- |||||||||| 5-fluorouracil / Generic mfg.
A novel splicing factor, SPF45/RBM17, might influence 5-FU resistance of gastric carcinoma (Section 44) - Mar 5, 2024 - Abstract #AACR2024AACR_3672;
75 SPF45-positive-patients who received 5FU-based adjuvant chemotherapy (S-1, UFT, 5-DFUR) after surgery had significantly worse recurrence-free survival (RFS) than 140 SPF45-negative-patients (p=0.027)... Our results suggest that the splicing factor SPF45 influences anticancer drugs such as 5-FU resistance in gastric cancer.Acknowledgments: We thank Kazuhiro Fukumura and Akila Mayeda, Fujita Health University.
- |||||||||| Furtulon (doxifluridine) / Roche
Preclinical, Journal: Optimizing ex vivo culture conditions to study human gut microbiome. (Pubmed Central) - May 15, 2023
Our results revealed obvious variation in drug metabolism by microbiome from different donors, especially levodopa and doxifluridine. This work suggested the optimized culture medium had the potential for exploring the inter-individual impacts of host gut microbiome on drug metabolism.
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PK/PD data, Preclinical, Journal: Diurnal Changes in Capecitabine Clock-Controlled Metabolism Enzymes Are Responsible for Its Pharmacokinetics in Male Mice. (Pubmed Central) - Feb 10, 2023
Results indicated the levels of carboxylesterase 1 and 2, cytidine deaminase, uridine phosphorylase 2, and dihydropyrimidine dehydrogenase (p < 0.05) are being rhythmically regulated and, in turn, attributed different pharmacokinetics profiles of capecitabine and its metabolism. This study highlights the importance of capecitabine administration time to increase the efficacy with minimum adverse effects.
- |||||||||| Furtulon (doxifluridine) / Roche
Clinical, Journal, Adverse events: Fluoropyridmidine use and hypertriglyceridemia among Japanese patients: analysis of adverse event database. (Pubmed Central) - Feb 26, 2022
Multivariate logistic analysis showed that both hypertriglyceridemia and an increase in serum triglyceride levels among fluoropyrimidines users were significantly associated with doxifluridine use (odds ratio [OR] 42.50; 95% CI 5.34-338.00; P < .001), tegafur use (OR 9.56; 95% CI 2.08-43.90; P < .001), capecitabine use (OR 12.30; 95% CI 2.67-56.80; P < .001), and breast cancer (OR 5.61; 95% CI 1.07-29.50; P = .042). Conclusion This study suggests that the use of tegafur and doxifluridine is associated with an increased risk of hypertriglyceridemia similar to that with the use of capecitabine; in particular, fluoropyrimidine users with breast cancer may have a high risk of hypertriglyceridemia.
- |||||||||| Furtulon (doxifluridine) / Roche
Journal: Construction of synergistic pH/HO-responsive prodrug for prolonging blood circulation and accelerating cellular internalization. (Pubmed Central) - Feb 19, 2022
The shielding group (5'-DFUR) was found to be effective in prolonging circulation at physiological pH 7.4 and improving accumulation in the acidic microenvironment of the tumor. Based on this strategy, the stability and stimulus responsive properties of prodrug could enhance drug release efficiency and exhibit fewer side effects, thereby providing a unique opportunity for diagnosis and imaging additional analytes or enzymatic activities.
- |||||||||| fluorouracil / Generic mfg.
Preclinical, Review, Journal: In Vitro Assessment of Fluoropyrimidine-Metabolizing Enzymes: Dihydropyrimidine Dehydrogenase, Dihydropyrimidinase, and β-Ureidopropionase. (Pubmed Central) - Jul 28, 2020
This is due to several studies that evaluated FP activities after enzyme metabolism using transient expression systems in Escherichia coli or mammalian cells; however, there are no comparative reports of these results. Thus, in this review, we summarized the results of in vitro analyses involving DPD, DHP, and β-UP in an attempt to encourage further comparative studies using these drug types and to aid in the elucidation of their underlying mechanisms.
- |||||||||| Furtulon (doxifluridine) / Roche, Arimidex (anastrozole) / AstraZeneca, Remedica
Clinical, Review, Journal: Radiation-Associated Angiosarcoma That Developed in the Irradiated Residual Breast after Breast-Conserving Surgery for Breast Cancer-A Case Report and Review of the Literature (Pubmed Central) - Jul 22, 2020
RAAS is rare, but it should be considered in patients with skin lesions, such as erosion and bloody bulla, after BCS and RT for breast cancer. To our knowledge, only 12 cases of RAAS, including the present case, have been reported in Japan, and we reviewed the Japanese RAAS cases in comparison with those reported in the Western literature.
- |||||||||| Furtulon (doxifluridine) / Roche, capecitabine / Generic mfg.
Journal: Glycosyl ortho-(1-phenylvinyl)benzoates versatile glycosyl donors for highly efficient synthesis of both O-glycosides and nucleosides. (Pubmed Central) - May 13, 2020
This glycosylation protocol enjoys the various features, including readily prepared and stable donors, cheap and readily available promoters, mild reaction conditions, good to excellent yields, and broad substrate scopes. In particular, the applications of the current glycosylation protocol are demonstrated by one-pot synthesis of several bioactive oligosaccharides and highly efficient synthesis of nucleosides drugs capecitabine, galocitabine and doxifluridine.
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