- |||||||||| colchicine / Generic mfg., albendazole / Generic mfg., paclitaxel / Generic mfg.
Novel heterocyclic amides as anti-tubulin agents: evaluation of antiplasmodial activity (Convention Center - Hall 4A (4th Floor); In-Person-Only) - Oct 9, 2022 - Abstract #ASTMH2022ASTMH_827;
Preliminary results show that one analog (C24) inhibits male gamete exflagellations and reduces ookinete formation at 10 µM, indicating transmission-blocking activity. Our results demonstrated that the anti-tubulin compounds examined have the potential for further development as antimalarials.
- |||||||||| amodiaquine hydrochloride / Generic mfg., albendazole / Generic mfg., sulfadoxine/pyrimethamine / Generic mfg.
Safety and efficacy of Dihydroartemisinin-Piperaquine for Seasonal Malaria Chemoprevention in school aged children, Mali (Convention Center - Hall 4A (4th Floor); In-Person-Only) - Oct 9, 2022 - Abstract #ASTMH2022ASTMH_615;
Implementation of Seasonal malaria chemoprevention (SMC) with Sulfadoxine pyrimethamine and Amodiaquine (SP-AQ) has reduced malaria burden in children under 5 but contrasted with increased cases in school-aged children...A double-blind randomized controlled trial was conducted with 345 participants from 6-15 years old randomized in ratio 1:1:1 in 3 arms to receive either DHA-PQ or SP-AQ or albendazole...Gametocyte density was higher in control arm (mean = 44.4 ± 0.0) and lower in SP-AQ and DHA-PQ arm (0.4 ± 1.8 and 0.3 ± 1.2) respectively. DHA-PQ showed high efficacy and good safety in SMC in school aged children and may be an alternative to SP-AQ for SMC.
- |||||||||| albendazole / Generic mfg.
Impact of mass drug administration of ivermectin on malaria transmission in rural Mozambique, efficacy results from the BOHEMIA cluster randomized trial (Convention Center - Hall 4A (4th Floor); In-Person-Only) - Oct 9, 2022 - Abstract #ASTMH2022ASTMH_498;
There are three intervention groups: (A) ivermectin is administered to eligible humans only, (B) ivermectin is administered to eligible humans and livestock, and (C) albendazole is administered to eligible humans as control group...The differential incidence between intervention and control clusters will be compared with a regression model using generalized estimating equations with exchangeable correlation structure that considers the cluster design effect. We present data on enrollment, acceptability, and efficacy obtained during the first six months of the trial.
- |||||||||| albendazole / Generic mfg.
24- Human Gut Microbiome Changes Are Associated with Single Dose Albendazole Treatment Outcomes of Hookworm Infections (Convention Center - Room 605/610 (6th Floor); In-Person-Only) - Oct 9, 2022 - Abstract #ASTMH2022ASTMH_241;
This study suggests a relationship between human gut microbiota and albendazole therapy outcomes of hookworm infection. Moving forward, we will conduct further studies to hone in on specific biomarkers identified within this study to establish their potential for assessment of pharmacological responses to anthelminthic therapies.
- |||||||||| albendazole / Generic mfg.
Genetic differences among human Trichuris populations with differing responses to albendazole-ivermectin combination treatment (Convention Center - Room 605/610 (6th Floor); In-Person-Only) - Oct 9, 2022 - Abstract #ASTMH2022ASTMH_240;
Phylogenetic analysis of the ribosomal ITS-1 and ITS-2 loci revealed that haplotypes from the samples in Cote d'Ivoire clustered separately from those found in Tanzania and Laos populations in a clade containing Trichuris sequences from non-human primates and Trichuris suis. This study demonstrates that the Trichuris population in Cote d'Ivoire is genetically divergent to those from Tanzania and Laos, likely a cryptic species, and has a lower sensitivity to albendazole-ivermectin combination treatment.
- |||||||||| albendazole / Generic mfg.
Community-wide deworming leads to a lower burden of STH infection in school-aged children compared with school-based deworming alone: Results from the Community-Deworming against Soil-Transmitted Helminths (CoDe-STH) trial (Convention Center - Room 605/610 (6th Floor); In-Person-Only) - Oct 9, 2022 - Abstract #ASTMH2022ASTMH_239;
It is the largest ever trial using qPCR for STH diagnostics.Conducted in 64 primary schools in Dak Lak province, Vietnam, over 21,000 albendazole doses were given to SAC in both trial arms, and over 70,000 doses given to community members in the intervention arm at baseline...In a sensitivity analysis, whereby schools with baseline N. americanus prevalence of <5% were excluded, the incident rate ratio (IRR) of infection intensity was also significantly lower in the community group (uIRR 0.42, p=0.008; aIRR 0.48, p=0.009).CoDe-STH is the first demonstration that community-wide deworming lowers burden of STH infection in SAC more than school-based deworming alone. This trial demonstrates the health benefit of expanding deworming programs to include the wider community after 12 months and only one round of treatment.
- |||||||||| albendazole / Generic mfg.
Soil-transmitted helminthiasis is no longer a public health problem in Burkina Faso (Convention Center - Room 602/603/604 (6th Floor)) - Oct 9, 2022 - Abstract #ASTMH2022ASTMH_236;
Population 5 years and older were targeted with albendazole during LF/MDA and SAC were targeted with albendazole during SCH/MDA and since 1999, deworming of children under five years has been conducted biannually with vitamin A supplementation (VAS) campaigns...The results showed that multiple years of deworming may have successfully eliminated STH as a public health problem in Burkina Faso. STH MDA is no longer needed, but to maintain the progress made in controlling STH, targeted deworming will be implemented in collaboration with the Nutrition Directorate and the Family Health Directorate for pregnant women and women of childbearing age at health facilities.
- |||||||||| albendazole / Generic mfg.
Human Gut Microbiome Changes Are Associated with Single Dose Albendazole Treatment Outcomes of Hookworm Infections (Convention Center - Room 611/612 (6th Floor)) - Oct 9, 2022 - Abstract #ASTMH2022ASTMH_80;
This study suggests a relationship between human gut microbiota and albendazole therapy outcomes of hookworm infection. Moving forward, we will conduct further studies to hone in on specific biomarkers identified within this study to establish their potential for assessment of pharmacological responses to anthelminthic therapies.
- |||||||||| albendazole / Generic mfg.
Insights into Environmental Determinants of Soil-Transmitted Helminths Transmission Using GPS Tracking Technology (Convention Center - Room 605/610 (6th Floor)) - Oct 9, 2022 - Abstract #ASTMH2022ASTMH_43;
Soil-Transmitted Helminthiasis (STH) is targeted for elimination by year 2030 and there are concerns about achieving this target in Ghana due to reports of persistent low albendazole cure rates following treatment with a single dose...Our preliminary metagenomics analysis of larval DNA has identified Parastrongyloides trichosuri a nematode parasite of small mammals as dominant larvae in soil samples, which was expected. These are preliminary findings and therefore further studies are being conducted to increase sample sizes to enable firm conclusions to be drawn.
- |||||||||| moxidectin / Generic mfg.
Trial primary completion date: Moxidectin for LF, Cote d'Ivoire (DOLF) (clinicaltrials.gov) - Oct 6, 2022
P3, N=164, Active, not recruiting,
These are preliminary findings and therefore further studies are being conducted to increase sample sizes to enable firm conclusions to be drawn. Trial primary completion date: Sep 2022 --> Sep 2023
- |||||||||| albendazole / Generic mfg.
Journal: Giardia duodenalis: Flavohemoglobin is involved in drug biotransformation and resistance to albendazole. (Pubmed Central) - Oct 5, 2022
Furthermore, all albendazole-resistant clones transfected to overexpress gFlHb displayed higher susceptibility to the drug than the parent clones. Collectively these findings indicate a role for gFlHb in ABZ conversion to its sulfoxide and that gFlHb down-regulation acts as a passive pharmacokinetic mechanism of resistance in this parasite.
- |||||||||| albendazole / Generic mfg.
Journal: Antiparasitic Effects of Asteraceae Species Extracts on Echinococcus granulosus s.s. (Pubmed Central) - Oct 5, 2022
The existing treatment is limited to the use of benzimidazoles, mainly albendazole (ABZ)...The dosage of infected animals with the 50 mg kg dose of S. aristata extract resulted in a significant reduction in cyst weight in comparison with the control group. In conclusion, S. aristata extract was demonstrated to exert a marked effect, both in vitro and in the murine model.
- |||||||||| albendazole / Generic mfg.
Journal: Pancreatic echinococcosis in a 5-year-old girl. (Pubmed Central) - Oct 5, 2022
Exploratory laparotomy, cholecystectomy, and unroofing of the cyst were performed. The patient had a favorable course and continued with albendazole for 3 months after the surgery.
- |||||||||| albendazole / Generic mfg.
Journal: Risk Factors of Noncompliance to Preventive Mass Drug Administration for Eliminating Lymphatic Filariasis: A Case-Control Study in Jawi District, Northwest Ethiopia. (Pubmed Central) - Oct 4, 2022
Therefore, this study was conducted to identify the factors associated with noncompliance to prevent mass drug administration using ivermectin-with-albendazole for the elimination of lymphatic filariasis in Northwest Ethiopia...Noncompliance with lymphatic filariasis mass drug administration therapy was associated with specific demographic, individual, program, and drug delivery characteristics. This finding has important implications for program effectiveness and would be used to accelerate the elimination of lymphatic filariasis in the study area and other endemic settings.
- |||||||||| albendazole / Generic mfg., doxycycline / Generic mfg.
Journal: Topical interferon in recurrent inflammatory macular edema following a cat bite. (Pubmed Central) - Oct 4, 2022
Interruption of interferon therapy due to COVID-lock down resulted in recurrence of the CME, which again responded well to interferon monotherapy. Topical interferon may have a role in the treatment of inflammatory macular edema and can serve as a, safer, economical and non-invasive treatment option compared to intravitreal steroids and anti-VEGFs.
- |||||||||| ivermectin oral / Generic mfg.
Journal: Strongyloides stercoralis hyperinfection syndrome with cerebral involvement. (Pubmed Central) - Oct 1, 2022
The patient was treated with oral and rectal ivermectin and albendazole...Unfortunately, the patient eventually died from pulmonary oedema and insufficiency. This case highlights the global importance of Strongyloides CNS infection in endemic and non-endemic regions.
- |||||||||| albendazole / Generic mfg.
Journal: Diethylcarbamazine citrate-fortified salt for lymphatic filariasis elimination in India. (Pubmed Central) - Sep 28, 2022
The Government of India (GOI) prioritized the elimination of LF through the annual mass drug administration (MDA) programme in 2004 and continued with a single dose of diethylcarbamazine citrate (DEC), 6 mg/kg of body weight, plus albendazole annually over a period of 5-6 years...If implemented appropriately, this strategy will ensure the complete cessation of LF transmission within two years from its introduction. If the said strategy is implemented in 2022, it is expected that India will be able to achieve the LF elimination by 2024, much before the global target of 2030.
- |||||||||| albendazole / Generic mfg.
Trial completion date, Trial primary completion date: Efficacy of Oxfendazole in the Treatment of Trichuris Trichiura Infection in Adults (clinicaltrials.gov) - Sep 27, 2022
P2, N=250, Not yet recruiting,
If the said strategy is implemented in 2022, it is expected that India will be able to achieve the LF elimination by 2024, much before the global target of 2030. Trial completion date: Oct 2024 --> Oct 2025 | Trial primary completion date: Jul 2024 --> Jul 2025
- |||||||||| albendazole / Generic mfg.
Journal: Laparoscopic splenectomy for solitary splenic hydatid cyst: Case report. (Pubmed Central) - Sep 22, 2022
The condition was treated successfully with albendazole, but the patient requested the cyst removed...The patient recuperated well and was discharged on the post-operative day 5. Six months after the procedure, the patient has no complaints.
- |||||||||| albendazole / Generic mfg., ivermectin topical / Generic mfg.
Preclinical, Journal: Identification of promising nutraceuticals against filarial immune-modulatory proteins: insights from in silico and ex vivo studies. (Pubmed Central) - Sep 20, 2022
The anti-filarial drugs, diethylcarbamazine, albendazole, and ivermectin, are effective only at the larval stages and have proven completely ineffective as adulticides...Emodin significantly affected the motility, viability, ROS production, and genomic DNA fragmentation of filarial parasites. Further in vivo and in vitro studies will help in understanding the mechanism of action of emodin at the molecular level and would help in the development of more effective anti-filarial drugs.
- |||||||||| albendazole / Generic mfg.
Preclinical, Journal: β-cyclodextrin dendritic derivatives as permeation mediators to enhance the in vitro albendazole cysticidal activity by the improvement of the diffusion component. (Pubmed Central) - Sep 14, 2022
According to the EC values related to the cysticidal activity of albendazole, either free or complexed, the potency of this drug in the ICs experienced a significant increase, which may be attributed to the enhancement of its solubility but also to a better permeation mediated by the amphiphilic dendritic moieties, which ultimately positively impacts the diffusion of this drug through the tegument of the cysticerci. Additional considerations akin to synthetic ease of the dendritic nanocarriers, and production cost, along with the obtained outcomes, allowed us to place m2G followed by m3G as the best options to be considered for further in vivo assays.
- |||||||||| albendazole / Generic mfg.
Retrospective data, Journal: Hydatid Disease in Children from Diagnosis to Treatment: A 10-year Single Center Experience (Pubmed Central) - Sep 14, 2022
There were 52 (91.2%) patients who were given albendazole in conservative treatment and the mean duration of treatment was 15.5±17.2 months...Hydatid disease should definitely be considered in the presence of suspicious radiological and clinical findings in endemic areas. Controlled clinical studies are required for diagnosis and treatment procedures.
- |||||||||| ivermectin oral / Generic mfg., albendazole / Generic mfg.
Journal: Biodegradation of anthelmintics in soils: does prior exposure of soils to anthelmintics accelerate their dissipation? (Pubmed Central) - Sep 14, 2022
We employed studies with fumigated and non-fumigated soils collected from 12 sheep farms with a variable record of albendazole (ABZ), ivermectin (IVM) and eprinomectin (EPM) use...Soil adsorption of AHs increased in the order IVM > ABZ > EPM. TOC controlled soil adsorption of IVM and EPM, but not of ABZ, in support of the contrasting effect of TOC on IVM and ABZ dissipation.
- |||||||||| albendazole / Generic mfg.
Preclinical, Journal: Design, synthesis, and in vitro evaluation of thiosemicarbazone derivatives as anti-filarial agents. (Pubmed Central) - Sep 14, 2022
The standard drugs used at present for filaria, Albendazole, Ivermectin and Diethylcarbamazine were not able to kill the adult filarial worms effectively. In contrast, phenyl thiosemicarbazones with trifluoromethyl substitution at 3rd and 4th positions, 2-pyrrolyl, and isatinyl made the adult worms immotile and also showed 69%-83% inhibition in formazan formation an indicator of non viability.
- |||||||||| albendazole / Generic mfg.
Preclinical, Journal: Antinematodic effect of Enterococcus faecalis CECT7121 using Trichinella spiralis as a model of nematode infection in mice. (Pubmed Central) - Sep 14, 2022
In addition, the protective effect of EFCECT7121 combined with the conventional anthelmintic albendazole (ABZ, 5 mg/kg) was also assessed...ABZ alone and the combination EFCECT7121 + ABZ produced a reduction of the LPG of muscle tissue of 62 and 60.7%, respectively. Results obtained in the current work support the hypothesis that probiotics such as EFCECT7121 have an antinematodic effect, and their combination with conventional anthelmintic drugs may result useful for improving clinical and parasitological outcomes.
- |||||||||| albendazole / Generic mfg.
Journal: Nanocrystal Suspensions for Enhancing the Oral Absorption of Albendazole. (Pubmed Central) - Sep 13, 2022
The oral bioavailability of the total active ingredients (ABZ and its metabolites of albendazole sulfoxide (ABZSO) and albendazole sulfone (ABZSO2)) of the nanocrystals in rats was enhanced by 1.40 times compared to the native ABZ. These results suggest that nanocrystals might be a promising way to enhance the solubility and oral bioavailability of ABZ and other insoluble drugs.
- |||||||||| albendazole / Generic mfg.
Journal: A potential herbal therapeutic for trichinellosis. (Pubmed Central) - Sep 13, 2022
One infected group of mice was left untreated (negative control) while the remaining two infected groups received either 300 mg/kg of the ethanolic extract of A. annua or 50 mg/kg of albendazole (positive control)...Moreover, treatment with A. annua restored the normal intestinal architecture, reduced edema, alleviated inflammation as demonstrated by reduced inflammatory infiltrate and expression of TGF-β in intestinal tissues of A. annua-treated animals compared to infected untreated animals. Our findings show that A. annua extract is effective in treating experimentally induced trichinellosis which highlight the therapeutic potential of A. annua for intestinal trichinellosis.
- |||||||||| albendazole / Generic mfg.
Retrospective data, Review, Journal: Trichostrongyle infections in domestic ruminants from Egypt: A systematic review and meta-analysis. (Pubmed Central) - Sep 7, 2022
Anthelmintic resistance does not appear to be serious in trichostrongyle populations infecting ruminants from Egypt; nonetheless there have been a few cases of albendazole resistance in trichostrongyles infecting sheep. This paper contributes to a better understanding of the epidemiology and economic implications of trichostrongyle infections in ruminants from Egypt, which is crucial for establishing effective control strategies against these ubiquitous nematodes.
- |||||||||| lactulose / Generic mfg., albendazole / Generic mfg.
Isolated Pinworm in Ascites (Crown Ballroom) - Sep 4, 2022 - Abstract #ACG2022ACG_3776;
She initially received lactulose enemas with which her mentation improved...Treatment with albendazole 400 mg weekly for 4 weeks was effective in eradication of infection...Table: Table 1. Ascites fluid studies
- |||||||||| pantoprazole / Generic mfg., albendazole / Generic mfg.
Gastric Anisakiasis Masquerading as Gastroesophageal Reflux Disease (Crown Ballroom) - Sep 4, 2022 - Abstract #ACG2022ACG_3652;
Clinicians should consider anisakiasis in the differential diagnosis of patients presenting with gastrointestinal symptoms and recent consumption of raw or undercooked fish. Figure: Esophagogastroduodenoscopy revealed white, filiform worms invading into mucosa of the greater curve of the body and cardia at the gastroesophageal junction
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