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[VIRTUAL] LUNG CYST - DILEMMA IN MANAGEMENT () - Jun 2, 2021 - Abstract #ESPID2021ESPID_1514; ECMO flows gradually weaned and child was extubated , was uneventful,.Albendazole was started . Developed right lower limb edema .Doppler was suggestive of thrombosis of common femoral and superficial femoral vein thrombosis and low molecular weight heparin was restarted for the same.The child improved well Learning Points/ Cyst in lungs are diagnostic dilemma Management is associated with complications Proper and timely management saves life
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[VIRTUAL] AN EMERGING CASE OF PULMONARY PARASITIC DISEASE IN A 13-YEAR-OLD GIRL WITH EMPYEMA. () - Jun 2, 2021 - Abstract #ESPID2021ESPID_1353; The patient was treated with intravenous Cefotaxime...The patient received a 12 day regimen with albendazole and then surgery was performed with no spillage...In Greece, hydatidosis control programs aren’t yet systematically applied, even though the incidence of the disease remains high. In complicated pulmonary infections, if the evolution isn’t typical, clinicians should proceed to further investigations taking in consideration the local epidemiology.
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[VIRTUAL] ABDOMINAL ANGIOSTRONGYLIASIS: A RARE (AND SEVERE) PRESENTATION OF ACUTE ABDOMEN IN YOUNG INFANTS () - Jun 2, 2021 - Abstract #ESPID2021ESPID_1308; The patient was treated with albendazole for 14 days and discharged from the hospital after 64 days for follow-up at the outpatient clinic...The combination of abdominal pain, hypereosinophilia, and clinical signs resembling intestinal perforation suggest abdominal angiostrongyliasis. Microscopically, the definition of intestinal infection relies on thrombotic phenomena, massive eosinophilic infiltration of the intestinal wall.
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Review, Journal: Neurocysticercosis: Current Perspectives on Diagnosis and Management. (Pubmed Central) - May 28, 2021 With no vaccine available for humans, prevention of infection depends on communication to the public of the life cycle of a complex zoonosis to promote behavior change, underpinned by practical control measures including treatment of human taeniasis and (neuro)cysticercosis with albendazole and praziquantel [widely used as part of the mass drug administration (MDA) deworming programs], surgery where appropriate, and effective vaccination and deworming for pigs supported by meat inspection. Here, we review recent advances in tools and implementation for Taenia solium taeniasis/(neuro)cysticercosis (TSTC) control and milestones on the onward path to elimination.
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Clinical, Journal: Primary splenic hydatidosis: a case report. (Pubmed Central) - May 15, 2021 The patient was admitted to the hospital for gastrointestinal bleeding 3 months postoperatively, and she was successfully treated and discharged. No recurrence of hydatid foci has been observed since the follow-up.
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Preclinical, Journal: Current status of ex-vivo liver resection and autologous liver transplantation for end-stage hepatic alveolar echinococcosis. (Pubmed Central) - May 15, 2021 Radical resection combined with oral albendazole administration are the major methods for HAE treatment, whereas most patients delayed diagnosis and treatment because which was considered as benign disease...For summarizing the knowledge and experience details, we reviewed present opinions about ERAT for end-stage HAE patients, and presented the future perspectives about this topic in this manuscript. We aimed at discussing the feasibility, indications, preparation, technical details, and postoperative outcomes of ERAT for HAE patients.
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Clinical, Journal: Rare case of rapidly reaccumulating ascites. (Pubmed Central) - May 15, 2021 Parasitic workup resulted positively for Toxocara antibodies on ELISA. On 2-week outpatient follow-up, a course of albendazole resolved all gastrointestinal symptoms.
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Clinical, Review, Journal: Primary pancreatic hydatid cyst: a case report and literature review. (Pubmed Central) - May 15, 2021 Radical resection combined with oral albendazole administration is the standard treatment for pancreatic hydatid cysts. Avoiding perioperative cystic rupture and abdominal echinococcosis implantation metastasis is crucial for the success of the operation.
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Clinical, Journal: Clinical Profile, Risk Factors and Outcomes of Children With Cutaneous Larva Migrans Infection: A Hospital-Based Study. (Pubmed Central) - May 15, 2021 Fifty percent of patients needed treatment with Albendazole and antihistamine for more than three weeks to achieve complete cure...The common risk factors were the presence of dewormed pets at home and contamination with infected soil. The majority of children had a single lesion on presentation. Fifty percent of children needed more than three weeks of treatment to achieve a good response.
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Clinical, Journal: Setting the stage for a Global Programme to Eliminate Lymphatic Filariasis: the first 125 years (1875-2000). (Pubmed Central) - May 14, 2021 Recognition of this potential by the global health community (including the World Health Assembly) led two pharmaceutical companies (GlaxoSmithKline and Merck) to make enormous, unprecedented donations of albendazole and ivermectin to achieve this goal. Additional resource support from the public and private sectors and from health ministries in the 80 LF-endemic countries led to the creation of a Global Alliance to Eliminate LF, which launched the GPELF in 2000, just 125 y after the LF life cycle was first described.
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Journal: Trichinella induced polymyositis with unilateral lameness in a dog (Pubmed Central) - May 13, 2021 Furthermore different developmental stages of fungi were detected which were identified as Mucor sp. Treatment with albendazole and itraconazole significantly improved the patient's clinical signs.
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Trial completion: Urine Albendazole Levels for Coverage Assessment (clinicaltrials.gov) - May 10, 2021 P=N/A, N=12, Completed, Treatment with albendazole and itraconazole significantly improved the patient's clinical signs. Recruiting --> Completed
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Journal: Current epidemic situation of human toxocariasis in China. (Pubmed Central) - May 5, 2021 Albendazole is the preferred treatment for patients with VLM; steroids, such as prednisolone combined with albendazole, are frequently used in treating patients with OLM, and surgery serves as an alternative treatment; thiabendazole is effective in treating patients with NLM. The true number of cases and prevalence of toxocariasis in China seems to be underestimated and neglected because of the lack of population-based epidemiological studies and insufficient clinical awareness of this disease, which are aspects that need to be improved by the Chinese government.
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[VIRTUAL] Case 2 - RARE CASE OF CYST IN THE LUNG -HOW DO I MANAGE? (Hall 05) - May 4, 2021 - Abstract #ESPID2021ESPID_706; Cystectomy was performed without any complication . Recovered well and on oral albendazole which is planned to continue for least 3 months Learning Points/ Hydatid cyst is a rare cause of cyst in the lung This child was managed with pharmacotherapy and surgical intervention
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[VIRTUAL] Case 1 - JAUNDICE AS PRESENTATION OF CYSTIC ECHINOCCOCOSIS (Hall 05) - May 4, 2021 - Abstract #ESPID2021ESPID_705; Treatment with albendazole 15mg/kg/day PO was initiated...Management of cystic echinococcosis requires a multidisciplinary team involving paediatric surgery, especially in cysts bigger than 5cm. Echinococcosis is part of the differential diagnosis in patients with chronic abdominal pain coming from endemic countries.
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Journal: Neurotoxocariasis. (Pubmed Central) - May 4, 2021 Treatment is based on anti-helminthic drugs, commonly albendazole, generally administered with concomitant corticosteroids coverage...Nonetheless the possible role of Toxocara spp. in the pathogenesis of these disorders is still matter of debate.
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Preclinical, Journal: In vivo effect of magnetic microspheres loaded with E2-a in the treatment of alveolar echinococcosis. (Pubmed Central) - May 4, 2021 Novel compounds or therapy strategies for the treatment of alveolar echinococcosis are urgently needed due to the limitation of the widely used albendazole...Most importantly, one-third concentrations of E2-a from PLGA-Fe-E2 based on the release profile of E2-a was equally effective in inhibiting metacestode growth as E2-a treated group, supporting efficacy and bioavailability of a drug. It will be an alternative treatment for alveolar echinococcosis using magnetic microspheres as drug carriers.
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Clinical, Journal: A liver cycst hydatid case with widespread embolies to vena cava inferior (Pubmed Central) - May 4, 2021 Albendazole treatment was commenced and the hydatid cyst in the liver was excised by surgery, and surgery was planned for the hydatid cyst lesion in the right atrium...In our patient, pulmonary artery pressures and right heart functions were normal in repeated echocardiography. With this case, we wanted to emphasize that the cardiovascular involvement of hydatid cyst may not always require surgery.
- |||||||||| mebendazole / Generic mfg., albendazole / Generic mfg.
Journal: Screening of Benzimidazole-Based Anthelmintics and Their Enantiomers as Repurposed Drug Candidates in Cancer Therapy. (Pubmed Central) - May 1, 2021 In silico evaluation of their physicochemical, pharmacokinetics and medicinal chemistry properties also provided useful information related to the chemical structures and potential of these compounds. Furthermore, in view of the potential repurposing of these drugs in cancer therapy and considering that pharmaceutically active compounds may have different mechanisms of action, we performed an in silico target prediction to assess the polypharmacology of these benzimidazoles, which highlighted previously unknown cancer-relevant molecular targets.
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Journal: Nanosuspension coated multiparticulates for controlled delivery of albendazole. (Pubmed Central) - Apr 28, 2021 However, semiannual treatment was superior to annual treatment for achieving sustained clearance of O. volvulus MF from the skin (p=0.024). ALB is broad-spectrum anthelminthic BCS class II drug with aqueous solubility of solubility of 4.1 mg/l at 25 °C and oral bioavailability of <5%.
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