levofloxacin / Generic mfg. 
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  • ||||||||||  levofloxacin / Generic mfg.
    Journal:  Unraveling the role of toxin-antitoxin systems in Burkholderia pseudomallei: exploring bacterial pathogenesis and interactions within the HigBA families. (Pubmed Central) -  Jun 25, 2024   
    We have previously studied the link between one of those systems (defined as HigBA) with specific expression patterns associated with levofloxacin antibiotic exposure...Toxin-antitoxin (TA) systems play a significant role in bacterial persistence, a phenomenon where bacterial cells enter a dormant or slow-growing state to survive adverse conditions such as nutrient deprivation, antibiotic exposure, or host immune responses. By studying TA systems in Burkholderia pseudomallei, we can gain insights into how this pathogen survives and persists in the host environment, contributing to its virulence and ability to cause melioidosis chronic infections.
  • ||||||||||  Journal, Real-world evidence, Real-world:  Severe Acute Liver Injury After Hepatotoxic Medication Initiation in Real-World Data. (Pubmed Central) -  Jun 24, 2024   
    Seven medications (stavudine, erlotinib, lenalidomide or thalidomide, chlorpromazine, metronidazole, prochlorperazine, and isoniazid) exhibited rates of 10.0 or more events per 10?000 person-years, and 10 (moxifloxacin, azathioprine, levofloxacin, clarithromycin, ketoconazole, fluconazole, captopril, amoxicillin-clavulanate, sulfamethoxazole-trimethoprim, and ciprofloxacin) had rates between 5.0 and 9.9 events per 10?000 person-years...In this study, incidence rates of severe ALI using real-world data identified the most potentially hepatotoxic medications and can serve as a tool to investigate hepatotoxicity safety signals obtained from case reports. Case report counts did not accurately reflect the observed rates of severe ALI after medication initiation.
  • ||||||||||  lactulose / Generic mfg., levofloxacin / Generic mfg., minocycline / Generic mfg.
    Journal:  A late-onset hyperammonemia syndrome caused by Ureaplasma parvum infection after kidney transplantation. (Pubmed Central) -  Jun 24, 2024   
    Although common methods for ammonia clearance, such as haemodialysis and oral lactulose were initiated, his serum ammonia levels remained high...Levofloxacin and minocycline were administered respectively, which resulted in a decrease in ammonia levels, but normalization was not achieved...Once the mental status changes are identified, immediate empiric treatments should be initiated without waiting for a confirmed diagnosis of Ureaplasma spp. infection.
  • ||||||||||  etimicin / Aida Pharma
    Review, Journal:  Rhodococcus equi and Brucella pulmonary mass in immunocompetent: A case report and literature review. (Pubmed Central) -  Jun 24, 2024   
    Initial therapy with levofloxacin and vancomycin proved ineffective; however, a subsequent treatment regimen comprising azithromycin, etimicin, minocycline, and moxifloxacin resulted in substantial clinical improvement. This case accentuates the intricacies involved in diagnosing and managing atypical co-infections in immunocompetent individuals and underscores the importance of careful microbiological testing to inform effective therapeutic strategies.
  • ||||||||||  levofloxacin / Generic mfg., chlorpromazine / Generic mfg.
    Journal:  Photoprotective efficacy of Sunset Yellow via inhibition of type-I and type-II pathway under exposure of sunlight. (Pubmed Central) -  Jun 20, 2024   
    This case accentuates the intricacies involved in diagnosing and managing atypical co-infections in immunocompetent individuals and underscores the importance of careful microbiological testing to inform effective therapeutic strategies. Notably, SY demonstrates the ability to quench ROS, including singlet oxygen (1O2), superoxide radicals ( ), and hydroxyl radicals (
  • ||||||||||  ciprofloxacin oral / Generic mfg., levofloxacin / Generic mfg.
    Journal:  Effects of ciprofloxacin and levofloxacin on initial colonization of intestinal microbiota in Bufo gargarizans at embryonic stages. (Pubmed Central) -  Jun 19, 2024   
    Additionally, CIP exposure caused reduced total length and delayed the development in B. gargarizans embryos, while LEV increased the total length and promoted embryonic development. The present study revealed the adverse effects of CIP and LEV exposure on host gut microbiota, growth and development during the embryonic stage, and contributed new perspectives to the evaluation of early aquatic ecological risk under CIP and LEV exposure.
  • ||||||||||  levofloxacin / Generic mfg., clarithromycin / Generic mfg.
    Journal:  Prevalence of heteroresistant Helicobacter pylori and treatment follow-up in patients in Ilam, Iran. (Pubmed Central) -  Jun 17, 2024   
    Levofloxacin was applied in cases of heteroresistant samples, and the effectiveness was determined after one month of follow-up of patients...After one month of follow-up, it was found that the effectiveness of this antibiotic was good. Therefore, this antibiotic was introduced as a more effective drug in patients with heteroresistant H. pylori.
  • ||||||||||  cefazolin / Generic mfg., ceftriaxone / Generic mfg., levofloxacin / Generic mfg.
    Journal:  Case report: A case of piriformis pyomyositis and pyogenic sacroiliitis due to non-typhoidal Salmonella bacteremia in an immunocompetent healthy adult. (Pubmed Central) -  Jun 14, 2024   
    Cephazolin was started upon hospitalization; however, blood and stool cultures proved positive for NTS, and the antibiotics were changed to ceftriaxone...His buttock pain gradually improved, and the antibiotics were switched to oral levofloxacin, which enabled him to continue treatment in an outpatient setting...In the case of NTS bacteremia, the entry site must be identified for source control. Additionally, the background of the host, especially in such an immunocompetent case, needs to be clarified; therefore, the patient should be closely examined.
  • ||||||||||  Primaxin (cilastatin/imipenem) / Abbott
    Journal:  Central Nervous System Antimicrobial Exposure and Proposed Dosing for Anthrax Meningitis. (Pubmed Central) -  Jun 13, 2024   
    Our data suggest antimicrobials that should not be relied on to treat suspected or documented anthrax meningitis. Furthermore, the protein synthesis inhibitors clindamycin and linezolid can decrease toxin production and may be useful components of combination therapy.
  • ||||||||||  levofloxacin / Generic mfg., amikacin sulfate / Generic mfg.
    Journal:  First report of solitary cavitation nodules in the lungs with Mycobacterium canariasense. (Pubmed Central) -  Jun 12, 2024   
    In conclusion, 0.05% CsA eye drops is a useful adjunct to conventional treatment for restoring the ocular surface stability after corneal refractive surgery and is more potent in sustaining anti-inflammatory effects. This experience is instructive because clinical diagnostic and CT imaging characteristics and treatment strategy guidelines for pulmonary infections caused by M. canariasense have not yet been established.
  • ||||||||||  Journal:  Hospital wastewater as source of human pathogenic bacteria: a phenotypic and genomic analysis of international high-risk clone VIM-2-producing Pseudomonas aeruginosa ST235/O11. (Pubmed Central) -  Jun 10, 2024   
    Resistome comprehend of resistance genes to ?-lactams (blaVIM-2, blaOXA-4, blaOXA-488, blaPDC-35), aminoglycosides (aph(3')-IIb, aac(6')-IIc, aac(6')-Ib9, aadA1), fosfomycin (fosA), chloramphenicol (catB7) and sulfonamides (sul1)...GPAE0131 isolate was predicted to be pathogenic to humans and several virulence factors were found, including encoding gene for ExoU and exotoxin A. All of these features into a pathogenic international high-risk clone (ST235), classified as critical priority, stands out as public health concern due to the widespread dispersal of human pathogens through wastewater. It is suggested that mitigating measures be implemented, such as the treatment of hospital sewage and the addition of tertiary treatment, to prevent the escape of pathogens at this level into the environment.
  • ||||||||||  zoledronic acid / Generic mfg.
    Review, Journal:  Posterior scleritis following a single infusion of zoledronate for osteoporosis: A case report and literature review. (Pubmed Central) -  Jun 10, 2024   
    Treatment with methylprednisolone 80?mg intravenous infusion twice daily led to gradual symptom improvement and eventual resolution of inflammation. This report, based on a review of relevant literature, investigates the treatment and outcomes of zoledronic acid-induced scleritis, emphasizing the importance for clinicians to promptly identify and manage this rare and serious ocular adverse reaction.
  • ||||||||||  levofloxacin / Generic mfg., moxifloxacin intravenous / Generic mfg.
    Linezolid-Resistant Mycobacterium Tuberculosis: A highly concerning situation for the Tuberculosis Eradication Programme (PS-25; Poster board no. 19) -  May 31, 2024 - Abstract #ERS2024ERS_775;    
    Nonetheless, Genetic investigation is required for resistance mechanisms related to tuberculosis. The use of LZD in the treatment of drug-resistant tuberculosis has improved treatment outcomes; yet, the development of resistance to this medication calls for the surveillance of clinical isolates of M. tuberculosis for LZD sensitivity.
  • ||||||||||  levofloxacin / Generic mfg., rifampicin / Generic mfg., doxycycline / Generic mfg.
    PECULIARITIES OF BRUCELLIAN OSTEOARTICULAR INFECTIONS () -  May 29, 2024 - Abstract #EULAR2024EULAR_4484;    
    Early diagnosis helps limit complications and after-effects. Primary prevention by controlling animal brucellosis is essential.
  • ||||||||||  levofloxacin / Generic mfg., sulpiride / Generic mfg.
    Preclinical, Journal:  Validation of the Absorption-Enhancing Ability of Oligoarginines Grafted onto a Backbone of Hyaluronic Acid through Animal Studies from Rodents to Primates. (Pubmed Central) -  May 28, 2024   
    However, similar enhancement was not observed for levofloxacin, which has a similarly low molecular weight but is a well-absorptive organic compound, probably because its absorption was mostly dominated by passive diffusion...Drug concentrations in the brain assessed in mice and monkeys and those in the cerebral spinal fluids (CSFs) assessed in monkeys indicated that drugs would be delivered from the systemic circulation to the central nervous system by crossing the blood-brain and the blood-CSF barriers under coadministration with the hyaluronic acid derivative. In line with our original hypothesis, this new set of data supported that our oligoarginine-linked hyaluronic acid would locally perform on the mucosal surface and enhance the membrane permeation of drugs under its colocalization.