drospirenone/ethinyl estradiol / Generic mfg. 
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  • ||||||||||  drospirenone/ethinyl estradiol / Generic mfg.
    Journal:  Acute pancreatitis caused by oral contraceptives. (Pubmed Central) -  Mar 27, 2025   
    Numerous research findings indicate that acute pancreatitis triggered by hypertriglyceridemia (HTG-AP, hypertriglyceridemic acute pancreatitis) may lead to increased death rates compared to other acute pancreatitis causes hypertriglyceridemia, characterized by fasting serum triglycerides exceeding (150mg/dL; 1.7mmol/L), and severe hypertriglyceridemia, identified by levels above (885
  • ||||||||||  drospirenone/ethinyl estradiol / Generic mfg.
    Retrospective data, Journal:  Increased ferritin with contraceptives containing ethinyl estradiol drospirenone in polycystic ovary syndrome: a paradox of iron storage and iron deficiency. (Pubmed Central) -  Feb 21, 2025   
    Numerous research findings indicate that acute pancreatitis triggered by hypertriglyceridemia (HTG-AP, hypertriglyceridemic acute pancreatitis) may lead to increased death rates compared to other acute pancreatitis causes hypertriglyceridemia, characterized by fasting serum triglycerides exceeding (150mg/dL; 1.7mmol/L), and severe hypertriglyceridemia, identified by levels above (885 The study revealed a paradoxical increase in ferritin levels with EE/DRSP treatment, highlighting the complex role of ferritin as a metabolic marker in PCOS patients, particularly in relation to obesity, which is typically associated with low-grade chronic inflammation.
  • ||||||||||  ethinyl estradiol/levonorgestrel / Generic mfg., drospirenone/ethinyl estradiol / Generic mfg.
    Preclinical, Review, Journal:  Animal models of hormonal contraceptives: Understanding drug-specific and user-specific variables. (Pubmed Central) -  Feb 11, 2025   
    This review underscores the value of animal models in advancing our understanding of the broader neurobiological and behavioral impacts of HCs in humans. These studies are crucial for developing personalized medicine approaches and optimizing contraceptive regimens to mitigate risks.
  • ||||||||||  drospirenone/ethinyl estradiol / Generic mfg.
    Journal:  Drosophila suzukii (Diptera: Drosophilidae) Population Dynamics and Infestation in a Raspberry Orchard of Loukkos Area, Morocco. (Pubmed Central) -  Nov 4, 2024   
    Yazmin...Raspberry fruit infestation reached a maximum of 76%, 75%, and 64% at the beginning of May 2022, middle of April 2023, and end of April 2024, respectively. Under the climate change scenario, knowledge of the eco-ethology of this insect and its population dynamics is essential for developing an IPM control strategy in Morocco, and further studies are ongoing to establish a biological and reasoned chemical approach based on degree-days.
  • ||||||||||  obicetrapib (TA-8995) / NewAmsterdam Pharma
    Trial completion, Trial completion date, Trial primary completion date:  Evaluate the Pharmacokinetics of a Combined Oral Contraceptive (COC) With and Without Obicetrapib (clinicaltrials.gov) -  Sep 20, 2024   
    P1,  N=30, Completed, 
    However, firsocostat should not be coadministered with strong OATP1B/3 inhibitors, such as rifampin and cyclosporine A. Firsocostat can be administered with CYP3A substrates or combined oral contraceptives without dose modification. Recruiting --> Completed | Trial completion date: Aug 2024 --> Apr 2024 | Trial primary completion date: Jul 2024 --> Apr 2024
  • ||||||||||  drospirenone/ethinyl estradiol / Generic mfg., dydrogesterone / Generic mfg.
    Journal:  The efficacy of levonorgestrelintrauterine system, drospirenone & ethinylestradiol tablets (II) and dydrogesterone in preventing the recurrence of endometrial polyps. (Pubmed Central) -  Sep 2, 2024   
    Recruiting --> Completed | Trial completion date: Aug 2024 --> Apr 2024 | Trial primary completion date: Jul 2024 --> Apr 2024 Dydrogesterone, drospirenone & ethinylestradiol tablets (II), and levonorgestrelintrauterine system all play a role in preventing the recurrence of endometrial polyps, but levonorgestrelintrauterine system is significantly better than dydrogesterone and Drospirenone & ethinylestradiol tablets (II) in terms of postoperative recurrence rate, endometrial thickness, menstrual changes, and compliance, and is worth promoting in clinical application.
  • ||||||||||  drospirenone/ethinyl estradiol / Generic mfg.
    Trial completion:  Efficacy and Safety of Dingkundan Combined With Combination Oral Contraceptives in the Treatment of PCOS (clinicaltrials.gov) -  May 29, 2024   
    P=N/A,  N=120, Completed, 
    The suggested chemometric methods are reliable, rapid, and inexpensive, and can be used as an environmentally friendly alternative to HPLC for the simultaneous estimation of the mentioned drugs in commercial pharmaceutical products. Recruiting --> Completed
  • ||||||||||  drospirenone/ethinyl estradiol / Generic mfg.
    Enrollment open:  Drospirenone (3 mg) + Ethinyl Estradiol (0.02 mg) Tablets Relative to Yaz (clinicaltrials.gov) -  Mar 12, 2024   
    P1,  N=32, Recruiting, 
    In contrast, E4/DRSP induced only minor histopathological changes and an increase in the proportion of males, at the highest concentration tested (?30 Not yet recruiting --> Recruiting
  • ||||||||||  BI 1358894 / Boehringer Ingelheim
    Trial completion date, Trial termination, Trial primary completion date:  A Study in Healthy Women to Test Whether BI 1358894 Influences the Amount of a Contraceptive in the Blood (clinicaltrials.gov) -  Feb 20, 2024   
    P1,  N=29, Terminated, 
    This interaction may result in elevated DVT risk due to a synergistic impairment of fibrinolysis and a decrease in plasmin production. Trial completion date: May 2024 --> Feb 2024 | Active, not recruiting --> Terminated | Trial primary completion date: May 2024 --> Feb 2024; Company decision
  • ||||||||||  retatrutide (LY3437943) / Eli Lilly
    Trial completion date, Trial primary completion date:  A Study of LY3437943 in Postmenopausal Female Participants Who Are Overweight or Obese (clinicaltrials.gov) -  Jan 25, 2024   
    P1,  N=47, Active, not recruiting, 
    While HC may have played a role, standard Vit D supplementation could not account for the noted improvement in FSFI in women with PCOS. Trial completion date: Jan 2025 --> Jul 2024 | Trial primary completion date: Jan 2025 --> Jul 2024
  • ||||||||||  progesterone / Generic mfg., drospirenone/ethinyl estradiol / Generic mfg., norethindrone / Generic mfg.
    Incidence of ACL Injuries in Females by Selective Use of Oral Contraceptive Pills (Green Room (Sunset Center)) -  Dec 13, 2023 - Abstract #WRMC2024WRMC_97;    
    Further research is warranted to explore variables impacting the association between OCP use and ACL injury, such as contraceptive formulation and method, mechanism of injury, and demographics. This is an initial evaluation of OCP use and ACL injury associations and whether OCPs could serve protective effects against ACL injuries in females.
  • ||||||||||  retatrutide (LY3437943) / Eli Lilly
    Enrollment closed:  A Study of LY3437943 in Postmenopausal Female Participants Who Are Overweight or Obese (clinicaltrials.gov) -  Dec 8, 2023   
    P1,  N=47, Active, not recruiting, 
    This is an initial evaluation of OCP use and ACL injury associations and whether OCPs could serve protective effects against ACL injuries in females. Recruiting --> Active, not recruiting
  • ||||||||||  milvexian (BMS-986177) / BMS, J&J
    Trial completion:  A Study of Milvexian in Healthy Adult Females (clinicaltrials.gov) -  Aug 18, 2023   
    P1,  N=20, Completed, 
    Its applicability was confirmed by the analysis of EE and DP levels in plasma samples in a designed pharmacokinetic study in rats after oral administration. Active, not recruiting --> Completed
  • ||||||||||  drospirenone/ethinyl estradiol / Generic mfg., gemfibrozil / Generic mfg., spironolactone / Generic mfg.
    Unveiling the Link: Hypertriglyceridemia Induced Acute Pancreatitis in a Young Female on Oral Contraceptives - A Case Report (Exhibit Hall) -  Jul 29, 2023 - Abstract #ACG2023ACG_1997;    
    Case Description/ A 24-year-old female with a history of cystic acne on spironolactone and Loryna (drospirenone and ethinyl estradiol tablets) presented to the Emergency Department with severe left flank pain rated 9/10...Management involved NPO status, an insulin drip, discontinuation of Loryna and spironolactone, and initiating Gemfibrozil and Omega 3 therapy...Further research is needed to assess the value of routine triglyceride monitoring in oral contraceptive users. Figure: CT abdomen findings
  • ||||||||||  drospirenone/ethinyl estradiol / Generic mfg.
    Journal:  Hormonal contraception use and insomnia: A nested case-control study. (Pubmed Central) -  Jul 20, 2023   
    The users of the fixed combination of drospirenone and ethinylestradiol as well as that of cyproterone and ethinylestradiol had significantly decreased odds for insomnia, whereas the users levonorgestrel-releasing intrauterine devise as well as those of vaginal ring with etonogestrel and ethinylestradiol had significantly increased odds for insomnia as compared with non-users. Our findings suggest that different products prescribed for hormonal contraception may be differentially associated with the occurrence of insomnia.
  • ||||||||||  drospirenone/ethinyl estradiol / Generic mfg.
    Review, Journal:  Oral contraceptives containing drospirenone for premenstrual syndrome. (Pubmed Central) -  Jul 1, 2023   
    COCs containing drospirenone and EE may lead to more adverse effects compared to placebo. We do not know whether it works after three cycles, helps women with less severe symptoms, or is better than other combined oral contraceptives that contain a different progestogen.
  • ||||||||||  milvexian (BMS-986177) / BMS, J&J
    Enrollment closed:  A Study of Milvexian in Healthy Adult Females (clinicaltrials.gov) -  Jun 29, 2023   
    P1,  N=20, Active, not recruiting, 
    We do not know whether it works after three cycles, helps women with less severe symptoms, or is better than other combined oral contraceptives that contain a different progestogen. Recruiting --> Active, not recruiting
  • ||||||||||  ethinyl estradiol/levonorgestrel / Generic mfg., drospirenone/ethinyl estradiol / Generic mfg.
    Effects of combined oral contraceptives on social recognition behavior in pubertal and adult mice (Montreal Bonaventure Hotel (CAN meeting headquarters)) -  Jun 10, 2023 - Abstract #CANACN2023CAN_ACN_295;    
    Preliminary results indicate a sex difference in chemo-investigation time with males investigating more than females as well as a trend in mean difference between the EE/LNG treatment group and controls, with controls showing increased investigation time of the familiar stimulus mouse. This study will provide further understanding on the effects of COCs on cognitive functioning and women's health, which is fundamental as over 150 million women worldwide use COCs.
  • ||||||||||  Livial (tibolone) / Organon, Visanne (dienogest) / Mochida, Bayer
    Journal:  A robust multi-residue method for the monitoring of 25 endocrine disruptors at ultra-trace levels in surface waters by SPE-LC-MS/MS. (Pubmed Central) -  Jun 5, 2023   
    The method was extensively validated and applied to seven representative Slovenian water samples, where we detected 21 out of 25 analytes; 13 were quantified in at least one sample. Estrone and progesterone were quantified in all samples, reaching levels up to 50 ng L; ethinylestradiol was higher than the current EQS (0.035 ng L) in three samples, and estradiol was above its EQS (0.4 ng L) in one sample, proving the method's applicability and the necessity for monitoring these pollutants.
  • ||||||||||  milvexian (BMS-986177) / BMS, J&J
    Enrollment open:  A Study of Milvexian in Healthy Adult Females (clinicaltrials.gov) -  Feb 9, 2023   
    P1,  N=20, Recruiting, 
    There were no significant correlations between the difference in acne severity before and after treatment with the three treatments and factors of dairy or sweet consumption. Not yet recruiting --> Recruiting
  • ||||||||||  Estelle (estetrol/drospirenone) / Mithra, Mayne Pharma
    Review, Journal:  Pharmacological and metabolic effects of drospirenone as a progestin-only pill compared to combined formulations with estrogen. (Pubmed Central) -  Feb 7, 2023   
    The spironolactone derivative drospirenone is combined with ethinylestradiol or estetrol in combined oral contraceptives...There is no influence on blood pressure with ethinylestradiol/drospirenone and estetrol/drospirenone formulations, while in clinical trials, a reduction has been observed with 17-β-estradiol/drospirenone and drospirenone-only...To sum up, the advantages of drospirenone in hormonal contraception and treatment of menopausal symptoms have been demonstrated for all the formulations described here. Combination with estrogen confers benefits and risks, which must be considered.