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- || ampicillin/sulbactam / Generic mfg.
Clinical, Journal: A case of Lemierre's syndrome with double vision as the first symptom. (Pubmed Central) - Jan 19, 2022
Lemierre's syndrome can be complicated with atypical symptoms such as double vision if the cranial nerves are involved. It might be important to consider this disease in the differential diagnosis in the presence of cranial nerve symptoms of unknown origin with fever or inflammatory findings.
- || Clinical, Journal: High frequency of multidrug-resistant (MDR) Klebsiella pneumoniae harboring several β-lactamase and integron genes collected from several hospitals in the north of Iran. (Pubmed Central) - Jan 15, 2022
Our results indicate co-presence of a series of β-lactamase and integron types on the MDR strains recovered from hospitalized patients. The increasing rate of these isolates emphasizes the importance of choosing an appropriate antimicrobial regimen based on antibiotic susceptibility pattern.
- | amoxycillin/clavulanate / Generic mfg.
Journal: Exploring the genetic mechanisms underlying amoxicillin-clavulanate resistance in waterborne Escherichia coli. (Pubmed Central) - Jan 12, 2022
Hyperproduction of bla, presence of plasimd-mediated ampC or promoter/attenuator mutations in the chromososmal ampC might not be related to IRT-like phenotype or AMC-resistance. This suggests that other mechanisms like, increased plasmid copy numbers or gene amplification or deficiency in the expression/function of porins might be responsible for AMC-resistance in waterborne E. coli.
- | ampicillin/sulbactam / Generic mfg., cefazolin / Generic mfg.
Retrospective data, Journal: Significance of Antimicrobial Prophylaxis for the Prevention of Early-Onset Pneumonia After Radical Esophageal Cancer Resection: A Retrospective Analysis of 356 Patients Undergoing Thoracoscopic Esophagectomy. (Pubmed Central) - Jan 6, 2022
This suggests that other mechanisms like, increased plasmid copy numbers or gene amplification or deficiency in the expression/function of porins might be responsible for AMC-resistance in waterborne E. coli. ABPC/SBT after esophagectomy was better at preventing early-onset pneumonia compared with CEZ and was feasible regarding the development of antimicrobial resistance.
- | ampicillin/sulbactam / Generic mfg., colistin sulphate / Generic mfg.
Preclinical, Journal: In vitro synergistic effect of colistin and ampicillin/sulbactam with several antibiotics against clinical strains of multi-drug resistant Acinetobacter baumannii. (Pubmed Central) - Jan 1, 2022
ABPC/SBT after esophagectomy was better at preventing early-onset pneumonia compared with CEZ and was feasible regarding the development of antimicrobial resistance. Colistin and ampicillin/sulbactam have substantial synergistic effect with several antibiotics especially doxycycline, co-trimoxazole, azithromycin, and amikacin (with ampicillin/sulbactam) against MDR strains of Acinetobacter baumannii.
- || ceftriaxone / Generic mfg., cefuroxime / Generic mfg.
Clinical, Journal: Antimicrobial resistance of Haemophilus influenzae isolates from pediatric hospitals in Mainland China: Report from the ISPED program, 2017-2019. (Pubmed Central) - Dec 30, 2021
Antimicrobial resistance of H. influenzae deserves our ongoing attention. Third-generation cephalosporin could be the preferred treatment option of infections caused by ampicillin-resistant H. influenzae.
- | Journal: Prevalence of Shiga Toxin-Producing Escherichia coli O157 and Non-O157 Serogroups Isolated from Fresh Raw Beef Meat Samples in an Industrial Slaughterhouse. (Pubmed Central) - Dec 28, 2021
The analysis of the ERIC-PCR results showed five different ERIC types among the STEC isolates. The isolation of different clones STECs from beef and the presence of antibiotic-resistant isolates indicate that more attention should be paid to the hygiene of slaughterhouses.
- | ampicillin/sulbactam / Generic mfg., vancomycin / Generic mfg.
Journal: Comparing Treatment Outcomes of Ampicillin-Sulbactam, Other β-Lactams, and Vancomycin in Blood Culture-Negative Infective Endocarditis. (Pubmed Central) - Dec 27, 2021
This study showed no clear difference in the outcomes of BCNIE as per the antibiotic therapy but suggested the beneficial effect of surgical treatment. With increasing global concern of antimicrobial resistance, it might be reasonable to select ampicillin-sulbactam-based antibiotic therapy while actively considering surgical treatment in BCNIE.
- || Clinical, Observational data, Journal: Adherence to National Antimicrobial Guidelines in Hospitalized Geriatric Patients with Community-Acquired Pneumonia: A Prospective Observational study in a Malaysian Hospital. (Pubmed Central) - Dec 27, 2021
The duration of intravenous antibiotics in patients with severe pneumonia was 6-7 days for 32.2% of patients. The present findings revealed the adherence of antibiotic prescribing practices to the Malaysian National Antimicrobial Guideline 2019 for CAP therapy among geriatric patients and adherence to the CAP criteria for hospital admissions.
- | Retrospective data, Journal: Prevalence and Antimicrobial Resistance of Enterococcus Species: A Retrospective Cohort Study in Italy. (Pubmed Central) - Dec 27, 2021
Studies of surveillance are an important tool to detect changes in the resistance profiles of the main pathogens. These antimicrobial susceptibility patterns are necessary to improve the empirical treatment guideline of infections.
- || ampicillin/sulbactam / Generic mfg.
PK/PD data, Journal: Prostatic Pharmacokinetic/Pharmacodynamic Evaluation of Ampicillin-Sulbactam for Bacterial Prostatitis and Preoperative Prophylaxis. (Pubmed Central) - Dec 22, 2021
For prophylactic use, aiming for a bacteriostatic target of 30% T > MIC, 3 g ampicillin-sulbactam four times daily achieved ?90% expected probability of attaining the bacteriostatic target against E. faecalis and Proteus species when CL = 30 mL/min. Based on prostatic simulations, the present study provides helpful recommendations for the treatment of bacterial prostatitis and preoperative prophylaxis in prostatectomy.
- | ampicillin/sulbactam / Generic mfg.
Observational data, Retrospective data, Journal: Effects of dosing frequency on the clinical efficacy of ampicillin/sulbactam in Japanese elderly patients with pneumonia: A single-center retrospective observational study. (Pubmed Central) - Dec 18, 2021
The present retrospective survey demonstrated that ABPC/SBT treatment for elderly patients with pneumonia and renal dysfunction was more effective with QID than with BID. Therefore, the QID regimen is worthy of consideration to improve the clinical outcomes of ABPC/SBT therapy in the present patient population.
- || Clinical, Journal: Musculoskeletal actinomycosis in children: a case report. (Pubmed Central) - Dec 18, 2021
Pediatric actinomycosis is a rare and challenging infectious disease. Early accurate diagnosis and optimal surgical debridement are important for the management of pediatric actinomycosis.
- || ampicillin/sulbactam / Generic mfg.
Is there any guidance on renal dose adjustments for high dose ampicillin-sulbactam for treatment of CRAB? #IDtwitter @OncIDPharmd @ClancyNeil @pranita_tamma (Twitter) - Dec 2, 2021
- || Clinical, Journal: A Four-year Follow-Up Survey of Antimicrobial Resistance Among Acinetobacter baumannii complex From Inpatients in Southern Brazil. (Pubmed Central) - Dec 1, 2021
Polymyxin B has been the only antimicrobial agent that remain with a good in vitro activity. Strict surveillance and infection control measures are mandatory.
- | ampicillin/sulbactam / Generic mfg., tetracycline / Generic mfg., cloxacillin / Generic mfg.
Observational data, Retrospective data, Journal: Prevalence and Treatment Outcomes of Skin Infections among Elderly Population: A Retrospective Cross-Sectional Study. (Pubmed Central) - Nov 29, 2021
Eczema is the most prevalent skin infection among the elderly population. Age, consumption of alcohol, usage of more than five medicines simultaneously and presence of co-morbidities are the main factors that are involved in better treatment outcomes of skin infections among study population.
- || piperacillin sodium/tazobactam sodium / Generic mfg.
Clinical, Journal: Antibiotic Prophylaxis with Piperacillin-Tazobactam Reduces Post-Operative Infectious Complication after Pancreatic Surgery: An Interventional, Non-Randomized Study. (Pubmed Central) - Nov 29, 2021
Adopting antibiotic prophylaxis based on piperacillin-tazobactam is associated with a reduction in post-operative SSI, particularly superficial-SSIs. Further randomized studies would be warranted to evaluate this antibiotic combination more extensively in preventive strategies.
- | Journal: Antimicrobial Susceptibility and Detection of Virulence-Associated Genes in Escherichia coli Strains Isolated from Commercial Broilers. (Pubmed Central) - Nov 29, 2021
Genotypic analysis of resistance revealed the presence of bla and bla in two isolates from broilers. Commercial broilers can be reservoirs of virulent and resistant genes as well as E. coli causing (extra-)intestinal infections, which can be a potential threat to humans via direct contact and food.
- | ceftriaxone / Generic mfg.
Journal: Antimicrobial Drug-Resistant Salmonella in Urban Cats: Is There an Actual Risk to Public Health? (Pubmed Central) - Nov 29, 2021
No resistance was expressed against ciprofloxacin, ertapenem, imipenem, levofloxacin, piperacillin/tazobactam, and tobramycin. The results of this study highlight a substantial public health issue and medical concern, especially in vulnerable people, such as children, the elderly, and immunocompromised individuals.
- || ampicillin/sulbactam / Generic mfg., levofloxacin / Generic mfg., minocycline / Generic mfg.
Clinical, Journal: Postoperative mediastinitis after cardiac surgery caused by Mycoplasma hominis: a case report. (Pubmed Central) - Nov 24, 2021
M. hominis should be considered when culture-negative purulent discharge is observed or there is no response to standard empiric treatment of postoperative infections.
- || ampicillin/sulbactam / Generic mfg.
To clarify, that’s the dose of ampicillin-sulbactam (9g = 6g ampicillin + 3g sulbactam). If you have sulbactam alone, which we don’t in the US, the dose is 3g sulbactam q8h instead of 9g ampicillin-sulbactam q8h (Twitter) - Nov 24, 2021
- | ampicillin/sulbactam / Generic mfg.
Preclinical, Journal: Effect of Modulation of the Astrocytic Glutamate Transporters' Expression on Cocaine-Induced Reinstatement in Male P Rats Exposed to Ethanol. (Pubmed Central) - Nov 24, 2021
hominis should be considered when culture-negative purulent discharge is observed or there is no response to standard empiric treatment of postoperative infections. Our findings demonstrate that astrocytic glutamate transporters within the mesocorticolimbic area are critical targets in modulating cocaine-seeking behavior while being consuming ethanol.
- || ampicillin/sulbactam / Generic mfg.
Clinical, Journal: Dosing Optimization of Ampicillin-Sulbactam Based on Cystatin C in Elderly Patients with Pneumonia. (Pubmed Central) - Nov 24, 2021
Based on this formula, we calculated the clearance of ampicillin and developed dosing regimens for the elderly. Serum cystatin-c concentration is an ideal index to optimize ampicillin-sulbactam antimicrobial therapy in elderly patients with pneumonia.
- || ampicillin/sulbactam / Generic mfg., ciprofloxacin oral / Generic mfg., trimethoprim/sulfamethoxazole / Generic mfg.
Clinical, Retrospective data, Journal: A Cross-Sectional Assessment of Urinary Tract Infections Among Geriatric Patients: Prevalence, Medication Regimen Complexity, and Factors Associated With Treatment Outcomes. (Pubmed Central) - Nov 24, 2021
Cystitis is the most common UTI observed in older adults. Gender, the burden of polypharmacy, and the presence of comorbidities are the factors that directly affect the treatment outcomes of UTIs among the study population.
- || ampicillin/sulbactam / Generic mfg.
Haha, TY! As peds pharm, I pretty much never think of amp-sulbactam as the total LOL....so 6 gm amp then? Still a lot! Not concerned about toxicity, but supply to sustain that high of a daily dose (9 vials/day), esp. given supply chain issues/shortages. Time to read in entirety. (Twitter) - Nov 23, 2021
- || ampicillin/sulbactam / Generic mfg., ampicillin / Generic mfg.
WoW! That's a lot of ampicillin in the amp-sulbactam dose recommendation....9 gm q8h?! (Twitter) - Nov 23, 2021
- | ampicillin/sulbactam / Generic mfg., amikacin sulfate / Generic mfg., gentamicin sulfate / Generic mfg.
Journal: Optimal First-Line Antibiotic Treatment for Pediatric Complicated Appendicitis Based on Peritoneal Fluid Culture. (Pubmed Central) - Nov 21, 2021
Tazobactam/piperacillin or meropenem is a reasonable first-line antibiotic treatment for pediatric complicated appendicitis. In the case of aminoglycoside use, amikacin is recommended.
- Effect of Intraoperative-Only Antibiotic Prophylaxis Prior to Radical Cystectomy on 90 Day Complication Rate () - Nov 19, 2021 - Abstract #SUO2021SUO_383;
Use of intraoperative-only antibiotic prophylaxis during radical cystectomy with ileal conduit urinary diversion appears safe without increased risk of postoperative UTI or surgical site infection compared to 24-hr antibiotic prophylaxis. The findings seen in this retrospective review should be validated in a prospective, randomized fashion.
- || ampicillin/sulbactam / Generic mfg., nalidixic acid / Generic mfg.
Clinical, Journal: Genomic Epidemiology and Antimicrobial Susceptibility Profile of Enterotoxigenic Escherichia coli From Outpatients With Diarrhea in Shenzhen, China, 2015-2020. (Pubmed Central) - Nov 17, 2021
Antimicrobial resistance mutation/gene profiles of genomes were concordant with the phenotype testing results of 52 representative isolates, which revealed high resistance rate to nalidixic acid (71%), ampicillin (69%), and ampicillin/sulbactam (46%), and demonstrated that the novel L2/4 was a multidrug-resistant lineage. This study provides novel insight into the genomic epidemiology and antimicrobial susceptibility profile of ETEC infections in indigenous adults for the first time, which further improves our understanding on ETEC epidemiology and has implications for the development of vaccine and future surveillance and prevention of ETEC infections.
- | ampicillin/sulbactam / Generic mfg.
Preclinical, Journal: In vitro evaluation of Tc-sultamicillin for infection imaging. (Pubmed Central) - Nov 17, 2021
Sultamicillin is the tosylate salt of the double ester of sulbactam plus ampicillin...Maximum bacterial uptake of Tc-sultamicillin was 80.7 ± 11.00 % at four hours for living S. aureus and 93.2 ± 4.40 % at two hours for E. coli. Bacterial uptake study results show that Sultamicillin has the potential to be a nuclear imaging agent, especially in infections caused by Gram-negative E. coli and gram-positive S. aureus.
- || ampicillin/sulbactam / Generic mfg., cefazolin / Generic mfg.
Clinical, Journal: Surveillance of Wisconsin Organisms for Trends in Antimicrobial Resistance and Epidemiology (SWOTARE): 2018-2019 Report on Enterobacter cloacae and Klebsiella pneumoniae Clinical Isolates. (Pubmed Central) - Nov 5, 2021
With respect to E. cloacae, further surveillance efforts may be necessary in the Northcentral and Southeast regions of Wisconsin. Subanalysis of demographic data indicated cephem-resistance correlates that are not apparent at the statewide level.
- ceftriaxone / Generic mfg., cefuroxime / Generic mfg.
THE NONIRRITATING DELAYED INTRADERMAL CONCENTRATIONS OF COMMONLY USED BETA-LACTAM CONTAINING ANTIBIOTICS OTHER THAN PENICILLIN (Hall B (1st Floor); Monitor 10) - Nov 2, 2021 - Abstract #ACAAI2021ACAAI_955;
There was no irritation with cefazolin, cefuroxime, cefoxitin, ceftazidime, ceftaroline, meropenem, ertapenem, imipenem-cilastatin, ampicillin, ampicillin-sulbactam, and oxacillin...Using a ≥3mm induration cut-off, d-IDTs were positive with piperacillin-tazobactam, ceftriaxone, cefepime, aztreonam, and nafcillin...Conclusions In our cohort NICs for beta-lactam d-IDT were higher than previously reported. Diagnostics of delayed reactions requires further studying.
- || Timcynis (ticarcillin and clavulanic acid) / Emcure Pharma
Clinical, Journal: Analysis of virulence phenotypes and antibiotic resistance in clinical strains of Acinetobacter baumannii isolated in Nashville, Tennessee. (Pubmed Central) - Oct 31, 2021
Strain dependent variations in biofilm and motility are associated with anatomical site of isolation. Biofilm and hemolysis production both have an inverse association with motility in the cohort of strains utilized in this study, and motility and hemolysis were inversely correlated with resistance to numerous antibiotics.
- | ceftriaxone / Generic mfg., sirolimus / Generic mfg.
Journal: Effects of Broad Spectrum Antibiotics on Measurement of Immunosuppressant Drugs. (Pubmed Central) - Oct 28, 2021
This study demonstrated the potential of antibiotic use affecting immunosuppressant levels. Antibiotic interference, especially in transplant patients, may cause erroneous immunosuppression, increasing the likelihood of rejection.
- || ampicillin/sulbactam / Generic mfg.
Clinical, Journal: Raoultella ornithinolytica urinary tract infection in a pediatric patient with T-cell precursor acute lymphoblastic leukemia. (Pubmed Central) - Oct 27, 2021
Antibiotic interference, especially in transplant patients, may cause erroneous immunosuppression, increasing the likelihood of rejection. To the extent of our knowledge, we report the seventh case in a pediatric patient and only the third case of a urinary tract infection in this age group caused by R. ornithinolytica.
- || cefazolin / Generic mfg.
Clinical, Clinical data, Journal: Impact of Cefazolin Shortage on Clinical Outcomes of Adult Patients with Bacteremia Caused by Methicillin-Susceptible Staphylococcus aureus in a Tertiary Care University Hospital. (Pubmed Central) - Oct 25, 2021
Multivariate analysis revealed that the broad-spectrum antibiotics for definitive therapy, such as antipseudomonal penicillin, were associated with treatment failure in patients with MSSA bacteremia (OR = 17, p = 0.003). Hence, narrow-spectrum antibiotics should be prescribed for MSSA bacteremia as alternatives during a cefazolin shortage.
- ceftriaxone / Generic mfg.
[VIRTUAL] EPIDEMIOLOGY OF INFECTIONS IN HOSPITALIZED PATIENTS WITH CIRRHOSIS () - Oct 21, 2021 - Abstract #AASLD2021AASLD_2262;
Among hospitalized patients with cirrhosis, we observed a high prevalence of antibiotic resistant infections . Further studies are warranted to understand broader antibiotic resistance patterns and guide strategies for implementation of prophylactic or empiric antibiotic use .
- || sulbactam-durlobactam (ETX2514SUL) / Entasis Therap, ZAI Lab, Xerava (eravacycline) / SOM Biotech, Ewha Womans University, La Jolla Pharma, PAION
Review, Journal: Contemporary Perspective on the Treatment of Acinetobacter baumannii Infections: Insights from the Society of Infectious Diseases Pharmacists. (Pubmed Central) - Oct 15, 2021
Traditional agents with retained in vitro activity (aminoglycosides, polymyxins, and tetracyclines) are limited by suboptimal pharmacokinetic characteristics, emergence of resistance, and/or toxicity...On balance, cefiderocol and eravacycline demonstrate potent in vitro activity and are well tolerated, but clinical data for patients with CRAB infections do not yet support widespread use...Our preferred regimen for critically ill patients infected, or considered to be at high risk for CRAB, includes meropenem, polymyxin B, and ampicillin/sulbactam...Promising therapies that are in clinical development and/or under investigation include durlobactam-sulbactam, cefiderocol combination regimens, and bacteriophage therapy, which may over time eliminate the need for the continued use of polymyxins. Future goals for CRAB management include pathogen-focused treatment paradigms that are based on molecular mechanisms of resistance, local susceptibility rates, and the availability of well-tolerated, effective treatment options.
- || ampicillin / Generic mfg.
Clinical, Journal: Epidemiology of urinary tract infections in children: Causative bacteria and antimicrobial therapy. (Pubmed Central) - Oct 15, 2021
Escherichia coli is the most common pathogen among pediatric UTIs. For antibacterial therapy, third-generation cephalosporin monotherapy is effective and may not require combination therapy with ampicillin.
- ampicillin/sulbactam / Generic mfg.
[VIRTUAL] ACUTE PULMONARY EMBOLISM COMPLICATED BY PARENCHYMAL CAVITATION AND STERILE NECROSIS () - Oct 13, 2021 - Abstract #CHEST2021CHEST_2260;
Large pulmonary infarcts caused by PEs can develop cavitations that reflect sterile necrosis or secondary infection. Early follow-up imaging should be considered in patients with large pulmonary infarcts.
- Invanz (ertapenem) / Merck (MSD)
[VIRTUAL] ERTAPENEM-INDUCED ENCEPHALOPATHY IN A PATIENT WITH BORDERLINE RENAL FUNCTION AND MULTIPLE RISK FACTORS () - Oct 13, 2021 - Abstract #CHEST2021CHEST_2067;
It is important to be aware of the potential neurotoxicity of ertapenem in a patient with borderline renal functions and potentiating risk factors. In our patient, encephalopathy improved after discontinuation of ertapenem.
- amoxicillin / Generic mfg.
[VIRTUAL] A RARE CASE OF CONCURRENT PULMONARY ACTINOMYCOSIS AND ALLERGIC BRONCHOPULMONARY ASPERGILLOSIS IN A PARTICIPANT OF NATIVE AMERICAN SWEAT LODGE CEREMONIES () - Oct 13, 2021 - Abstract #CHEST2021CHEST_1281;
He was discharged on a prolonged course of ampicillin/sulbactam, subsequently transitioned to amoxicillin, corticosteroids, and voriconazole with significant improvement of respiratory status, imaging, and IgE levels on outpatient follow-up. Pulmonary actinomycosis is a rare cause of airway obstruction and may be more prevalent in patients with underlying respiratory disorders such as ABPA, which may arise following sweat lodge exposure.
- ketamine / Generic mfg.
[VIRTUAL] DOUBLE-EDGED SWORD: STATUS ASTHMATICUS COMPLICATIONS IN AN OPIATE TOLERANT PATIENT () - Oct 13, 2021 - Abstract #CHEST2021CHEST_1032;
After intubation, our patient received fentanyl and propofol, which may have exacerbated his respiratory acidosis, masked opiate withdrawal symptoms, and complicated his extubation... New strategies are needed to manage SAE in opiate tolerant patients.
- dexamethasone / Generic mfg., ceftriaxone / Generic mfg.
[VIRTUAL] CEREBRAL VASCULITIS: A FEARED COMPLICATION OF PNEUMOCOCCAL MENINGITIS IN A CASE OF POSSIBLE AUSTRIAN SYNDROME () - Oct 13, 2021 - Abstract #CHEST2021CHEST_627;
This case also raises the question of whether MRI is indicated to detect signs of vasculitis, ischemia, or thrombosis. With a negative non-contrast CT on admission and a subacute stroke on day three, perhaps this could have been detected earlier with MRI.
- ampicillin/sulbactam / Generic mfg., atovaquone / Generic mfg.
[VIRTUAL] COVID-19 INFECTION AND STEVENS-JOHNSON SYNDROME/TOXIC EPIDERMAL NECROLYSIS: ONE MORE THING TO WORRY ABOUT? () - Oct 13, 2021 - Abstract #CHEST2021CHEST_597;
This case may lead clinicians to include SCAR as a differential when evaluating newly developed cutaneous lesions in COVID-19 patients. It is also essential to monitor the skin when COVID-19 patients are being treated with possible culprits.
- ceftriaxone / Generic mfg.
[VIRTUAL] CATCH ME IF YOU CAN: AN UNUSUAL CASE OF BACTEREMIA FROM ARTHROBACTER CUMMINSII () - Oct 13, 2021 - Abstract #CHEST2021CHEST_542;
Urine cultures initially revealed Escherichia coli and therefore he was deescalated to ceftriaxone...Having completed his course for the urinary tract infection he was changed to ampicillin-sulbactam for the bacteremia... In conclusion, for the routine clinical laboratory, cultures with nonfermenting, short, gram-positive rods without a typical corynebacterial Gram staining result, but with whitish-grayish colonies of <2 mm in diameter, should raise the suspicion of Arthrobacter cumminsii(3).
- [VIRTUAL] FUSOBACTERIUM: AN UNCOMMON CAUSE OF POST-PARTUM SEPTIC SHOCK AND SEPTIC EMBOLI IN A YOUNG FEMALE () - Oct 13, 2021 - Abstract #CHEST2021CHEST_531;
FB is a potentially fatal infection in the postpartum patient. Unless clinicians are aware of this disease process, diagnosis and treatment can be delayed leading to higher morbidity and mortality.3
- ceftriaxone / Generic mfg.
[VIRTUAL] CAPNOCYTOPHAGA CANIMORSUS CAUSING SEPTIC SHOCK IN AN ASPLENIC PATIENT () - Oct 13, 2021 - Abstract #CHEST2021CHEST_522;
Sensitivities were unable to be done as there are no clear Clinical Laboratory and Standards Institute breakpoints for this organism. Literature had shown that C. canimorsus to be sensitive to penicillins.
- [VIRTUAL] CONTAMINANT OR DEADLY INFECTION? () - Oct 13, 2021 - Abstract #CHEST2021CHEST_444;
She was started on Propylthiouracil and stress dose steroids, but propranolol was not started given her vasopressor need...Her antimicrobials were broadened to vancomycin, piperacillin-tazobactam, metronidazole, doxycycline and fluconazole...She received 7 days of IV ampicillin-sulbactam and metronidazole and transitioned to cefadroxil on discharge... Single positive blood cultures for S. Lugdunensis should not be dismissed as contaminants and should be considered in the clinical picture.
- || Baxdela (delafloxacin) / Menarini, Melinta Therap
Clinical, Retrospective data, Journal: Comparative efficacy of delafloxacin for complicated and acute bacterial skin and skin structure infections: results from a network meta-analysis. (Pubmed Central) - Oct 7, 2021
Single positive blood cultures for S. Lugdunensis should not be dismissed as contaminants and should be considered in the clinical picture. Delafloxacin is a promising new antibiotic for ABSSSI demonstrating greater improvement (composite clinical response) compared to ceftobiprole, fusidic acid, iclaprim, telavancin and vancomycin and comparable effectiveness versus standard of care for all outcomes considered in the study.