| JYNNEOS (live modified vaccinia virus ankara) / Bavarian Nordic |
NCT05734508: Assessment of Safety Profile of MVA-BN Vaccine in the PALM-007 Study in DRC |
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| Completed | 4 | 500 | RoW | MVA-BN vaccine, JYNNEOS | National Institute of Allergy and Infectious Diseases (NIAID), Institut National de Recherche Biomédicale. Kinshasa, République Démocratique du Congo | Monkeypox | 06/24 | 06/24 | | |
| Recruiting | 4 | 1560 | RoW | Bavarian Nordic smallpox vaccine, Imvamune, Typhoid VI Polysaccharide Vaccine Injectable Solution | McMaster University | Monkeypox | 06/25 | 12/25 | | |
NCT02977715: JYNNEOS Smallpox Vaccine in Adult Healthcare Personnel at Risk for Mpox in the Democratic Republic of the Congo |
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| Active, not recruiting | 3 | 1600 | RoW | JYNNEOS (Liquid Formulation), Modified Vaccinia Ankara (MVA), MVA-BN, IMVAMUNE, IMVANEX, JYNNEOS (Lyophilized Formulation) | Centers for Disease Control and Prevention, Ministry of Public Health, Democratic Republic of the Congo, Kinshasa School of Public Health, Bavarian Nordic | Monkeypox Virus Infection | 12/25 | 12/25 | | |
2012-005137-37: Vaccination trial in children using a new smallpox vaccine Impfstudie in Kindern mit einem neu entwickelten Pockenimpfstoff |
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| Ongoing | 2 | 342 | Europe | IMVANEX, MVA-BN, | Bavarian Nordic A/S, Bavarian Nordic A/S | Prevention of smallpox infection in children Pocken | | | | |
NCT04957485: Study to Assess the Safety and Immunogenicity of TPOXX® When Administered Orally for 28 Days With JYNNEOS |
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| Active, not recruiting | 2 | 100 | US | Tecovirimat, TPOXX, Smallpox and Mpox Vaccine, JYNNEOS, Placebo | SIGA Technologies, United States Department of Defense | Smallpox | 05/25 | 07/25 | | |
NCT05512949: Trial to Evaluate the Immunogenicity of Dose Reduction Strategies of the MVA-BN Monkeypox Vaccine |
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| Completed | 2 | 229 | US | JYNNEOS | National Institute of Allergy and Infectious Diseases (NIAID) | Monkeypox | 12/22 | 10/23 | | |
NCT05740982: A Phase 2 Randomized Multisite Trial to Inform Public Health Strategies Involving the Use of MVA-BN Vaccine for Mpox |
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| Active, not recruiting | 2 | 450 | US | JYNNEOS | National Institute of Allergy and Infectious Diseases (NIAID) | Monkeypox | 08/24 | 06/25 | | |
POX-MVA-045, NCT06549530: Open-label, Multicenter Immunogenicity and Safety Study of MVA-BN Vaccine in Children From 2 Years to Less Than 12 Years of Age Compared to Adults for the Prevention of Smallpox, Mpox, and Related Orthopoxvirus Infections |
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| Recruiting | 2 | 460 | RoW | MVA-BN | Bavarian Nordic, Coalition for Epidemic Preparedness Innovations | Monkeypox (Mpox) | 06/25 | 05/26 | | |
| Terminated | 1/2 | 1 | Canada | Imvamune, MVA-BN Smallpox vaccine, Modified Vaccinia Ankara Smallpox Vaccine | Ivan Litvinov | Non-melanoma Skin Cancer, Basal Cell Carcinoma, Squamous Cell Carcinoma | 05/23 | 05/23 | | |
NCT06366672: Evaluating the Human Immune Response to the JYNNEOS Vaccine |
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| Recruiting | 1 | 20 | US | JYNNEOS (Smallpox and Monkeypox Vaccine, Live, Nonreplicating) suspension for subcutaneous injection, Phlebotomy, Research bronchoscopy, Skin punch biopsy, Bone marrow aspiration | Washington University School of Medicine | Vaccinia, Virus Diseases | 12/25 | 12/25 | | |
| Active, not recruiting | N/A | 164 | Europe | Vaccination with MVA vaccine ( IMVANEX® and JYNNEOS®) | Assistance Publique - Hôpitaux de Paris, DGOS | Monkey Pox, Monkey Diseases | 10/24 | 10/24 | | |
| Not yet recruiting | N/A | 2350 | NA | JYNNEOS | Womack Army Medical Center, United States Naval Medical Center, San Diego, C.R.Darnall Army Medical Center | Myopericarditis, Small Pox | 03/29 | 10/33 | | |
