- |||||||||| levofloxacin / Generic mfg.
Trial completion date, Trial primary completion date: Safety and Efficacy Study of Levofloxacin Combined With Endovascular Thrombectomy for Acute Ischemic Stroke (clinicaltrials.gov) - Mar 2, 2024
P=N/A, N=80, Not yet recruiting,
Besides, considering antibacterial and osteogenic efficiency and a high degree of safety in rat osteomyelitis model, shock wave-assisted vancomycin treatment may thus represent a possible adjuvant therapy for chronic osteomyelitis. Trial completion date: May 2024 --> Jul 2025 | Trial primary completion date: Feb 2024 --> Apr 2025
- |||||||||| Journal: Distribution and Drug Resistance of Common Pathogens Causing Lower Respiratory Tract Infection in Xinjiang Region. (Pubmed Central) - Mar 2, 2024
The sensitivity of Pseudomonas aeruginosa (PA) to piperacillin, gentamicin, imipenem, meropenem, ciprofloxacin and levofloxacin ranged from 50% to 80%...In addition, the susceptibility rate of these strains to rifampicin and linezolid was greater than 70%...Both resistant and non-resistant strains showed sensitivity to amikacin and tigecycline. Additionally, staphylococcus accounted for half of the total number of gram-positive bacteria, among which methicillin-resistant strains were more sensitive to vancomycin and linezolid.
- |||||||||| Takecab (vonoprazan) / Takeda, Phathom Pharma
Clinical, Journal, HEOR, Cost-effectiveness, Cost effectiveness: Efficacy And Cost-Effectiveness, Comparison Of 7-Days Vonoprazan Versus 14-Days Esomeprazole Based Triple Therapies For Treating Helicobacter Pylori Infection In Pakistani Population: A Randomized Clinical Trial. (Pubmed Central) - Mar 1, 2024
Cost effective ratio for Vonoprazan triple therapy was lower (731.8PKR) than the Esomeprazole group. One two-week Vonoprazan regimen demonstrated improved eradication rate, good compliance, and better tolerability in patients with less cost and a half duration of treatment in comparison with two weeks Esomeprazole regimen, attesting that one week Vonoprazan therapy is more cost efficacious in producing better results.
- |||||||||| Journal: Extensively Drug-Resistant Enteric Fever In Children: Surging Threats Of Antimicrobial Resistance And Possible Solutions. (Pubmed Central) - Mar 1, 2024
One two-week Vonoprazan regimen demonstrated improved eradication rate, good compliance, and better tolerability in patients with less cost and a half duration of treatment in comparison with two weeks Esomeprazole regimen, attesting that one week Vonoprazan therapy is more cost efficacious in producing better results. Paediatric patients with XDR enteric fever mainly presented with fever, anorexia and pain abdomen and showed good response to therapy with the combination of ceftriaxone and levofloxacin inspite of the apparent resistance on blood culture and sensitivity.
- |||||||||| Journal: Microbiology and Antimicrobial Susceptibility in Adult Dacryocystitis. (Pubmed Central) - Feb 28, 2024
Meropenem (95%), amikacin (93%), and levofloxacin (91%) were sensitive to more than 90% of gram-negative aerobes in current study...More gram-negative pathogens and more resistant species are rising in adult dacryocystitis. Understanding the bacteriology and antimicrobial susceptibility of the region is crucial for the empirical antibiotic selection in clinical practice.
- |||||||||| levofloxacin / Generic mfg.
Journal, Heterogeneity: Phenotypic heterogeneity unveils a negative correlation between antibiotic resistance and quorum sensing in Pseudomonas aeruginosa clinical isolates. (Pubmed Central) - Feb 27, 2024
Moreover, in vitro evolution experiments demonstrated that antibiotic-mediated selective pressure, particularly from Levofloxacin contributed to the emergence of extracellular protease-negative strains. Therefore, this study provides evidence for the connection of P. aeruginosa QS system and antibiotic resistance, and holds significance for developing targeted strategies to address antibiotic resistance and improving the management of antibiotic-resistant infections in chronic respiratory diseases.
- |||||||||| BURDEN OF PNEUMOCOCCAL INFECTIONS IN AN ADULT COHORT WITH CARDIAC DISEASES- A REPORT FROM A PUBLIC SECTOR HOSPITAL (Poster Area; Board 235) - Feb 24, 2024 - Abstract #ISPPD2024ISPPD_381;
EUCAST oxacillin screen test was used for antibiotic susceptibility testing according to which all isolates were sensitive to ampicillin, amoxicillin, ceftriaxone, pipercillin tazobactam and meropenem...Almost 65% isolates were sensitive to levofloxacin... A significant burden of penicillin resistant pneumococcal infection exists in patients with cardiac diseases.Pneumonia is the most common presentation
- |||||||||| ciprofloxacin oral / Generic mfg., levofloxacin / Generic mfg.
Journal: Levofloxacin and Ciprofloxacin Co-Crystals with Flavonoids: Solid-State Investigation for a Multitarget Strategy against Helicobacter pylori. (Pubmed Central) - Feb 24, 2024
The antibacterial performance of the four co-crystals LEV?QUE, LEV?MYR, LEV2?HES, and CIP?QUE in comparison with that of the physical mixtures of the separate components was tested via evaluation of the minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC). The results obtained indicate that the association with the co-formers, whether co-crystallized or forming a physical mixture with the active pharmaceutical ingredients (API), enhances the antimicrobial activity of the fluoroquinolones, allowing them to significantly reduce the amount of API otherwise required to display the same activity against H. pylori.
- |||||||||| levofloxacin / Generic mfg.
Journal: Ferroptosis as a Potential Therapeutic Target for Reducing Inflammation and Corneal Scarring in Bacterial Keratitis. (Pubmed Central) - Feb 21, 2024
The mice were treated with levofloxacin (LEV) or levofloxacin combined with ferrostatin-1 (LEV+Fer-1)...The inhibition of ferroptosis holds promise for mitigating inflammation, reducing corneal scarring, and ultimately enhancing the prognosis of BK. Consequently, this study provides a potential target for innovative therapeutic strategies for BK, which holds immense potential to transform the treatment of BK.
- |||||||||| Mycamine (micafungin) / Astellas
The emerging global threat of multidrug-resistant Candida auris (San Diego Convention Center (Upper Level, Sails Pavilion, Poster Center 1)) - Feb 20, 2024 - Abstract #AAD2024AAD_3350;
A 78-year-old man with rheumatoid arthritis, treated with methotrexate, suffered a laceration to his left thumb...He was treated with trimethoprim/sulfamethoxazole, itraconazole, doxycycline, levofloxacin, vancomycin, piperacillin/tazobactam, and linezolid without significant improvement...The patient completed twelve weeks of intravenous micafungin with resolution of his lesions...Laboratory identification is extremely challenging, and this, coupled with its ability to evade typical antifungal treatments, makes it a formidable microbe. Our case serves as an example of a deep fungal cutaneous infection caused by Candida auris and highlights the diagnostic and treatment challenges of this newly reported pathogen.
- |||||||||| Remicade (infliximab) / J&J, Humira (adalimumab) / AbbVie, Rituxan (rituximab) / Roche
Patient Demographics and Treatment Strategies Observed in The Follicular Occlusion Triad and Tetrad () - Feb 20, 2024 - Abstract #AAD2024AAD_2368;
Although the FOT is commonly described among dermatology literature, this review highlights the lack of an established FOT treatment algorithm. Future experimental studies are needed to compare the efficacy of the treatment options discussed in this review.
- |||||||||| levofloxacin / Generic mfg., trimethoprim/sulfamethoxazole / Generic mfg., doxycycline / Generic mfg.
A Rare Case of Pulmonary Mucoepidermoid Carcinoma Manifesting as Recurrent Post-obstructive Pneumonia (San Diego Convention Center, Area J (Hall H, Ground Level)) - Feb 20, 2024 - Abstract #ATS2024ATS_6899;
After two additional weeks of persistent intermittent cough, the patient was prescribed levofloxacin...Complete surgical resection is the treatment of choice for pulmonary MEC, resulting in better long-term survival. MEC should be considered in the differential diagnosis of a young patient presenting with a solitary pulmonary nodule without other risk factors.
- |||||||||| levofloxacin / Generic mfg., itraconazole / Generic mfg.
Allergic Bronchopulmonary Aspergillosis - An Unsuspecting Case (San Diego Convention Center, Area L (Hall H, Ground Level)) - Feb 20, 2024 - Abstract #ATS2024ATS_6654;
This case illustrates that in the presence of multiple central bronchiectasis, even without a previous diagnosis of asthma, suspicion of an ABPA diagnosis should be raised. When left untreated, structural damage may be severe.
- |||||||||| Primaxin (cilastatin/imipenem) / Abbott
A Case of a Recurrent Pleural Effusion Caused by Mycobacterium Fortuitum (San Diego Convention Center, Area L (Hall H, Ground Level)) - Feb 20, 2024 - Abstract #ATS2024ATS_6641;
The patient was discharged with an outpatient regimen comprising Trimethoprim/Sulfamethoxazole 160/800 mg orally every 12 hours and levofloxacin 750 mg orally every 24 hours for 12 months, followed by subsequent culture monitoring...Hirabayashi et al. suggest a treatment plan consisting of eight weeks of imipenem/cilastatin, minocycline, and levofloxacin, followed by four months of maintenance therapy using minocycline and levofloxacin.
- |||||||||| Lamprene (clofazimine) / Novartis
A Case of Nontuberculous Mycobacterium Infection in an Immunocompetent Patient From a Low-Middle Income Country (San Diego Convention Center, Area L (Hall H, Ground Level)) - Feb 20, 2024 - Abstract #ATS2024ATS_6639;
DiscussionWorldwide, Mycobacterium tuberculosis keep being the main etiology of pulmonary infections; however, sometimes when there is not an improvement of the symptoms with the prescribed treatment, it is necessary to look for another etiology (3). With this case we highlight the importance to carry out an early culture to receive a specific treatment to avoid the risk of resistance, even in a country where most of the cases are due to Mycobacterium tuberculosis (5) and there are few reports about M. abscessus.
- |||||||||| montelukast / Generic mfg., azithromycin / Generic mfg., fluticasone / Generic mfg.
Treatment of Acute Respiratory Failure Secondary to Chronic Graft-Versus-Host Disease With Fluticasone, Azithromycin, Montelukast, and High-Dose Glucocorticoids (San Diego Convention Center, Area D (Hall A-B2, Ground Level)) - Feb 20, 2024 - Abstract #ATS2024ATS_6242;
He was recently treated as an outpatient with levofloxacin, amoxicillin/clavulanic acid, and albuterol/ipratropium nebulizers for presumed pulmonary infections...Four months after discharge, he completed his prednisone taper and was asymptomatic from a respiratory standpoint, requiring no supplemental oxygen...Recent data has suggested that FAM and steroids can improve mortality in these patients. This case highlights FAM and an extended steroid taper, extrapolated from non-GVHD bronchiolitis obliterans and organizing pneumonia studies, as a possible therapeutic plan for providers to consider in chronic lung GVHD patients after HSCT.
- |||||||||| levofloxacin / Generic mfg.
Diagnostic and Therapeutic Challenges in Superinfected Giant Bulla: A Case Report (San Diego Convention Center, Area G (Hall A-B2, Ground Level)) - Feb 20, 2024 - Abstract #ATS2024ATS_6163;
A chest tube was successfully removed after two days and the patient was discharged with pulmonary rehabilitation and oral Levofloxacin for 1 month...However, the benefits of opening of the bulla versus complete resection are controversial, with our patient illustrating a favorable clinical course of the latter approach. Although not an indication for bullectomy, early surgical intervention should be considered in patients that have an infected giant bulla with minimal perioperative risk.
- |||||||||| Rituxan (rituximab) / Roche
From Actinomyces to Granulomatosis With Polyangiitis (San Diego Convention Center, Area H (Hall H, Ground Level)) - Feb 20, 2024 - Abstract #ATS2024ATS_5689;
She was initially treated with IV antibiotics and later discharged on levofloxacin...Due to persistent symptoms and a workup suggestive of vasculitis, induction therapy with corticosteroids for a potential diagnosis of granulomatosis with polyangiitis (GPA), this was followed by four doses of rituximab...The presence of elevated inflammatory markers, a positive ANCA test, and significant symptom improvement following corticosteroid induction therapy further supported the diagnosis of vasculitis. In summary, when encountering patients with recurrent otitis media that doesn't respond to multiple antibiotic courses and abscesses are present, clinicians should consider the possibility of vasculitis.
- |||||||||| Remicade (infliximab) / J&J, Mycobutin (rifabutin) / Pfizer, Lupin
Colonic Tuberculosis Mimicking Inflammatory Bowel Disease With Subsequent Disseminated Disease (San Diego Convention Center, Area H (Hall H, Ground Level)) - Feb 20, 2024 - Abstract #ATS2024ATS_4157;
He was started on tumor necrosis alpha (TNF-alfa) inhibitor (infliximab) after presenting with diffuse abdominal pain, diarrhea, and bright red blood per rectum...The new regimen started was rifabutin, levofloxacin, and linezolid with therapeutic drug monitoring... TB continues to be a challenging diagnosis, a delay can have catastrophic consequences leading to disseminated disease.
- |||||||||| levofloxacin / Generic mfg., rifampicin / Generic mfg., itraconazole / Generic mfg.
Tuberculosis and Histoplasmosis Co-Infection (San Diego Convention Center, Area H (Hall H, Ground Level)) - Feb 20, 2024 - Abstract #ATS2024ATS_4149;
He was initially started on four-drug therapy with rifampin, isoniazid, ethambutol and pyrazinamide...Ultimately he was definitively managed on a twelve month regimen of levofloxacin, linezolid, isoniazid and pyrazinamide for tuberculosis and twelve months of itraconazole, with good clinical response...PIK3CD gain-of-function mutations, such as was present in this case, can cause T-cell dysfunction. This case also highlights the challenge of treating mycobacterial and endemic fungal co-infections given interactions between rifamycins and azoles.
- |||||||||| levofloxacin / Generic mfg., amikacin sulfate / Generic mfg.
Giant Cavity, Giant Challenge (San Diego Convention Center, Area H (Hall H, Ground Level)) - Feb 20, 2024 - Abstract #ATS2024ATS_4148;
His extensive pulmonary disease also led to perfusion independent ADH mediated hyponatremia. We also shed light on the importance of following the department of public health's guidelines in duration of treatment and ensuring 3 consecutive negative AFB smears prior to discharge to decrease potential spread.
- |||||||||| levofloxacin / Generic mfg., amikacin sulfate / Generic mfg.
Severe Cystic Pulmonary Tuberculosis: A Rare Presentation in the United States (San Diego Convention Center, Area H (Hall H, Ground Level)) - Feb 20, 2024 - Abstract #ATS2024ATS_4138;
Her course was also complicated by multiple superimposed bacterial pneumonias, continued respiratory failure requiring tracheostomy, malnutrition requiring TPN, and persistent AFB positive sputum requiring addition of levofloxacin and amikacin. Though severe cystic lung disease caused by tuberculosis is rarely encountered, a high level of suspicion is required for rapid diagnosis and treatment to prevent mortality.
- |||||||||| Endemic Dangers: A Rare Case of Dual Infection With Legionella and Blastomycosis Requiring Veno-venous Extracorporeal Membrane Oxygenation (San Diego Convention Center, Area H (Hall H, Ground Level)) - Feb 20, 2024 - Abstract #ATS2024ATS_4086;
Case:A 51-year-old immunocompetent female with BMI 40, mild intermittent asthma, and relapsing-remitting multiple sclerosis (not requiring treatment) presented with worsening pneumonia despite outpatient treatment with cefdinir, azithromycin, amoxicillin-clavulanic acid, and methylprednisolone...She was treated with levofloxacin and amphotericin B and was able to successfully decannulate on HD 8...1% but can remain positive as long as 300 days. In summary, this case of coinfection with Blastomycosis and Legionella poses interesting challenges in pulmonary infection diagnostics and serves as a reminder about the risks of endemic pneumonias.
- |||||||||| levofloxacin / Generic mfg., azithromycin / Generic mfg.
Legionella Pneumonia With Rhabdomyolysis With Extremely High Creatine Phosphokinase (CPK) Without Acute Kidney Injury (AKI) (San Diego Convention Center, Area H (Hall H, Ground Level)) - Feb 20, 2024 - Abstract #ATS2024ATS_4081;
Azithromycin was changed to Levofloxacin on day 5 due to possible rare treatment failure as the patient showed minimal improvement. LP with rhabdomyolysis with extremely high CPK levels is usually associated with AKI but preserved kidney function is possible and early diagnosis and treatment can lead to decreased mortality and morbidity in severe disease.
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