed Central) -  Nov 24, 2023   
    In this research work, the photocatalytic capacity shown by the nanoparticles of the CaTiO system was evaluated to degrade two pollutants of emerging concern, namely methyl orange (MO)-considered an organic contaminating substance of the textile industry that is non-biodegradable when dissolved in water-and levofloxacin (LVF), an antibiotic widely used in the treatment of infectious diseases that is released mostly to the environment in its original chemical form...To quantify the coloring concentration, UV-visible spectroscopy was used considering the variation in the intensity of the characteristic of the greatest absorption, which correlated with the change in the concentration of the contaminant in the solution. The results showed that after irradiation with ultraviolet light, the degradation of the contaminants MO and LVF was 79.4% and 98.1% with concentrations of 5 g/L and 10 g/L, respectively.
  • ||||||||||  Journal:  Occurrence and Antimicrobial Resistance among Staphylococci Isolated from the Skin Microbiota of Healthy Goats and Sheep. (Pubmed Central) -  Nov 24, 2023   
    All isolates were susceptible to eight antibiotics (amikacin, gentamycin, ciprofloxacin, levofloxacin, rifampicin, chloramphenicol, trimethoprim-sulfamethoxazole, and tigecycline), representing six different classes...Moreover, the staphylococci isolated from the healthy animals carried genes conferring resistance to ?-lactams (mecA, blaZ), tetracyclines (tetL, tetK), macrolides (ermB, ermC), lincosamides (lnu), and fluoroquinolones (grlA). However, the prevalence of these genes was low.
  • ||||||||||  levofloxacin / Generic mfg.
    Journal:  ?-Glutamylation of Isopropylamine by Fermentation. (Pubmed Central) -  Nov 21, 2023   
    The energy consumption of VUV/O/PMS decreased by 22.6%- strain KIE171, GIPA is an intermediate in the biosynthesis of l-alaninol (2-amino-1-propanol), a precursor of the fluorochinolone antibiotic levofloxacin and of the chloroacetanilide herbicide metolachlor...In fed-batch bioreactor cultivations, GIPA accumulated to a titer of 11
  • ||||||||||  levofloxacin / Generic mfg.
    Journal:  Pharmacological effects and mechanism of Maxing Shigan decoction in the treatment of Pseudomonas aeruginosa pneumonia. (Pubmed Central) -  Nov 21, 2023   
    strain KIE171, GIPA is an intermediate in the biosynthesis of l-alaninol (2-amino-1-propanol), a precursor of the fluorochinolone antibiotic levofloxacin and of the chloroacetanilide herbicide metolachlor...In fed-batch bioreactor cultivations, GIPA accumulated to a titer of 11 We demonstrated the efficacy and mechanism of MXSG in the treatment of acute P. aeruginosa pneumonia, which provides a scientific basis for its clinical application.
  • ||||||||||  Journal:  Effectiveness of Helicobacter pylori treatments according to antibiotic resistance. (Pubmed Central) -  Nov 20, 2023   
    It will be of great clinical significance to continuously monitor the antibiotic-resistance patterns of H. pylori in the pediatric population. In regions where the antibiotic resistance rate of H. pylori is high, eradication treatment with the three-in-one single-capsule, the quadruple with bismuth and concomitant with tinidazole are the best options in na
  • ||||||||||  levofloxacin / Generic mfg.
    Preclinical, Journal:  Hypoglycemia and anxiolysis mediated by levofloxacin treatment in diabetic rats. (Pubmed Central) -  Nov 17, 2023   
    Strategically designed therapeutics, incorporating CPPs with antibacterial properties, have the potential to reduce microbial infections in the treatment of malignancies. The non-diabetic rats were considered as control and received saline.Diabetic rats received metformin (50
  • ||||||||||  levofloxacin / Generic mfg.
    Trial completion, Phase classification, Enrollment change:  Effectiveness of Preurodynamic With Posturodynamic Levofloxacin on the Incidence of UTI (clinicaltrials.gov) -  Nov 13, 2023   
    P1/2,  N=134, Completed, 
    This research utilized a pair of Gram-positive bacteria (Staphylococcus aureus and Bacillus subtilis) and a pair of Gram-negative bacteria (Pseudomonas aeruginosa and Escherichia coli) to evaluate the antibacterial efficacy of TWB. Enrolling by invitation --> Completed | Phase classification: P2 --> P1/2 | N=100 --> 134
  • ||||||||||  levofloxacin / Generic mfg.
    Preclinical, Journal, IO biomarker:  Punica granatum peel extract modulates levofloxacin-induced oxidative stress and testicular damage in rats. (Pubmed Central) -  Nov 13, 2023   
    Furthermore, PGPE pretreatment of LEV-treated rats restored the majority of the tested parameters when compared to the LEV-treated group. In conclusion, pomegranate peel extract had a powerful modulating role against the adverse effects of levofloxacin in rat testes and represents a perspective of the utilization of food waste by-products.
  • ||||||||||  levofloxacin / Generic mfg.
    Journal:  An Oxygen Supply Strategy for Sonodynamic Therapy in Tuberculous Granuloma Lesions Using a Catalase-Loaded Nanoplatform. (Pubmed Central) -  Nov 12, 2023   
    A PLGA nanoparticle (LEV@CAT-NPs) loaded with levofloxacin (LEV) and catalase (CAT) was fabricated by a double emulsification method, and its physical characteristics, oxygen production capacity, drug release capacity, and biosafety were thoroughly investigated...This study provides a non-invasive and new avenue for treating refractory tuberculosis infections. The potential role of regulating hypoxia within infected lesions as a therapeutic target for infection deserves further exploration in future studies.
  • ||||||||||  ceftriaxone / Generic mfg., levofloxacin / Generic mfg.
    Journal:  Effects of antibiotics ceftriaxone and levofloxacin on the growth of Lucilia sericata (Diptera: Calliphoridae). (Pubmed Central) -  Nov 8, 2023   
    The mortality was significantly increased in all treatments with antibiotics compared to the control, whereby the survivability of all treatments remained over 80%. Because of the high doses needed to produce an effect, we concluded that an overestimation of the post-mortem interval is unlikely but higher antibiotic concentrations or possible interactions with other medications could increase the maggot development time.
  • ||||||||||  levofloxacin / Generic mfg., amikacin sulfate / Generic mfg., rifampicin / Generic mfg.
    Journal:  Analysis of Drug-Resistant Tuberculosis in Children in Shenyang, China, 2017-2021. (Pubmed Central) -  Nov 7, 2023   
    RR-TB, MDR-TB, and even Pre-XDR-TB require attention in children with drug-resistant TB. Xpert MTB/RIF helped to detect more rifampicin-resistant pediatric patients; thus Xpert MTB/RIF should be widely used as an important complementary tool to detect rifampicin-resistant TB in children.
  • ||||||||||  levofloxacin / Generic mfg.
    Journal:  Pulp Regenerative Therapy using Autologous Dental Pulp Stem Cells in a Mature Tooth with Apical Periodontitis: A Case Report. (Pubmed Central) -  Nov 6, 2023   
    Root canal disinfection was performed by irrigation and intracanal medication by nanobubbles with levofloxacin and amphotericin B in addition to conventional irrigation...The signal intensity on magnetic resonance imaging of the regenerated tissue in the affected tooth was comparable to that of the normal pulp in the adjacent teeth after 24 weeks. This case report demonstrated the potential use of DPSCs for pulp regenerative therapy in mature teeth with apical periodontitis.
  • ||||||||||  levofloxacin / Generic mfg., clarithromycin / Generic mfg.
    Biomarker, Journal, Biopsy:  Molecular Characterization and Mutational Analysis of Clarithromycin- and Levofloxacin-Resistance Genes in Helicobacter pylori from Gastric Biopsies in Southern Croatia. (Pubmed Central) -  Nov 3, 2023   
    Molecular docking analyses revealed that mutant H. pylori strains with resistance-related mutations exhibited a lower susceptibility to CAM and LVX compared with wild-type strains due to significant differences in non-covalent interactions (e.g., hydrogen bonds, ionic interactions) leading to destabilized antibiotic-protein binding, ultimately resulting in antibiotic resistance. Dual resistance to CAM and LVX was found, indicating the successful evolution of H. pylori resistance to unrelated antimicrobials and thus an increased risk to human health.
  • ||||||||||  levofloxacin / Generic mfg., valacyclovir / Generic mfg., trimethoprim/sulfamethoxazole / Generic mfg.
    Flat Dose Intravenous Immunoglobulin Primary Infection Prophylaxis in Multiple Myeloma Patients on Bispecific Antibody Therapy: Vanderbilt Experience (SDCC - Halls G-H) -  Nov 3, 2023 - Abstract #ASH2023ASH_4738;    
    CONCLUSIONS We observed relatively lower rate of severe or = G3 infectious events with 10g flat IVIG dosing schedule. While our results represent a small, single-institutional cohort of predominantly anti-GPRC5D treated RRMM patients and require prospective validation in a randomized (IVIG 10g vs 0.4g/kg body weight) fashion, they demonstrate feasibility of reduced level dosing of a critical resource such as IVIG, in the fast expanding, national/global BsAb-based MM armamentarium.