- |||||||||| prednisolone / Generic mfg.
The unusual suspect () - Jun 23, 2022 - Abstract #BAD2022BAD_730;
Where treatment is required, EC normally responds very rapidly to oral prednisolone but can often relapse when the dose is reduced. Our patient responded very well to 6 weeks of oral prednisolone; no relapse was recorded.
- |||||||||| prednisolone / Generic mfg., doxycycline / Generic mfg.
Phototherapy to treat a COVID-19 vaccine reaction () - Jun 23, 2022 - Abstract #BAD2022BAD_712;
Direct immunofluorescence was negative. He received a tapering dose of oral prednisolone with mometasone topically...He was trialled on oral doxycycline for 1 month, which led to a marked improvement in the morbilliform rash...Our case highlights that phototherapy can be used in the treatment of cutaneous side-effects that arise after COVID-19 vaccines. To the best of our knowledge, this case is one of the first to use narrowband UVB phototherapy to treat a cutaneous side-effect of an mRNA vaccine.
- |||||||||| Psoralen / EMD Serono, Remicade (infliximab) / Merck (MSD), Mitsubishi Tanabe, J&J, Rituxan (rituximab) / Biogen, Zenyaku Kogyo, Roche
Eosinophilic fasciitis triggered by intensive exercise () - Jun 23, 2022 - Abstract #BAD2022BAD_677;
Haematological associations have been seen, including aplastic anaemia; lymphoma. Treatment options for EF include prednisolone, UVA1/psoralen + UVA, immunosuppressive systemic agents (including ciclosporin; methotrexate), biological agents (including infliximab; rituximab); physiotherapy.
- |||||||||| An unusual case of secondary syphilis masquerading as pemphigus vulgaris () - Jun 23, 2022 - Abstract #BAD2022BAD_292;
Treatment was commenced with oral prednisolone; aciclovir to cover for a likely superimposed herpes simplex infection, due to the well-circumscribed appearance of the erosions. One week later our patient presented to the emergency department with unilateral weakness; slurred speech...She was commenced on intravenous (IV) steroids, doxycycline; nicotinamide...Treatment was commenced with IV benzylpenicillin; her cutaneous symptoms resolved over the subsequent days...As our case illustrates, syphilis is also associated with a multitude of complications that may further impede or delay diagnosis; recovery for our patients. It is imperative that clinicians continue to have a high index of suspicion for the diagnosis of syphilis in unusual dermatological presentations that are slow to respond to standard treatment.
- |||||||||| piperacillin sodium/tazobactam sodium / Generic mfg., prednisolone / Generic mfg., azacitidine / Generic mfg.
Sweet syndrome: the phenotypic spectrum identified through clinicopathological correlation () - Jun 23, 2022 - Abstract #BAD2022BAD_234;
Despite a week of intravenous piperacillin/tazobactam for a suspected localized infection, there was no improvement; skin biopsies were taken...Oral prednisolone was commenced with full resolution of symptoms; weaned while a further two cycles of azacitidine were given, with no recurrence of SS...The presence of deep extension of the inflammatory infiltrate, in conjunction with necrosis, raises the differential diagnosis of necrotizing SS; necrotizing fasciitis, which requires close clinicopathological; microbiological correlation to reach the correct diagnostic conclusion. Identifying this variant of SS ensures that the correct management is instigated avoiding inappropriate antibiotic use or extensive surgical intervention.
- |||||||||| Severe epidermolysis bullosa acquisita in a patient with graft-versus-host disease: causal or coincidental? (Alsh 1 & 2) - Jun 23, 2022 - Abstract #BAD2022BAD_225;
Dapsone was considered but precluded by G6PD deficiency; there were clinical; adherence concerns about using mycophenolate mofetil...Ann Dermatol Venereol 2014; 141: 369–73 (in French)]. As a fifth case of EBA, our patient provides further evidence of a likely pathophysiological relationship between GvHD; autoimmune subepidermal bullous dermatoses,; highlights the significant challenges of managing these vulnerable patient groups during the COVID-19 pandemic.
- |||||||||| Plasma cell mucositis: a complex and challenging condition (Lomond) - Jun 23, 2022 - Abstract #BAD2022BAD_209;
Surgical intervention is occasionally indicated to treat associated complications such as tracheal strictures. This reported case of plasma cell mucositis, with a wide range of clinical presentations illustrates the diagnostic and management challenges requiring multidisciplinary input across many specialties.
- |||||||||| Stelara (ustekinumab) / J&J
Getting to the bottom of things () - Jun 23, 2022 - Abstract #BAD2022BAD_163;
Tinea incognito was considered but mycology was negative; there was no response to a prolonged course of oral itraconazole...However, when she replaced her toilet seat with a plastic one her rash promptly resolved, allowing methotrexate to be stopped...Severe cases have been linked to exotic hard woods like teak. This case stresses the importance of recognizing characteristic distribution of toilet seat dermatitis; of patch testing patients to their own toilet seats.
- |||||||||| First reported case of parvovirus triggering painful widespread livedoid vasculopathy: another virus causing hypercoagulability? (Lomond) - Jun 23, 2022 - Abstract #BAD2022BAD_155;
Codeine, Oramorph, amitriptyline; pregabalin were required for lower limb pain...Pentoxifylline 400 mg twice daily was also initiated; over months areas slowly healed; after a year, the oral steroids; azathioprine were slowly weaned...Hypercoagulability after viral infection or viral antigen exposure has been hugely topical throughout the COVID-19 pandemic. LV cases that are otherwise being classed as ‘idiopathic’ owing to no autoimmune or coagulopathy being identified could be further investigated for parvovirus; other seasonal virus infections to see if this is an important aetiological factor.
- |||||||||| prednisolone / Generic mfg.
The interest of magnesium sulfate nebulization in asthma exacerbation (TP-15 in thematic poster area) - Jun 22, 2022 - Abstract #ERS2022ERS_3269;
Patients in the placebo group received 0.03 cc /kg of salbutamol + 2.5 cc of saline three times 20 min in combination with each oral prednisolone...The difference in the MPIS score between the two groups was not significant (p > 0.05) for reduced seizures (MPIS less than 10) as well as for severe seizures (MPIS greater to 10). Conclusion The addition of nebulized magnesium sulphate in asthma exacerbation as an adjuvant treatment to standard treatment has shown no benefit
- |||||||||| fluticasone propionate/salmeterol xinafoate inhalation powder / Generic mfg.
Maintenance and reliever therapy with budesonide/formoterol versus fixed dose fluticasone/salmeterol in patients with COPD (TP-9 in thematic poster area) - Jun 22, 2022 - Abstract #ERS2022ERS_3145;
The primary outcome was the rate of moderate/severe exacerbations, defined by treatment with oral prednisolone and/or antibiotics. This first study of MART in COPD found that budesonide/formoterol MART is similarly effective as fluticasone/salmeterol fixed-dose therapy in moderate-severe COPD patients, at a lower daily inhaled corticosteroid dosage.
- |||||||||| prednisolone / Generic mfg.
Comparison of resolution of Tuberculous pleural effusion on Anti – tubercular treatment with and without steroids : A one-year follow–up (TP-21 in thematic poster area) - Jun 22, 2022 - Abstract #ERS2022ERS_2681;
2.To study radiological improvement post steroid treatment METHODOLOGY- 40 patients of TB pleural effusion were divided into two groups: one received ATT regimen and other group received oral prednisolone 0.75mg/kg in addition to ATT for 4 wks...Conclusions- We found that adjunctive prednisolone therapy was associated with decreased incidence of radiographic and functional sequelae in free-flowing type TPE patients. Resolution of clinical symptoms and effusion were significantly higher in steroid group as compared to control group.
- |||||||||| prednisolone / Generic mfg.
Optimizing adrenal insufficiency screening in severe asthma patients on biologic therapy (TP-10 in thematic poster area) - Jun 22, 2022 - Abstract #ERS2022ERS_1037;
Measurement of baseline and 60 min serum cortisol levels alone were sufficiently able to identify all patients with AI; avoiding the need for an additional 30 min cortisol blood test. Reliance on the 30 min cortisol sample alone could led to an overdiagnosis of AI and prolonged exposure to OCS.
- |||||||||| Kaposi varicelliform eruption in a pemphigus foliaceus patient (e-Poster Hall) - Jun 13, 2022 - Abstract #EADVSp2022EADV_Sp_379;
The immunosuppressive therapy for his PF included oral prednisolone, azathioprine, calcium supplement and PPIs prophylaxis...The patient was administered oral valacyclovir 1g x 3 times a day for 10 days, intravenous ceftriaxone 2g daily for 7 days and topical fusidic acid cream twice daily...For this reason the clinical suspicion of HSV infection should be verified by laboratory tests such as Tzanck smear, viral culture or polymerase chain reaction (PCR) detection of HSV DNA. Appropriate treatment should not be postponed due to the significant percentage of morbidity and mortality related to bacterial superinfections with impetiginization, bacteremia and viremia with systemic dissemination in immunosuppressed patients.
- |||||||||| dapsone / Generic mfg., prednisolone / Generic mfg., thalidomide / Generic mfg.
Leprosy with Lucio Phenomenon: A Report of Two Patients In Malaysia and Clinical Outcome (e-Poster Hall) - Jun 13, 2022 - Abstract #EADVSp2022EADV_Sp_375;
These two cases illustrate the good response to steroid treatment together with MDT. Complications including prolonged treatment duration, scarring and physical disabilities, can be minimized by early detection and aggressive treatment.
- |||||||||| vancomycin / Generic mfg., prednisolone / Generic mfg.
Linear Ig A bullous dermatosis following Oxford Astrazenaca COVID-19 vaccine (e-Poster Hall) - Jun 13, 2022 - Abstract #EADVSp2022EADV_Sp_194;
Discussion There are multiple reports in the literature on drugs that cause LABD, particularly vancomycin.Drug-induced LABD is defined by its polymorphic clinical features, which are more severe than in spontaneous forms...Vaccination is a rare trigger for this condition. While this case may be a simple coincidence, it is worth keeping in mind that COVID-19 vaccination could induce immune-mediated bullous disease in susceptible people
- |||||||||| Vaxzevria (ChAdOx1-S recombinant) / Oxford Biomedica, Emergent Biosolutions, Jenner Institute, Vaccitech, AstraZeneca, University of Oxford
New-onset leukocyclastic vasculitis following ChAdOx1 nCoV-19 COVID-19 vaccine (e-Poster Hall) - Jun 13, 2022 - Abstract #EADVSp2022EADV_Sp_190;
No systemic involvement was described in all of these cases and clinical course was rapidly regressive when treated with tapering doses of oral prednisolone. As reports of similar cutaneous eruptions add-up, health care providers must be aware of such manifestations after COVID-19 vaccines.
- |||||||||| Ibrance (palbociclib) / Pfizer, Kisqali (ribociclib) / Novartis, Verzenio (abemaciclib) / Eli Lilly
Cutaneous reactions to cyclin-dependent kinase 4/6 inhibitors (e-Poster Hall) - Jun 13, 2022 - Abstract #EADVSp2022EADV_Sp_50;
Introduction Three cyclin-dependent kinase 4/6 inhibitors, palbociclib, ribociclib and abemaciclib, are currently used in positive hormone receptor and negative human epidermal growth factor receptor-2 metastatic breast cancer, associated with endocrine therapy...The patient was treated with a course of oral prednisolone with marked improvement...Discussion Considering the increasing use of these molecules and the prevalence of breast cancer, it’s important for both dermatologists and oncologists to know the associated skin toxicities and the symptoms management. Scarce information exists about this topic, so the presented cases help to elucidate the skin manifestation of the cyclin- dependent kinase 4/6 inhibitors.
- |||||||||| Humira (adalimumab) / Eisai, AbbVie
Follicular occlusion tetrad with urological complications (e-Poster Hall) - Jun 13, 2022 - Abstract #EADVSp2022EADV_Sp_16;
Taking into account no marked improvement several attempts of short course oral prednisolone 50 mg/day had been tried in combination with isotretinoin with positive effect on hidradenitis suppurativa, however when the daily dosage was reduced to 20 mg per day exacerbations occurred...The patient was recommended adalimumab with the standard dosing schedule...Discussion Due to the severity of the condition, the duration of the course and the disease burden in patients with follicular occlusion syndrome, the earliest possible therapy with biological agents is indicated. Prolongation of isotretinoin, combination therapy and dose increase is ineffective.
- |||||||||| prednisolone / Generic mfg., azathioprine / Generic mfg.
Journal: A Case of Pemphigus Vulgaris Showing a Local Nose Erosion as the First Clinical Manifestation (Pubmed Central) - Jun 8, 2022
His skin eruption responded well to oral prednisolone and azathioprine and gradually improved. Pemphigus was a candidate as a differential diagnosis in this case, in which the direct mechanical friction from wearing a mask was thought to be an exacerbating factor of skin eruption.
- |||||||||| Henletor (torsemide) / Orchid
Journal: Minimal Change Disease in an Adult: A Case Report. (Pubmed Central) - Jun 5, 2022
Hence, minimal change disease should also be considered as a differential diagnosis in adults presenting with the features of nephrotic syndrome. electron microscopy; minimal change disease; nephrotic syndrome; prednisolone.
- |||||||||| JNJ-1887 / J&J
Trial completion: AAVCAGsCD59 for the Treatment of Wet AMD (clinicaltrials.gov) - May 25, 2022
P1, N=25, Completed,
Further studies may be warranted. Active, not recruiting --> Completed
- |||||||||| prednisolone / Generic mfg.
INFLAMMATORY MYOSITIS – FINAL ANSWER? () - May 24, 2022 - Abstract #EULAR2022EULAR_4442;
On review of her clinical progress, we noted poor response to steroids and EMG results pointing at an alternative diagnosis of MND. This case highlights the importance of EMG in the assessment and management of patients with suspected inflammatory myositis as well as the need to closely monitor progress and re-evaluation where needed.
- |||||||||| prednisolone / Generic mfg., acitretin / Generic mfg., lenvatinib / Generic mfg.
Journal: Dramatic improvement of lenvatinib-induced hand-foot skin reaction with 7-day oral prednisolone and acitretin. (Pubmed Central) - May 20, 2022
After 7-day oral prednisolone and acitretin, hyperkeratotic plaques improved dramatically and painful condition as well got relieved. We considered the combination therapy of oral prednisolone and acitretin can be a prospective therapeutic option to reduce chances of cancer treatment being interrupted by HFSR.
- |||||||||| prednisolone / Generic mfg., prednisone / Generic mfg.
Trial completion date, Trial primary completion date, Head-to-Head: ADAPTinMCN: Active Vitamin D And Reduced Dose Prednisolone for Treatment in Minimal Change Nephropathy (clinicaltrials.gov) - May 20, 2022
P4, N=96, Recruiting,
We considered the combination therapy of oral prednisolone and acitretin can be a prospective therapeutic option to reduce chances of cancer treatment being interrupted by HFSR. Trial completion date: Dec 2024 --> Dec 2025 | Trial primary completion date: Dec 2023 --> Dec 2024
- |||||||||| prednisolone / Generic mfg., cyclophosphamide / Generic mfg.
Acquired haemophilia presenting in a 14-year-old girl (Exhibition) - May 13, 2022 - Abstract #ISTH2022ISTH_171;
Past medical and family histories were negative. Prior to admission the girl was seen by several paediatricians, rheumatologists and orthopaedists.
|
