- |||||||||| dapsone / Generic mfg., prednisolone / Generic mfg., azathioprine / Generic mfg.
Navigating the Therapeutic Challenges of Chronic Gestational Pemphigoid: A Case Report (e-Poster Hall) - Aug 8, 2023 - Abstract #EADV2023EADV_1961;
Due to the limited number of reported cases in the literature and considering the similar pathophysiology to bullous pemphigoid, an equivalent approach was adopted, which successfully controlled the dermatosis. Dapsone exerts its anti-inflammatory action by reversibly inhibiting a neutrophil myeloperoxidase that generates a reactive oxygen species from the neutrophil
- |||||||||| Rituxan (rituximab) / Biogen, Zenyaku Holdings, Roche
Adjuvant therapy of severe and/or refractory bullous pemphigoid with immunoadsorption - A prospective monocentric exploratory pilot study - (e-Poster Hall) - Aug 8, 2023 - Abstract #EADV2023EADV_1884;
While remission is achieved in the majority of BP patients by first-line therapy, the guidelines recommend therapy with the anti-CD20 antibody rituximab, high-dose intravenous immunoglobulins, or immunoadsorption (IA) in refractory patients...In addition, all patients received therapy with oral prednisolone (0.5 mg/kg/day, tapered), dapsone (1.5 mg/kg/day) and topical mometasone furoate ointment (lesional application, twice daily)... IA is a relatively safe and effective therapy, even in older age, for patients with severe or refractory BP.
- |||||||||| prednisolone / Generic mfg., prednisone / Generic mfg., methotrexate / Generic mfg.
Trial completion date, Trial primary completion date: CHASM-CS-RCT: Cardiac Sarcoidosis Randomized Trial (clinicaltrials.gov) - Jul 28, 2023
P3, N=194, Recruiting,
The national registry of clinical personal records of primary MPGN could provide an informative insight into the characteristics, clinical features, and treatment approaches for patients with primary MPGN in Japan. Trial completion date: Dec 2024 --> Dec 2025 | Trial primary completion date: Dec 2023 --> Dec 2025
- |||||||||| Some Kids That (South: Hall D-7) - Jul 20, 2023 - Abstract #ASA2023ASA_2916;
Two weeks earlier, the patient had been seen by his primary care physician who prescribed amoxicillin, albuterol, and oral prednisolone for a respiratory tract infection (RTI) with croup...Empirically, the patient received an epinephrine nebulizer and oral prednisolone without improvement of his stridor...Another midazolam 1mg IV dose is administered with good effect.What are your goals for airway management?...Because you wish to maintain spontaneous ventilation, Sevoflurane 2% is started...Rocuronium was administered prior to advancing the ETT with a flexible bronchoscope; rapid return to SpO2 95% and normalization of the heart rate ensued.Could this code event have been prevented?...Pathology revealed poorly differentiated neuroblastoma. The patient was extubated after 7 weeks and discharged home 4 months after arriving in the ED.
- |||||||||| Some Kids That (South: Hall D-7) - Jul 20, 2023 - Abstract #ASA2023ASA_1846;
Two weeks earlier, the patient had been seen by his primary care physician who prescribed amoxicillin, albuterol, and oral prednisolone for a respiratory tract infection (RTI) with croup...Empirically, the patient received an epinephrine nebulizer and oral prednisolone without improvement of his stridor...Another midazolam 1mg IV dose is administered with good effect.What are your goals for airway management?...Because you wish to maintain spontaneous ventilation, Sevoflurane 2% is started...Rocuronium was administered prior to advancing the ETT with a flexible bronchoscope; rapid return to SpO2 95% and normalization of the heart rate ensued.Could this code event have been prevented?...Pathology revealed poorly differentiated neuroblastoma. The patient was extubated after 7 weeks and discharged home 4 months after arriving in the ED.
- |||||||||| prednisolone / Generic mfg.
Successful treatment of skin-limited crystalglobulinemia with oral corticosteroids and review of the literature (Level 6 - Hall 602) - Jul 3, 2023 - Abstract #WCD2023WCD_7784;
She was initiated on a course of oral prednisolone (1 mg/kg/day)...We hypothesize that skin-limited crystalglobulinemia in the setting of MGUS may confer a better prognosis compared to MM, allowing the avoidance of toxic systemic chemotherapy. In these patients, we propose a trial of corticosteroid therapy with serial monitoring for progression of disease
- |||||||||| prednisolone / Generic mfg., thalidomide / Generic mfg., acyclovir / Generic mfg.
Varied uncommon presentation of Erythema nodosum leprosum: A case series () - Jul 3, 2023 - Abstract #WCD2023WCD_7666;
KEY MESSAGE: All our cases had de-novo presentation of uncommon morphology of ENL and were diagnosed on basis of histopathology. Hence in vesicular and pustular lesions in endemic areas of leprosy, ENL should be kept as differential for early diagnosis and treatment
- |||||||||| Localised erythema nodosum leprosum () - Jul 3, 2023 - Abstract #WCD2023WCD_7521;
Reports of localised ENL are rare and may not be immediately recognised because it differs markedly from the more common widespread distribution of ENL. The response of this patient to thalidomide which is effective in managing ENL but not T1R supports the diagnosis of localised ENL
- |||||||||| prednisolone / Generic mfg.
Intralymphatic histiocytosis associated with polymyalgia rheumatica and total hip replacement () - Jul 3, 2023 - Abstract #WCD2023WCD_7027;
In view of the raised inflammatory markers and PMR symptoms oral prednisolone 15mg once daily was started...It presents with isolated asymmetrical plaques, macules or nodules and often presents in patients with underlying rheumatoid arthritis, malignancy, and metal implantation. This is the first case in the literature of ILH associated with PMR and a THR
- |||||||||| prednisolone / Generic mfg., hydrocortisone / Generic mfg., mycophenolate mofetil / Generic mfg.
Toxic epidermal necrolysis like presentation of lupus erythematosus: A series of two pediatric cases () - Jul 3, 2023 - Abstract #WCD2023WCD_6508;
One of the cases with two consecutive episodes was later started on oral prednisolone and mycophenolate mofetil, because of grade 4 lupus nephritis...There may be history of intake of antipyretics and analgesics for fever and joint pain which may again add to the diagnostic dilemma. Less severe mucosal involvement as compared the extent of skin lesions may help in differentiation
- |||||||||| prednisolone / Generic mfg.
Behcet () - Jul 3, 2023 - Abstract #WCD2023WCD_6333;
The child is treated with oral prednisolone in a tapering dose showing good response and is being followed up... Behcet
- |||||||||| prednisolone / Generic mfg.
Langerhans cell histiocytosis presenting as generalized exfoliative dermatitis () - Jul 3, 2023 - Abstract #WCD2023WCD_6137;
The patient was started on a course of oral prednisolone (0.5mg/kg) in view of the raised eosinophilia which subsequently normalised...KEY MESSAGE: LCH involving the lymph nodes can rarely manifest as generalized exfoliative dermatitis. Elderly patients presenting with acute erythroderma, lymphadenopathy and peripheral eosinophilia raise suspicion to evaluate for underlying systemic disease
- |||||||||| dapsone / Generic mfg.
A cup of tea with a drop of dapsone () - Jul 3, 2023 - Abstract #WCD2023WCD_6115;
The patient had no active lesions and was weaned to 15mg oral daily prednisolone from 87.5mg daily 8 weeks prior...A left buccal lesion appeared, and the patient was commenced on intravenous rituximab...KEY MESSAGE: Myalgia and neutropaenia are known side effects of dapsone. The paper highlights the importance of a thorough medical history including herbal supplementation
- |||||||||| hydroxychloroquine / Generic mfg., prednisolone / Generic mfg.
Ulcerative Pyoderma gangrenosum like Cutaneous Sarcoidosis-A case report () - Jul 3, 2023 - Abstract #WCD2023WCD_6044;
KEY MESSAGE: Ulcerative pyoderma gangrenosum like Sarcoidosis is a rare presentation of cutaneous Sarcoidosis. Clinicopathological correlation is vital in diagnosing rare forms of a recognized clinical entity which paves the way for better clinical outcomes
- |||||||||| Atypical presentation of ganglioneuroma- a case report () - Jul 3, 2023 - Abstract #WCD2023WCD_5487;
It suggested Lupus Erythematous Panniculitis and she was prescribed oral prednisolone, mycophenolate mofetil and hydroxychloroquine...Upon taking the medications for 6 months with no improvement of the lesion, we changed her medicines to oral methotrexate and prednisolone, which resolved her thigh lesion...However, we highlight unusual clinical presentation of ganglioneuroma as tender nodules like in panniculitis and with involvement of striae distensae on the lower abdomen (HPE report). Clinicians should be aware of such presentations of ganglioneuroma during diagnostic dilemma and consider it a differential of panniculitis
- |||||||||| prednisolone / Generic mfg., isotretinoin oral / Generic mfg.
Secondary adrenal insufficiency by pituitary adenoma masked by prolonged steroids in dermatophytosis () - Jul 3, 2023 - Abstract #WCD2023WCD_5468;
Thus the dermatologist should be knowledgeable on indications where steroids should be started and also when to continue or stop the drug. This case also highlights the fact that in this era where young women in pursuit of faster resolution of their cosmetic problem tend to use inappropriate medications leading to medical complications; the duty of dermatologist is to not only treat but to counsel all patients irrespective of severity of their disease or cosmetological problem
- |||||||||| Rituxan (rituximab) / Biogen, Zenyaku Kogyo, Roche
Pemphigus in pregnancy- A catch-22 situation. A series of 2 case scenarios () - Jul 3, 2023 - Abstract #WCD2023WCD_5466;
However, with minimal control in disease activity, she decided to get a medical termination of her pregnancy, following which rituximab was administered as per rheumatoid protocol...She was managed on oral prednisolone, which was tapered to 20 mg/day after achieving initial disease control...KEY MESSAGE: Systemic corticosteroids remain the cornerstone of treatment of a pregnant patient with pemphigus. A consortium of dermatologists and gynaecologists is needed to ensure the best outcome
- |||||||||| Drug induced lupus erythematosus in a HIV infected child, a rare case report () - Jul 3, 2023 - Abstract #WCD2023WCD_5242;
OBSERVATION: A 12 years male child on ART consisting of Lamivudine, Efavirenz and Abacavir for the past five years was brought to the skin outpatient department with fever, non-scaly dusky macular lesions over face, trunk, upper limbs, multiple ulcers and crusted erosions over the lips and hard palate since 7 days...He was managed with Tablet Hydroxychloroquine 50 mg BD and oral Prednisolone syrup starting at 10 mg/day with slow tapering and revised ART consisting of Zidovudine, Lamivudine, Lopinavir and Ritonavir...Drugs causing DILE are procainamide, hydralazine, penicillamine, isoniazid, quinidine, interferon alpha, methyldopa, diltiazem and chlorpromazine. The immunological profile of patients with DILE reveals positive ANA antibodies with homogeneous pattern, positive anti-histone antibodies, negative anti-Smith and generally low or absent anti-double stranded DNA antibodies.
- |||||||||| prednisolone / Generic mfg., fluoxetine / Generic mfg.
A case of Steven-Johnson Syndrome with hyaluronic acid lip fillers () - Jul 3, 2023 - Abstract #WCD2023WCD_5222;
She takes fluoxetine regularly for the past 5 years...We initiated supportive treatments which include intravenous antibiotics, topical corticosteroids of various potency, emollients, oral Prednisolone mouthwash and antiseptic wash...To our best knowledge, this is the first ever case reported where cosmetic procedure has been implicated in a case of SJS. This is particularly relevant with the rising number of cosmetic procedures globally
- |||||||||| azathioprine / Generic mfg.
A case of azathioprine inducing severe myelosuppression and progressive hair loss in a patient with pemphigus vulgaris () - Jul 3, 2023 - Abstract #WCD2023WCD_5215;
This prodrug is activated to form thioguanine nucleotides, its major active metabolites, which are catalyzed by the enzyme nudix hydrolase 15 (NUDT15)...OBSERVATIONS: A 56-year-old woman who presented to our clinic with pemphigus vulgaris was treated with oral prednisolone...For disease control and further reduction of prednisone, oral azathioprine of 100 mg was added...We replaced it with lenograstim...KEY MESSAGE: Administering azathioprine to patients with NUDT15 variants can cause serious complications. Confirming NUDT15 polymorphism before azathioprine administration is desirable, especially in Asians
- |||||||||| CoronaVac / Sinovac, Bio Farma Indonesia, Comirnaty (tozinameran) / Pfizer, Fosun Pharma, BioNTech, Vaxzevria (ChAdOx1-S recombinant) / University of Oxford, Emergent Biosolutions, Jenner Institute, Vaccitech, AstraZeneca
Clinical And Histopathological Correlation Of Covid-19 Vaccine Induced Erythroderma - A Case Series in Ipoh, Malaysia () - Jul 3, 2023 - Abstract #WCD2023WCD_5159;
Three of them required Methotrexate to control their disease...KEY MESSAGE: Erythroderma can be one of the cutaneous manifestations following Covid-19 vaccination. Clinicians should have high index of suspicion about this ADR when encountering patients with erythroderma during this pandemic period
- |||||||||| Rituxan (rituximab) / Biogen, Zenyaku Kogyo, Roche
Rituximab treatment for pediatric pemphigus foliaceous: A case report in a 3-year-old child () - Jul 3, 2023 - Abstract #WCD2023WCD_5087;
It is imperative that practitioners consider PF in the differential diagnosis of children who present with blisters and oozing on the scalp and seborrheic area, which are frequently misdiagnosed as impetigo, inverse psoriasis, seborrheic dermatitis, or LCH. For treatment of pediatric PF, the use of rituximab remains extremely promising
- |||||||||| Olumiant (baricitinib) / Incyte, Eli Lilly, Dupixent (dupilumab) / Sanofi, Regeneron, Rinvoq (upadacitinib) / AbbVie
Erythrodermic atopic dermatitis resistant to dupilumab and baricitinib successfully treated with upadacitinib () - Jul 3, 2023 - Abstract #WCD2023WCD_4943;
Oral prednisolone was stopped, and the patient started cyclosporine 4mg/kg/day and, a month later, dupilumab 300mg q2w...After 8 weeks, there was a noticeable worsening of his AD, so methotrexate 15mg/week was further added to baricitinib, yet no relief was observed at 16 weeks...This case demonstrates the effectiveness of upadacitinib in this group of patients. Additionally, the rapid and remarkable improvement seen in our case supports a role for upadacitinib 30mg ED as first line therapy in the severe cases where rapid relief is needed, such as erythrodermic AD
- |||||||||| apremilast / Generic mfg.
Apremilast In Recalcitrant Dissecting Cellulitis Of Scalp () - Jul 3, 2023 - Abstract #WCD2023WCD_4136;
Thus Apremilast is a promising drug that can be used as definitive treatment in such recalcitrant cases along with adjuvant treatment with systemic corticosteroids. To our knowledge, this is the first case of recalcitrant dissecting cellulitis of scalp treated with Apremilast
- |||||||||| prednisolone / Generic mfg., aspirin / Generic mfg.
Good Outcome Of Late Reperfusion Of The Upper Labial Artery: Better Late Than Never () - Jul 3, 2023 - Abstract #WCD2023WCD_3819;
Delay in diagnosing and treating vascular occlusion can lead to necrosis. In this case, although treatment started 96 hours after the vascular accident, we observed that the use of ultrasound to guide intraarterial hyaluronidase and using high doses played an important role in the outcome
- |||||||||| prednisolone / Generic mfg., cyclophosphamide / Generic mfg.
Journal: Splenic Small Cell Lymphoma with Presumed Secondary Immune-Mediated Hemolytic Anemia in an African Penguin (Spheniscus demersus). (Pubmed Central) - Jun 26, 2023
The penguin was treated with oral prednisolone as an immunomodulatory agent; however, it did not result in a positive treatment response...Additional therapy with cyclophosphamide was initiated, and the penguin improved clinically, but then declined...Microscopic review of submitted postmortem tissue samples demonstrated a monomorphic population of neoplastic small lymphocytes infiltrating the spleen, consistent with splenic small cell lymphoma. The neoplastic cells did not label with the T-cell marker CD3 or B-cell markers CD20, CD79a, and Pax-5.
- |||||||||| PADciclo (ciclosporin ophthalmic) / MC2 Therap, Moorfields Eye Hospital
Journal: Peripheral Ulcerative Keratitis Associated With Lichen Planus. (Pubmed Central) - Jun 16, 2023
Ocular manifestations of lichen planus are rare and mostly involve the conjunctiva; however, PUK might also develop, presumably due to its similar mechanisms with other T-cell autoimmune diseases. Systemic immunosuppression is required initially but further control of the ocular surface can be achieved successfully with topical ciclosporin.
- |||||||||| prednisolone / Generic mfg.
Drug Reaction with Eosinophilia and Systemic Symptoms (Poster Zone A) - Jun 9, 2023 - Abstract #EAACI2023EAACI_2596;
Cats in the GC treatment (GCT) group were given 1 Suspected antibiotics were suspended and oral prednisolone was initiated...
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