- |||||||||| Enbrel (etanercept) / Takeda, Pfizer, Amgen, Entyvio (vedolizumab) / Takeda
A Case of IgA Vasculitis in Crohn’s Disease and Recurrent Clostridioides difficile Infection (Exhibit Halls 3 and 4 (Street Level)) - Aug 8, 2019 - Abstract #ACG2019ACG_2830; This case highlights anti-TNF therapy, infection and inflammatory bowel diseases as potential causes of systemic vasculitis. A high clinical suspicion is needed in order to obtain an early histopathologic diagnosis for IgAV and prompt evaluation of other organ system involvement.
- |||||||||| Remicade (infliximab) / Mitsubishi Tanabe, J&J, Entyvio (vedolizumab) / Takeda, Humira (adalimumab) / Eisai, AbbVie
A Double Whammy: A Case of Anterior Uveitis and Optic Neuritis in Patient With Crohn’s Disease on TNF Inhibitor Therapy (Exhibit Halls 3 and 4 (Street Level)) - Aug 8, 2019 - Abstract #ACG2019ACG_2817; The Adalimumab was discontinued, and the patient declined Vedolizumab as an alternative therapy...Both partial improvement and complete resolution of symptoms from optic neuritis has been reported upon discontinuation of TNF inhibitor therapy. Our patient continues to be off all biologics and his vision continues to improve.
- |||||||||| Remicade (infliximab) / Mitsubishi Tanabe, J&J
Orofacial Granulomatosis: The Proof Is in the (Cinnamon) Pudding (Exhibit Halls 3 and 4 (Street Level)) - Aug 8, 2019 - Abstract #ACG2019ACG_2811; Despite pro-active optimisation of Infliximab and Azathioprine levels, her oral manifestations of Crohn’s disease worsen (image 2)...The debate regarding whether OFG is a distinct disease entity from oral CD continues. More studies are required to guide treatment options in this group of patients.
- |||||||||| Mastocytosis Complicated by Upper and Lower GI Bleeding (Exhibit Halls 3 and 4 (Street Level)) - Aug 8, 2019 - Abstract #ACG2019ACG_2698;
She was on a chronic high-dose of famotidine and prednisolone taken as needed...Oral corticosteroids may relieve malabsorption and ascites in the rare cases of liver involvement. Lifestyle modifications include avoidance of triggers and stress management if possible.
- |||||||||| Rituxan (rituximab) / Roche, Biogen
A Rare Case of Primary Colonic Lymphoma With Paraneoplastic Hypercalcemia (Exhibit Halls 3 and 4 (Street Level)) - Aug 8, 2019 - Abstract #ACG2019ACG_2466; Hypercalcemia in NHL is mostly due to extrarenal production of 1,25-dihydroxyvitamin D facilitated by the 1α-hydroxylase enzymes in the macrophages that surrounds the malignant lymphocytes. In most series, surgery followed by multiagent chemotherapy (R-CHOP) has led to improved outcome.
- |||||||||| Simponi (golimumab) / Merck (MSD), Mitsubishi Tanabe, J&J
An Unexpected Cause of Colonic Ulcers in a Young Chinese Male Resulting in a Total Colectomy - Intestinal Behcet’s Disease (Exhibit Halls 3 and 4 (Street Level)) - Aug 8, 2019 - Abstract #ACG2019ACG_2415; Case Description/ A 32-year-old Chinese male with HLA-B27 positive spondyloarthropathy was undergoing treatment with golimumab and methotrexate...Intravenous hydrocortisone and heparin were started...Treatment included prednisolone, cyclophosphamide, and he was later transitioned to azathioprine...Endoscopic features may be helpful but are not pathognomonic of GIBD. This case highlights the diagnostic and management difficulties in GIBD and need for heightened awareness as outcomes in GIBD are potentially catastrophic.
- |||||||||| Rituxan (rituximab) / Roche, Biogen
Rare Presentation of Large Pancreatic Mass With Chylous Ascites (Exhibit Halls 3 and 4 (Street Level)) - Aug 8, 2019 - Abstract #ACG2019ACG_2341; Long term remission can be obtained with CHOP chemotherapy alone in majority of patients. Addition of rituximab results in overall improvement in patient survival.
- |||||||||| Tamoxis (tamoxifen) / Bioprofarma
A Bloody Mess: A Rare Cause of Ascites From a Different Field of Medicine (Exhibit Halls 3 and 4 (Street Level)) - Aug 8, 2019 - Abstract #ACG2019ACG_1278; Other causes include malignancy, infections, and various rheumatologic conditions. Management is based on the offending cause (e.g., stopping PD) but is largely empiric, based on case reports and series utilizing prednisolone and/or tamoxifen.
- |||||||||| prednisolone / generics
An Unusual Complication of Acute Viral Hepatitis A: Hemolytic Anemia (Exhibit Halls 3 and 4 (Street Level)) - Aug 8, 2019 - Abstract #ACG2019ACG_1218; Prednisolone 40mg daily was initiated given concern for hemolytic anemia...However, no studies prove which intervention is the most effective. Anemia typically recovers as acute HAV resolves.
- |||||||||| prednisolone / generics
Revised Lille Score for Predicting 90 Days Mortality in Severe Alcoholic Hepatitis (Exhibit Halls 3 and 4 (Street Level)) - Aug 8, 2019 - Abstract #ACG2019ACG_1082; Apart from all parameters included in the Lille score, transferrin saturation was identified as an independent predictor of 90-days mortality on univariate analysis (Table 1). Revised Lille score was generated by the formula mentioned below.
- |||||||||| azathioprine orodispersible / Generic Mfg.
NUDT 15 C415T Variant as a Cause of Azathioprine-Induced Pancytopenia With Severe Sepsis (Exhibit Halls 3 and 4 (Street Level)) - Aug 8, 2019 - Abstract #ACG2019ACG_1003; In this report, we present a case of Azathioprine toxicity with pancytopenia with severe sepsis in a young patient with homozygous NUDT 15 variant and wild type TPMT genotype. This case, along with recent researches enlightens us to consider NUDT 15 variant analysis before starting thiopurines in any patient, particularly in Asian population.
- |||||||||| prednisolone / generics
Clinical, Journal: A case of IgG4-related kidney disease with predominantly unilateral renal atrophy. (Pubmed Central) - Aug 7, 2019 ...She was treated with prednisolone (PSL) 30 mg/day, and her AIP symptoms promptly improved, after which the PSL dose was gradually tapered to 5 mg/day...1 month after administration, multiple low-density lesions on both kidneys were improved slightly but almost all lesions persisted as atrophic scars. Our case suggested that unilateral renal atrophy can develop in patients with IgG4-related tubulointerstitial nephritis without hydronephrosis caused by retroperitoneal fibrosis, and that monitoring the serum creatinine levels is not always sufficient, thereby highlighting the importance of regular imaging monitoring to detect newly developing kidney lesions.
- |||||||||| vamorolone (VBP15) / Santhera
Journal: Membrane Stabilization by Modified Steroid Offers a Potential Therapy for Muscular Dystrophy Due to Dysferlin Deficit. (Pubmed Central) - Aug 7, 2019 Instead, prednisolone treatment increased muscle weakness and myofiber atrophy in B6A/J mice-findings that correlate with reports of prednisolone worsening symptoms of LGMD2B patients. Our findings showing improved cellular and pre-clinical efficacy of vamorolone compared to prednisolone and better safety profile of vamorolone indicates the suitability of vamorolone for clinical trials in LGMD2B.
- |||||||||| Veramyst (fluticasone furoate nasal spray) / GSK
Journal: OTC drugs for seasonal allergies. (Pubmed Central) - Aug 6, 2019 Leukocyte migration test may be more useful than DLST for this purpose, but further clinical studies are necessary to verify effectiveness.. No abstract available
- |||||||||| prednisolone / generics
Journal: Prednisolone in phospholipid nanoparticles: prolonged circulation and increased antiinflammatory effect (Pubmed Central) - Aug 3, 2019 Maximal suppression (62.2% as compared with 49.6% for free prednisolone) was observed even at a minimal dose (2.5 mg/kg), at which the free drug did not act at all. The results indicate an increase in the efficiency of prednisolone included in phospholipid nanoparticles, that makes it possible to diminish its administered doses and thereby reduce the risk of side effects.
- |||||||||| hydroxychloroquine / VG Lifesciences
Clinical, Journal: Effectiveness and safety of hydroxychloroquine therapy with or without corticosteroid in patients with systemic lupus erythematosus. (Pubmed Central) - Aug 1, 2019 Our case suggested that a patient with cryoglobulinemia and persistent organ manifestations can receive a renal graft if the cryoglobulin concentration is sufficiently controlled by pretransplant treatment. The results of this study suggested that, with attention paid to possible adverse events immediately after initiation, HCQ may be initiated as a mainstay of SLE therapy in Japanese patients, either as a concomitant medication in the remission induction phase, as a maintenance therapy, or as a monotherapy.
- |||||||||| hydroxychloroquine / VG Lifesciences
Clinical, Journal: Low additive effect of hydroxychloroquine on Japanese patients with systemic lupus erythematosus taking calcineurin inhibitor. (Pubmed Central) - Aug 1, 2019 The results of this study suggested that, with attention paid to possible adverse events immediately after initiation, HCQ may be initiated as a mainstay of SLE therapy in Japanese patients, either as a concomitant medication in the remission induction phase, as a maintenance therapy, or as a monotherapy. The addition of HCQ reduced disease activity, PSL dose, and flares in Japanese SLE patients but conferred less additive clinical efficacy when added to CNIs.
- |||||||||| Rituxan (rituximab) / Roche, Biogen
Journal: Treatment of Acute Kidney Injury in Hemolythic Uremic Syndrome (TTP). (Pubmed Central) - Aug 1, 2019 early diagnosis and early start of plasmapheresis therapy is vital for treatment of patients with acute kidney injury and TTP (HUS). A small number of patients is refractory to plasmapheresis and introducing Rituximab and plasmapheresis treatment is recommended.
- |||||||||| prednisolone / generics
Clinical, Journal: A Proposal of a Clinically Based Classification for Idiopathic Granulomatous Mastitis (Pubmed Central) - Aug 1, 2019 CONCLUSIONS With the advances in the desensitizing procedures in the developing world, kidney transplantation across a combined HLA and ABO incompatible barrier can be offered to these highly sensitized patients, even in case of retransplantation. ...D were treated by a combination of surgery and prednisolone...Treatment of IGMin any institution should be the responsibility of a multidisciplinary team.
- |||||||||| ciprofloxacin / generics, dexamethasone / generics, ibuprofen / generics
Journal: Adrenal insufficiency from steroid-containing complementary therapy: importance of detailed history (Pubmed Central) - Jul 31, 2019 ISRCTN16645249; EudraCT 2010-022489-29. ...She had also received short courses of oral prednisolone for acute asthma exacerbations in the last 2 years...Toxicology analysis showed presence of dexamethasone, ciprofloxacin, paracetamol, diclofenac, ibuprofen and cimetidine in the herbal medication...Patients should be advised to stop taking CAM preparation when it contains steroids and hydrocortisone replacement therapy commenced, with periodic reassessment of adrenal function, and then if indicated weaned accordingly.Patients should be informed about the contents of CAM therapies, so they can make a truly informed choice regarding the risks and benefits.This case also highlights a need to increase regulatory processes over CAM therapies, given their propensity to contain a number of undisclosed medications and potent steroids.
- |||||||||| prednisolone / Generic mfg.
Enrollment open, Trial initiation date: Effect of Prednisolone Treatment on Uterine Natural Killer Cells (clinicaltrials.gov) - Jul 30, 2019 P3, N=84, Recruiting, High variation of drug prices within the same city demonstrates how comparison shopping can provide cost savings for patients and may reduce cost-related nonadherence. Not yet recruiting --> Recruiting | Initiation date: May 2019 --> Jul 2019
- |||||||||| tacrolimus / generics
Journal: Bilateral ciliary body oedema under treatment with ciclosporine (Pubmed Central) - Jul 26, 2019 After application of topical atropine and prednisolone acetate and conversion from cyclosporine to tacrolimus, the ophthalmologic symptoms resolved completely. Since an infectious etiology was not evident, we hypothesize that ciliary body edema was caused by impairment of microvascular integrity by cyclosporine.
- |||||||||| abiraterone acetate / Generic mfg.
Clinical, Clinical guideline, Journal: Optimizing Anticancer Therapy in Metastatic Non-Castrate Prostate Cancer: American Society of Clinical Oncology Clinical Practice Guideline. (Pubmed Central) - Jul 26, 2019 Purpose This clinical practice guideline addresses abiraterone or docetaxel with androgen-deprivation therapy (ADT) for metastatic prostate cancer that has not been treated (or has been minimally treated) with testosterone-lowering agents...LATITUDE and STAMPEDE examined the impact on OS of adding abiraterone (with prednisone or prednisolone) to ADT...Fitness for chemotherapy, patient comorbidities, toxicity profiles, quality of life, drug availability, and cost should be considered in this decision. Additional information is available at www.asco.org/genitourinary-cancer-guidelines .
- |||||||||| prednisolone / generics
Clinical, Journal: Giant cell arteritis without cranial manifestations caused mesenteric involvement: a case report. (Pubmed Central) - Jul 26, 2019 Recognition of paraneoplastic immunoglobulin A nephropathy and early diagnosis of associated malignancy can be life-saving. We hereby report a rare case of mesenteric involvement in GCA without cranial manifestations and elucidate the histopathological features of extracranial GCA in arteries as well as veins and jejunum.
- |||||||||| Rituxan (rituximab) / Roche, Biogen
Retrospective data, Review, Journal: Comparison of up-front treatments for newly diagnosed immune thrombocytopenia - a systematic review and network meta-analysis. (Pubmed Central) - Jul 26, 2019 Recombinant human thrombopoietin agonist containing regimens may be beneficial up-front therapies in addition to the conventional corticosteroid monotherapies. Future head-to-head trials including these regimens and rituximab-containing treatments are necessary in order to overcome the limitations of the small number in our study and determine the most suitable initial therapies for newly diagnosed immune thrombocytopenia.
- |||||||||| prednisolone / generics
Clinical, Journal: Dendritic cell phenotype in severe asthma reflects clinical responsiveness to glucocorticoids. (Pubmed Central) - Jul 26, 2019 Future head-to-head trials including these regimens and rituximab-containing treatments are necessary in order to overcome the limitations of the small number in our study and determine the most suitable initial therapies for newly diagnosed immune thrombocytopenia. Myeloid DC frequency is elevated in SR compared with SS asthmatics, and mDC show a differential response to oral prednisolone therapy.
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