- |||||||||| Journal: Antimicrobial susceptibility to last-resort antibiotics in carbapenemase-producing bacteria from Ukrainian patients. (Pubmed Central) - Nov 7, 2024
For most CPE, a low minimal inhibitory concentration (MIC) of <0.5 mg/L was measured for tigecycline and ceftazidime-avibactam-aztreonam...For CRAB, ampicillin-sulbactam MICs were ?128 mg/L; for sulbactam-durlobactam, 1-2 mg/L...Our research revealed that there was extensive phenotypic resistance to last-resort antibiotics. Healthcare professionals should be aware of multidrug-resistant microorganisms when treating patients recently admitted in Ukraine, suspected for Gram-negative bacterial infection.
- |||||||||| ampicillin/sulbactam / Generic mfg., cefazolin / Generic mfg., clindamycin phosphate / Generic mfg.
Journal: Bilateral parapneumonic empyema caused by Fusobacterium necrophorum infection in a healthy individual. (Pubmed Central) - Nov 5, 2024 The antibiotic was switched to clindamycin, cefazolin, cefotiam, and flomoxef...This report presents the case of a previously healthy patient with bilateral parapneumonic empyema caused by F. necrophorum, without manifestations of pharyngotonsillitis, bacteremia, or Lemierre's syndrome. Extensive thoracic drainage, effective antibiotics, and timely surgical interventions are imperative.
- |||||||||| Xacduro (sulbactam-durlobactam) / Innoviva
Journal: Successful Treatment of Carbapenem-Resistant Acinetobacter baumannii Meningitis with Sulbactam-Durlobactam. (Pubmed Central) - Oct 15, 2024 This protocol is different from the recommended guidelines for using empirical antibiotics. This case describes successful treatment of refractory CRAB meningitis with the administration of sulbactam-durlobactam and meropenem and highlights the need to be cognizant of the paradoxical effect that can be observed with broth microdilution testing of CRAB isolates with cefiderocol.
- |||||||||| Aeromonas hydrophila as a cause of acute diarrhea from western and coastal regions in Kenya (Convention Center - Hall I-1 (1st Floor); In-Person-Only) - Oct 11, 2024 - Abstract #ASTMH2024ASTMH_2176;
The isolation of Aeromonas hydrophila is indicative that it may be a potential pathogen that causes acute diarrhea. The isolates were also found to be more resistant to the sulfonamide and beta lactams hence possible transfer to other gut pathogens or normal flora leading to increased antimicrobial resistance.
- |||||||||| Zavicefta (ceftazidime/avibactam) / Pfizer, AbbVie
Journal: Resistance is reality: findings from the first Ukrainian cumulative antibiogram. (Pubmed Central) - Oct 10, 2024 For Escherichia coli, 66% and 69% of isolates were susceptible to ceftazidime and ceftriaxone, respectively, and 99% were susceptible to meropenem...Of those that were resistant to meropenem and underwent additional susceptibility testing, only 12% were susceptible to ceftazidime/avibactam...Susceptibility to ampicillin/sulbactam was also low at 45%...CuAbgms should be prioritized in laboratories in Ukraine to guide empirical antimicrobial therapy, infection control and antimicrobial stewardship policies. This is of heightened relevance during wartime, when there is a need for healthcare systems to treat complex and infected penetrating and blast-related injuries.
- |||||||||| Fatal Pulmonary Mucormycosis in a Kidney Transplant Patient: Missed "Opportunism" (Exhibit Hall, Convention Center) - Sep 23, 2024 - Abstract #KIDNEYWEEK2024KIDNEY_WEEK_3394;
PM is rapidly progressive, invasive, and carries a 60-70% mortality rate. This case highlights the pitfalls of empiric approaches to infections in immunocompromised hosts and the need for early suspicion for opportunistic infection and tissue diagnosis to optimize outcomes.
- |||||||||| Sirturo (bedaquiline) / J&J, Pharmstandard
Wasting K, the Ampicillin Way: An Uncommon Cause of Hypokalemia (Exhibit Hall, Convention Center) - Sep 23, 2024 - Abstract #KIDNEYWEEK2024KIDNEY_WEEK_1401; His home TB regimen was converted to IV linezolid and moxifloxacin...The following day, he was initiated on ampicillin/sulbactam 3 g TID and meropenem 2 g TID to replace long-acting bedaquiline from his home regimen...In our case, the high urine anion gap suggests the presence of nonreabsorbable anions. The proposed mechanism is the inability to reabsorb the anion along the nephron, preserving a negative luminal charge and resulting in K secretion at the distal tubule.
- |||||||||| Invanz (ertapenem) / Merck (MSD)
Retrospective data, Review, Journal: Antibiotic resistance rates in hypervirulent Klebsiella pneumoniae strains: a systematic review and meta-analysis. (Pubmed Central) - Sep 12, 2024 This study emphasizes the growing issue of antibiotic resistance in hvKp strains, with notable resistance to both older and newer antibiotics, increasing resistance over time, regional disparities and methodological variations. Effective responses should involve international cooperation, standardized testing and tailored regional interventions.
- |||||||||| A RARE CASE OF ACUTE EPIGLOTTITIS FROM PASTEURELLA MULTOCIDA IN AN IMMUNOCOMPETENT PATIENT (Convention Center Exhibit Hall: Rapid Fire Area 2A) - Sep 11, 2024 - Abstract #CHEST2024CHEST_7107;
Although rare, P. multocida should be considered as a potential causative pathogen in acute epiglottitis, particularly in those with a history of dog or cat exposure. The prompt diagnosis and management of P. multocida epiglottitis is interdisciplinary and reliant on a thorough exposure history to pets with relevant laboratory and diagnostic findings.
- |||||||||| ampicillin/sulbactam / Generic mfg., methamphetamine / Generic mfg.
CAT GOT YOUR TONGUE? A CASE OF PASTEURELLA MULTOCIDA-ASSOCIATED MILLER FISHER SYNDROME (Convention Center Exhibit Hall: Rapid Fire Area 3D) - Sep 11, 2024 - Abstract #CHEST2024CHEST_6919; Incidentally, she was also discovered to have used 3,4-methylenedioxy-methamphetamine (MDMA) around this timeline...Antibiotics were narrowed and she received 5 days of ampicillin-sulbactam... In summary, MFS is a rare and aggressive form of GBS, and even more rarely may be associated with P multicoda associated infection.
- |||||||||| PLEURAL ACTINOMYCOSIS IN A YOUNG WOMAN PRESENTING AS CULTURE NEGATIVE MULTILOCULATED PLEURAL EFFUSION: A CASE REPORT (Convention Center Exhibit Hall: Poster Area 3) - Sep 11, 2024 - Abstract #CHEST2024CHEST_6590;
Pleural actinomycosis is an insidious onset illness that can be culture negative and present subtly with anorexia, mimicking malignancies and tuberculosis. A strong suspicion for actinomycosis must be maintained for chronic unexplained pleural effusions and pulmonary consolidations, and treatment with penicillin begun while awaiting cultures and pathology.
- |||||||||| Invanz (ertapenem) / Merck (MSD)
PROPIONIBACTERIUM ACNES: A RARE CAUSE OF PROSTHETIC VALVE ENDOCARDITIS (Convention Center 255) - Sep 11, 2024 - Abstract #CHEST2024CHEST_6464; acnes infection is characterized by paucity of common symptoms of infection and inflammation. High index of suspicion is therefore needed especially for late onset-prosthetic valve infections to initiate prompt and appropriate treatment.
- |||||||||| THE MYSTERIOUS VISITOR: A CHILLING ENCOUNTER WITH ELIZABETHKINGIA MIRICOLA (Convention Center Exhibit Hall: Rapid Fire Area 1B) - Sep 11, 2024 - Abstract #CHEST2024CHEST_6435;
She received ampicillin-sulbactam for aspiration pneumonia, zoledronic acid for hypercalcemia, and promethazine/diphenhydramine for nausea...Levetiracetam was administered, and she was intubated for airway protection. Midazolam and propofol were started for analgosedation and she was transferred to our hospital for continuous electroencephalogram (EEG).Objective data at our facility: hypernatremia (146 mmol/L), normal anion gap acidosis (bicarbonate: 15 mmol/L, chloride: 120 mmol/L), severe hypocalcemia (6 mg/dL), normocytic anemia (hemoglobin: 8.9 g/dL), elevated lipase (239 U/L), and AKI (creatinine: 1.64 mg/dL)...leading to initiation of vancomycin, piperacillin-tazobactam and doxycycline...Susceptibility testing indicated resistance to piperacillin-tazobactam, tetracycline, cefepime, and sensitivity to ciprofloxacin, levofloxacin, and trimethoprim-sulfamethoxazole...Some research studies demonstrate resistance to beta lactam, monobactam, vancomycin, carbapenems, and aminoglycosides, with variable susceptibility to minocycline, trimethoprim-sulfmethoxazole, piperacillin-tazobactam and levofloxacin [10
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