- |||||||||| albendazole / Generic mfg.
Preclinical, Journal: Does the in vitro egg hatch test predict the failure of benzimidazole treatment in Haemonchus contortus? (Pubmed Central) - Aug 27, 2021
The results of the in vivo FECRT indicated that albendazole treatment reduced infections consisting of composite doses of 10, 20, 30, 40, 60, and 80% larvae of the resistant isolate by 91.3, 78.0, 63.3, 48.4, 36.5, and 41.4%, respectively...The EHT could thus accurately estimate the in vivo efficacy of the drug and percentage of the resistance allele in the population using hatching parameters in delineation doses. This finding was also supported by comparing the FECRT data to the hatching percentages in the EHT on 30 goat farms in Slovakia with natural mixed infections of gastrointestinal parasites.
- |||||||||| NN1213 / Novo Nordisk
Trial completion date, Trial primary completion date: BEED: The Bangladesh Environmental Enteric Dysfunction Study (clinicaltrials.gov) - Aug 25, 2021
P=N/A, N=1575, Recruiting,
The measurement in urine samples of the amino-ALB-sulphone (NHALBSO) derivative and ALBSO for up to 96 hours suggests that it may be feasible to develop a non-invasive tool to evaluate compliance/adherence to ALB treatment. Trial completion date: Jun 2021 --> Dec 2021 | Trial primary completion date: Jun 2021 --> Dec 2021
- |||||||||| albendazole / Generic mfg.
Preclinical, Journal: In vitro and in vivo Effects of Artesunate on Echinococcus granulosus Protoscoleces and Metacestodes. (Pubmed Central) - Aug 25, 2021
For the in vivo assay, CE-infected mice were divided into model group, albendazole (ABZ) group (200 mg/kg), low AS (AS-L) group (50 mg/kg), moderate AS (AS-M) group (100 mg/kg), and high AS (AS-H) group (200 mg/kg)...The content of HO in hydatid fluid treated by AS showed significant decrease compared with the model group (P < 0.01), while the T-SOD level showed significant elevation compared with model group (P < 0.01). In this study, we confirmed that the effects of AS on Echinococcus granulosus protoscoleces and metacestodes may be related to the DNA damages induced by oxidative stress, which provided solid information for the research and development of drugs for cystic echinococcosis.
- |||||||||| albendazole / Generic mfg.
Trial completion, Trial completion date, Trial primary completion date: EchinoVISTA: Alveolar Echinococcosis: Parasite Viability and Innovative Markers for the Follow-up of Patients Treated With Albendazole (clinicaltrials.gov) - Aug 23, 2021
P=N/A, N=50, Completed,
In this study, we confirmed that the effects of AS on Echinococcus granulosus protoscoleces and metacestodes may be related to the DNA damages induced by oxidative stress, which provided solid information for the research and development of drugs for cystic echinococcosis. Active, not recruiting --> Completed | Trial completion date: Jun 2023 --> Aug 2021 | Trial primary completion date: Jun 2020 --> Aug 2021
- |||||||||| albendazole / Generic mfg.
Journal: Quantitative benzimidazole resistance and fitness effects of parasitic nematode beta-tubulin alleles. (Pubmed Central) - Aug 22, 2021
These genome-edited strains were exposed to both albendazole and fenbendazole to quantitatively measure animal responses to BZs...We performed competitive fitness assays and demonstrated that the E198V allele reduces animal health, supporting the hypothesis that this allele might be less fit in field populations. Overall, we present a powerful platform to quantitatively assess anthelmintic resistance and effects of specific resistance alleles on organismal fitness in the presence or absence of the drug.
- |||||||||| albendazole / Generic mfg.
Journal: Role of anti-filarial drugs in inducing ER stress mediated signaling in bovine filarial parasitosis Setaria cervi. (Pubmed Central) - Aug 22, 2021
In this ex vivo study, S. cervi parasitoses were treated with Ivermectin (50 μM), Albendazole (200 μM) alone and Ivermectin + Albendazole (50 + 200 μM) at 37°C for 8 h and the motility and viability of the parasitoses were evaluated...Trafficking protein, acyl transferase, MATH involved in protein folding were also found to be downregulated. Thus, this study based on biochemical and proteomic approaches indicates that a combination of anti-filarial drugs Iver and Alb can alter calcium homeostasis in bovine filarial parasitosis leading to induction of ER stress culminating into apoptosis.
- |||||||||| moxidectin / Generic mfg., albendazole / Generic mfg.
Enrollment closed: Efficacy and Safety of MOX/ALB Co-administration (clinicaltrials.gov) - Aug 20, 2021
P3, N=282, Active, not recruiting,
To the knowledge of the authors, this is the first report of reduced albendazole efficacy in cattle in Sudan and is the first study describing an E198L substitution in phenotypically BZ-resistant nematodes collected from cattle. Recruiting --> Active, not recruiting
- |||||||||| albendazole / Generic mfg.
Clinical, Journal: Unusual case of disappearing hepatic hydatid cyst: COVID-19 times. (Pubmed Central) - Aug 15, 2021
However, a follow-up CECT showed complete resolution of the hepatic hydatid with calcification. In conclusion, medical treatment with a few cycles of albendazole and ERCP with stenting could be a good treatment option.
- |||||||||| mebendazole / Generic mfg., albendazole / Generic mfg.
[VIRTUAL] Screening for anthelmintic drugs: New molecules, new mechanisms? (Room: Zoom Room 01) - Aug 13, 2021 - Abstract #ACSFall2021ACS_Fall_1808;
Over the past few years we have initiated a collaborative drug discovery programme to develop new anthelmintic agents with activity against whipworm as a priority.2-5 An overview of our drug discovery pipeline will be provided, alongside the discovery and systematic investigation of the structure-activity relationship of a series of dihydrobenzoxazepinone (DHB) compounds that block motility of the murine intestinal nematode parasite, Trichuris muris ex vivo.2,5 Excitingly these compounds also show activity against other parasitic nematodes, including Brugia malayi and Heligmosomoides polygyrus and the trematode Schistosoma mansoni, a parasite that causes schistosomiasis, demonstrating their potential for optimisation as broad-spectrum anthelmintics.5 More recently we have discovered additional classes of small molecule which kill Trichuris muris in vitro and which significantly reduce the worm burden of infected mice in vivo following oral administration. Our lead compound retains similar levels of activity in a benzimidazole-resistant model parasite, showing that it acts through a distinct mechanism of action to front-line agents.
- |||||||||| moxidectin / Generic mfg., albendazole / Generic mfg., levamisole / Generic mfg.
PK/PD data, Journal: Pharmacokinetic comparison of six anthelmintics in sheep, goats, and cattle. (Pubmed Central) - Aug 13, 2021
The results from this study suggest drug approval across these three ruminants is not a viable concept. However, the resulting PK profiles for each combination of drug and ruminant species represents a new dataset that can be used to support the US FDA Center for Veterinary Medicine's Minor Use/Minor Species indexing process for drug approvals in minor species such as sheep and goats.
- |||||||||| mebendazole / Generic mfg.
Journal: HPMA-Based Polymer Conjugates for Repurposed Drug Mebendazole and Other Imidazole-Based Therapeutics. (Pubmed Central) - Aug 11, 2021
The overall synthetic strategy was designed to enable the modification and polymer conjugation of most benzimidazole-based anthelmintics, such as albendazole, fenbendazole or albendazole, besides the mebendazole. Furthermore, the described methodology may be suitable for conjugation of other biologically active compounds with a heterocyclic N-H group in their molecules.
- |||||||||| albendazole / Generic mfg.
Preclinical, Journal: Impact on Bile Acid Concentrations by Alveolar Echinococcosis and Treatment with Albendazole in Mice. (Pubmed Central) - Aug 7, 2021
ABZ itself had no effect on the bile acid profiles and the expression of relevant enzymes and transporters. Further research is needed to uncover the exact mechanism of the AE-induced changes in bile acid homeostasis and to test whether serum bile acids and ratios thereof can serve as biomarkers of AE and for monitoring therapeutic efficacy.
- |||||||||| albendazole / Generic mfg., praziquantel / Generic mfg.
Review, Journal: Anthelmintics for people with neurocysticercosis. (Pubmed Central) - Aug 5, 2021
We also found that albendazole probably increases radiological clearance and evolution of lesions. There were very few studies reporting praziquantel outcomes, and these findings apply to albendazole only.
- |||||||||| ivermectin oral / Generic mfg.
Review, Journal: Ivermectin treatment in humans for reducing malaria transmission. (Pubmed Central) - Aug 5, 2021
There were very few studies reporting praziquantel outcomes, and these findings apply to albendazole only. We are uncertain whether community administration of ivermectin has an effect on malaria transmission, based on one trial published to date.
- |||||||||| methotrexate / Generic mfg., cyclosporine / Generic mfg.
Review, Journal: Experimental research in topical psoriasis therapy (Review). (Pubmed Central) - Aug 3, 2021
Recent research in topical psoriasis underlines the importance of animal experimental research in dermatology, providing a starting point for developing new therapeutic approaches in one of the most frequently diagnosed chronic dermatologic diseases. Vesicular systems are now providing the best vehicle for topical therapy, thus easing the action of the active substances at their target sites.
- |||||||||| albendazole / Generic mfg.
Clinical, Journal: Primary Posterior Fossa Hydatid Cyst in a Child. (Pubmed Central) - Aug 1, 2021
The authors started the treatment with Albendazole and the patient was operated with left sub-occipital craniotomy...Postoperative period was uneventful and patient's symptoms improved totally after 1 week. Histopathologic examination confirmed the diagnosis of hydatid cyst.
- |||||||||| albendazole / Generic mfg.
Journal: Routine vitamin A supplementation and other high impact interventions in Sierra Leone. (Pubmed Central) - Jul 30, 2021
Most caregivers (77.2%) knew that complementary feeding should be introduced at 6 months, 44.9% were providing three or more (of six) food groups, 84.9% were aware of family planning and 37.5% were using a modern contraceptive. Integration of reproductive and child health services appears to be a suitable platform for routine VAS and Albendazole whilst improving complementary feeding practices and access to family planning.
- |||||||||| albendazole / Generic mfg.
Clinical, Journal: Total Splenectomy for a Giant Isolated Splenic Hydatid Cyst Compressing the Abdominal Viscera: A Case Report. (Pubmed Central) - Jul 29, 2021
The efficacy of perioperative administration of albendazole (400 mg twice a day) has been proven; however, the appropriate surgical procedure for the treatment of giant, centrally located splenic hydatid cysts remains controversial...Surgical resection remains the most effective treatment that completely resolves this condition. A comparison of randomized trials is needed to compare the recurrence rates between splenectomy and spleen-preserving procedures in the treatment of giant splenic hydatid cysts.
- |||||||||| albendazole / Generic mfg.
[VIRTUAL] Primary heterotopic pleural hydatidosis: a rare entity () - Jul 29, 2021 - Abstract #ERS2021ERS_4422;
A comparison of randomized trials is needed to compare the recurrence rates between splenectomy and spleen-preserving procedures in the treatment of giant splenic hydatid cysts. Primary heterotopic pleural hydatidosis is an extremely rare entity even in highly endemic countries.The lack of clinical and radiological specificities makes this pathology often difficult to diagnose and treat.
- |||||||||| albendazole / Generic mfg.
[VIRTUAL] Secondary bronchogenic pulmonary hydatidosis: a rare entity () - Jul 29, 2021 - Abstract #ERS2021ERS_4419;
SBH is a rare complication of lung hidatid cyst. Surgery remains the only effective treatment consisting on regulated resection if the number of cysts is important, and cystectomy if the number is limited.
- |||||||||| albendazole / Generic mfg.
[VIRTUAL] Secondary pleural hydatidosis: complication of abdominal hydatid cysts () - Jul 29, 2021 - Abstract #ERS2021ERS_4417;
Secondary pleural hydatidosis is frequently seen after rupture of abdominal cyst in the pleural cavity. The treatment of both lesions is possible via a thoracotomy and a transdiaphragmatic incision that allows the treatment of thoracic cysts and hepatic lesions at once.
- |||||||||| ibuprofen / Generic mfg.
Preclinical, Journal: Assessment of pharmacological activities of Lygodium microphyllum Cav. leaves in the management of pain, inflammation, pyrexia, diarrhea, and helminths: In vivo, in vitro and in silico approaches. (Pubmed Central) - Jul 28, 2021
Isoeleutherol, isoquercetin and quercetin were found prominent in molecular docking study and ADME/T analysis verified their drug likeliness. The research validates the moderate analgesic, anti-inflammatory, and remarkable antipyretic, antidiarrheal, anthelmintic activities of the plant extract which can be used an alternative source of novel therapeutics.
- |||||||||| albendazole / Generic mfg.
Journal: Computer-assisted UHPLC method development and optimization for the determination of albendazole and its related substances. (Pubmed Central) - Jul 23, 2021
The experimental design-based and software-assisted method development proved to be a fast and reliable way of replacing a method with inadequate selectivity and long runtime with a robust UHPLC-based method, which offers baseline separation for all monitored impurities in 10 min. Results confirm that software-based chromatographic modelling can not only speed up the analytical method development process, but also improve the reliability of the developed method.
- |||||||||| Review, Journal: Antimicrobial resistance of the enteric protozoon Giardia duodenalis - A narrative review. (Pubmed Central) - Jul 9, 2021
In case of therapeutic failure of first line nitroimidazoles, salvage strategies including various options for combination therapy exist in spite of limited evidence and lacking routine diagnostic-compatible assays for antimicrobial susceptibility testing in G. duodenalis. Sufficiently powered clinical and diagnostic studies are needed to overcome both the lacking evidence regarding salvage therapy and the diagnostic neglect of antimicrobial resistance.
- |||||||||| albendazole / Generic mfg.
Preclinical, Journal: A massive systematic infection of Encephalitozoon cuniculi genotype III in mice does not cause clinical signs. (Pubmed Central) - Jul 9, 2021
Treatment with 0.2 mg Albendazole/mouse/day temporarily reduces the number of affected organs in immunocompetent C57Bl/6 mice, but not in CD4 and CD8 mice...The E. cuniculi genotype III spore burden in individual organs reached up to 10 or 10 in immunocompetent or immunodeficient mice, respectively; however, these mice did not demonstrate any obvious clinical signs of microsporidiosis, and the immunodeficient mice survived longer. Our findings clearly show that the survival of mice does not correspond to spore burden, which provides new insight into latent microsporidiosis from an epidemiological point of view.
- |||||||||| moxidectin / Generic mfg., albendazole / Generic mfg.
Enrollment open: Efficacy and Safety of MOX/ALB Co-administration (clinicaltrials.gov) - Jul 8, 2021
P3, N=282, Recruiting,
These results demonstrate a clear dose-response relationship for the effect of ALB on clearance of CFA and microfilaremia. Not yet recruiting --> Recruiting
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