- |||||||||| Metapain (nefopam/paracetamol) / Aptys Pharma, Loramyc (miconazole muco-adhesive buccal tablet) / Onxeo, Sosei, GALT Pharma
APTYS PHARMA (Theater 3) - Jun 4, 2022 - Abstract #BIO2022BIO_131;
Loramyc® and Testocream® are based on Aptys pharma technologies...Our clients come to us because we can solve formulation problems and make from a bright idea an industrial reality because our team is made of flexible and open mind scientists. At the end Aptys can deliver a ready-to-use package: formula + recipe + validated analytical methods + stability data.
- |||||||||| miconazole oil / Hill Dermaceuticals, Loramyc (SO-1105) / Onxeo, Sosei
Review, Journal: Malassezia Yeasts in Veterinary Dermatology: An Updated Overview. (Pubmed Central) - Mar 18, 2021
These observations have prompted increased interest in alternative topical antifungal drugs, such as chlorhexidine, and various essential oils. Further clinical trials are awaited with interest.
- |||||||||| Loramyc (SO-1105) / Onxeo, Sosei
Journal: Antibacterial, Antifungal, Antioxidant, and Docking Studies of Potential Dinaphthodiospyrols from Diospyros lotus Linn Roots. (Pubmed Central) - Mar 9, 2021
Among all the screened compounds, 7 exhibited good activity (30-49 mm), followed by compounds 5 and 6, (35-46 mm), while compounds 1-4 showed a moderate effect (8-28 mm) against the selected fungal strain against miconazole which showed potent effects (101-110.98 mm)...From the docking analysis, it was found that the docking results are well correlated with the experimental observations. In conclusion, the dinaphthodiospyrols exhibited excellent antibacterial, antifungal, and free radical scavenging potential.
- |||||||||| Loramyc (SO-1105) / Onxeo, Sosei
Journal: Design, Synthesis and Anticandidal Evaluation of Indazole and Pyrazole Derivatives. (Pubmed Central) - Mar 7, 2021
Particularly, compound 10g, with N,N-diethylcarboxamide substituent, was the most active against C. albicans and both miconazole susceptible and resistant C. glabrata species. Therefore, the 3-phenyl-1H-indazole scaffold represents an opportunity for the development of new anticandidal agents with a new chemotype.
- |||||||||| Loramyc (SO-1105) / Onxeo, Sosei
Journal: Antifungal Activity of 1,4-Dialkoxynaphthalen-2-Acyl Imidazolium Salts by Inducing Apoptosis of Pathogenic Candida spp. (Pubmed Central) - Mar 7, 2021
Among the tested compounds, NAIMS 7c showed strongest antifungal activity with 3.125 μg/mL MIC value compared with miconazole which showed 12.5 μg/mL MIC value against Candida spp., and more importantly >100 μg/mL MIC value against C.auris...The expression of apoptosis-related genes was induced in C. albicans by NAIMS 7c treatment. Taken together, the synthetic NAIMSs are of high interest as novel antifungal agents given further in vivo examination.
- |||||||||| Loramyc (SO-1105) / Onxeo, Sosei
Journal: Antifungal susceptibility profiles of otomycosis etiological agents in Ahvaz, Iran. (Pubmed Central) - Feb 26, 2021
Based on the results, 77.8% of Candida species were resistant to caspofungin; however, miconazole and econazole had low MIC ranges...In addition, terbinafine was identified as the best antifungal for both Aspergillus and Candida species. Moreover, tested azoles had relatively low MICs, whereas most of the isolates had the MIC values beyond the caspofungin ECVs.
- |||||||||| Loramyc (SO-1105) / Onxeo, Sosei
Review, Journal: Prescribing over-the-counter medication in an OMFS department: a service review. (Pubmed Central) - Feb 11, 2021
Those most frequently prescribed were Difflam™ (Mylan) mouthwash and spray; chlorhexidine mouthwash, and miconazole oral gel...There is a need to educate nationally to reduce spending on OTC medications, which would help to relieve financial pressures on other NHS services. As a department, we can also hope for further improvement.
- |||||||||| Loramyc (SO-1105) / Onxeo, Sosei
Journal: Miconazole Contributes to NRF2 Activation by Noncanonical P62-KEAP1 Pathway in Bladder Cancer Cells. (Pubmed Central) - Feb 9, 2021
Pretreatment of bladder cancer cells with ROS scavengers abolished NRF2 expression and nuclear translocation, indicating that miconazole activates the noncanonical p62-KEAP1-NRF2 pathway, which is regulated by ROS production. Our study elucidates the mechanisms through which miconazole stimulates NRF2 which may contribute to cancer chemopreventive effects.
- |||||||||| Loramyc (SO-1105) / Onxeo, Sosei
Journal: Miconazole induces protective autophagy in bladder cancer cells. (Pubmed Central) - Jan 26, 2021
Finally, miconazole and autophagy inhibitor 3-methyladenine cotreatment further reduced the cell viability and induced apoptosis in BC cells, proving that miconazole provokes protective autophagy in BC cells. Our findings approve that miconazole has an antitumor effect in promoting cell apoptosis; however, its function of protective autophagy is needed to be concerned in cancer treatment.
- |||||||||| clotrimazole / Generic mfg.
Journal: Preparation of Nanofungicides Based on Imidazole Drugs and their Antifungal Evaluation. (Pubmed Central) - Dec 31, 2020
Excellent in-vitro antifungal activity was displayed by clotrimazole nano-formulation with ED50 1.18 μg/mL against R. solani, econazole nitrate nano-formulation with respective ED50 5.25 μg/mL against S. rolfsii and miconazole nitrate with respective ED50 1.49 and 1.82 μg/mL against M. phaseolina and F. oxysporum. Further, in-vivo studies against test fungi demonstrated the antifungal potency of all the nano-formulations with 11.11-27.38 percent disease incidence in plants treated with nano-formulations of test chemicals as compared to inoculated control (39.68-72.38%).
- |||||||||| clotrimazole / Generic mfg.
Clinical, Observational data, Journal: Prevalence and antifungal susceptibility of gastrointestinal candidiasis among diabetic patients: A cross-sectional study. (Pubmed Central) - Dec 30, 2020
Gastrointestinal candidiasis was associated with poor glucose control (p ≤ 0.001), prior use of antibiotics (p ≤ 0.001), antifungals (p ≤ 0.001) and corticosteroids (p ≤ 0.001) and was more common among female patients (p = 0.01). Occurrence of gastrointestinal candidiasis was relatively low among our participants, and infection was associated with poor glucose control, female sex and use of antifungals, antibiotics and corticosteroids.
- |||||||||| Loramyc (SO-1105) / Onxeo, Sosei
Retrospective data, Review, Journal: The effectiveness of microwave disinfection in treating Candida-associated denture stomatitis: a systematic review and metaanalysis. (Pubmed Central) - Dec 22, 2020
In summary, this finding is an important contribution to alert hospital microbiology routine laboratories to perform azole resistance surveillance and antifungal susceptibility tests of A. fumigatus causing infection or colonization in high-risk patients for systemic aspergillosis. Our findings provide evidence regarding the treatment of CADS using microwave disinfection, and also indicating the best cost-effective option for this treatment modality.
- |||||||||| Loramyc (SO-1105) / Onxeo, Sosei
Clinical, Journal: Candidiasis of the tongue in cannabis users: a report of 2 cases. (Pubmed Central) - Dec 18, 2020
Miconazole gel therapy was then prescribed, and clinical improvement was observed after 2 weeks...The second patient declined treatment. The reported cases demonstrate that, although it is infrequently reported, oral candidiasis may occur in cannabis smokers.
- |||||||||| Loramyc (SO-1105) / Onxeo, Sosei
Journal: Allergic contact dermatitis to topical medicaments: Revisited. (Pubmed Central) - Dec 5, 2020
Polysensitization and history of previous exposure, either as treatment or overusing of drugs, significantly associated with medicament positive patients. This study supports the inclusion of medicaments within the standard series of patch test.
- |||||||||| clotrimazole / Generic mfg.
Clinical, Review, Journal: Fungal infections in dentistry: clinical presentations, diagnosis, and treatment alternatives. (Pubmed Central) - Nov 28, 2020
Polyenes (nystatin, amphotericin B); azoles (ketoconazole, miconazole, clotrimazole, fluconazole, itraconazole, voriconazole, posaconazole, isavuconazole); and echinocandins (caspofungin, micafungin, anidulafungin) are discussed. Novel approaches in antifungal therapy with the use of probiotics are also reviewed.
- |||||||||| Loramyc (SO-1105) / Onxeo, Sosei
Journal: Antibacterial azole derivatives: Antibacterial activity, cytotoxicity, and in silico mechanistic studies. (Pubmed Central) - Nov 22, 2020
Antibacterial effects of some topical antifungals, such as miconazole and econazole, have lately been revealed, which suggests a promising venue in antimicrobial chemotherapy...As a result, the current study revealed several potential azole derivatives with both antifungal and antibacterial activities. Inhibition of bacterial flavoHb was suggested as a possible mechanism of action for the title compounds.
- |||||||||| fluconazole / Generic mfg., clotrimazole / Generic mfg.
Journal: Ctt1 catalase activity potentiates antifungal azoles in the emerging opportunistic pathogen Saccharomyces cerevisiae. (Pubmed Central) - Oct 25, 2020
At sub-MIC concentrations, fluconazole and miconazole stimulate catalase activity 2-3-fold but, unexpectedly, deletion of cytosolic catalase (ctt1) makes cells more resistant to these azoles and to clotrimazole, itraconazole and posaconazole...In fact, the ctt1Δ mutant has double the Sod2 activity of wild-type cells so ctt1 deletion increases azole resistance in part by Sod2 upregulation. Notably, deletion of peroxisomal/mitochondrial cta1 or cytosolic sod1 does not alter fluconazole or miconazole potency.
- |||||||||| ceftazidime / Generic mfg.
[VIRTUAL] A Rare Case of Trichoderma-Related Peritonitis in a Patient on Peritoneal Dialysis (On-Demand) - Oct 11, 2020 - Abstract #KIDNEYWEEK2020KIDNEY_WEEK_2929;
Repeat PD cultures were negative and he was discharged on oral Voriconazole with follow up in ID clinic...Most isolates of Trichoderma spp have shown resistance to fluconazole and 5- Fluorocytosine but show intermediate susceptibility to Amphotericin B, Itraconazole, Ketoconazole and Miconazole...Prompt antifungal treatment should be considered in cases of recurring peritonitis in the appropriate patients. More research is needed to guide early diagnosis and guide effective treatment of this rare fungal disease with high mortality.
- |||||||||| fluconazole / Generic mfg.
Clinical, Journal: Antifungal susceptibility of oral isolates of Candida species from chronic kidney disease patients on chronic dialysis. (Pubmed Central) - Sep 27, 2020
For the antifungal susceptibility test, the M44 A-3 method (CLSI) using fluconazole (FCZ), miconazole (MCZ), nystatin (NYS), and voriconazole (VCZ)...glabrata showed a reduced response to FCZ in 50% of isolates and C. albicans had a reduced response in 16% of the isolates. Antifungal agent with the least efficacious response or with the lowest susceptibility in the isolates of these patients was MCZ, followed by VCZ and FCZ, whereas NYS induced the best antifungal response.
- |||||||||| fluconazole / Generic mfg.
Preclinical, Journal: In Vitro and In Vivo Inhibitory Activity of Limonene against Different Isolates of Candida spp. (Pubmed Central) - Sep 27, 2020
The most prevalent treatments against candidiasis involve fluconazole, itraconazole, miconazole, and caspofungin...In addition, intravaginal fungal infection assays using a murine model infected by Candida albicans were carried out and the fungal burden, histopathology, and scanning electron microscopy were evaluated. All of our results suggest that limonene may play a protective role against the infection process by yeast from the genus Candida.
- |||||||||| Loramyc (SO-1105) / Onxeo, Sosei
Journal: Development of a Surface Coating Technique with Predictive Value for Bead Coating in the Manufacturing of Amorphous Solid Dispersions. (Pubmed Central) - Sep 20, 2020
ASDs of miconazole (MIC) and poly(vinylpyrrolidone-co-vinyl acetate) (PVP-VA) in methanol (MeOH) were studied as a model system...Finally, spray drying was also evaluated for its ability to manufacture high drug-loaded ASDs. The highest possible drug loadings that still result in a one-phase amorphous system were obtained for bead coating and its predictive intermittent surface coating technique, followed by spray drying and finally by film casting and the continuous surface coating technique, thereby underlining the importance for further research into the underexplored bead coating process.
- |||||||||| clotrimazole / Generic mfg.
Clinical, Journal: High multi-azole-resistant Malassezia pachydermatis clinical isolates from canine Malassezia dermatitis. (Pubmed Central) - Sep 16, 2020
Similarly, MICs for ITZ- or RVZ-resistant strains (MICs >32 mg/l) were also >32 mg/l for clotrimazole (CTZ), >32 mg/l for miconazole (MCZ), and 0.25 to >32 mg/L for voriconazole (VRZ)...Therefore, RVZ has considerable therapeutic potential for treating ITZ-resistant canine Malassezia dermatitis. However, RVZ-resistant strains already exist in canine Malassezia dermatitis in Japan.
- |||||||||| Loramyc (SO-1105) / Onxeo, Sosei
Journal: A nanocarrier system that potentiates the effect of miconazole within different interkingdom biofilms. (Pubmed Central) - Sep 16, 2020
percentage reduced in the gingivitis and caries models, respectively. In conclusion, the IONPs-CS-MCZ nanocarrier was efficient against three in vitro models of pathogenic oral biofilms, showing potential to possibly interfere in the synergistic interactions among fungal and bacterial cells within polymicrobial consortia.
- |||||||||| Loramyc (SO-1105) / Onxeo, Sosei
Preclinical, Journal: Intermolecular interaction energies and molecular conformations in N-substituted 4-aryl-2-methylimidazoles with promising in vitro antifungal activity. (Pubmed Central) - Sep 10, 2020
The analysis of the whole-of-molecule interactions shows that, despite the difference in the atom-atom contacts forming the crystals, dispersion energies make the largest contribution to the formation of the solids, giving an isotropic tendency in the topology of the energy framework diagrams for pairs of molecules. In addition, the in vitro antifungal activity of both families of compounds [ketones (4) and alcohols (5)] against Candida albicans and Cryptococcus neoformans was evaluated, where the 2,4-dichlorophenyl-substituted alcohol (5f), an isomer of the drug miconazole, showed the highest activity (IC = 7.8 µg ml against C. neoformans).
- |||||||||| Loramyc (SO-1105) / Onxeo, Sosei
Journal: Calmodulin inhibition as a mode of action of antifungal imidazole pharmaceuticals in non-target organisms. (Pubmed Central) - Sep 10, 2020
These findings suggest that CaM inhibition by miconazole leads to protein overexpression that compensates for the loss in the protein activity, with no measurable downstream effects on NO pathways. The inhibition of CaM in D. magna may have implications for effect assessment of exposure to mixtures of imidazoles in aquatic non-target species.
- |||||||||| Loramyc (SO-1105) / Onxeo, Sosei
Journal: Mollisiaceae: An overlooked lineage of diverse endophytes. (Pubmed Central) - Aug 30, 2020
Generic boundaries within Mollisiaceae are poorly resolved and based on phylogenetic evidence the family included species placed in Acephala, Acidomelania, Barrenia, Bispora, Cheirospora, Cystodendron, Fuscosclera, Hysteronaevia, Loramyces, Mollisia, Neopyrenopeziza, Obtectodiscus, Ombrophila, Patellariopsis, Phialocephala, Pulvinata, Tapesia (=Mollisia), and Trimmatostroma. Taxonomic novelties included the description of five novel Mollisia species and five novel Phialocephala species and the synonymy of Fuscosclera with Phialocephala, Acidomelania with Mollisia, and Loramycetaceae with Mollisiaceae.
- |||||||||| Loramyc (SO-1105) / Onxeo, Sosei
Preclinical, Journal: Synthesis of new bis-pyrazole linked hydrazides and their in vitro evaluation as antimicrobial and anti-biofilm agents: A mechanistic role on ergosterol biosynthesis inhibition in Candida albicans. (Pubmed Central) - Aug 27, 2020
Although the derivatives exhibited good antibacterial activity, some of the derivatives (13d, 13j, 13l, 13p, and 13r) showed excellent anti-Candida activity with MICs values of 3.9 μg/ml, which was equipotent to that of the standard Miconazole (3.9 μg/ml), which has inspired us to further explore their anti-Candida activity...These potential conjugates (13l and 13r) also demonstrated promising ergosterol biosynthesis inhibition against some of the strains Candida albicans, which were further validated through molecular docking studies. In silico computational studies were carried out to predict the binding modes and pharmacokinetic parameters of these conjugates.
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