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- | Journal: Detection of metallo-beta-lactamase-producing genes blaSPM and blaNDM in Pseudomonas aeruginosa isolated from wastewater in Southern Brazil. (Pubmed Central) - Apr 28, 2024
Among these isolates, 20% were classified as multidrug-resistant and were found to carry the blaNDM and blaSPM genes. The results suggest that evaluating resistance genes in bacteria from urban raw sewage can provide data that assist in surveillance, as this environment can stimulate increased bacterial resistance.
- | ibuprofen / Generic mfg.
Journal: Blending polydopamine-derived imprinted polymers with rice straw-based fluorescent carbon dots for selective detection and adsorptive removal of ibuprofen. (Pubmed Central) - Apr 28, 2024
The results suggest that evaluating resistance genes in bacteria from urban raw sewage can provide data that assist in surveillance, as this environment can stimulate increased bacterial resistance. PIP-FCDs show high sensitivity (limit of detection?=?1.58?
- | Journal: A Case of Thyroid Gland Abscess Caused by Brucella melitensis (Pubmed Central) - Apr 28, 2024
If diagnosis is delayed, complications may develop due to involvement in almost every part of the body, depending on the affected organs and systems. In areas where brucellosis is endemic, patients with symptoms such as neck swelling, shortness of breath and difficulty in swallowing, thyroid tissue involvement due to brucellosis should definitely be considered etiologically.
- | Biomarker, Journal: Molecular Analysis of Antibiotic Resistance in CarbapenemResistant Pseudomonas aeruginosa Isolates Isolated from Clinical Samples (Pubmed Central) - Apr 28, 2024
In areas where brucellosis is endemic, patients with symptoms such as neck swelling, shortness of breath and difficulty in swallowing, thyroid tissue involvement due to brucellosis should definitely be considered etiologically. In the study, identification of the bacterial isolates and their susceptibility to some antibiotics (imipenem, meropenem, aztreonam, amikacin, netilmicin, tobramycin, piperacillin, piperacillin/tazobactam, ceftazidime, cefepime, ciprofloxacin and levofloxacin) were determined by the VITEK
- | levofloxacin / Generic mfg.
Journal: In-situ assembling novel N-Ti3C2/BiOClxBr1-x composites with enhanced photocatalytic degradation and nitrogen reduction activity. (Pubmed Central) - Apr 27, 2024
Compared to that of BiOClxBr1-x, the maximum improvements of 1.16, 1.25 and 1.26 folds are severally confirmed for the photocatalytic degradation of levofloxacin, Rhodamine B, and methylene blue over N-Ti3C2/BiOClxBr1-x composites...Additionally, the stable photocatalytic properties of N-Ti3C2/BiOClxBr1-x are confirmed by three photocatalytic recycle tests on pollutant degradation and nitrogen reduction combined with X-ray diffraction patterns before and after three recycles. This study suggests that N-Ti3C2 is an efficient ornamentation for boosting photocatalytic activity ofBiOClxBr1-x, which can also be expanded as a promising modifier for other semiconductors.
- | levofloxacin / Generic mfg.
Journal: Ultra-sensitive electrochemical detection of levofloxacin using a binder-free copper and graphene composite. (Pubmed Central) - Apr 27, 2024
This study suggests that N-Ti3C2 is an efficient ornamentation for boosting photocatalytic activity ofBiOClxBr1-x, which can also be expanded as a promising modifier for other semiconductors. Using cyclic voltammetry, an impressive sensitivity of 19.7
- Observational data: The Percentage of Antibiotic Resistance in Uncomplicated Community-Acquired Urinary Tract Infections-Findings of the RedAres Project. (Pubmed Central) - Apr 26, 2024
Forrecurrent UTI, all but trimethoprim and cotrimoxazolecan be recommended. The second-choice antibioticsexamined do not have a more favorable resistanceprofile than the first-choice antibiotics.
- | Journal: Helicobacter pylori Secondary Antibiotic Resistance after One or More Eradication Failure: A Genotypic Stool Analysis Study. (Pubmed Central) - Apr 26, 2024
The only tetracycline-resistant patient had received Pylera. In conclusion, our data seem to show that, even though secondary resistance is not very high, resistance to clarithromycin could be very likely related to previous exposure to this antibiotic.
- | levofloxacin / Generic mfg.
Journal: Mechanochemically Induced Solid-State Transformations of Levofloxacin. (Pubmed Central) - Apr 25, 2024
Dynamic vapor sorption studies of both LVXam samples showed comparable stability properties and crystallized to the most stable hemihydrate form upon analysis. In summary, this work contributed to the detailed understanding of solid-state transformations of essential fluoroquinolones while employing greener and more sustainable manufacturing methods.
- | ceftriaxone / Generic mfg., levofloxacin / Generic mfg.
Observational data, Retrospective data, Journal, Adherence: Evaluating Antibiotic Treatment Guideline Adherence to Ongoing Antibiotic Stewardship in a Tertiary Care Setting: A Retrospective Observational Study. (Pubmed Central) - Apr 25, 2024
This study revealed a low adherence rate despite the availability of updated guidelines for antibiotic prescriptions. The findings confer an urgent need to confront antibiotic prescription patterns in such tertiary care centers for tailored interventions to improve adherence to antibiotic guidelines.
- levofloxacin / Generic mfg., valacyclovir / Generic mfg., acyclovir / Generic mfg.
Time to antibiotic administration in patients undergoing HSCT with neutropenic fever. () - Apr 24, 2024 - Abstract #ASCO2024ASCO_6242;
Hypotheses for this delay include improper chart documentation, nurse training (delay in physician notification), and provider comfort (antimicrobials deferred to day team, ID consults). The latter is of particular concern given incidents of >10 hour delay to antibiotic initiation.
- | Journal: A sophisticated virulence repertoire and colistin resistance of Citrobacter freundii ST150 from a patient with sepsis admitted to ICU in a tertiary care hospital in Uganda, East Africa: Insight from genomic and molecular docking analyses. (Pubmed Central) - Apr 24, 2024
Detailed genome analysis revealed chromosomal beta lactam resistance genes, i.e. blaCMY-79, blaCMY-116 and blaTEM-1B, along with multiple mutations of the lipopolysaccharide modifying operon genes PmrA/PmrB, pmrD, mgrA/mgrB and PhoP/PhoQ, conferring colistin resistance. From these findings, we infer that Citrobacter freundii strain RSM030 is implicated in sepsis and resistance to standard antibiotics, including colistin, the last resort.
- | Journal: Exploring variations in recommended first-choice therapy for complicated urinary tract infections in males: Insights from outpatient settings across age, race, and ethnicity. (Pubmed Central) - Apr 24, 2024
Nearly half of the patients included in this study did not receive recommended first-choice therapies; however, racial and ethnic disparities were not identified. Underutilization of recommended first-choice antibiotic therapy in complicated UTIs continues to be an area of focus for antimicrobial stewardship programs.
- | levofloxacin / Generic mfg.
Journal: Uropathogenic Escherichia coli infection: innate immune disorder, bladder damage, and Tailin Fang II. (Pubmed Central) - Apr 23, 2024
Levofloxacin was used as a positive control...Our findings suggest that TLF-II combats UPEC-induced bladder infections by effectively mitigating bladder inflammation and preventing bacterial escape from fusiform vesicles into the cytoplasm. The findings suggest that TLF-II is a promising option for treating UTI and reducing its recurrence.
- | ciprofloxacin oral / Generic mfg., levofloxacin / Generic mfg.
Trial completion date, Trial primary completion date: Ciprofloxacin Versus Levofloxacin in Stem Cell Transplant (clinicaltrials.gov) - Apr 23, 2024
P2, N=308, Active, not recruiting, Sponsor: Henry Ford Health System
The findings suggest that TLF-II is a promising option for treating UTI and reducing its recurrence. Trial completion date: Apr 2024 --> Aug 2024 | Trial primary completion date: Apr 2024 --> Aug 2024
- | Preclinical, Journal: In vitro activity of ceftazidime/avibactam, cefiderocol, meropenem/vaborbactam and imipenem/relebactam against clinical strains of the Stenotrophomonas maltophilia complex. (Pubmed Central) - Apr 22, 2024
Cefiderocol could be considered as a potential new option for multidrug resistant infections. Tetracyclines had the best in vitro activity of all antibiotics evaluated.
- | levofloxacin / Generic mfg.
Retrospective data, Journal: A retrospective study of the efficacy and safety of levofloxacin in children with severe infection. (Pubmed Central) - Apr 22, 2024
The effectiveness of levofloxacin use in children with serious infections is promising, especially for the treatment of multidrug-resistant bacteria. Adverse events occurring during the initiation of levofloxacin therapy in children are reported to be relatively common, but in this study, only a small percentage of them were possibly related to levofloxacin, and none of them were highly possibly related to levofloxacin.
- | Invanz (ertapenem) / Merck (MSD)
Trial primary completion date: Prophylactic Antibiotics for Urinary Tract Infections After Robot-Assisted Radical Cystectomy (clinicaltrials.gov) - Apr 22, 2024
P4, N=100, Recruiting, Sponsor: Roswell Park Cancer Institute
Adverse events occurring during the initiation of levofloxacin therapy in children are reported to be relatively common, but in this study, only a small percentage of them were possibly related to levofloxacin, and none of them were highly possibly related to levofloxacin. Trial primary completion date: Sep 2024 --> Mar 2025
- | levofloxacin / Generic mfg., trimethoprim/sulfamethoxazole / Generic mfg.
Journal: Molecular epidemiological and clinical infection characteristics analysis of Ralstonia. (Pubmed Central) - Apr 19, 2024
ST9 is the most common sequence types of Ralstonia pickettii. The most common clinical characteristics of Ralstonia pickettii infected patients were cough, sputum, shortness of breath and pulmonary rales.
- | Journal: Distribution of pathogenic bacteria and antimicrobial sensitivity of eye infections in Suzhou. (Pubmed Central) - Apr 19, 2024
Gram-positive bacteria are the dominant bacteria in eye infections, followed by gram-negative bacteria and fungi. Considering the resistance of gram-negative bacteria to multiple drugs, monitoring of bacteria should be strengthened in eye bacterial infections for effective prevention and control to reduce complications caused by eye infections.
- levofloxacin / Generic mfg.
Reversal of levofloxacin resistance in cystic fibrosis-associated Pseudomonas aeruginosa through dual inhibition of efflux pumps and DNA topoisomerases (ePoster Corner C - Room M2) - Apr 19, 2024 - Abstract #ECFS2024ECFS_947;
This study was part of a PhD project funded by Chiesi. In vitro induced LVX resistance in Pa can be reversed through a combination of efflux pump and DNA topoisomerase inhibition, challenging the belief that acquired resistance mutations inevitably lead to irreversible resistance.
- || Review, Journal: Challenges in the treatment of pediatric Mycoplasma pneumoniae pneumonia. (Pubmed Central) - Apr 18, 2024
- | levofloxacin / Generic mfg.
Preclinical, Journal: Developmental stage and infection status may affect drug distribution in the prostate of rats. (Pubmed Central) - Apr 18, 2024
Dialysates of levofloxacin and cefradine were collected from the prostate gland and jugular vein and evaluated...The mean values in group B were lower than those in group A, and those in group C were higher than those in group B.The maturity of the prostate may affect the ability of the drug to cross the BPB. Infection may disrupt the BPB, affecting drug permeability.
- | Journal: Antimicrobial Susceptibility Profiles and Key Determinants for Mortality in Burkholderia cepacia Complex Infections. (Pubmed Central) - Apr 18, 2024
Increasing antibiotic resistance and higher mortality rates justify that B. cepacia complex is a significant threat to hospitalized patients, especially in ICUs. Elevated levels of NLR, AST, creatinine, procalcitonin, and decreased platelet may predict poor clinical outcomes and could help clinicians in the management of this notorious bacterial pathogen.
- | levofloxacin / Generic mfg.
Journal: Insight into the catalytic performances of Fe0@chitosan/cellulose green hybrid structure for enhanced photo-Fenton's oxidation of levofloxacin toxic residuals: Pathway and toxicity. (Pubmed Central) - Apr 18, 2024
Elevated levels of NLR, AST, creatinine, procalcitonin, and decreased platelet may predict poor clinical outcomes and could help clinicians in the management of this notorious bacterial pathogen. However, the sample that was treated for 100
- | levofloxacin / Generic mfg., fosfomycin tromethamine / Generic mfg.
Trial completion: Effectiveness of Single Dose Fosfomycin and Single Dose Levofloxacin as Pre-urodynamic Antibiotic for UTI Prevention (clinicaltrials.gov) - Apr 18, 2024
P1/2, N=126, Completed, Sponsor: Indonesia University
However, the sample that was treated for 100 Recruiting --> Completed
- | levofloxacin / Generic mfg., voriconazole / Generic mfg.
Journal: Periprosthetic bacterial and fugal infection after total knee arthroplasty with one-stage debridement: a case report. (Pubmed Central) - Apr 17, 2024
Recruiting --> Completed In addition to the case study, we provide an analysis of the diagnosis and treatment of fungal infection after arthroplasty, especially the efficacy of debridement, antibiotics, and implant retention for a short-term outcome.
- || Invanz (ertapenem) / Merck (MSD)
Clinical, Journal: Three-Year Outcomes of Oral Antibiotics vs Intravenous and Oral Antibiotics for Uncomplicated Acute Appendicitis: A Secondary Analysis of the APPAC II Randomized Clinical Trial. (Pubmed Central) - Apr 17, 2024
P=N/A
The results encourage future studies to assess oral antibiotic monotherapy as a viable treatment alternative for uncomplicated acute appendicitis. ClinicalTrials.gov Identifier: NCT03236961.
- | ciprofloxacin oral / Generic mfg.
Journal: Persistent Colonization of Ciprofloxacin-Resistant and Extended-Spectrum ?-Lactamase (ESBL)-Producing Salmonella enterica Serovar Kentucky ST198 in a Patient with Inflammatory Bowel Disease. (Pubmed Central) - Apr 17, 2024
Long-term colonization of ciprofloxacin-resistant and ESBL-producing S. Kentucky ST198 in a single patient is a matter of concern. Due to the potential transfer of S. Kentucky ST198 from food sources to humans, ongoing surveillance of this particular clone in animals, animal-derived food products, and humans should be strengthened.
- | Xerava (eravacycline) / SOM Biotech, Ewha Womans University, PAION, Innoviva
Journal: Emergence of eravacycline heteroresistance in carbapenem-resistant Acinetobacter baumannii isolates in China. (Pubmed Central) - Apr 15, 2024
Decreasing the expression of adeABC or adeRS by antisense RNA silencing significantly inhibited eravacycline heteroresistance. In conclusion, this study identified the emergence of eravacycline heteroresistance in CRAB isolates in China, which is associated with high expression of AdeABC and AdeRS.
- | levofloxacin / Generic mfg.
Journal: Levofloxacin loaded chitosan and poly-lactic-co-glycolic acid nano-particles against resistant bacteria: Synthesis, characterization and antibacterial activity. (Pubmed Central) - Apr 15, 2024
In conclusion, this study identified the emergence of eravacycline heteroresistance in CRAB isolates in China, which is associated with high expression of AdeABC and AdeRS. These data suggested that available antibiotics can effectively be utilized as nano-antibiotics against resistant bacterial strains, causing severe infections, for improved antibiotic sensitivity without compromising patient safety.
- Pneumosil (10-valent pneumococcal conjugate vaccine) / Serum Institute of India
ASSESSING NASOPHARYNGEAL STREPTOCOCCUS PNEUMONIAE CARRIAGE IN SALVADORAN CHILDREN UNDER 4: INFLUENCE OF PNEUMOCOCCAL CONJUGATE VACCINATION. (STATION 2) - Apr 14, 2024 - Abstract #ESPID2024ESPID_637;
Comparison of nasopharyngeal carriage proportions between PCV10-vaccinated (31.5%) and PCV13-vaccinated (10%) children using the Z test revealed a statistically significant difference (p=0.00000372020)...The most prevalent serotype was 22F, followed by 23B and serotypes 19F and 19Fv. Both vaccinated and non-vaccinated cases showed 100% sensitivity to third-generation cephalosporin and vancomycin.
- || Takecab (vonoprazan) / Takeda, Phathom Pharma
Clinical, Journal: Therapeutic efficacy and drug safety comparison of one-week Vonoprazan triple therapy with two-weeks Esomeprazole triple therapy in Helicobacter pylori infection: Findings from a single-centre randomized clinical trial in population of Pakistan. (Pubmed Central) - Apr 13, 2024
Both vaccinated and non-vaccinated cases showed 100% sensitivity to third-generation cephalosporin and vancomycin. Vonoprazan-based triple therapy was found to be more effective with less reported adverse effects and potential benefits of better patient compliance due to shorter therapy duration.
- | levofloxacin / Generic mfg.
Journal: Nitrocellulose for Prolonged Permeation of Levofloxacin HCl-Salicylic Acid In Situ Gel. (Pubmed Central) - Apr 13, 2024
The low viscosity of LvSa25Nc makes it appropriate for injectable treatments targeting periodontitis, while the higher viscosity of LvSa40Nc renders it appropriate for topical applications in acne treatment. Therefore, the nitrocellulose in situ gel loaded with combined levofloxacin HCl and salicylic acid emerges as a promising dosage form for treating acne and periodontitis.
- | Retrospective data, Journal: Microbiological Characteristics and Resistance Patterns in a Neonatal Intensive Care Unit: A Retrospective Surveillance Study. (Pubmed Central) - Apr 12, 2024
aureus exhibited increased resistance to erythromycin, fusidic acid, gentamicin, and levofloxacin, while E. coli demonstrated decreased resistance against cephalothin, gentamicin, and trimethoprim/sulfa. The antibiotics currently employed empirically appear to provide adequate coverage against the most prevalent bacteria causing early- and late-onset neonatal infections.
- | levofloxacin / Generic mfg.
Journal: Levofloxacin loaded poly (ethylene oxide)-chitosan/quercetin loaded poly (D,L-lactide-co-glycolide) core-shell electrospun nanofibers for burn wound healing. (Pubmed Central) - Apr 12, 2024
Thanks to the synergistic therapeutic effect of LEV and QS, a significantly higher wound closure rate was recorded for the drug loaded core-shell nanofibrous dressing than the drug free nanofibers and control. Conclusively, PEO-CS-LEV/PLGA-QS core-shell nanofibers were shown to be a promising wound healing material that could drive the healing cascade through local co-delivery of LEV and QS to burn wounds.
- | levofloxacin / Generic mfg., rifampicin / Generic mfg.
Journal, Immunomodulating: Immunomodulatory zymosan/?-carrageenan/ agarose hydrogel for targeting M2 to M1 macrophages (antitumoral). (Pubmed Central) - Apr 12, 2024
Conclusively, PEO-CS-LEV/PLGA-QS core-shell nanofibers were shown to be a promising wound healing material that could drive the healing cascade through local co-delivery of LEV and QS to burn wounds. Seaweed derived carrageenan/ZM/agarose hydrogel was successfully prepared (@5?:?5 wt%) and was seen to support the growth of L929 cells (1
- | levofloxacin / Generic mfg.
Enrollment change, Trial withdrawal, Surgery: A Study of Levofloxacin Ocular Implant in Patients Undergoing Routine Bilateral Cataract Surgery (clinicaltrials.gov) - Apr 11, 2024
P1, N=0, Withdrawn, Sponsor: PolyActiva Pty Ltd
Seaweed derived carrageenan/ZM/agarose hydrogel was successfully prepared (@5?:?5 wt%) and was seen to support the growth of L929 cells (1 N=12 --> 0 | Suspended --> Withdrawn
- | Journal: Refractoriness to anti-Helicobacter pylori treatment attributed to phenotypic resistance patterns in patients with gastroduodenopathy in Guayaquil-Ecuador. (Pubmed Central) - Apr 10, 2024
In vitro testing revealed resistance to all five antibiotics, indicating that H. pylori exhibited resistance phenotypes to these antibiotics. Consequently, the effectiveness of triple treatments may be compromised, and further studies are needed to assess refractoriness in quadruple and concomitant therapies.
- || tetracycline / Generic mfg.
Retrospective data, Review, Journal: Effectiveness and safety of tetracyclines and quinolones in people with Mycoplasma pneumonia: a systematic review and network meta-analysis. (Pubmed Central) - Apr 10, 2024
Consequently, the effectiveness of triple treatments may be compromised, and further studies are needed to assess refractoriness in quadruple and concomitant therapies. However, the comprehensive NMA analysis of clinical response (in 70 studies; n
- | Journal: Antimicrobial resistance of avian pathogenic Escherichia coli isolated from broiler, layer, and breeder chickens. (Pubmed Central) - Apr 10, 2024
Similarly, a significant phenotype-genotype correlation (p < 0.001) was observed between chloramphenicol and the tetB, and colistin with blaTEM and resistance gene of quinolone (qnrA)...We deciphered the complex nature of AMR in APEC populations. This information of molecular surveillance is useful to combat AMR in APEC and to contribute to manage APEC associated diseases and develop policies and guidelines to enhance the commercial chicken production.
- | tetracycline / Generic mfg., cefuroxime / Generic mfg.
New P4 trial: Efficacy and Safety of Bismuth Quadruple Therapy Containing Cefuroxime and Tetracycline as First-line Therapy for Eradicating Helicobacter Pylori in Patients Allergic to Penicillin (clinicaltrials.gov) - Apr 7, 2024
P4, N=248, Not yet recruiting, Sponsor: Qilu Hospital of Shandong University
- | levofloxacin / Generic mfg.
Retrospective data, Journal, Surgery: Clinical Experience of Using a Combination of Dexamethasone and Levofloxacin After Cataract Surgery. (Pubmed Central) - Apr 7, 2024
The prescribed regimen effectively managed the postoperative recovery of the participants, and the medication was well-tolerated. Our research found that a new combination of levofloxacin and dexamethasone, when used topically, may require a shorter treatment period, reducing the risk of antibiotic resistance and providing a safe alternative for endophthalmitis prevention.
- | Invanz (ertapenem) / Merck (MSD)
Journal: A multicenter clinical epidemiology of pediatric pneumococcal meningitis in China: results from the Chinese Pediatric Bacterial Meningitis Surveillance (CPBMS) 2019-2020. (Pubmed Central) - Apr 5, 2024
S. pneumoniae strains are susceptible to vancomycin, linezolid, ertapenem, levofloxacin, moxifloxacin, rifampicin, and chloramphenicol.
- | ciprofloxacin oral / Generic mfg., levofloxacin / Generic mfg., tetracycline / Generic mfg.
Journal: Antibiotic residues in pasteurised and Raw Cow's milk in Dhaka, Bangladesh. (Pubmed Central) - Apr 5, 2024
pneumoniae strains are susceptible to vancomycin, linezolid, ertapenem, levofloxacin, moxifloxacin, rifampicin, and chloramphenicol. Notably, pasteurised milk samples contained enrofloxacin, levofloxacin and oxytetracycline, with groups P6 and P7 exceeding the Maximum Residue Limit for enrofloxacin, levofloxacin and ciprofloxacin (121?
- | levofloxacin / Generic mfg.
Trial completion: The V-QUIN MDR TRIAL: A randomized controlled trial of six months of daily levofloxacin for the prevention of tuberculosis among household contacts of patients with multi-drug resistant tuberculosis (EUDRACT) - Apr 5, 2024
P3, N=2006, Completed, Sponsor: University of Sydney
Notably, pasteurised milk samples contained enrofloxacin, levofloxacin and oxytetracycline, with groups P6 and P7 exceeding the Maximum Residue Limit for enrofloxacin, levofloxacin and ciprofloxacin (121? Active, not recruiting --> Completed
- || levofloxacin / Generic mfg., meropenem / Generic mfg.
Review, Journal: Abdominal abscess caused by Raoultella ornithinolytica secondary to postoperative gastric fistula: case report and review of literature. (Pubmed Central) - Apr 3, 2024
We share a case of a woman with non-viscerally abdominal abscess secondary to postoperative gastric fistula, R. ornithinolytica was isolated from the patient's pus, and the pathogenic bacteria may originate from the gastrointestinal tract. Based on this case, We should be cautious that invasive treatment may greatly increase the probability of infection with this pathogenic bacterium.
- | levofloxacin / Generic mfg.
Journal: Effects of Nanobubbles on Photochemical Processes of Levofloxacin Photosensitizer. (Pubmed Central) - Apr 3, 2024
The mechanism elucidated herein sheds light on how N2-NBs intricately influence both electron-transfer and energy-transfer reactions in the photosensitizer LEV. These findings not only contribute to a nuanced understanding of the underlying processes but also furnish novel insights that may inform the application of NBs in the realm of photodynamic therapy.
- | ciprofloxacin oral / Generic mfg., levofloxacin / Generic mfg.
Journal: Differential impacts of DNA repair machinery on fluoroquinolone persisters with different chromosome abundances. (Pubmed Central) - Apr 2, 2024
Here, we explore how an under-appreciated phenotypic variable, chromosome copy number (#Chr), influences the DNA repair systems persisters use to survive fluoroquinolone treatments. We found that #Chr significantly biases the DNA repair systems used by persisters, which suggests that #Chr heterogeneity should be considered when devising strategies to eradicate these troublesome bacterial variants.
- | levofloxacin / Generic mfg., azithromycin / Generic mfg., colistin sulphate / Generic mfg.
Journal, Combination therapy: The Potentiation Activity of Azithromycin in Combination with Colistin or Levofloxacin Against Pseudomonas aeruginosa Biofilm Infection. (Pubmed Central) - Apr 2, 2024
For CRPAO1 biofilm, only azithromycin-colistin combination and colistin monotherapy eradicated the bacteria in 60% and 40% of mice at the 6th day. Azithromycin-based combinations containing levofloxacin or colistin had no synergistic effect in vitro, and they are promising for clinical applications due to the good synergistic activity against PAO1 biofilms in vivo.