prednisolone / Generic mfg. 
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  • ||||||||||  prednisolone / Generic mfg.
    Point of care blood eosinophil guided oral prednisolone for COPD exacerbations: a multi-centre double blind randomised controlled trial (The STARR2 trial) (Windsor, 5th floor) -  Nov 15, 2022 - Abstract #BTSWM2022BTS_WM_226;    
    P4
    There were no statistically or clinically meaningful difference in the COPD assessment test, forced expiratory volume in 1 second and the symptom visual analogue scales between participants in the eosinophil-biomarker guided and standard care armsConclusion Reduction of prednisolone therapy, using near-patient testing can be safely performed using an eosinophil-biomarker guided approach in primary care for treatment of an exacerbation of COPD. This should become part of clinical practice.Trial Registration NCT04458636 Please refer to page A208 for declarations of interest related to this .
  • ||||||||||  enzalutamide capsule / Generic mfg., docetaxel / Generic mfg.
    P3 data, Journal:  Continuous enzalutamide after progression of metastatic castration-resistant prostate cancer treated with docetaxel (PRESIDE): an international, randomised, phase 3b study. (Pubmed Central) -  Nov 8, 2022   
    P3
    Neonatal lupus liver disease is a rare cause of neonatal cholestasis that can rarely present with neonatal hemochromatosis picture which unlike other causes of neonatal hemochromatosis can be reversed with steroid therapy. PRESIDE met its primary endpoint and showed that continuing enzalutamide with docetaxel plus androgen deprivation therapy delayed time to progression compared with docetaxel plus androgen deprivation therapy alone, supporting the hypothesis that enzalutamide maintenance could control persistent androgen-dependent clones in men with mCRPC who progress after treatment with enzalutamide alone.
  • ||||||||||  prednisolone / Generic mfg.
    Enrollment open:  RhinoPOCRCT: Oral Prednisolone for Acute Rhinovirus Induced Wheezing in Children Less Than 2 Years of Age (clinicaltrials.gov) -  Nov 7, 2022   
    P4,  N=210, Recruiting, 
    PRESIDE met its primary endpoint and showed that continuing enzalutamide with docetaxel plus androgen deprivation therapy delayed time to progression compared with docetaxel plus androgen deprivation therapy alone, supporting the hypothesis that enzalutamide maintenance could control persistent androgen-dependent clones in men with mCRPC who progress after treatment with enzalutamide alone. Not yet recruiting --> Recruiting
  • ||||||||||  prednisolone / Generic mfg.
    Journal, Video:  Bilateral cholesterol granulomas in the middle ear cavities of a cat with sinonasal disease successfully removed via video-otoscopy. (Pubmed Central) -  Nov 4, 2022   
    CONCLUSION Treatment of all risk classes of APML with ATO and ATRA without chemotherapy is associated with excellent long-term outcomes in the real-world setting. To our knowledge, this is the first case of bilateral CGs diagnosed with a combination of CT, MRI, VO, and histopathology and removed minimal invasively via VO, without a need for ventral bulla osteotomy, which led to complete remission of all signs and no relapse until the follow up 6 months later.
  • ||||||||||  prednisolone / Generic mfg.
    Trial completion date, Trial primary completion date:  Effect of Prednisolone Treatment on Uterine Natural Killer Cells (clinicaltrials.gov) -  Nov 1, 2022   
    P3,  N=84, Recruiting, 
    This case reinforces the need for thorough clinical evaluation of hypoglycemia to allow prompt and definitive management. Trial completion date: Apr 2023 --> Apr 2028 | Trial primary completion date: Apr 2022 --> Apr 2027
  • ||||||||||  prednisolone / Generic mfg., prednisone / Generic mfg.
    Journal:  Dutch guideline to prevent perioperative pulmonal complications: how is the adherence? (Pubmed Central) -  Oct 28, 2022   
    There are also notable differences between the vision of pulmonologists and the anesthesiologists. Further research is needed to solidify the guideline, anticipating aforementioned compliance barriers to achieve better implementation.
  • ||||||||||  prednisolone / Generic mfg.
    Journal:  Erythematous flexural eruption in a young man. (Pubmed Central) -  Oct 25, 2022   
    He had received topical corticosteroids, antifungals and oral prednisolone without improvement. Histopathological examination revealed confluent parakeratosis with retention of basophilic keratohyalin granules within the stratum corneum.
  • ||||||||||  Actemra IV (tocilizumab) / Roche, JW Pharma
    Journal:  Acute heart failure due to left common iliac arteriovenous fistula: A case of VEXAS syndrome. (Pubmed Central) -  Oct 21, 2022   
    Although the patient achieved remission with high-dose oral prednisolone, the inflammatory symptoms relapsed, and he was resistant to colchicine and cyclosporine...We treated him with tocilizumab in addition to prednisolone, and the febrile events and elevated C-reactive protein levels improved...This case suggests that arteriovenous fistula could be a complication of VEXAS syndrome with large-vessel vasculitis, and adequate surgical intervention and prompt diagnosis are essential for rescue. Although arteriovenous fistula is a rare complication of VEXAS syndrome, physicians should be aware of this complication to ensure prompt diagnosis and timely surgical intervention.
  • ||||||||||  Humira (adalimumab) / Eisai, AbbVie
    Clinical, Journal:  Unique Features of Posterior Ocular Involvement of Whipple's Disease in a Patient with No Gastrointestinal Symptoms. (Pubmed Central) -  Oct 18, 2022   
    A diagnosis of noninfectious uveitis was made and oral prednisolone was started...Because of the initial response, the anti-tumor necrosis factor agent Adalimumab was started...WD was considered and confirmed by polymerase chain reaction test and duodenal biopsy. Posterior ocular involvement in WD may present with a wide clinical spectrum including intraocular inflammation and unique features of sub-RPE deposits, widespread retinal hemorrhages, and optic disc edema.
  • ||||||||||  Spikevax (elasomeran) / Moderna
    Journal:  Vogt-Koyanagi-Harada Disease following mRNA-1273 (Moderna) COVID-19 Vaccination. (Pubmed Central) -  Oct 18, 2022   
    After treatment with oral prednisolone, the serous retinal detachment resolved and vision improved. COVID-19 vaccination might be associated with VKH disease development, and the ingredients of the mRNA vaccine or viral peptide encoded by mRNA may have activated the immunological process and induced VKH disease.
  • ||||||||||  prednisolone / Generic mfg.
    Journal:  Case Report: Retinal vasculitis in two adolescents after COVID-19 vaccination. (Pubmed Central) -  Oct 14, 2022   
    Both patients' retinal vasculitis settled with a short course of oral prednisolone...mRNA vaccinations may cause an autoimmune reaction via host antigenic mimicry, and systemic vasculitis has previously been described. We believe that a short interval between COVID-19 vaccination doses might be a risk factor for the development of retinal vasculitis in adolescents, and clinicians should be aware to elicit vaccination history.
  • ||||||||||  Rituxan (rituximab) / Biogen, Zenyaku Kogyo, Roche
    Outcomes of Idiopathic Membranous Nephropathy: A Single Centre Experience (Exhibit Hall, Orange County Convention Center, West Building) -  Oct 13, 2022 - Abstract #KIDNEYWEEK2022KIDNEY_WEEK_1523;    
    Conclusion We have been unable to identify a difference in outcomes between C+P and Tac immunosuppression treatment regimens. Published literature suggest Rituximab is superior in patients who are PLA2R antibody positive and we are in the process of analysing this in our population.
  • ||||||||||  Azilva (azilsartan) / Takeda, Entresto (sacubitril/valsartan) / Novartis, ROVI Pharmaceuticals Laboratories
    Glomerular Microangiopathy in a Patient With Takayasu Arteritis (Exhibit Hall, Orange County Convention Center, West Building) -  Oct 13, 2022 - Abstract #KIDNEYWEEK2022KIDNEY_WEEK_1482;    
    Thus, while oral prednisolone was started to suppress TA-induced inflammation, azilsartan was replaced with sacubitril valsartan, an angiotensin receptor-neprilysin inhibitor (ARNI), for treating refractory hypertension...In the present case, ARNI significantly reduced sBP which might directly contribute to the improvement of proteinuria. ARNI can be potent to control hypertension more effectively than conventional hypertensive agents in TA patients.
  • ||||||||||  prednisolone / Generic mfg.
    Journal:  IgG4-related Inflammatory Pseudotumor with Imaging Findings Similar to Meningioma: A Case Report. (Pubmed Central) -  Oct 13, 2022   
    Tumorectomy was discontinued because of the intraoperative rapid diagnosis, which revealed the infiltration of lymphocytes and plasma cells. She received oral prednisolone therapy for IgG4-related inflammatory pseudotumor, and the tumor size had significantly decreased after six months of treatment.
  • ||||||||||  Remicade (infliximab) / Merck (MSD), Mitsubishi Tanabe, J&J
    Development of symptomatic hyponatremia due to salt-losing nephropathy from ciclosporin A used for acute severe ulcerative colitis () -  Oct 4, 2022 - Abstract #AGW2022AGW_455;    
    The use of CsA for ASUC can cause several serum electrolyte abnormalities; however, hyponatremia is uncommon, and the mechanism can be difficult to identify and manage. If a salt-losing nephropathy is suspected, given it is usually reversible and dose dependent, a reduction in the CsA dose to target a lower trough level, if the patient's colitis is well controlled, and use of oral sodium replacement appear to be pragmatic solutions.
  • ||||||||||  Comirnaty (tozinameran) / Pfizer, Fosun Pharma, BioNTech, Vaxzevria (ChAdOx1-S recombinant) / Oxford Biomedica, Emergent Biosolutions, Jenner Institute, Vaccitech, AstraZeneca, University of Oxford
    Liver injury due to COVID-19 vaccination () -  Oct 4, 2022 - Abstract #AGW2022AGW_334;    
    These case reports show that COVID-19 vaccination is a rare cause of drug-induced liver injury, with varying patterns of liver function derangement. This highlights the importance of obtaining an accurate vaccination history in the evaluation of patients with deranged LFT results to establish the diagnosis.
  • ||||||||||  prednisolone / Generic mfg., budesonide / Generic mfg.
    Esophageal stricture prophylaxis following extensive endoscopic resection () -  Oct 4, 2022 - Abstract #AGW2022AGW_293;    
    Stricture prophylaxis in this group does not prevent strictures from forming but likely decreases their severity and avoids unplanned presentations with dysphagia. This study highlights the importance of stricture prophylaxis and the need for additional studies to improve the efficacy of available treatments.
  • ||||||||||  prednisolone / Generic mfg.
    Journal:  Acute Idiopathic Blind Spot Enlargement Syndrome-New Perspectives in the OCT Era. (Pubmed Central) -  Sep 24, 2022   
    Two patients received weight-adapted oral prednisolone, which was gradually tapered over six to eight weeks...Early corticosteroid treatment may support outer retinal reorganisation, which can be followed with OCT in accordance with visual field restoration. This should be addressed in a prospective study.
  • ||||||||||  prednisolone / Generic mfg.
    CXCR4-targeted Functionally Selective Immunomodulator Shows Robust Efficacy in Pristane-induced Murine Lupus Model (Virtual Poster Hall) -  Sep 17, 2022 - Abstract #ACRConvergence2022ACR_CONVERGENCE_2331;    
    Treatment rapidly induced decreased levels of anti-dsDNA antibodies, which were maintained, and decreased levels of key pro-inflammatory cytokines in serum at study end. The suppression of kidney interstitial inflammation with ER145 treatment is convincing and suggests that with time, it would have impacted glomerular pathology and tubular cast formation.
  • ||||||||||  dexamethasone / Generic mfg., prednisolone / Generic mfg.
    Observational data, Retrospective data, Journal:  Exposure to corticosteroids in the first trimester is associated with an increased risk of urogenital congenital anomalies. (Pubmed Central) -  Sep 10, 2022   
    The findings of this study, the largest of its kind, suggest that caution should be heeded when prescribing corticosteroids to women undergoing IVF/ICSI, given that this study has now identified three previously unassociated serious neonatal complications (talipes, hypospadias and cryptorchidism), plus a potential alteration in sex ratio. Physicians should be careful in using corticosteroids in the critical first trimester and should counsel patients regarding the potential risks of this treatment.
  • ||||||||||  prednisolone / Generic mfg.
    Journal:  Lung Cancer Complicated by Relapsing Polychondritis. (Pubmed Central) -  Sep 8, 2022   
    We finally diagnosed him with lung cancer complicated by relapsing polychondritis. Treatment with oral prednisolone was initiated, followed by sequential chemoradiotherapy for lung cancer.