- |||||||||| Journal: Presumed Choroidopathy of IgG4-Related Disease Discovered During 16-Year Follow-Up of a Patient With Polycystic Kidney Disease. (Pubmed Central) - Nov 4, 2024
At the age of 52 years, she switched to candesartan 8 mg daily and began to have tolvaptan (a selective competitive vasopressin receptor 2 (V2) antagonist) 90 mg daily for polycystic kidney disease with liver cysts...In the following four years to the latest visit at 61 years, she kept stable but high levels of serum IgG4 around 300 mg/dL. Serum IgG4 measurement is helpful to make a clinical diagnosis and, hence, a clinical decision since the spectrum of IgG4-related disease remains obscure.
- |||||||||| farletuzumab ecteribulin (MORAb-202) / Eisai
Trial completion date, Trial primary completion date: MORAb-202-G000-201: A Study to Evaluate the Safety, Tolerability, and Efficacy of MORAb-202 (Herein Referred to as Farletuzumab Ecteribulin), a Folate Receptor Alpha (FR?)-Targeting Antibody-drug Conjugate (ADC) in Participants With Selected Tumor Types (clinicaltrials.gov) - Oct 31, 2024
P1/2, N=142, Recruiting,
Serum IgG4 measurement is helpful to make a clinical diagnosis and, hence, a clinical decision since the spectrum of IgG4-related disease remains obscure. Trial completion date: Mar 2025 --> Oct 2024 | Trial primary completion date: Mar 2025 --> Oct 2024
- |||||||||| Remicade (infliximab) / J&J, Enbrel (etanercept) / Pfizer, Amgen, Humira (adalimumab) / AbbVie
Journal: Inflammatory back pain as an unusual manifestation of Takayasu arteritis: a case report. (Pubmed Central) - Oct 31, 2024
Oral prednisolone was initiated at a dose of 60 mg/day with symptomatic improvement in both his inflammatory back pain and his chest pain, but he had to be switched to methotrexate and infliximab due to steroid side effects. Inflammatory aortitis should be considered as a possibility during the assessment of inflammatory back pain to mitigate the risks of delayed diagnosis.
- |||||||||| Venclexta (venetoclax) / Roche, AbbVie, Blincyto (blinatumomab) / Astellas, Amgen
Trial completion date, Trial initiation date, Trial primary completion date, Combination therapy: Testing the Addition of the Anti-cancer Drug Venetoclax and/or the Anti-cancer Immunotherapy Blinatumomab to the Usual Chemotherapy Treatment for Infants With Newly Diagnosed KMT2A-rearranged or KMT2A-non-rearranged Leukemia (clinicaltrials.gov) - Oct 15, 2024
P2, N=171, Not yet recruiting,
The patient was administered oral prednisolone that led to noticeable clinical and radiological improvement within three months. Trial completion date: Dec 2027 --> Dec 2028 | Initiation date: Oct 2024 --> Jan 2025 | Trial primary completion date: Dec 2027 --> Dec 2028
- |||||||||| prednisolone / Generic mfg.
Journal: Parvovirus B19-Induced Lower Motor Neuron Facial Nerve Palsy and Cutaneous Small-Vessel Vasculitis: A Case Report. (Pubmed Central) - Oct 14, 2024
The patient was treated with oral prednisolone, resulting in significant improvement in his symptoms over the course of one month...Early diagnosis and appropriate management are crucial for improving patient outcomes in such atypical presentations. This report adds to the growing body of literature on the diverse clinical manifestations of parvovirus B19, emphasizing the importance of recognizing and treating these rare complications promptly.
- |||||||||| docetaxel / Generic mfg.
PNEUMONITIS CHRONICLES: UNRAVELING DOCETAXEL'S VEILED IMPACT- A CASE REPORT () - Oct 11, 2024 - Abstract #ASCOMOS2024ASCOMOS_201;
Risk factors include high cumulative dose (100mg/m2), weekly regimen, co-administration of gemcitabine or radiation and pre-existing lung disease...Given the clinical presentation, negative infective work-up and CT findings, a diagnosis of docetaxel-induced pneumonitis was made and started on oral prednisolone 1mg/kg/day...CONCLUSION Docetaxel-induced pneumonitis, while rare, can lead to life-threatening event. This case underscores the importance of maintaining high index of suspicion among patients who present with respiratory symptoms after administration of docetaxel as prompt recognition and timely initiation of corticosteroid treatment lead to favourable outcome.
- |||||||||| prednisolone / Generic mfg.
Journal: Presumptive motor neuron degeneration in an adult cat. (Pubmed Central) - Oct 2, 2024
Before referral, the cat was treated with immunosuppressive doses of oral prednisolone, intermittently for 6 mo, and had responded well when the immunosuppressive dose was maintained...Key clinical message: In this case, an adult cat had a chronic, progressive history of lower motor neuron weakness and absent spinal reflexes; biopsies revealed a neurogenic pattern of muscle fiber atrophy and histologically normal peripheral nerve and intramuscular nerve branches. Although reports of motor neuron disease are rare in the veterinary literature, this case report highlights the importance of muscle and nerve biopsies that lead to a presumptive diagnosis of motor neuron degeneration.
- |||||||||| prednisolone / Generic mfg., albendazole / Generic mfg.
Journal: Two Case Reports of Isolated Intramuscular Cysticercosis: An Uncommon Pediatric Pseudotumor. (Pubmed Central) - Sep 30, 2024
Magnetic resonance imaging (MRI) is the most accurate way to diagnose intramuscular cysticercosis, as it can show live scolex, cysts, and degenerating cysts. In every case, there is edema to varied degrees, with fluid-filled lesions without peripheral enhancement visible in early stages and peripheral rim augmentation and perilesional edema observed in later stages.
- |||||||||| prednisolone / Generic mfg.
Journal, Adverse events: Low remission rates and high incidence of adverse events in a prospective VEXAS syndrome registry. (Pubmed Central) - Sep 29, 2024
In every case, there is edema to varied degrees, with fluid-filled lesions without peripheral enhancement visible in early stages and peripheral rim augmentation and perilesional edema observed in later stages. Patients with VEXAS syndrome required high-dose glucocorticoids to achieve remission, and complications-such as malignancy, thrombosis, and infection-occurred frequently within a short observation period.
- |||||||||| Desonate (desonide gel) / LEO Pharma, Dupixent (dupilumab) / Sanofi, Regeneron
ALLERGIC CONTACT DERMATITIS TO TOPICAL CORTICOSTEROIDS: WHAT IS THE NEXT STEP IN MANAGEMENT? (Monitor 15; Hall A) - Sep 29, 2024 - Abstract #ACAAI2024ACAAI_935;
Adjustments to treatment, including introduction of pimecrolimus and topical mupirocin ointment, also failed to produce any improvement...However, the patient showed improvement with the administration of oral prednisolone...Patch tests for triamcinolone acetonide, desonide, and fluocinolone acetonide were positive, showing localized inflammation and worsening of eczema at application sites...Early consideration and use of dupilumab can result in notable clinical benefits for such patients. Consent granted from patient's parents to present case.
- |||||||||| URTICARIA PIGMENTOSA PRESENTING AS A BULLOUS RASH IN A 4-MONTH-OLD (Monitor 15; Hall A) - Sep 29, 2024 - Abstract #ACAAI2024ACAAI_673;
The patient was discharged with loratadine, diphenhydramine, saline washes and topical antibiotics for flares...The pediatric AI team started montelukast and oral prednisolone with significant improvement...Bullous Lesions on 4-month old patient Bullous lesions on scalp and in neck folds during initial hospitalization. Abstracts: Medically Challenging Case Abstracts / Ann Allergy Asthma Immunol 00 (2024) 1?110 101
- |||||||||| zilovertamab vedotin (MK-2140) / Merck (MSD)
Enrollment closed, Trial completion date, Trial primary completion date, Combination therapy: waveLINE-007: A Study of Zilovertamab Vedotin (MK-2140) in Combination With Cyclophosphamide, Doxorubicin, and Prednisone Plus Rituximab or Rituximab Biosimilar (Truxima) (R-CHP) in Participants With Diffuse Large B-Cell Lymphoma (DLBCL) (MK-2140-007) (clinicaltrials.gov) - Sep 26, 2024
P2, N=60, Active, not recruiting,
Abstracts: Medically Challenging Case Abstracts / Ann Allergy Asthma Immunol 00 (2024) 1?110 101 Recruiting --> Active, not recruiting | Trial completion date: Jan 2026 --> Apr 2029 | Trial primary completion date: Jan 2026 --> Apr 2029
- |||||||||| ketoconazole / Generic mfg., prednisolone / Generic mfg., griseofulvin / Generic mfg.
Journal: Clinical Consequences of Delayed Treatment for Tinea Capitis (Ringworm of the Scalp): A Case Report. (Pubmed Central) - Sep 13, 2024
This case highlights how there exist areas of improvement in terms of interprofessional communication between physicians, as well a need to increase awareness of the proper treatment for this common pediatric skin condition. We postulate that in doing so, similar cases could be spared the unfortunate results of untreated tinea capitis, that is, kerion formation and the possible scarring this lesion can produce.
- |||||||||| Dupixent (dupilumab) / Sanofi, Regeneron, Nemluvio (nemolizumab-ilto) / Galderma
Journal: A case of bullous pemphigoid following administration of anti-IL-31 receptor A antibody. (Pubmed Central) - Sep 2, 2024
Oral prednisolone (PSL) was initiated and nemolizumab was never used again...Adding high-dose cyclosporine and intravenous gamma globulin reduced new blister formation after 9?weeks, and PSL and cyclosporine were gradually tapered...This may be countered by blocking the IL-4/13 pathway with dupilumab. To our knowledge, this is the first case of nemolizumab-exacerbated BP.
- |||||||||| triamcinolone acetonide / Generic mfg., prednisolone / Generic mfg., prednisone / Generic mfg.
Journal: Suprachoroidal Triamcinolone Injection in Posterior Scleritis: A Case Report. (Pubmed Central) - Aug 27, 2024
Suprachoroidal triamcinolone acetonide (SCS-TA) injections were recently approved to treat macular edema secondary to noninfectious uveitis...She was previously prescribed topical prednisolone and oral prednisone with minimal improvement...Via its novel delivery method, SCS-TA may be an effective treatment for posterior scleritis. Further studies are needed to establish long-term efficacy and safety of this treatment modality.
- |||||||||| prednisolone / Generic mfg., valacyclovir / Generic mfg.
Journal: Focal Posterior Herpetic Retinitis. (Pubmed Central) - Aug 27, 2024
A vitreous tap confirmed a positive result for HSV-1, and the patient was prescribed oral valacyclovir 3?g. This treatment led to a resolution of the retinitis and a restoration of the patient's vision to 20/25.
- |||||||||| Immune Checkpoint Inhibitor-Induced Hemorrhagic Gastritis: Case Report (Exhibit Hall E) - Aug 20, 2024 - Abstract #ACG2024ACG_5596;
Immunotherapy was held and he began metoclopramide and omeprazole...Sucralfate and cyproheptadine were started but he returned one week later for nausea and vomiting with hematemesis and significant weight loss...Treatment with oral prednisolone was initiated and the patient reported complete resolution of symptoms one week later...Ultimately, alternate immunotherapy with nivolumab was initiated without gastritis recurrence...Figure: EGD images showing hemorrhagic, sloughing gastritis with erosions, ulcerations, and friable mucosa throughout the stomach. EGD - esophagogastroduodenoscopy.
- |||||||||| Uncommon Dermatoses of Pregnancy (Poster Area) - Aug 5, 2024 - Abstract #EADV2024EADV_4363;
The patient received local therapy with clobetasol cream, tablet chlorpheniramine p.o. with marked improvement of her skin lesions, the patient was followed up regularly. Management of dermatologic diseases during pregnancy might be challenging as it requires special attention to both mother and fetus.
- |||||||||| Kineret (anakinra) / SOBI, Humira (adalimumab) / AbbVie
Non-classifiable pyoderma gangrenosum-associated autoinflammatory syndrome: successful treatment with anti-IL-1 therapy (Poster Area) - Aug 5, 2024 - Abstract #EADV2024EADV_4224;
Progressive worsening was observed, with large cutaneous aseptic abscesses requiring surgical drainage and maintained therapy with oral prednisolone in a dose above 20 mg per day... Patients may present with a clinical picture suggestive of PGAAIS while not falling into the existing categories, and IL-1 presents itself as a potential therapy, even in these non-classifiable cases.
- |||||||||| prednisolone / Generic mfg.
Utility of High-frequency ultrasonography in the diagnosis of peripheral nerve involvement in leprosy (Poster Area) - Aug 5, 2024 - Abstract #EADV2024EADV_3994;
Considering the slow and incomplete recovery of nerve dysfunction in leprosy, it is important to diagnose nerve pathologies early in the course of the disease to preserve nerve function. HFUS is found to be a simple, non- invasive accurate, reproducible, and objective method to diagnose nerve involvement in Leprosy.
- |||||||||| prednisolone / Generic mfg., acitretin / Generic mfg., azathioprine / Generic mfg.
More Than Meets The Eye (Poster Area) - Aug 5, 2024 - Abstract #EADV2024EADV_3625;
Oral mucosal manifestations of lipoid proteinosis may resemble several other cutaneous and systemic diseases. Histopathological examination as well as genetic analysis and counselling should be carried out.
- |||||||||| hydroxychloroquine / Generic mfg., prednisolone / Generic mfg.
Subcutaneous panniculitis-like T-cell lymphoma and lupus erythematosus profundus: a diagnostic dilemma (Poster Area) - Aug 5, 2024 - Abstract #EADV2024EADV_3369;
In a patient presenting with SPTCL, an associated autoimmune disease should also always be considered and appropriate serology undertaken. When LEP is the dominant histological appearance, the pathologist should look carefully for tiny foci suggestive of SPTCL, particularly as the latter disease may be associated with subsequent development of HLH.
- |||||||||| Mucocutaneous manifestations as a clue for reactive and disabling arthritis (Poster Area) - Aug 5, 2024 - Abstract #EADV2024EADV_3349;
This case highlights the importance of skin inspection facing a case of arthritis, for the diagnosis of a reactive disorder. In our case, keratoderma blenorragica, circinate balanitis and nail dystrophy were the cardinal features.
- |||||||||| Lynparza (olaparib) / Merck (MSD), AstraZeneca
A rare case of erythema gyratum repens in ovarian cancer: a case report (Poster Area) - Aug 5, 2024 - Abstract #EADV2024EADV_3245;
To the best of our knowledge, our report is the first documented case of EGR as a paraneoplastic eruption of ovarian carcinoma. EGR histology is often non-specific, therefore it is crucial that suspected EGR must be diagnosed in correlation with clinical examination.
- |||||||||| Dupixent (dupilumab) / Sanofi, Regeneron
Successful Treatment Of Recalcitrant Bullous Pemphigoid In A 73 Year Old Female With Subcutaneous Dupilumab (Poster Area) - Aug 5, 2024 - Abstract #EADV2024EADV_2673;
We present a case of a 73-year-old lady who had significant symptom burden secondary to BP for over two years refractory to systemic therapy who had complete resolution of pruritis and blistering with dupilumab. There is growing evidence base to suggest safe and efficacious use of this novel therapy for BP patients with significant symptom burden who are unsuitable for common systemic agents.
- |||||||||| generalized lichen planus pigmentosus and a new management approach (Poster Area) - Aug 5, 2024 - Abstract #EADV2024EADV_2671;
There is growing evidence base to suggest safe and efficacious use of this novel therapy for BP patients with significant symptom burden who are unsuitable for common systemic agents. She had Hashimoto hypothyroidism, which was managed with levothyroxine...She had undergone two skin biopsies, both of which indicated atypical findings of Lichen Planus pigmentosus and she was prescribed oral prednisolone (20mg daily); but no significant improvements were detected in her lesions after six months...To our knowledge, this is the first report in which tofacitinib dramatically improves the generalized LPP with palmar involvement.
- |||||||||| Dupixent (dupilumab) / Sanofi, Regeneron, Opdivo (nivolumab) / BMS, Xolair (omalizumab) / Roche, Novartis
Omalizumab and dupilumab (Poster Area) - Aug 5, 2024 - Abstract #EADV2024EADV_2629;
The patient was initially treated with oral prednisolone 0.5mg/kg, doxycycline 100mg twice daily and topical clobetasol propionate...Despite treatment with oral prednisolone, mycophenolate mofetil, IVIg and rituximab her condition continued to progress... Given the many inherent risks and complications associated with immunosuppression in this patient group, targeted therapies such as dupilumab and omalizumab may provide a safe and efficacious option, either as single agents or in severe refractory cases such as this one, as combination therapy.
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