- |||||||||| levofloxacin / Generic mfg.
Journal: The Acute Toxicity and Cardiotoxic Effects of Levofloxacin on Zebrafish (Danio rerio). (Pubmed Central) - Feb 25, 2025
These findings indicate that levofloxacin exposure exerts significant toxic effects on both embryonic and larval growth as well as heart development and gene expression in zebrafish. This study provides critical insights into the potential ecological risks posed by levofloxacin along with other antibiotics while laying a foundation for further investigation into their toxicological mechanisms.
- |||||||||| levofloxacin / Generic mfg.
Journal: N-doped MoS2 nanoflowers for the ultrasonic-vibration-driven high piezoelectric catalytic degradation. (Pubmed Central) - Feb 24, 2025
This is ultimately a risk to public health, evincing the need for antibiotic stewardship. Benefiting from the optimized proportion of minority layers at edge positions and higher conductivity by N doping, the optimal N-doped few-layer MoS2 (120 mg of added urea) sample showed the optimal piezocatalytic activity for Rhodamine B (RhB) and levofloxacin (LEV), reaching 84.6 and 73.1% with the reaction kinetic rate constant of 0.020?86 and 0.017?05
- |||||||||| ciprofloxacin oral / Generic mfg., levofloxacin / Generic mfg., norfloxacin / Generic mfg.
Review, Journal: Sample Preparation Approaches for Determination of Quinolones in Aqueous Matrixes: Systematic Review. (Pubmed Central) - Feb 24, 2025
Additionally, among the selected studies in this review, 44% employed liquid-liquid extraction techniques and its miniaturized versions, while 56% opted for solid-phase extraction and its miniaturized variations. Finally, it is important to note that the final method efficiency relies on the entire process, from selecting the instrumental technique with appropriate detection limits, going through the entire sample preparation, to achieving a good recovery through adjustments in the extraction parameters to archive the determination of trace levels.
- |||||||||| Gatiflox (gatifloxacin) / Orient Europharma
Journal: Pathogen Distribution, Drug Resistance, and Postoperative High-Quality Nursing Intervention Effectiveness in Knee Osteoarthritis Patients After Knee Arthroplasty With Postoperative Infection. (Pubmed Central) - Feb 24, 2025
Gram-negative bacteria showed high resistance to ciprofloxacin, levofloxacin, gentamicin, and tobramycin, but low resistance to cefepime, imipenem, meropenem, gatifloxacin, and amikacin...Serum levels of inflammatory markers are significantly higher in infection patients compared to non-infection patients. High-quality nursing interventions can effectively alleviate postoperative pain, promote recovery of knee joint function, enhance activities of daily living, and improve patient satisfaction.
- |||||||||| ciprofloxacin oral / Generic mfg., levofloxacin / Generic mfg., tetracycline / Generic mfg.
Preclinical, Journal: An Insight into Newly Emerging Avian Pathogenic E. coli Serogroups, Biofilm formation, ESBLs and Integron detection and In Vivo Pathogenicity in chicken. (Pubmed Central) - Feb 23, 2025
High-quality nursing interventions can effectively alleviate postoperative pain, promote recovery of knee joint function, enhance activities of daily living, and improve patient satisfaction. The antimicrobial susceptibility testing of E. coli isolates revealed high antibiotic resistance against imipenem, tetracycline, ciprofloxacin and levofloxacin (96
- |||||||||| levofloxacin / Generic mfg.
Journal: Generative latent diffusion language modeling yields anti-infective synthetic peptides. (Pubmed Central) - Feb 20, 2025
In preclinical mouse models of infection, lead peptides effectively reduced bacterial burdens, displaying efficacy comparable to polymyxin B and levofloxacin, with no detectable adverse effects. This study highlights the potential of AMP-Diffusion as a robust generative platform for designing novel antibiotics and bioactive peptides, offering a promising strategy to address the escalating challenge of antimicrobial resistance.
- |||||||||| Entresto (sacubitril/valsartan) / Novartis, ROVI Pharmaceuticals Laboratories
Journal: Unlocking the Future of Patient Education: ChatGPT vs. LexiComp (Pubmed Central) - Feb 19, 2025
Despite comparable PEMAT-P scores, ChatGPT PEMs did not meet grade level targets. Lower word count and passive text with ChatGPT PEMs could benefit patients, but the variable accuracy scores prevent routine use of ChatGPT to produce medication-related PEMs at this time.
- |||||||||| levofloxacin / Generic mfg.
Journal: Chemical proteomics reveal human off-targets of fluoroquinolone induced mitochondrial toxicity. (Pubmed Central) - Feb 18, 2025
In this study, focusing on the most commonly prescribed FQs Ciprofloxacin and Levofloxacin, whole proteome analyses revealed prominent mitochondrial dysfunction in human cells, specifically of the complexes I and IV of the electron transport chain (ETC)...Of note, the FQ induced ETC dysfunction via AIFM1 activates the reverse carboxylation pathway of IDH2 for rescue, however, its simultaneous inhibition further enhances mitochondrial toxicity. This off-target discovery study provides unique insights into FQ toxicity enabling the utilization of identified molecular principles for the design of a safer FQ generation.
- |||||||||| Journal: Effects of UVC doses on the removal of antimicrobial resistance elements from secondary treated sewage. (Pubmed Central) - Feb 18, 2025
Samples of influent and effluent from the UVC photoreactor were collected, and the concentration levels of norfloxacin (NOR), ciprofloxacin (CIP), and levofloxacin (LEV) were assessed. The qnrB, sul1, ermB, integron-integrase (intI1), and 16S rRNA genes, total heterotrophic bacteria (THB), and bacterial resistance to azithromycin and sulfamethoxazole were also investigated...These results demonstrated that UVC photoreactors can be an alternative to complement biological treatment in sewage treatment plants at the dose normally applied in full-scale WWTPs (>?15
- |||||||||| levofloxacin / Generic mfg.
Phase classification, Trial completion date, Trial primary completion date: Early De-escalation of Empirical Antibiotics Treatment for Neutropenic Fever (clinicaltrials.gov) - Feb 18, 2025
P=N/A, N=200, Recruiting,
The qnrB, sul1, ermB, integron-integrase (intI1), and 16S rRNA genes, total heterotrophic bacteria (THB), and bacterial resistance to azithromycin and sulfamethoxazole were also investigated...These results demonstrated that UVC photoreactors can be an alternative to complement biological treatment in sewage treatment plants at the dose normally applied in full-scale WWTPs (>?15 Phase classification: P3 --> P=N/A | Trial completion date: Dec 2021 --> Jun 2026 | Trial primary completion date: Dec 2021 --> Dec 2025
- |||||||||| levofloxacin / Generic mfg.
Journal: Fast Release of Carboxylic Acid inside Cells. (Pubmed Central) - Feb 17, 2025
Fluorescence-based assays using the pro-fluorescent BODIPY structure have demonstrated the rapid intracellular release of carboxylic acids within minutes in both eukaryotic and prokaryotic cells. The approach was tested on antibiotics, and among them, levofloxacin ester prodrug, having the 2-hydroxyethyl-dithio-benzyl ester functional group, showed significantly enhanced antimicrobial activity against resistant and intracellular bacteria compared to its methyl ester analogue.
- |||||||||| Retrospective data, Journal: Trends in Antimicrobial Resistance of Staphylococcus aureus Uropathogens: A Retrospective Study From Duhok Province, Kurdistan Region, Iraq. (Pubmed Central) - Feb 17, 2025
Conclusion According to the results, S. aureus isolated from urine samples varied in terms of the antibiotic susceptibility pattern with high resistance rates to erythromycin, penicillin, and oxacillin, while showing high sensitivity rates to levofloxacin, nitrofurantoin, and vancomycin. Further studies are needed with a broader geographical involvement to investigate the antibiotic sensitivity pattern in Iraq.
- |||||||||| ciprofloxacin oral / Generic mfg., levofloxacin / Generic mfg., trimethoprim/sulfamethoxazole / Generic mfg.
Journal: Polymicrobial Osteomyelitis in a Patient With Isolation of Trueperella bernardiae: A Case Report and Literature Review. (Pubmed Central) - Feb 14, 2025
Empirical treatment was initiated with levofloxacin...Diagnosis was changed to polymicrobial osteomyelitis, and antibiotic therapy with ciprofloxacin and trimethoprim-sulfamethoxazole was prescribed for a 4-week course of treatment, achieving the complete remission of symptoms...Their isolation as part of polymicrobial infections highlights relevant interspecies interactions. Research is still lacking in determining standardized methodologies for susceptibility testing and specific clinical breakpoints to guide clinical decisions.
- |||||||||| Minocin for injection (minocycline intravenous) / Melinta Therap
Journal: "Unmasking the Uncommon": A case series of multi-drug resistant Elizabethkingia meningoseptica causing late-onset sepsis and meningitis in preterm neonates. (Pubmed Central) - Feb 13, 2025
Antibiotic susceptibility testing (AST) revealed resistance to Piperacillin/Tazobactam, but sensitivity to Vancomycin, Levofloxacin, and Minocycline...Intravenous Ciprofloxacin was initiated with clinical improvement and negative follow-up blood cultures...A combination of Levofloxacin and Colistin was added, and blood cultures were negative after seven days, with clinical improvement...Clinicians must have a high degree of suspicion of E. meningoseptica for gram-negative bacilli causing sepsis and meningitis in high-risk patients. Recent technological advances have enabled accurate speciation to guide therapy and reduce morbidity and mortality rates.
- |||||||||| rifampicin / Generic mfg.
Journal: Fluoroquinolones and rifampin combination in the backdrop of heteroresistant tuberculosis. (Pubmed Central) - Feb 13, 2025
Moxifloxacin-rifampin combination sterilized the HFS-TB units inoculated with the isoniazid-resistant Mtb in 14 days compared with 21 days of treatment with levofloxacin-rifampin, with no further emergence of drug resistance. Early detection of isoniazid and rifampin heteroresistance could provide an opportunity to individualize the therapy and protect fluoroquinolones when added to the MDR-TB treatment regimen.
- |||||||||| levofloxacin / Generic mfg.
Journal: Precision Formulation of Ocular Films for Eye Infections Using Innovative Quality by Design Optimization. (Pubmed Central) - Feb 12, 2025
We conclude that the BMD assay provides reliable results, and its implementation in our MTBC routine workflow will produce valuable data that improve our understanding and management of MTBC drug resistance. The study concluded that combining ABLM with HPMC K4M enabled con-sistent, diffusion-controlled release of LFX, offering an effective and sustained formulation for treating conjunctivitis.
- |||||||||| levofloxacin / Generic mfg., rifampicin / Generic mfg.
Journal: Extreme and Severe Systemic Pain Caused by Rifampicin: A Case Report of a Rare Allergic Reaction. (Pubmed Central) - Feb 11, 2025
LVX prophylaxis in the setting of allo-HCT does not prevent infective complications and increases the prevalence of antibiotic-resistant strains. This case highlights a previously unreported presentation of rifampicin hypersensitivity and emphasizes the importance of careful risk assessment in patients with autoimmune features before initiating rifampicin therapy.
- |||||||||| levofloxacin / Generic mfg.
Journal: Intrahepatic Gossypiboma as a Complication of Cholecystectomy: A Case Report. (Pubmed Central) - Feb 11, 2025
Postoperative care involved a levofloxacin-based antibiotic regimen, leading to a favorable clinical outcome. This case represents an instance of a gossypiboma becoming fully internalized within the hepatic parenchyma following non-traumatic surgery.
- |||||||||| levofloxacin / Generic mfg.
Journal: Effects of Rifampicin Plus Levofloxacin or Isoniazid on Immune Function of Patients with Pulmonary Tuberculosis. (Pubmed Central) - Feb 7, 2025
Compared with rifampicin + isoniazid, rifampicin + levofloxacin had a better clinical effect in the treatment of pulmonary TB and could effectively regulate patients' immune functions and inhibit inflammatory reactions. The current research team recommends that rifampicin + levofloxacin become the preferred treatment for pulmonary TB in the absence of a drug allergy.
- |||||||||| levofloxacin / Generic mfg.
Journal: Decreased Crystal Plasticity by Solvation - the Case of Levofloxacin Acesulfame. (Pubmed Central) - Feb 6, 2025
The lower plasticity of the solvate is confirmed by crystal structure analysis and energy framework calculations. If this correlation between crystal packing efficiency and plasticity is robust, then we can objectively predict material plasticity of structurally related crystals based on crystal packing efficiency.
- |||||||||| tamsulosin / Generic mfg., levofloxacin / Generic mfg., celecoxib oral / Generic mfg.
Journal: Evaluation of concomitant treatment for Chronic Pelvic Pain Syndrome. (Pubmed Central) - Feb 6, 2025
Weight gain decreased the chances of pain reduction (OR?=?0.303), while increased BMI (OR?=?0.476) and smoking (OR?=?0.801) also negatively influenced pain relief. The results of this study showed that the concomitant use of tamsulosin, levofloxacin and celecoxib in patients with chronic pelvic pain syndrome had acceptable results in reducing the symptoms of patients.
- |||||||||| Journal: Temperate phage-antibiotic synergy is widespread-extending to Pseudomonas-but varies by phage, host strain, and antibiotic pairing. (Pubmed Central) - Feb 5, 2025
The recent discovery that otherwise therapeutically unusable temperate phages can potentiate the activity of antibiotics, resulting in a potent synergy, has only been tested in E. coli, and with a single model phage. Here, working with clinical isolates of Pseudomonas and phages from these isolates, we highlight the broad applicability of this synergy-across a variety of mechanisms but also highlight the limitations of predicting the phage, host, and antibiotic combinations that will synergize.
- |||||||||| Journal: Emergence of mcr-8.1-bearing MDR-hypervirulent Klebsiella pneumoniae ST307. (Pubmed Central) - Feb 4, 2025
Specifically, isolates designated as ARM03 and ARM06 were resistant to piperacillin-tazobactam, ARM04 and ARM05 had intermediate resistance to both piperacillin-tazobactam and imipenem, and ARM03 showed intermediate resistance to amikacin...Additionally, ARM03 and ARM06 also obtained dfrA5, sul1, sul3, cmlA1, mphA, aph3-Ia and the unique colistin resistance gene mcr-8.1, which was absent in all other publicly available ST307 isolates...In addition, the Armenian isolates obtained plasmids carrying virulence and AMR genes during the transmission event. Our study emphasises the importance of genomic surveillance of this emerging MDR-hypervirulent pathogen to provide early interventions.
- |||||||||| vancomycin / Generic mfg., levofloxacin / Generic mfg., ceftazidime / Generic mfg.
Journal: Successful management of drug-resistant rhizobium radiobacter endophthalmitis: A case report. (Pubmed Central) - Feb 4, 2025
Early vitrectomy and vitreous culture prove effective in managing postoperative endophthalmitis in drug-resistant Rhizobium radiobacter. IVI of Levofloxacin, though rare, proved to be effective in treating Ceftazidime-resistant and Levofloxacin-sensitive pathogens in our case.
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