- |||||||||| moxifloxacin intravenous / Generic mfg., pirfenidone / Generic mfg.
Journal: Liposomal Forms of Fluoroquinolones and Antifibrotics Decorated with Mannosylated Chitosan for Inhalation Drug Delivery. (Pubmed Central) - Apr 28, 2023
The role of the polymer shell in the stabilization of vesicles and the delayed release of the contents has been demonstrated. For the liquid-polymer formulation of moxifloxacin, a prolonged accumulation of the drug in lung tissues was found after a single endotracheal administration to mice, significantly exceeding the control intravenous and endotracheal administration of the drug.
- |||||||||| aztreonam/avibactam (PF-06947387) / Pfizer, AbbVie, imipenem/relebactam / Merck (MSD), Zavicefta (ceftazidime/avibactam) / Pfizer, AbbVie
Journal: Chimeric Tobramycin-Based Adjuvant TOB-TOB-CIP Potentiates Fluoroquinolone and ?-Lactam Antibiotics against Multidrug-Resistant Pseudomonas aeruginosa. (Pubmed Central) - Apr 17, 2023
Moreover, the susceptibility breakpoints of ceftazidime, aztreonam, and imipenem were reached using the triple combination of chimera 4 with ceftazidime/avibactam, aztreonam/avibactam, and imipenem/relebactam, respectively, against ?-lactamase-harboring P. aeruginosa. Our findings demonstrate that tobramycin-based chimeras form a novel class of antibiotic potentiators capable of restoring the activity of antibiotics against P. aeruginosa.
- |||||||||| gemifloxacin mesylate / Generic mfg., moxifloxacin intravenous / Generic mfg.
Clinical, P1 data, Journal: The Effects of Moxifloxacin and Gemifloxacin on the ECG Morphology in Healthy Volunteers: A Phase 1 Randomized Clinical Trial. (Pubmed Central) - Apr 13, 2023
P1
It is concluded that both drugs have the potential for considerable QT interval prolongation (QTIP) effects, which is one of the risk factors for developing torsade de pointes (TdPs) in cardiac patients. Thus, clinicians should exercise caution when prescribing moxifloxacin and gemifloxacin to cardiac patients and should consider alternate treatment options.
- |||||||||| Journal: An Antibiogram Study for Urine Culture Testing in Makkah Region Hospitals. (Pubmed Central) - Apr 12, 2023
Thus, clinicians should exercise caution when prescribing moxifloxacin and gemifloxacin to cardiac patients and should consider alternate treatment options. There was clear evidence that ampicillin, cefepime, erythromycin, and moxifloxacin were not effective antibiotics for uropathogens in the Makkah area, KSA.
- |||||||||| Invanz (ertapenem) / Merck (MSD)
Antibiograms of select anaerobic bacteria over 10 years (P821) (Exhibit Hall; Poster Board No. P821) - Apr 11, 2023 - Abstract #IMMUNOLOGY2023IMMUNOLOGY_1750;
In the absence of local anaerobe antibiograms, providers may refer to such antibiogram data to guide empiric anti-anaerobic therapy at their institutions. In conclusion, anaerobe antibiotic susceptibility patterns must be monitored to ensure appropriate antibiotic empiric therapy and stewardship.
- |||||||||| pretomanid (PA-824) / Global Alliance for TB Drug Development, Sirturo (bedaquiline) / J&J, Pharmstandard
Increasing Fluoroquinolone Resistance In Drug Resistant TB () - Apr 6, 2023 - Abstract #AFMRSER2023AFMR_SER_6;
This is concerning as these agents are essential in first-line regimens for the treatment of DRTB. If the MICs continue to uptrend at a similar pace, we anticipate that more strains will surpass the breakpoint of 1 mg/L leading to potential ineffectiveness of both levofloxacin and moxifloxacin in the treatment of tuberculosis.
- |||||||||| lomefloxacin / Generic mfg.
Journal, Heterogeneity: Degradation of lomefloxacin by MoS/MIL-53(Fe, Cu) catalyst in heterogeneous electro-Fenton process. (Pubmed Central) - Apr 5, 2023
If the MICs continue to uptrend at a similar pace, we anticipate that more strains will surpass the breakpoint of 1 mg/L leading to potential ineffectiveness of both levofloxacin and moxifloxacin in the treatment of tuberculosis. Furthermore, the hetero-EF system could achieve the total removal of moxifloxacin and tetracycline within 6
- |||||||||| moxifloxacin intravenous / Generic mfg.
Journal: Composite PLGA-Nanobioceramic Coating on Moxifloxacin-Loaded Akermanite 3D Porous Scaffolds for Bone Tissue Regeneration. (Pubmed Central) - Mar 30, 2023
Their mechanical properties, apatite forming ability, degradation, pharmacokinetics, and hemocompatibility were also investigated. The addition of NPs improved the compressive strength, hemocompatibility, and in vitro degradation of the composite scaffolds, resulting in them keeping a 3D porous structure and a more prolonged release profile of MOX that makes them promising for bone regeneration applications.
- |||||||||| Zerbaxa (ceftolozane /tazobactam) / Merck (MSD), Cubicin (daptomycin) / Merck (MSD)
STABILITY OF NARROW-SPECTRUM ANTIBIOTICS IN PERITONEAL DIALYSIS SOLUTIONS () - Mar 28, 2023 - Abstract #ISNWCN2023ISN_WCN_1402;
Conclusions Given that the physicochemical behaviour of drugs varies across different PD solutions, stability data cannot be extrapolated from one PD solution to another. With the increasing evidence pointing towards using neutral-pH and low-glucose degradation products (GDP) PD solutions, more stability data on these solutions are warranted to ensure safe and effective treatment outcomes in patients with PD-associated peritonitis.
- |||||||||| Disseminated Nocardial Infection With Bacteremia and Brain Involvement in Lung Transplant Recipient (Walter E. Washington Convention Center, Area A, Hall C (Lower Level)) - Mar 25, 2023 - Abstract #ATS2023ATS_7078;
Our case highlights rare presentation of concomitant nocardial pneumonia complicated by bacteremia and CNS infection, with adequate response to antibiotic treatment noted in brain MRI before and after treatment. Clinicians should maintain high index of suspicion for nocardial infections in immunocompromised patients.
- |||||||||| Fasenra (benralizumab) / AstraZeneca
Blastomycosis and Multiple Concurrent Pulmonary Infections in a Benralizumab-Treated Asthmatic (Walter E. Washington Convention Center, Area A, Hall C (Lower Level)) - Mar 25, 2023 - Abstract #ATS2023ATS_7031;
Prior to consultation, three prednisone courses had failed to improve his symptoms.The medical review was significant for involuntary weight loss and exposition to residential excavation work in his neighborhood the previous spring, a Blastomycoses dermatitidis endemic region...Repeat CXR 4 weeks later (FigB) showed frank progression of diffuse alveolo-nodular opacities despite doxycycline and moxifloxacin...The consultant infectiologist confirmed the presence of Blastomyces and itraconazole was initiated...Discussion We report a first case of blastomycosis concurrently with positive cultures for nontuberculous mycobacteria and other pathogens in a benralizumab-treated asthmatic. Considering that NK cells play an important role in the host response against invasive fungal and mycobacterial infections, our case report supports the previously suggested hypothesis that eosinophilic depletion with benralizumab may be associated with dysfunctional NK cell immunity.
- |||||||||| Mycobutin (rifabutin) / Pfizer, Lupin
Mycobacterium Nebraskense as a Rare Cause of Non-tuberculous Mycobacterial Disease (Walter E. Washington Convention Center, Area I, Hall C (Lower Level)) - Mar 25, 2023 - Abstract #ATS2023ATS_5488;
The organism was sensitive to amikacin, clarithromycin, linezolid, rifabutin, and trimethoprim/sulfamethoxazole...Our patient developed patchy consolidations in conjunction with bronchiectasis and micronodular infiltrates, thus demonstrating the wide array of radiographic findings seen in infected patients. This case adds further insight into the importance of recognizing M. nebraskense as a potentially significant cause of clinically apparent pulmonary disease.
- |||||||||| rifampicin/isoniazid/ethambutol/pyrazinamide / Generic mfg., moxifloxacin intravenous / Generic mfg.
Incidental Discovery of Endobronchial Tuberculosis in an Elderly Man (Walter E. Washington Convention Center, Area I, Hall C (Lower Level)) - Mar 25, 2023 - Abstract #ATS2023ATS_5393;
This case illustrates that, despite previous reports identifying features often shared among patients diagnosed with EBTB, absence of such features does not exclude EBTB. Reliance on recognition of these commonly-reported features, therefore, may lead to missed diagnoses of EBTB and thus to unmitigated spread of disease by individuals whose tuberculosis infections remain unidentified and untreated.
- |||||||||| Rituxan (rituximab) / Biogen, Zenyaku Kogyo, Roche, Cimzia (certolizumab pegol) / Astellas, UCB
The Many Faces of Tuberculosis: A Case of Pulmonary Tuberculosis Mimicking Granulomatosis With Polyangiitis (Walter E. Washington Convention Center, Area I, Hall C (Lower Level)) - Mar 25, 2023 - Abstract #ATS2023ATS_5377;
One year after initial presentation, she continued to have scleritis and was started on certolizumab, an anti-TNF therapy...Rituximab and prednisone were discontinued, and she was initiated on treatment for active TB with Rifampin, Isoniazid, Pyrazinamide, Ethambutol as well as moxifloxacin given previous treatment with Rifampin for LTBI...This case highlights caution interpreting antibody testing that can have false positives with infection. To our knowledge, this is the first case of pulmonary tuberculosis mimicking GPA.
- |||||||||| A Rare Case of Pulmonary Valve Infective Endocarditis (Walter E. Washington Convention Center, Room 209 A-C (Level 2)) - Mar 25, 2023 - Abstract #ATS2023ATS_3550;
Antibiotics, including cefoperazone sulbactam, moxifloxacin, azithromycin, and meropenem, all failed to lower the temperature and inflammatory biomarkers...She received two weeks of vancomycin and six weeks of penicillin... Pulmonary valve infective endocarditis is rare but should be suspected in patients with congenital heart disease and an unknown origin of infection.
- |||||||||| Lumigan (bimatoprost) / Senju, AbbVie
Review, Journal: Intracameral Drug Delivery: A Review of Agents, Indications, and Outcomes. (Pubmed Central) - Mar 24, 2023
The complications such as hemorrhagic occlusive retinal vasculitis and toxic anterior segment syndrome have been documented with IC prophylaxis but are rare. In this review, we provide an overview of available IC drugs, their pharmacokinetics, the spectrum of activity, dosage and preparation, prophylactic and therapeutic usage, clinical efficacy, and safety profiles.
- |||||||||| Journal: Is EMA warning on quinolones and fluoroquinolones really assessed? An EudraVigilance database analysis. (Pubmed Central) - Mar 21, 2023
In this review, we provide an overview of available IC drugs, their pharmacokinetics, the spectrum of activity, dosage and preparation, prophylactic and therapeutic usage, clinical efficacy, and safety profiles. Our analysis clearly showed no significant differences before and after EMA warning, opening new insights in the role of the EMA warning in clinical practice.
- |||||||||| Verquvo (vericiguat) / Bayer, Merck (MSD), moxifloxacin intravenous / Generic mfg.
Clinical, Journal: Vericiguat: A Randomized, Phase Ib, Placebo-Controlled, Double-Blind, QTc Interval Study in Patients with Chronic Coronary Syndromes. (Pubmed Central) - Mar 14, 2023
P1
Overall, this study has demonstrated that smaller safety pharmacology in vivo QTc assessments using all the available data in larger data aggregates can achieve sensitivity comparable to a human TQT study. As part of an integrative risk assessment, this study demonstrated no clinically relevant corrected QT prolongation with vericiguat 10 mg once daily at steady state.
- |||||||||| Timcynis (ticarcillin and clavulanic acid) / Emcure
Neonatal anaerobe-targeted antibiotic therapy: Indications and utilization () - Mar 14, 2023 - Abstract #PAS2023PAS_1908;
Piperacillin-tazobactam was most commonly administered (5,037; 0.3%). Neonates administered an ATA course were more often very low birth weight (VLBW), had longer lengths of stay, and higher mortality compared to infants administered non-ATA course or no antibiotics ( Table 1 ).
- |||||||||| moxifloxacin intravenous / Generic mfg.
Journal: Synthesis and characterization of citric acid crosslinked carboxymethyl tamarind gum-polyvinyl alcohol hydrogel films. (Pubmed Central) - Mar 11, 2023
The films were evaluated for total carboxyl content (TCC), tensile strength, protein adsorption, permeability properties, hemocompatibility, swellability, moxifloxacin (MFX) loading and release, in-vivo wound healing activity and characterized using instrumental techniques...In-vivo study revealed good wound healing activity for hydrogel films. From the overall study, it can be concluded that the citric acid crosslinked CMTG-PVA hydrogel films can be effectively used for wound treatment.
- |||||||||| vancomycin / Generic mfg., ceftazidime / Generic mfg., moxifloxacin intravenous / Generic mfg.
Review, Journal: Cutibacterium (Formerly Propionibacterium) acnes Keratitis: A Review. (Pubmed Central) - Mar 9, 2023
Severe infections causing VA of 20/200 or worse are common and often do not significantly improve even after treatment. Vancomycin is considered the most potent antibiotic against CAK, although other antibiotics such as moxifloxacin and ceftazidime are more commonly used as first-line treatment.
- |||||||||| Sivextro (tedizolid) / Merck (MSD), Nabriva Therap, Zavicefta (ceftazidime/avibactam) / Pfizer, AbbVie
Ceftazidime/avibactam and tedizolid as adjuvant salvage therapy after bilateral partial lung resection for refractory macrolide- and amikacin-resistant lung disease caused by Mycobacterium intracellulare: a case report (Poster area foyer hall) - Mar 7, 2023 - Abstract #DGP2023DGP_63;
In the following years, recurring, pronounced and typical side effects such as hepatopathy, cutaneous lupus erythematosus, hearing loss and renal insufficiency, critically prolonged QTc interval >500 ms and sensorimotor polyneuropathy led to multiple regimen changes of rifampicin, ethambutol, inhaled (liposomal) and parenteral amikacin, clofazimine , moxifloxacin and linezolid...In other regular sputum checks, no NTM has been detected since March 2020 (as of 09/2022). Refractory nontuberculous mycobacterial lung disease (NTM-PD) represents a therapeutic challenge.
- |||||||||| moxifloxacin intravenous / Generic mfg.
Journal: Post-Keratoplasty Infectious Keratitis Caused by Elizabethkingia meningoseptica. (Pubmed Central) - Mar 7, 2023
He showed significant improvement after treatment with topical moxifloxacin and topical steroids...A high index of suspicion, along with timely diagnosis and management, may improve the outcome and clinical response and reduce the morbidity associated with these infections. Prevention of infectious keratitis is essential and may be achieved by optimizing the ocular surface and treating the risk factors for infection.
- |||||||||| levofloxacin / Generic mfg., Gatiflox (gatifloxacin) / Orient Europharma, moxifloxacin intravenous / Generic mfg.
Journal: Clinical Ocular Exposure Extrapolation for Ophthalmic Solutions Using PBPK Modeling and Simulation. (Pubmed Central) - Feb 27, 2023
Restriction of antacid usage and of high-risk antibiotics in the community may help reduce the incidence of CO-CDI. Even though additional case studies for different types of active pharmaceutical ingredients (APIs) and formulations will be needed, the current study represents an important step in the validation of the extrapolation method to predict human ocular exposure for ophthalmic drug products using PBPK models.
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