- |||||||||| moxifloxacin intravenous / Generic mfg.
Review, Journal: Fluoroquinolone heteroresistance, antimicrobial tolerance, and lethality enhancement. (Pubmed Central) - Oct 18, 2022
That enhances moxifloxacin lethality with M. tuberculosis in culture, during infection of cultured macrophages, and with infection of mice. Addition of ROS stimulators to fluoroquinolone treatment of tuberculosis constitutes a new direction for suppressing the transition of MDR-TB to XDR-TB.
- |||||||||| moxifloxacin intravenous / Generic mfg.
Lung abscess with bacterial superinfection in cocaine abuser, a case report. () - Oct 17, 2022 - Abstract #EUSEM2022EUSEM_3657;
The clinical presentation and outcome of investigations suggest the diagnosis of cocaine-induced lung abscess complicated by bacterial overinfection...In some cases it may be necessary to exclude rarer causes such as hiatid cysts, necrotising pneumonia and nocardiosis. Empirical antibiotic therapy must necessarily be broad-spectrum, with a combination of antimycotic agents in immunocompromised patients.
- |||||||||| moxifloxacin intravenous / Generic mfg.
Lung abscess with bacterial superinfection in cocaine abuser, a case report. () - Oct 17, 2022 - Abstract #EUSEM2022EUSEM_3656;
The clinical presentation and outcome of investigations suggest the diagnosis of cocaine-induced lung abscess complicated by bacterial overinfection...In some cases it may be necessary to exclude rarer causes such as hiatid cysts, necrotising pneumonia and nocardiosis. Empirical antibiotic therapy must necessarily be broad-spectrum, with a combination of antimycotic agents in immunocompromised patients.
- |||||||||| moxifloxacin intravenous / Generic mfg.
Lung abscess with bacterial superinfection in cocaine abuser, a case report. () - Oct 17, 2022 - Abstract #EUSEM2022EUSEM_3655;
The clinical presentation and outcome of investigations suggest the diagnosis of cocaine-induced lung abscess complicated by bacterial overinfection...In some cases it may be necessary to exclude rarer causes such as hiatid cysts, necrotising pneumonia and nocardiosis. Empirical antibiotic therapy must necessarily be broad-spectrum, with a combination of antimycotic agents in immunocompromised patients.
- |||||||||| moxifloxacin intravenous / Generic mfg.
Lung abscess with bacterial superinfection in cocaine abuser, a case report. () - Oct 17, 2022 - Abstract #EUSEM2022EUSEM_3654;
The clinical presentation and outcome of investigations suggest the diagnosis of cocaine-induced lung abscess complicated by bacterial overinfection...In some cases it may be necessary to exclude rarer causes such as hiatid cysts, necrotising pneumonia and nocardiosis. Empirical antibiotic therapy must necessarily be broad-spectrum, with a combination of antimycotic agents in immunocompromised patients.
- |||||||||| moxifloxacin intravenous / Generic mfg.
Journal: Biochar composite derived from cellulase hydrolysis apple branch for quinolone antibiotics enhanced removal: Precursor pyrolysis performance, functional group introduction and adsorption mechanisms. (Pubmed Central) - Oct 14, 2022
In this study, magnetic biochar (MAB) and humic acid (HA)-coated magnetic biochar produced from apple branches without and after cellulase hydrolysis (HMAB and CHMAB, respectively) were prepared and tested as adsorbents of enrofloxacin (ENR) and moxifloxacin (MFX) in aqueous solution...Synergism between the pore-filling effect, π-π electron-donor-acceptor interactions, regular and negative charge-assisted H-bonding, surface complexation, electrostatic interactions and hydrophobic interactions may dominate the adsorption process. This study demonstrated that a novel magnetic biochar composite prepared through pyrolysis of agricultural waste lignocellulose hydrolyzed by cellulase in combination with HA coating was a promising adsorbent for eliminating quinolone antibiotics from aqueous media.
- |||||||||| levofloxacin / Generic mfg., moxifloxacin intravenous / Generic mfg.
Retrospective data, Review, Journal: The treatment effect of Levofloxacin, Moxifloxacin, and Gatifloxacin contained in the conventional therapy regimen for pulmonary tuberculosis: Systematic review and network meta-analysis. (Pubmed Central) - Oct 12, 2022
Levofloxacin, Moxifloxacin, and Gatifloxacin have different superiority, comparing to CT regimen in spectrum culture negative, treatment success rate, and adverse events. Hence, combined utilization of these quinolone is important on the clinical treatment for tuberculosis.
- |||||||||| Lamprene (clofazimine) / Novartis, Sirturo (bedaquiline) / J&J, Pharmstandard, Orapenem (tebipenem pivoxil) / Meiji Seika, GSK
Antimicrobial activity of nitric oxide against cystic fibrosis pathogens (Exhibition Hall) - Oct 8, 2022 - Abstract #NACFC2022NACFC_1068;
cepaciainfection and when combined with specific antibiotics. Furtherstudies are ongoing to better characterize these effects.
- |||||||||| FML, FML Forte (fluorometholone ophthalmic suspension) / AbbVie
Journal: Venom ophthalmia (keratoconjunctivitis) caused by nuchal gland secretion of Rhabdophis tigrinus: case report. (Pubmed Central) - Oct 8, 2022
While corneal edema may resolve spontaneously in a few days when inhibition of the toxin has ceased, the use of topical steroids is recommended, as it can increase the activity of Na/K pumps that remained functional, thereby accelerating recovery. In fact, our patient used a topical steroid and recovered without sequelae.
- |||||||||| hydroxychloroquine / Generic mfg., favipiravir / Generic mfg., moxifloxacin intravenous / Generic mfg.
Journal: The association between QT interval changes and the treatment protocols of COVID-19 patients. (Pubmed Central) - Oct 7, 2022
In fact, our patient used a topical steroid and recovered without sequelae. We thought that, if there is a COVID-19 infection with an additional bacterial infection, and if there is a need of using moxifloxacin alone or together with HCQ, additional risk factors that may cause QT interval prolongation should be reviewed and ECG monitoring of the patients should be performed during the treatment period.
- |||||||||| moxifloxacin intravenous / Generic mfg.
Journal, Combination therapy: Effect of hyperglycaemia in combination with moxifloxacin on cardiac repolarization in male and female patients with type I diabetes. (Pubmed Central) - Oct 5, 2022
P1
Hyperglycaemia was found to be a significant cause of QTc prolongation and the additional effect of a QTc-prolonging positive control (moxifloxacin) was found to be additive. Given the high risk of sudden cardiac death in type 1 diabetes mellitus, extra caution should be exercised when prescribing any medication in this cohort for QTc effects, and further research needs to be undertaken to elucidate the exact mechanism underlying this finding and explore the potential prescribing risk in diabetes.
- |||||||||| moxifloxacin intravenous / Generic mfg.
Preclinical, Journal: Moxifloxacin induces aortic aneurysm and dissection by increasing osteopontin in mice. (Pubmed Central) - Oct 5, 2022
Furthermore, moxifloxacin (100 mg kg day) increased the protein expression of osteopontin and matrix metalloproteinases-2 in the aortic tissues when compared to control. Moxifloxacin may induce the onset of AAD and weakening of the aortic media by increasing the expression of osteopontin and matrix metalloproteinase-2 and decreasing that of smooth muscle protein 22α in aortic tissue.
- |||||||||| Carogra (carotegrast methyl) / Kissei, Eisai
Journal: Appraisal of ICH E14/S7B Q&As adopted in February 2022 using thorough QT/QTc study data for α4-integrin antagonist carotegrast methyl in Japanese healthy subjects. (Pubmed Central) - Oct 4, 2022
In concentration-response analysis, moxifloxacin attained the estimated mean values for ΔQTcF and ΔΔQTcF of 11.4 ms (8.5, 14.4) and 16.7 ms (14.0, 19.4) at the mean C, whereas carotegrast methyl provided those of -4.6 ms (-7.3, -1.9) and 0.7 ms (-1.4, 2.8), respectively. Thus, lack of placebo control did not influence the interpretation of TQT study with either of the analysis in line with updated E14/S7B Q&As.
- |||||||||| GSK3640254 / GSK, ViiV Healthcare
Effects of the HIV-1 maturation inhibitor GSK3640254 on QT interval in healthy participants () - Oct 4, 2022 - Abstract #HIVGlasgow2022HIV_Glasgow_335;
No clinically relevant effects on QTc prolongation, heart rate, or cardiac conduction were seen in healthy participants at concentrations associated with projected therapeutic GSK’254 doses being evaluated in phase IIb studies. These results support continued clinical development of GSK’254.
- |||||||||| levofloxacin / Generic mfg.
Levofloxacin-resistant Helicobacter pylori in Australia: A growing issue for refractory infection () - Oct 4, 2022 - Abstract #AGW2022AGW_557;
The high rate of levofloxacin resistance (>20%) raises substantial concern about recommending the use of levofloxacin in empirical second-line regimens. Increased awareness of current H. pylori resistance rates in Australia is needed to guide local eradication practices, and current antimicrobial prescribing guidelines for both primary and secondary therapy need to be revisited.
- |||||||||| moxifloxacin intravenous / Generic mfg.
Journal: Dose- and time-dependent manners of moxifloxacin induced liver injury by targeted metabolomics study. (Pubmed Central) - Oct 4, 2022
Targeted metabolomics study demonstrated that serum concentrations of fatty acyl carnitines, fatty acids and dehydroepiandrosterone can change dynamically with the severity of moxifloxacin related liver injury. The elevated serum levels of fatty acyl carnitine, fatty acid and dehydroepiandrosterone were promising in predicting the hepatotoxicity induced by moxifloxacin.
- |||||||||| cefixime / Generic mfg., vancomycin / Generic mfg., moxifloxacin intravenous / Generic mfg.
Clinical, Journal: A tale of orbital cellulitis and retinopathy of prematurity in an infant: First case report. (Pubmed Central) - Oct 4, 2022
There is a high probability of missing the posterior segment pathology in such cases. Meticulous history taking, detailed ocular examination along with Bruckner's reflex help in immediately clinching the correct diagnosis in such cases and safeguards the clinician from any medicolegal issues in the future.
- |||||||||| Retrospective data, Review, Journal: Systematic Review and Meta-Analysis on the Frequency of Antibiotic-Resistant Clostridium Species in Saudi Arabia. (Pubmed Central) - Sep 25, 2022
We found that the rates of resistance of Clostridium difficile to antibiotics were as follows: 42% for ciprofloxacin, 83% for gentamicin, 28% for clindamycin, 25% for penicillin, 100% for levofloxacin, 24% for tetracycline, 77% for nalidixic acid, 50% for erythromycin, 72% for ampicillin, and 28% for moxifloxacin; whereas those of C. perfringens were: 21% for metronidazole, 83% for ceftiofur, 39% for clindamycin, 59% for penicillin, 62% for erythromycin, 47% for oxytetracycline, and 47% for lincomycin. The current findings suggest that ceftiofur, erythromycin, lincomycin, and oxytetracycline should not be used in C. perfringens infection treatments in humans or animals in Saudi Arabia.
- |||||||||| Journal: High Rates of Antimicrobial Resistance in Rapidly Growing Mycobacterial Infections in Taiwan. (Pubmed Central) - Sep 24, 2022
The quinolones (ciprofloxacin and moxifloxacin) showed better in vitro activity against M. fortuitum isolates (50% susceptibility) than the M. abscessus isolates (31.8% susceptibility)...The MICs of E-test were higher than broth microdilution and may result in reports of false resistance. In conclusion, the implementation of the modified broth microdilution plates into the routine clinical laboratory workflow to provide antimicrobial susceptibility early, allows for the timely selection of appropriate treatment of RGM infections to improve outcome.
- |||||||||| dofetilide / Generic mfg., moxifloxacin intravenous / Generic mfg.
Journal: QT ratio: A simple solution to individual QT correction. (Pubmed Central) - Sep 24, 2022
It produced similar or lower MDDs compared to individual and Bazett's correction, respectively, with more consistent reduction in standard error. This simple and effective method has the potential for easy translatability across species.
- |||||||||| Sirturo (bedaquiline) / J&J, Pharmstandard
Journal: Development and Validation of a Nomogram for Prediction of QT Interval Prolongation in Patients Administered Bedaquiline-Containing Regimens in China: a Modeling Study. (Pubmed Central) - Sep 24, 2022
Nomogram analysis revealed concordance index values of 0.723 (95% confidence interval [CI], 0.695 to 0.750) for the training cohort and 0.710 (95% CI, 0.627 to 0.821) for the external validation cohort, thus indicating relatively fair agreement between predicted and observed probabilities of QTc prolongation occurrence based on data obtained during 8-week, 16-week, and 24-week anti-TB treatment of both cohorts. Taken together, results obtained using these models demonstrated that coadministration of clofazimine and abnormal baseline QTc interval significantly contributed to QTc prolongation development during MDR-TB patient treatment with a BDQ-containing anti-TB treatment regimen.
- |||||||||| moxifloxacin intravenous / Generic mfg.
Journal: AIE-Active Antibiotic Photosensitizer with Enhanced Fluorescence in Bacteria Infected Cells and Better Therapy Effect toward Drug-Resistant Bacteria. (Pubmed Central) - Sep 20, 2022
In this work, we covalently attached an AIE photosensitizer to the antibiotic of moxifloxacin hydrochloride (MXF-HCl) and synthesized an antibiotic derivative, MXF-R, with pharmacological activity and photodynamic activation...Thus, as a promising multifunctional antibacterial agent, MXF-R will have tremendous potential in in situ visualization study and killing of drug-resistant bacteria. This work provides an innovative strategy for solving critical disease through the combination of materials and biomedical sciences.
- |||||||||| pretomanid (PA-824) / Global Alliance for TB Drug Development
Review, Journal: Pretomanid for tuberculosis treatment: An update for clinical purposes. (Pubmed Central) - Sep 20, 2022
Although further studies on the subject are needed, PA may also represent a treatment option for drug-susceptible TB (DS-TB), latent TB infection (LTBI) and non tuberculous mycobacteria (NTM). This narrative review aims to examine current implementation options and future possibilities for PA in the never-ending fight against TB.
- |||||||||| doxycycline / Generic mfg., azithromycin / Generic mfg., moxifloxacin intravenous / Generic mfg.
Journal, Combination therapy: Combination therapy for Mycoplasma genitalium, and new insights into the utility of parC mutant detection to improve cure. (Pubmed Central) - Sep 20, 2022
However, in the context of a high prevalence of the parC S83I mutation (23%) in macrolide-resistant infections, doxycycline + moxifloxacin cured only 85%. Infections that were wild-type for S83/D87 experienced high cure following doxycycline + moxifloxacin, supporting the use of a parC-resistance/susceptibility testing strategy in clinical care.
- |||||||||| Mycobutin (rifabutin) / Pfizer, Lupin
Open-Heart Surgeries Leading to Unexpected Latent Disease - A Rare Case of Disseminated Mycobacterium Chimaera (Zone 4, Science and Technology Hall, Level 3; Poster Board no. 4206) - Sep 18, 2022 - Abstract #AHA2022AHA_7285;
He has since developed additional spinal involvement described as destructive osteomyelitis/discitis and confirmed via biopsy. As he continues to combat this clinically devastating bacterial pathogen, his multi-system complications with such an insidious presentation serve as a reminder to maintain a high clinical suspicion for the possibility of disseminated mycobacterial and other similar infectious processes in the differential diagnoses of all cardiothoracic surgical patients.
- |||||||||| rifampicin / Generic mfg., moxifloxacin intravenous / Generic mfg.
Journal: Predicting antibiotic resistance in complex protein targets using alchemical free energy methods. (Pubmed Central) - Sep 14, 2022
We find that moderate numbers (n = 3-15) of short RBFE calculations can predict resistance in cases where the mutation results in a large change in the binding free energy. We show that the method lacks discrimination in cases with either a small change in energy or that involve charged amino acids, and we investigate how these calculation errors may be decreased.
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