- |||||||||| levofloxacin / Generic mfg., azithromycin / Generic mfg.
Journal: A Case of Legionella Pneumonia with Rhabdomyolysis, with Extremely high Creatinine Kinase without Acute Kidney Injury in an Adult. (Pubmed Central) - Aug 12, 2024
The treatment algorithm was composed of multiple antimicrobial combinations and overall achieved ?98% PPV (LB Legionella pneumonia is difficult to distinguish from bacterial pneumonia, therefore rapid Legionella testing, particularly in areas with high rates of incidence, is important for targeted therapy.Legionella pneumonia with rhabdomyolysis with extremely high CPK levels is usually associated with AKI but preserved kidney function is possible and early diagnosis and treatment can lead to decreased mortality and morbidity in severe cases.
- |||||||||| Journal: Green adsorbents for pharmaceutics removal from urine: Analysis of isotherms, kinetics, adsorption interactions, cost estimation, and environmental impact. (Pubmed Central) - Aug 11, 2024
The natural adsorbents were used to remove pharmaceuticals such as diclofenac, ciprofloxacin, and acetaminophen in a mixture of distilled water...Therefore, CH was selected and used to remove other fluoroquinolones, such as levofloxacin and Norfloxacin...In addition, the life cycle analysis presents, for the 11 categories evaluated, a lower environmental impact of the CIP removal in urine with CH than for the preparation of adsorbent, confirming that the adsorption process is more environmentally friendly than materials synthesis or other alternatives of treatments. Furthermore, future directions of the study based on real applications were proposed.
- |||||||||| hydroxychloroquine / Generic mfg.
Observational data, Journal: The evaluation of the short-term and long-term hydroxychloroquine therapy on ECG parameters. (Pubmed Central) - Aug 9, 2024
HCQ's impact on QTc prolongation is influenced by therapeutic context, coadministered drugs, and patient demographics. The findings underscore the necessity of cautious HCQ use, particularly in acute settings like COVID-19, where monitoring and consideration of drug interactions and patient-specific factors are critical.
- |||||||||| levofloxacin / Generic mfg.
Journal: MIC distribution analysis identifies differences in AMR between population sub-groups. (Pubmed Central) - Aug 9, 2024
For example, within Staphylococcus aureus, MIC distributions by age group and infection site displayed clear trends, especially for levofloxacin with higher resistance levels in older age groups (odds of 2.17 in those aged 85+ compared to 19-64), which appeared more often in men...We found that MIC distributions can be used to identify differences in AMR levels between population sub-groups. Our methodology could be used more widely to unveil hidden transmission sources and effects of antibiotic use in different patient sub-groups, highlighting opportunities to improve stewardship programmes and interventions, particularly at local scales.
- |||||||||| Zavicefta (ceftazidime/avibactam) / Pfizer, AbbVie
Journal: Double blaKPC-2 copies quadrupled minimum inhibitory concentration of ceftazidime-avibactam in hospital-derived Klebsiella pneumoniae. (Pubmed Central) - Aug 8, 2024
It should be kept in mind that severe coagulopathy due to vitamin K deficiency caused by antimicrobial treatment with hyponutrition can occur in postoperative infections. The Kpn_XM9 was resistant to amikacin, aztreonam, ticarcillin/clavulanic acid, piperacillin/tazobactam, ceftazidime, cefepime, imipenem, meropenem, tobramycin, ciprofloxacin, levofloxacin, doxycycline, minocycline, tigecycline, colistin, and trimethoprim/sulfamethoxazole; it was barely susceptible to CZA with a minimum inhibitory concentration of 8/4
- |||||||||| ciprofloxacin oral / Generic mfg., levofloxacin / Generic mfg.
Journal: Small RNA GadY in Escherichia coli enhances conjugation system of IncP-1 by targeting SdiA. (Pubmed Central) - Aug 7, 2024
When under ciprofloxacin or levofloxacin treatment, GadY expression in donor strain was enhanced, and it positively regulated quinolone-induced SM10??-PAO1 conjugation. Thus, our study provides a novel role for sRNA GadY in regulating plasmid-mediated conjugation, which helps us better understand bacterial conjugation to counter antibiotic resistance.
- |||||||||| Thinking outside the 'Sputum Box' (Theater B (Exhibit & Poster Hall)) - Aug 6, 2024 - Abstract #NACFC2024NACFC_667;
Our study is ongoing, and we anticipate presenting results from larger subject cohorts and various sample types at the conference. Sharing our findings is timely given the urgency of this research priority within the CF community.
- |||||||||| levofloxacin / Generic mfg.
Uncommon Complication of Herpetic Infection: A Literature Review of Neurogenic Bladder in Herpes-Zoster (Poster Area) - Aug 5, 2024 - Abstract #EADV2024EADV_4074;
A 66-year-old male patient, treated for prostatic hyperplasia, with current lumbosacral HZ, complained of prostate irritation symptoms, being prescribed ketoprofen and levofloxacin... It is important to reduce the time of diagnosis, manage the clinical condition in order to prevent AKI and minimize negative impacts of HZ causing NB.
- |||||||||| levofloxacin / Generic mfg., clarithromycin / Generic mfg.
Abscesos gl (Poster Area) - Aug 5, 2024 - Abstract #EADV2024EADV_3947;
Questioning of patient history is key for diagnosis. This case is presented to demonstrate that simple procedures can cause chronic and complicated infections.
- |||||||||| levofloxacin / Generic mfg.
CAVITARY SQUAMOUS CELL CARCINOMA MASQUERADING AS CAVITARY LUNG ABSCESS (Convention Center Exhibit Hall: Poster Area 3) - Jul 31, 2024 - Abstract #CHEST2024CHEST_5496;
Although there was initial concern regarding the lesion's progression requiring a lobectomy, the patient responded well to antibiotics and was subsequently discharged on a one-month course of levofloxacin with outpatient follow-up with infectious disease (ID) and thoracic surgery.When seen outpatient, the cavitary lesion decreased in size with antibiotic therapy, obviating the need for bronchoscopy with a plan to follow up in the ID clinic... In summary, effective management of cavitary lung lesions should include a long-term follow-up plan for surveillance of cavitary lung lesions to avoid missing a malignancy diagnosis and ensure resolution and monitoring for any potential recurrence or complications.
- |||||||||| Soliris (eculizumab) / AstraZeneca
HEMOLYTIC UREMIC SYNDROME: NOT JUST A PEDIATRIC DISEASE (Convention Center Exhibit Hall: Poster Area 2) - Jul 31, 2024 - Abstract #CHEST2024CHEST_5265;
This case illustrates the importance of prompt recognition of hemolytic uremic syndrome compared to other hemolytic microangiopathies. In a community hospital where special labs have a longer turnaround time, it is imperative that the critical care team recognizes and treats the patient appropriately
- |||||||||| Gatiflox (gatifloxacin) / Orient Europharma
THE HIGHS AND LOWS OF FLUOROQUINOLONE-INDUCED DYSGLYCEMIA (Convention Center Exhibit Hall: Poster Area 2) - Jul 31, 2024 - Abstract #CHEST2024CHEST_5192;
The entity however requires a high index of suspicion to recognize the need to discontinue the medication. It is our hope that raising awareness for this condition will help mitigate potentially life-threatening events.
- |||||||||| levofloxacin / Generic mfg., azithromycin / Generic mfg.
THE PNEUMONIA ENIGMA: A CASE OF ENDOBRONCHIAL CARCINOID TUMOR MASKED BEHIND MYCOPLASMA PNEUMONIA (Convention Center Exhibit Hall: Rapid Fire Area 3C) - Jul 31, 2024 - Abstract #CHEST2024CHEST_4580;
In our patient with no previous history of hemoptysis or cough, initial presentation and workup was consistent with post obstructive pneumonia. Imaging and bronchoscopy later revealed stage IIIA (T4N0M0) NET which was amenable to complete resection.
- |||||||||| Xifaxan (rifaximin) / Alfa Wassermann, Bausch Health
HYPERAMMONEMIA: A RARE BUT FATAL PHENOMENON FOLLOWING LUNG TRANSPLANTATION (Convention Center Exhibit Hall: Poster Area 5) - Jul 31, 2024 - Abstract #CHEST2024CHEST_3067;
Early recognition and treatment are crucial in improving survival and preventing neurological sequela. This can be achieved by checking serial ammonia levels following lung transplantation.
- |||||||||| Rituxan (rituximab) / Roche
A RARE CASE OF GEOTRICHUM CANDIDEMIA IN AN IMMUNOCOMPROMISED PATIENT (Convention Center Exhibit Hall: Poster Area 2) - Jul 31, 2024 - Abstract #CHEST2024CHEST_2639;
Systemic Geotrichum Candidum is rare fungal infection in immunocompromised patients which if undetected can be fatal. Timely treatment with voriconazole is vital.
- |||||||||| levofloxacin / Generic mfg.
OCHROBACTRUM ANTHROPI: A CASE OF VENTILATOR-ASSOCIATED PNEUMONIA (Convention Center Exhibit Hall: Poster Area 2) - Jul 31, 2024 - Abstract #CHEST2024CHEST_2556;
Legionella as a cause of DAH is rare but should be considered especially in immunocompromised patients as it can result in morbidity and mortality if not detected and treated [7]. Routine post intubation cultures allowed for rapid identification of this novel organism, Orchobactrum anthrophi, as well as initiation of effective treatment with Levofloxacin.
- |||||||||| levofloxacin / Generic mfg.
A CASE OF STENOTROPHOMONAS MALTOPHILIA EMPYEMA IN AN IMMUNOCOMPETENT HOST (Convention Center Exhibit Hall: Poster Area 2) - Jul 31, 2024 - Abstract #CHEST2024CHEST_2516;
There are very few case reports documenting stenotrophomonas infection in immunocompetent hosts. Prompt recognition and management improve outcomes in patients with Stenotrophomonas infected pleural effusion.
- |||||||||| levofloxacin / Generic mfg.
LEVOFLOXACIN-INDUCED PNEUMONITIS IN A HISPANIC FEMALE (Convention Center Exhibit Hall: Poster Area 1) - Jul 31, 2024 - Abstract #CHEST2024CHEST_2395;
Levofloxacin is a frequently used antibiotic, that very rarely, may cause a drug-induced lung injury (DLI). Like in our case, this may continue to be a diagnosis of exclusion once, infective and autoimmune causes have been ruled out and reversibility of tissue function demonstrated, with drug discontinuation.
- |||||||||| levofloxacin / Generic mfg.
PERSISTENT PSEUDOMONAS PNEUMONIA IN BRONCHOSCOPIC LUNG VOLUME REDUCTION-TREATED LOBE: INDICATION FOR VALVE REMOVAL? (Convention Center Exhibit Hall: Rapid Fire Area 3B) - Jul 31, 2024 - Abstract #CHEST2024CHEST_1909;
Experts[4] recommend broad-spectrum oral antibiotics in case of bacterial pneumonia, strong consideration of valve removal after poor response to broad-spectrum intravenous antibiotics. Our patient developed clinical worsening despite progression of post BLVRS atelectasis which in actuality represented partial atelectasis and post-obstructive pneumonia.
- |||||||||| Incruse Ellipta (umeclidinium) / GSK, Xolair (omalizumab) / Roche, Novartis
THE ASTHMATIC SPECTRUM: ABPA TO CHRONIC PULMONARY ASPERGILLOSIS IN ADULTS (Convention Center Exhibit Hall: Rapid Fire Area 1B) - Jul 31, 2024 - Abstract #CHEST2024CHEST_1676;
He had previously been stable on a regimen of prednisone, fluticasone, umeclidinium, and omalizumab along with Mucinex and albuterol as needed...Treatment with voriconazole, levofloxacin, inhaled tiotropium, and budesonide led to remarkable recovery, and the patient currently remains stable with follow-up... Preventing further lung damage involves starting antifungal therapy and minimizing corticosteroid use, as increased corticosteroid treatment may compromise the immune response and promote Aspergillus growth.
- |||||||||| FOXES IN LAMB'S WOOL: A CASE OF LUNG ADENOCARCINOMA MASQUERADING AS RECURRENT PNEUMONIA (Convention Center Exhibit Hall: Poster Area 3) - Jul 31, 2024 - Abstract #CHEST2024CHEST_1577;
A chest X-ray showed consolidation in the right lower lobe, leading to a presumptive diagnosis of community-acquired pneumonia and treatment with levofloxacin, providing partial relief...She was admitted for pneumonia that failed outpatient treatment and was managed with Zosyn and vancomycin, then transitioned to cefdinir and doxycycline, resulting in improved symptoms... This case features the importance of integrating clinical and radiographic findings to conduct a thorough workup in patients presenting with "recurrent pneumonia." This highlights the need to revisit diagnoses when treatments do not align with anticipated responses, emphasizing a thorough diagnostic strategy.
- |||||||||| ELIZABETHKINGIA MENINGOSEPTICA PNEUMONIA AND BACTEREMIA IN AN ELDERLY, IMMUNOCOMPROMISED FARMER (Convention Center Exhibit Hall: Rapid Fire Area 1A) - Jul 31, 2024 - Abstract #CHEST2024CHEST_1556;
Elizabethkingia meningoseptica is an emerging pathogen with a unique multidrug resistance profile among Gram-negative bacilli and should be considered in cephalosporin and carbapenem-resistant infections affecting hospitalized, immunocompromised hosts. Our successful treatment of a high-risk patient with both piperacillin-tazobactam and levofloxacin supports the use of combination therapy in cases of severe infection.
- |||||||||| piperacillin sodium/tazobactam sodium / Generic mfg., levofloxacin / Generic mfg.
SPHINGOMONAS PAUCIMOBILIS AND ROSEOMONAS GILARDII: RARE BUT EMERGING GRAM-NEGATIVE PATHOGENS (Convention Center Exhibit Hall: Poster Area 2) - Jul 31, 2024 - Abstract #CHEST2024CHEST_1367;
Further research is important to develop novel diagnostic tests capable of early detection of slow-growing organisms, facilitating prompt diagnosis and appropriate treatment. This approach aims to mitigate unnecessary exposure to broad-spectrum antibiotics.
- |||||||||| ceftriaxone / Generic mfg., levofloxacin / Generic mfg., meropenem / Generic mfg.
COMMUNITY-ACQUIRED PNEUMONIA IN A YOUNG VAPER DUE TO SHEWANELLA PUTREFACIENS: A CASE REPORT. (Convention Center Exhibit Hall: Poster Area 2) - Jul 31, 2024 - Abstract #CHEST2024CHEST_1250;
Shewanella putrefaciens is an opportunistic gram-negative bacillus that lives in the marine ecosystem, the clinical infection rate in humans is very low and usually causes otitis media and soft tissue infections. Until now, only six cases of pneumonia secondary to this pathogen have been reported, this being the first case to link exposure to the marine environment, pneumonia due to S. putrefaciens and the use of electronic cigarettes.
- |||||||||| levofloxacin / Generic mfg.
WHEN IT RAINS IT POURS: A CASE OF FUNGAL CARDIAC TAMPONADE AND MILIARY TUBERCULOSIS (Convention Center Exhibit Hall: Poster Area 2) - Jul 31, 2024 - Abstract #CHEST2024CHEST_1230;
Patient was started on RIPE therapy with levofloxacin, isoniazaid, ethambutol, pyrazinamide, and vitamin B6 for pulmonary miliary TB... Candidal pericarditis is a rare disease but those with immunosuppression and pulmonary TB infection are at increased risk so warrant close monitoring and prompt intervention.
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