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- | levofloxacin / Generic mfg.
Journal: An innovative Z-type Sb2S3/In2S3/TiO2 heterostructure: superior performance in the photocatalytic removal of levofloxacin and mechanistic insight. (Pubmed Central) - Feb 9, 2024
In addition, ?OH and ?O2- play a dominant role in the photodegradation process. This work contributes to the design of novel photocatalytic materials with dual Z-type heterojunctions and efficient photocatalysts for the degradation of antibiotics.
- || Retrospective data, Review, Journal: Proportions of Pseudomonas aeruginosa and Antimicrobial-Resistant P aeruginosa Among Patients With Surgical Site Infections in China: A Systematic Review and Meta-analysis. (Pubmed Central) - Feb 8, 2024
The proportion of P aeruginosa infection among patients with SSIs was higher than the data reported by the Chinese Antimicrobial Resistance Surveillance System, indicating rising antimicrobial resistance. The existing antimicrobial drug management plan should be strengthened to prevent a hospital epidemic of drug-resistant P aeruginosa strains.
- | Actemra IV (tocilizumab) / Roche, JW Pharma
Journal: Antimicrobial consumption in an acute NHS Trust during the COVID-19 pandemic: intervention time series analysis. (Pubmed Central) - Feb 8, 2024
This study determined the consumption of antimicrobials trends before and during the pandemic. The individual wave antimicrobial consumption indicates maximum consumption in the first wave, advocating for antimicrobial stewardship and preparedness for future pandemics.
- | levofloxacin / Generic mfg.
Journal: Co-resistance to isoniazid and second-line anti-tuberculosis drugs in isoniazid-resistant tuberculosis at a tertiary care hospital in Thailand. (Pubmed Central) - Feb 7, 2024
In addition, the Hr-TB clinical isolates presented co-resistance to ethambutol (3/161, 1.9%), levofloxacin (2/96, 2.1%), and pyrazinamide (24/118, 20.3%)...The susceptibility profiles of Hr-TB clinical isolates, especially when they are co-resistant to second-line drugs, are critical in the selection of the appropriate treatment regimen to prevent treatment failure. This study highlights the susceptibility profiles of the WHO-recommended treatment regimen in Hr-TB clinical isolates from a tertiary care hospital in Thailand and the concordance and importance of using the phenotypic drug susceptibility testing or genotypic drug susceptibility testing for accurate and comprehensive interpretation of results.
- || levofloxacin / Generic mfg.
PK/PD data, Journal: Population pharmacokinetics and dose optimization of levofloxacin in elderly patients with pneumonia. (Pubmed Central) - Feb 6, 2024
This study highlights the susceptibility profiles of the WHO-recommended treatment regimen in Hr-TB clinical isolates from a tertiary care hospital in Thailand and the concordance and importance of using the phenotypic drug susceptibility testing or genotypic drug susceptibility testing for accurate and comprehensive interpretation of results. The population pharmacokinetic model of levofloxacin in elderly patients with pneumonia was established, and the dose optimization of levofloxacin was completed through Monte Carlo simulation.
- | levofloxacin / Generic mfg.
Journal: Levofloxacin susceptibility of Staphylococci from conjunctiva in patients with atopic dermatitis. (Pubmed Central) - Feb 4, 2024
The population pharmacokinetic model of levofloxacin in elderly patients with pneumonia was established, and the dose optimization of levofloxacin was completed through Monte Carlo simulation. Distinctive bacterial distribution and drug resistance need consideration in the managing of ocular disorders among patients with AD.
- | Fetroja (cefiderocol) / Shionogi
Preclinical, Journal, Gram negative: In vitro activity of cefiderocol and comparator antibiotics against multidrug-resistant non-fermenting Gram-negative bacilli. (Pubmed Central) - Feb 2, 2024
Cefiderocol may serve as an alternative treatment for multidrug-resistant A. baumannii, P. aeruginosa, BCC and S. maltophilia when other antibiotics have been ineffective or intolerable. The role of ceftazidime/avibactam and aztreonam/avibactam in the management of BCC or S. maltophilia infections warrants further investigation.
- levofloxacin / Generic mfg.
Long-term levofloxacin therapy stunts diversification of bacterial gut microbiota in infants (Hall J) - Feb 1, 2024 - Abstract #ECCMID2024ECCMID_859;
- | Journal: MICROBACTERIAL PROFILE OF SURGICAL SITE INFECTION AND THEIR PATTERN OF SENSITIVITY IN TERTIARY HOSPITAL IN NORTH CENTRAL HOSPITAL, NIGERIA. (Pubmed Central) - Feb 1, 2024
The resistance pattern of enterobacteriaceae to tested antibiotics were to ciprofloxacin (90.2%) levofloxacin (82.2%) augmentin (88.5%) ceftriaxone (85.2%) ceftazidime (80.3%), gentamicin (80.3%) meropenems (14.8%) amikacin (16.4%.). The study demonstrated a high alarming rate of multidrug resistance following SSI and this should call for concerns and surveillance among surgeons.
- | Journal: Treatment Outcome of Severe Respiratory Type B Tularemia Using Fluoroquinolones. (Pubmed Central) - Jan 31, 2024
Fluoroquinolone treatment is effective for severe tularemia. Subpleural round consolidations and mediastinal lymphadenopathy were typical findings on computed tomography among case-patients in this study.
- | Journal: Antimicrobial Susceptibility of Francisella tularensis Isolates in the United States, 2009-2018. (Pubmed Central) - Jan 31, 2024
We tested the susceptibility of 278 F. tularensis isolates from the United States received during 2009-2018 to 8 antimicrobial drugs (ciprofloxacin, levofloxacin, doxycycline, tetracycline, gentamicin, streptomycin, chloramphenicol, and erythromycin). All isolates were susceptible to all tested drugs.
- | Xifaxan (rifaximin) / Alfa Wassermann, Bausch Health, Norgine, ASKA Pharma
Journal: Antimicrobial Resistance of Clostridioides difficile in Children from a Tertiary Pediatric Hospital in Shanghai, China. (Pubmed Central) - Jan 31, 2024
difficile isolates from children with reduced susceptibility to metronidazole and vancomycin are emerging in pediatric CDI in China. The lack of pCD-METRO plasmid and vanA/B associated with reduced antibiotic susceptibility suggests there are additional mechanisms of resistance.
- | levofloxacin / Generic mfg.
Journal: Sensing Levofloxacin with an RNA Aptamer as a Bioreceptor. (Pubmed Central) - Jan 30, 2024
The lack of pCD-METRO plasmid and vanA/B associated with reduced antibiotic susceptibility suggests there are additional mechanisms of resistance. It binds levofloxacin with a K of 6
- | levofloxacin / Generic mfg.
Biomarker, Trial completion, Trial completion date, Trial primary completion date: Helicobacter Pylori 23S rRNA/gyrA Gene Mutation Detection Kit (Fluorescence PCR Fusion Curve Method) (clinicaltrials.gov) - Jan 29, 2024
P=N/A, N=1176, Completed, Sponsor: Nanjing First Hospital, Nanjing Medical University
It binds levofloxacin with a K of 6 Not yet recruiting --> Completed | Trial completion date: Dec 2023 --> Oct 2023 | Trial primary completion date: Jun 2022 --> Sep 2023
- | tamsulosin / Generic mfg., levofloxacin / Generic mfg.
Journal: Investigating how tamsulosin combined with levofloxacin impacts wound healing in patients with chronic prostatitis who may also have perineal or urethral wounds. (Pubmed Central) - Jan 29, 2024
In every domain, patient satisfaction scores were significantly higher in the treatment group. Thus the combination of tamsulosin and levofloxacin improved urinary function and wound repair in patients with chronic prostatitis, while also exhibiting tolerable profile of adverse effects.
- |||| Trial completion date, Trial primary completion date: Pharmacokinetic Properties of Antiretroviral and Anti-Tuberculosis Drugs During Pregnancy and Postpartum (clinicaltrials.gov) - Jan 29, 2024
P=N/A, N=325, Recruiting, Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Thus the combination of tamsulosin and levofloxacin improved urinary function and wound repair in patients with chronic prostatitis, while also exhibiting tolerable profile of adverse effects. Trial completion date: Oct 2025 --> Mar 2026 | Trial primary completion date: Oct 2025 --> Mar 2026
- | levofloxacin / Generic mfg.
Journal: Chloramine Disinfection of Levofloxacin and Sulfaphenazole: Unraveling Novel Disinfection Byproducts and Elucidating Formation Mechanisms for an Enhanced Understanding of Water Treatment. (Pubmed Central) - Jan 27, 2024
Furthermore, a pronounced elevation in DBP generation was observed in the pH range of 7 to 8. These findings present critical insights into the impact of the disinfection process on these antibiotics, emphasizing the innovation and significance of this research in assessing associated health risks.
- | Fetroja (cefiderocol) / Shionogi
Journal: Stenotrophomonas maltophilia Infections in Haematological Malignancies and Hematopoietic Stem Cell Transplantation: A Case Series including Cefiderocol-Based Regimens. (Pubmed Central) - Jan 27, 2024
The rest of the patients were treated with cotrimoxazole or levofloxacin in monotherapy. Despite a high rate of clinical improvement (90%) after starting antimicrobial therapy, we faced high 30-day mortality (30%) and in-hospital mortality (50%) rates in a highly comorbid population.
- | levofloxacin / Generic mfg.
Journal: Adsorption of Levofloxacin onto Graphene Oxide/Chitosan Composite Aerogel Microspheres. (Pubmed Central) - Jan 26, 2024
In addition, to obtain deeper insight into the adsorption process, the thermodynamics and kinetics of the process were also investigated with four different models of LOF adsorption. The thermodynamic modeling results revealed that LOF adsorption is exothermic, and the kinetic investigation demonstrated that LOF adsorption is generally consistent with a pseudo-first-order rate law.
- | levofloxacin / Generic mfg., minocycline / Generic mfg.
Journal, Machine learning: Machine learning and feature extraction for rapid antimicrobial resistance prediction of Acinetobacter baumannii from whole-genome sequencing data. (Pubmed Central) - Jan 26, 2024
Our study is the first to demonstrate that AMR prediction for A. baumannii using machine learning methods based on k-mer features has competitive performance over traditional workflows; hence, sequence-based AMR prediction and its application could be further promoted. The k-mer-based workflow developed in this study demonstrated high recall/sensitivity and specificity, making it a dependable tool for MIC prediction in clinical settings.
- cefepime hydrochloride / Generic mfg., levofloxacin / Generic mfg.
PSEUDOMONAS AERUGINOSA CULTURE-NEGATIVE KARIUS-POSITIVE PROSTHETIC VALVE ENDOCARDITIS (Hall B4-5) - Jan 26, 2024 - Abstract #ACC2024ACC_4877;
The k-mer-based workflow developed in this study demonstrated high recall/sensitivity and specificity, making it a dependable tool for MIC prediction in clinical settings. This case illustrates the unique diagnostic challenges of culture-negative PVE and the utility of Karius testing.
- | levofloxacin / Generic mfg.
New P4 trial, Surgery: Hyaluronic Acid-containing Artificial Tears in Post-cataract Surgery Dry Eye Disease (clinicaltrials.gov) - Jan 23, 2024
P4, N=70, Completed, Sponsor: Chang Gung Memorial Hospital
- || Clinical data, Retrospective data, Journal: Update on Urinary Tract Infection Antibiotic Resistance-A Retrospective Study in Females in Conjunction with Clinical Data. (Pubmed Central) - Jan 23, 2024
The best susceptibility rates were observed for fosfomycin, nitrofurantoin, and carbapenems. Our report aims to guide clinicians whenever they are forced to prescribe antibiotics empirically.
- | Journal: Antibiotic Resistance among Patients with Urinary Tract Infections in Kandahar, Afghanistan. (Pubmed Central) - Jan 22, 2024
Nitrofurantoin should be used as the first-line antibiotic in treating UTI patients. Public health authorities should make strict regulations and policies to reduce irrational use, inappropriate prescription, and over-the-counter availability of antibiotics in Kandahar.
- | New trial: Feasibility Study of the Proposed Test-and-treat Screening Program in Younger Participants With H. Pylori Infection (clinicaltrials.gov) - Jan 21, 2024
P=N/A, N=2000, Enrolling by invitation, Sponsor: National Institute of Public Health, Slovenia
- || Retrospective data, Review, Journal: Antibiotic resistance in Helicobacter pylori among children and adolescents in East Asia: A systematic review and meta-analysis. (Pubmed Central) - Jan 17, 2024
pylori isolates from East Asian children and adolescents exhibit high levels of metronidazole and clarithromycin resistance, particularly in the Chinese mainland. The non-negligible rates of dual and multiple resistance highlight the complexity of this problem.
- | levofloxacin / Generic mfg., meropenem / Generic mfg.
Journal: Comparative molecular profiling of multidrug-resistant Pseudomonas aeruginosa identifies novel mutations in regional clinical isolates from South India. (Pubmed Central) - Jan 17, 2024
Carbapenem resistance in MDR isolates was associated with loss-of-function mutations in oprD and high prevalence of NDM (bla) within our sample. This study provides insight into MDR mechanisms adopted by P. aeruginosa clinical isolates, which may guide the potential development of therapeutic regimens to improve clinical outcomes.
- | ceftriaxone / Generic mfg., levofloxacin / Generic mfg.
Biomarker, Observational data, Journal: Drug Utilization Research and Predictors of Outcomes in the Intensive Care Unit of a Tertiary Care Hospital: A Prospective Observational Study. (Pubmed Central) - Jan 17, 2024
For most of the drugs, the prescribed daily dose corresponded to the WHO-DDD except ceftriaxone and levofloxacin. Age, presence of cardiac disorders, and Glasgow Coma Scale (GCS) score at admission directly correlated with mortality while the use of diuretics had a negative correlation with the duration of ICU stay.
- | levofloxacin / Generic mfg., clindamycin phosphate / Generic mfg., amoxycillin/clavulanate / Generic mfg.
Trial initiation date, Head-to-Head: Efficacy of Oral vs IV Antibiotics in the Treatment of Orofacial Osteomyelitis (clinicaltrials.gov) - Jan 16, 2024
P=N/A, N=100, Not yet recruiting, Sponsor: University of Louisville
Age, presence of cardiac disorders, and Glasgow Coma Scale (GCS) score at admission directly correlated with mortality while the use of diuretics had a negative correlation with the duration of ICU stay. Initiation date: Nov 2023 --> Mar 2024
- | Baxdela (delafloxacin) / Menarini, Melinta Therap
Journal, Combination therapy: Efficacy of delafloxacin alone and in combination with cefotaxime against cefotaxime non-susceptible invasive isolates of Streptococcus pneumoniae. (Pubmed Central) - Jan 16, 2024
CNSSP showed a susceptibility to delafloxacin of 76.7%. Synergistic interactions between delafloxacin and cefotaxime were observed in vitro among CNSSP by GDS cross method.
- | levofloxacin / Generic mfg., trimethoprim/sulfamethoxazole / Generic mfg., cefadroxil / Generic mfg.
Enrollment open, Gram negative: BALANCE+ Vanguard Phase (clinicaltrials.gov) - Jan 16, 2024
P=N/A, N=72, Recruiting, Sponsor: Sunnybrook Health Sciences Centre
Synergistic interactions between delafloxacin and cefotaxime were observed in vitro among CNSSP by GDS cross method. Not yet recruiting --> Recruiting
- Impact of duration of pre-operative antibiotics on SIRS / urosepsis rates following (E05) - Jan 15, 2024 - Abstract #EAU2024EAU_3143;
- Exblifep (cefepime/enmetazobactam) / Allecra
Efficacy and safety of cefepime/enmetazobactam as compared to frequently used antibiotics in patients with complicated urinary tract infections including acute pyelonephritis: A Bayesian network meta analysis (E05) - Jan 15, 2024 - Abstract #EAU2024EAU_1280;
- | levofloxacin / Generic mfg.
Journal: Metabolic and transcriptional activities underlie stationary-phase Pseudomonas aeruginosa sensitivity to Levofloxacin. (Pubmed Central) - Jan 15, 2024
The heightened sensitivity of stationary-phase P. aeruginosa to fluoroquinolones is attributed to maintained transcriptional and reductase activity. Our data suggest that perturbations that suppress transcription and respiration in P. aeruginosa may actually protect the pathogen against this important class of antibiotics.
- | levofloxacin / Generic mfg.
Journal: Core-shell structured carbon dots with up-conversion fluorescence and photo-triggered nitric oxide-releasing properties. (Pubmed Central) - Jan 15, 2024
Moreover, the chromophores in the carbon core irradiated by visible LED light generate large amounts of reactive oxygen species (ROSs) that will oxidize the guanidine groups located on the shell of the Arg-CDs and further increase the NO releasing capacity remarkably. The as-synthesized Arg-CDs show excellent biocompatibility, bright up-conversion fluorescence, and a light-controlled ROS & NO releasing ability, which can be a potential light-modulated nanoplatform to integrate bioimaging and therapeutic functionalities.
- | Journal: Epidemiologic characteristics and drug resistance of isolated from blood culture escherichia coli in a hospital in Qinghai Province from 2016 to 2022 (Pubmed Central) - Jan 12, 2024
A fingerprint database of E. coli homologous protein was established, and it was found that the drug sensitivity data of E. coli were different among different fingerprint types. According to drug sensitivity, drug use could assist clinical experience and provide evidence for prevention and control of hospital illness.
- | levofloxacin / Generic mfg.
Journal: Enhanced Degradation of Levofloxacin through Visible-Light-Driven Peroxymonosulfate Activation over CuInS/g-CN Heterojunctions. (Pubmed Central) - Jan 11, 2024
Moreover, the 3CIS/GCN/vis-PMS system has very low metal leaching. Owing to xCIS/GCN having good properties for PMS activation, it has potential applications for LVF or other hazardous pollutants degradation.
- | ciprofloxacin oral / Generic mfg., levofloxacin / Generic mfg.
Journal: Poly(ethylene glycol) Methyl Ether Acrylate-Grafted Chitosan-Based Micro- and Nanoparticles as a Drug Delivery System for Antibiotics. (Pubmed Central) - Jan 11, 2024
The MPs/NPs were then used to encapsulate two separate drugs, LEV and CIP, and they showed excellent drug loading and release capacity. The MPs/NPs were also found to be safe for cells and blood, which demonstrated their potential as suitable drug delivery systems for biomedical applications.
- | levofloxacin / Generic mfg.
New trial: STBI: Effect of Intermittent Oro-esophageal Tube Feeding on Severe Traumatic Brain Injury Patients With Tracheostomy (clinicaltrials.gov) - Jan 11, 2024
P=N/A, N=104, Completed, Sponsor: The First Affiliated Hospital of Zhengzhou University
- | New P4 trial: Tailored vs. Empirical Helicobacter Pylori Infection Treatment (clinicaltrials.gov) - Jan 11, 2024
P4, N=160, Not yet recruiting, Sponsor: Manuel Coelho da Rocha
- | levofloxacin / Generic mfg.
Journal: Genome sequencing of Porostereum spadiceum to study the degradation of levofloxacin. (Pubmed Central) - Jan 10, 2024
Using UV and high-resolution mass spectrometry, we were able to detect five levofloxacin degradation products. Their putative identity based on their MS fragmentation patterns led to the conclusion that the piperazine moiety was the main target of oxidative modification of levofloxacin by P. spadiceum, leading to a decrease in antibiotic activity.
- | levofloxacin / Generic mfg., cefuroxime / Generic mfg.
Preclinical, Journal: Dietary nobiletin regulated cefuroxime- and levofloxacin-associated "gut microbiota-metabolism" imbalance and intestinal barrier dysfunction in mice. (Pubmed Central) - Jan 10, 2024
Notably, NOB supplementation resulted in elevated levels of butyric acid and lithocholic acid (LCA), which contributed to the repair of the intestinal mucosal barrier function and the maintenance of intestinal homeostasis. Collectively, our results propose a healthy dietary strategy for the prevention or mitigation of antibiotic-associated gut dysbiosis by dietary NOB.
- | ciprofloxacin oral / Generic mfg., azithromycin / Generic mfg., cefotaxime / Generic mfg.
Journal: Extensively drug-, ciprofloxacin-, cefotaxime-, and azithromycin-resistant Salmonella enterica serovars isolated from camel meat in Egypt. (Pubmed Central) - Jan 10, 2024
Collectively, our results propose a healthy dietary strategy for the prevention or mitigation of antibiotic-associated gut dysbiosis by dietary NOB. Interestingly, 56.3
- | levofloxacin / Generic mfg.
Journal: Levofloxacin alleviates blood-brain barrier disruption following cerebral ischemia and reperfusion via directly inhibiting A-FABP. (Pubmed Central) - Jan 8, 2024
Importantly, the BBB- and neuro-protective effects of levofloxacin were abolished in A-FABP or MMP-9 knockout mice, suggesting that the therapeutic effects of levofloxacin highly depended on specific targeting of the A-FABP-MMP-9 axis. Overall, our study demonstrates that levofloxacin alleviates A-FABP-induced BBB disruption and neural tissue injury following cerebral I/R, and unveils its therapeutic potential for the treatment of ischemic stroke.
- | Journal: Optimization of a solid phase extraction coupled with high performance liquid chromatography and diode array ultraviolet detection method for monitoring of different antibiotic classes residues in water samples. (Pubmed Central) - Jan 8, 2024
HPLC-DAD and fast HPLC methods were developed for separation of nine different antibiotics. The combination with the SPE procedure achieved low detection limits; from 0.2 to 3.8?ng/mL for SPE-HPLC-DAD and from 0.65 to 12.2?ng/mL for SPE-fast HPLC.
- | atorvastatin / Generic mfg., prednisone / Generic mfg., levofloxacin / Generic mfg.
Journal: Effects of Apex Size on Dissolution Profiles in the USP II Paddle Apparatus. (Pubmed Central) - Jan 6, 2024
Differences in apex centrality by 3 mm did not affect the dissolution rate. Our results indicate that apex vessels with low apex heights have a mount-resolving effect, but the degree of dissolution improvement by avoiding the coning phenomenon depends on the formulation characteristics used in the dissolution tests.
- | Journal, Next-generation sequencing: What samples are suitable for monitoring antimicrobial-resistant genes? Using NGS technology, a comparison between eDNA and mrDNA analysis from environmental water. (Pubmed Central) - Jan 5, 2024
However, mrDNA also revealed many sequence reads from multidrug-resistant bacteria, as well as nonspecific ARGs, whereas eDNA revealed specific ARGs such as pathogenic OXA-type and New Delhi metallo (NDM)-beta-lactamase ARGs. To estimate potential AMR pollution, our findings suggested that eDNA is preferable for detecting pathogen ARGs.
- Zeftera (ceftobiprole) / Basilea
INVASIVE PNEUMOCOCCAL PNEUMONIA IN ADULTS: SEROTYPE DISTRIBUTION AND ANTIMICROBIAL TRENDS OVER A 10-YEAR PERIOD IN ARGENTINA (2013-2022) (Station 04; Board 030) - Jan 4, 2024 - Abstract #ISPPD2024ISPPD_174;
All the isolates were susceptible to vancomycin, levofloxacin, chloramphenicol, ceftaroline and ceftobiprole. Penicillin MICs ?0.12
- | Journal: Vibrio species: development of EUCAST susceptibility testing methods and MIC and zone diameter distributions on which to determine clinical breakpoints. (Pubmed Central) - Jan 2, 2024
Penicillin MICs ?0.12 We demonstrated the validity of using standard BMD and EUCAST disc diffusion methodology for AST of five Vibrio spp., and generated suitable data to allow EUCAST to determine clinical MIC and zone diameter breakpoints for five pathogenic Vibrio spp., including both non-toxigenic and toxigenic V. cholerae.
- | levofloxacin / Generic mfg.
Journal: Photocatalytic activity evaluation of polyvinylpyrrolidone K30 assisted synthesis of 1D oxygen-vacancy-rich Bi5O7BrxI1-x nanorod solid solution. (Pubmed Central) - Jan 2, 2024
With the aid of regulating the energy band structure of photocatalytic materials and equilibrating the response towards visible light and redox ability, a novel oxygen-vacancy-rich BiOBrI nanorod solid solution was synthesized by polyvinylpyrrolidone K30 assisted solvothermal method, and its photocatalytic behavior was investigated for the degradation of antibiotic levofloxacin under visible light...The photocatalytic degradation pathways were explored and the toxicity of the intermediates was also appraised. The present work provides a mild and feasible construction of solid solutions and introduction of oxygen vacancies to eliminate environmentally refractory organic pollutants with photocatalytic technology.