- |||||||||| ampicillin/sulbactam / Generic mfg.
Kluyvera ascorbata Infection in a Patient With Metastatic Duodenal Adenocarcinoma (Exhibit Hall E) - Aug 20, 2024 - Abstract #ACG2024ACG_5451;
In the microbiological analysis of the drained liquid, Kluyvera ascorbata and Lactobacillus species were isolated, and a 6-week course of Ampicillin/Sulbactam was started...Figure: Image 1. EGD reveals a large frond-like/villous, circumferential, infiltrative, and ulcerated, partially obstructing mass with bleeding approximately 5 cm in length, extending from the duodenal sweep to the second portion of the duodenum (A and B).
- |||||||||| ampicillin/sulbactam / Generic mfg.
Pictures Aren't Always Worth a Thousand Words: Acute Cholecystitis Amidst Equivocal Imaging Studies (Exhibit Hall E) - Aug 20, 2024 - Abstract #ACG2024ACG_4046;
Consequently, she was admitted and started on ampicillin/sulbactam due to suspected acute cholecystitis...In our case, despite equivocal imaging findings, acute cholecystitis remained the primary diagnosis, ultimately leading to laparoscopic cholecystectomy with diagnostic confirmation via surgical pathology. In summary, it is crucial for physicians to consider acute cholecystitis in those presenting with RUQ abdominal pain and equivocal imaging, as delayed surgical intervention can lead to longer hospital stays, greater surgical complications, and increased mortality.
- |||||||||| ampicillin/sulbactam / Generic mfg., vancomycin / Generic mfg.
A Rare Case of Sterile Peritonitis in the Setting of Abdominal Infarct (Exhibit Hall E) - Aug 20, 2024 - Abstract #ACG2024ACG_3528;
Negative peritoneal cultures must still be interpreted in context and with caution as antibiotic treatment before fluid analysis can result in false negative cultures and an inappropriate diagnosis of sterile peritonitis. Incorrect diagnosis can prevent patients from receiving necessary lifelong SBP prophylaxis [3].
- |||||||||| ampicillin/sulbactam / Generic mfg.
Atraumatic Splenic Hemorrhage Post Acute Alcoholic Necrotizing Pancreatitis: A Case Report (Exhibit Hall E) - Aug 20, 2024 - Abstract #ACG2024ACG_3033;
He was started on Ampicillin-Sulbactam for prophylaxis against splenic abscess and received vaccination against encapsulated organisms...Healthcare professionals must remain vigilant regarding this potential complication to timely diagnose and manage this rare complication of acute pancreatitis. Figure: Coronal view of splenic hemorrhage prior to embolization
- |||||||||| Journal: Antibiotics in patients with severe burn injury-A modifiable variable in hypernatremia etiology. (Pubmed Central) - Aug 14, 2024
The amount of sodium in antibiotics seems to have a relevant impact on the serum Na during the early stages of severe burn injury. Therefore, this aspect should be taken into account when searching for the most appropriate antibiotic treatment for patients with severe burn injury, especially when being at acute risk for a clinical relevant hypernatremia.
- |||||||||| Got Milk (Allergy)? (Exhibit Hall) - Aug 6, 2024 - Abstract #ASA2024ASA_4835;
She remained stable without respiratory distress. Symptoms resolved; the case proceeded uneventfully.
- |||||||||| A CASE OF 'HONEYMOON' MENINGOENCEPHALITIS DUE TO GROUP B STREPTOCOCCUS IN A PREVIOUSLY HEALTHY ADULT MALE (Convention Center Exhibit Hall: Poster Area 2) - Jul 31, 2024 - Abstract #CHEST2024CHEST_5242;
The most important risk factors are diabetes mellitus and obesity, although infections can occur in patients without significant risk factors, such as the case reported here. While rare, this case exemplifies that GBS meningoencephalitis is not confined to neonates, postpartum women, or adults with significant comorbidities and should be kept in the differential diagnosis for bacterial meningitis in healthy adults.
- |||||||||| STREPTOCOCCUS PYOGENES CAUSING EMPYEMA IN A PATIENT WITH INFLUENZA-A INFECTION (Convention Center Exhibit Hall: Poster Area 2) - Jul 31, 2024 - Abstract #CHEST2024CHEST_5170;
IAV vaccination is beneficial in reducing these life threatening superinfections along with preventing flu. These infections are treated with IV antibiotics, IVIG has some utility but not incorporated into the evidence-based practice yet.
- |||||||||| minocycline / Generic mfg.
AN INTERESTING CASE OF EOSINOPHILIC PNEUMONIA DUE TO MINOCYCLINE (Convention Center Exhibit Hall: Poster Area 2) - Jul 31, 2024 - Abstract #CHEST2024CHEST_2766;
The diagnosis of EP is often missed given the similarity of its presentation with infectious pneumonia and can get fulminant rapidly. Our case signifies the importance of timely diagnosis and treatment of EP.
- |||||||||| ARE THERE PETS AT HOME? A CASE OF PASTEURELLA MULTOCIDA EPIGLOTTITIS (Convention Center Exhibit Hall: Poster Area 2) - Jul 31, 2024 - Abstract #CHEST2024CHEST_2727;
Adult patients are at risk of sudden decline despite stable presentation [2]. Thus, consultation with otolaryngology and anesthesia is recommended, with advanced airway teams if cricothyrotomy is necessary [2].
- |||||||||| THORACIC EMPYEMA DUE TO STREPTOCOCCUS CONSTELLATUS AND PARVIMONAS MICRA COINFECTION IN AN IMMUNOCOMPETENT MALE: A CASE REPORT (Convention Center Exhibit Hall: Poster Area 2) - Jul 31, 2024 - Abstract #CHEST2024CHEST_2519;
Empyema without pulmonary disease should be considered a diagnostic dilemma and pleural fluid should be tested by culture or PCR or mNGS, for identification of species and tailoring of treatment accordingly. A low mortality rate of 11.1% is associated with S. constellatus empyema, but a few patients can also develop ARDS, severe pneumonia and septic shock, signifying the importance of timely diagnosis and treatment.
- |||||||||| ampicillin/sulbactam / Generic mfg., amoxycillin/clavulanate / Generic mfg.
SERIAL IMAGING: A SAFEGUARD AGAINST LIFE-THREATENING PLEURAL EMPYEMA IN A PATIENT WITH HEPATIC ABSCESS (Convention Center Exhibit Hall: Poster Area 3) - Jul 31, 2024 - Abstract #CHEST2024CHEST_1680;
Patients with underlying lung disease and PLA in proximity to the right diaphragm are at heightened risk for developing pleural effusion and/or empyema from a liver abscess. Clinicians should have a low threshold to perform serial imaging and intervene early in such cases.
- |||||||||| Cubicin (daptomycin) / Merck (MSD)
DAPTOMYCIN-INDUCED PNEUMONIA: WHERE ARE THE EOSINOPHILS? (Convention Center Exhibit Hall: Poster Area 3) - Jul 31, 2024 - Abstract #CHEST2024CHEST_1478;
She was admitted for presumed osteomyelitis and treated with vancomycin and piperacillin/tazobactam...Antibiotics were de-escalated to daptomycin and ampicillin/sulbactam with clinical improvement...Due to worsening respiratory failure and no improvement with diuretics, daptomycin was discontinued and the patient was started on 60mg prednisone... This case highlights a rare side effect of daptomycin while serving as a reminder that not all presentations of drug toxicities are the same.
- |||||||||| ampicillin/sulbactam / Generic mfg., azacitidine / Generic mfg.
PAIN UNVEILED: A RARE COMPLICATION OF ENDURING SCIATIC PAIN CAUSED BY GLUTEAL ARTERY PSEUDOANEURYSM FOLLOWING BONE MARROW BIOPSY (Convention Center Exhibit Hall: Poster Area 2) - Jul 31, 2024 - Abstract #CHEST2024CHEST_1335;
In light of the limited reported adverse effects, we advocate for a shift in focus towards post-operative imaging as a proactive measure to monitor and promptly identify any possible adverse effects. Increased research in this direction could contribute significantly to refining our understanding and management of potential complications associated with bone marrow biopsies.
- |||||||||| Noxafil (posaconazole) / Merck (MSD), Cresemba (isavuconazonium sulfate) / Astellas, Basilea
INDOLENT MUCORMYCOSIS SECONDARY TO ABSIDIA SPECIES PRESENTING AS NONRESOLVING PULMONARY CAVITARY LESIONS (Convention Center Exhibit Hall: Poster Area 2) - Jul 31, 2024 - Abstract #CHEST2024CHEST_1198;
With isolated infection affecting the pulmonary system, diagnosis can be challenging. Here we present an unusual case of pulmonary Absidia infection presenting as chronic, non-resolving cavitary nodules spanning over a period of nearly 10 years.
- |||||||||| ODDBALL ALERT: A RARE CASE OF PROSTHETIC VALVE ENDOCARDITIS BY PARVIMONAS MICRA (Convention Center Exhibit Hall: Poster Area 1) - Jul 31, 2024 - Abstract #CHEST2024CHEST_1150;
CASE PRESENTATION: A 79-year-old female with a history of infective endocarditis status post mechanical mitral valve replacement 12 years prior, on lifelong warfarin, right total knee replacement 3 years prior, and a dental procedure with prophylactic antibiotics a few weeks prior, initially presented with a right knee periprosthetic joint infection requiring joint revision surgery...She was discharged on a 6-week course of IV Ceftriaxone to empirically cover for Cutibacterium acnes...She was discharged on IV ampicillin-sulbactam, however, eventually succumbed to multiple post-operative complications...While it is now known to be resistant to doxycycline and clindamycin, it remains susceptible to amoxicillin and metronidazole in vitro [5]... Transient anaerobic bacteremia in patients with prosthetic valves is a rare but important cause of fulminant infective endocarditis.
- |||||||||| ampicillin/sulbactam / Generic mfg.
VENTILATOR-ASSOCIATED PNEUMONIA IN PATIENT WITH TRACHEOBRONCHOMEGALY (MOUNIER-KUHN SYNDROME) (Convention Center Exhibit Hall: Poster Area 1) - Jul 31, 2024 - Abstract #CHEST2024CHEST_1095;
If a patient with this disorder requires intubation one must consider appropriate ETT size and ventilator settings consistent with those of patients with severe emphysema. One should also anticipate aspiration risk and may even consider empiric antibiotics for ventilator-associated pneumonia.
- |||||||||| Activase (alteplase) / Roche, Boehringer Ingelheim, Kyowa Kirin, Mitsubishi Tanabe
BILATERAL PASTEURELLA MULTICODA EMPYEMA (Convention Center 256) - Jul 31, 2024 - Abstract #CHEST2024CHEST_328;
Overall, immunocompromised pet owners are at risk for more severe infections caused by zoonotic bacteria (4, 5). Clinicians should continue to have a broad differential for sources of infection, and the potential pathogens involved.
- |||||||||| Fetroja (cefiderocol) / Shionogi
Review, Journal: Treatment of infections caused by carbapenem-resistant Acinetobacter baumannii. (Pubmed Central) - Jul 31, 2024
The Infectious Diseases Society of America (IDSA) has deemed high-dose ampicillin-sulbactam, which is typically combined with high-dose tigecycline, polymyxin, and other antibacterial agents, the best option for treating serious CRAB infections. A rational combination of drug use and the exploration of new therapeutic drugs can alleviate or prevent the effects of CRAB infections, shorten hospital stays, and reduce patient mortality.
- |||||||||| Retrospective data, Journal: Etiological structure and antibiotic resistance pattern of burn wound infections in hospitalized patients - a one-center study in Varna, Bulgaria. (Pubmed Central) - Jul 18, 2024
(2.9%). Glycopeptide antibiotics and linezolid were the most effective drugs against gram-positive isolates, followed by amikacin (for synergistic combinations), whereas colistin, imipenem, meropenem, cefoperazon/sulbactam, and piperacillin/tazobactam were the most active drugs against Gram-negative isolates, and colistin, ampicillin/sulbactam - against A. baumannii.
- |||||||||| levofloxacin / Generic mfg., clindamycin phosphate / Generic mfg., amoxycillin/clavulanate / Generic mfg.
Phase classification: Efficacy of Oral vs IV Antibiotics in the Treatment of Orofacial Osteomyelitis (clinicaltrials.gov) - Jul 17, 2024
P4, N=100, Not yet recruiting,
Glycopeptide antibiotics and linezolid were the most effective drugs against gram-positive isolates, followed by amikacin (for synergistic combinations), whereas colistin, imipenem, meropenem, cefoperazon/sulbactam, and piperacillin/tazobactam were the most active drugs against Gram-negative isolates, and colistin, ampicillin/sulbactam - against A. baumannii. Phase classification: P --> P4
- |||||||||| pretomanid (PA-824) / Global Alliance for TB Drug Development, Sirturo (bedaquiline) / J&J, Pharmstandard
Journal: Successful Multidisciplinary Treatment of Small Bowel Obstruction With an Ileal Stricture Resulting in Bowel Perforation in the Setting of Multidrug-Resistant Gastrointestinal Tuberculosis: A Case Report. (Pubmed Central) - Jul 15, 2024
Phase classification: P --> P4 We present the case of a male in his 40s who recently emigrated from Russia and was actively undergoing treatment for multidrug-resistant (MDR) pulmonary tuberculosis (TB) with the BPaL-M (bedaquiline, pretomanid, linezolid, moxifloxacin, and pyridoxine) regimen who presented to the emergency department (ED) with abdominal pain, vomiting, and no bowel movements...An oral BPaL-M regimen was held and an intravenous (IV) regimen consisting of linezolid, moxifloxacin, meropenem, and ampicillin/sulbactam was started per infectious disease (ID) recommendations...A
- |||||||||| ampicillin/sulbactam / Generic mfg., gentamicin sulfate / Generic mfg.
Journal: Prospective Clinical Follow-Up Results of Infective Endocarditis. (Pubmed Central) - Jul 15, 2024
Septic embolism and cardiac failure were the most common complications. This study's findings regarding the epidemiology and prognosis of infective endocarditis pointed out that it is still a disease with a high mortality rate.
- |||||||||| azithromycin / Generic mfg., erythromycin / Generic mfg.
Clinical, P2 data, Journal: A phase II, multicenter, nonblinded, randomized controlled trial for evaluating protective effects of ABPC/SBT plus, azithromycin versus erythromycin, in pregnant women with pPROM occurring at <28 weeks of gestation on the development of BPD in neonates: Study protocol. (Pubmed Central) - Jul 9, 2024
A regimen of ampicillin (ABPC) intravenous infusion for 2 days and subsequent amoxicillin (AMPC) oral administration for 5 days plus erythromycin (EM) intravenous infusion for 2 days followed by EM oral administration for 5 days is standard treatment for pPROM...Recently, it is reported that ampicillin/sulbactam (ABPC/SBT) plus azithromycin (AZM) was effective for the prevention of moderate/severe BPD36 in pPROM patients with amniotic infection of Ureaplasma species...We allocate patients at a rate of 1:1 considering two stratification factors: onset of pPROM (22-23 or 24-27 weeks) and presence/absence of a hospital policy for early neonatal administration of caffeine. Trial registration: The trial number in the Japan Registry of Clinical Trials is jRCTs031210631.
- |||||||||| ampicillin/sulbactam / Generic mfg.
Journal: Trauma surgical relevance of bite injuries by animals and humans (Pubmed Central) - Jul 2, 2024
The primary antibiotic treatment should be empirical with amoxicillin?+?clavulanic acid or ampicillin?+?sulbactam and, if necessary, adjusted according to the antibiogram. Depending on the findings, surgical treatment includes excision of the bite canal and a
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