- |||||||||| dexamethasone / Generic mfg., prednisolone / Generic mfg.
Journal: Combined Intratympanic and Systemic Steroid Therapy in Sudden Sensorineural Hearing Loss. (Pubmed Central) - Aug 30, 2022
The mean audiometric gain was 37.71 dB in recovered cases. The combination therapy of intratympanic dexamethasone and oral steroid is more effective in comparison with intratympanic or oral steroid alone in the treatment of SSNHL as the patients benefitted from the therapeutic effects of both local and systemic steroids.
- |||||||||| prednisolone / Generic mfg., acyclovir / Generic mfg.
Journal: Thrombotic Microangiopathy Secondary to Disseminated Varicella Zoster Virus Infection in an Adult Patient. (Pubmed Central) - Aug 30, 2022
Compared to the pediatric population, VZV infection tends to be more severe in the adult age group. This case demonstrates that a high index of suspicion for TMA in adult patients with VZV who present with thrombocytopenia, even when there is no definitive diagnosis, can result in early management with favorable outcome.
- |||||||||| prednisolone / Generic mfg.
Trial completion date, Trial primary completion date: RhinoPOCRCT: Oral Prednisolone for Acute Rhinovirus Induced Wheezing in Children Less Than 2 Years of Age (clinicaltrials.gov) - Aug 30, 2022
P4, N=210, Not yet recruiting,
This case demonstrates that a high index of suspicion for TMA in adult patients with VZV who present with thrombocytopenia, even when there is no definitive diagnosis, can result in early management with favorable outcome. Trial completion date: Feb 2026 --> Sep 2027 | Trial primary completion date: Feb 2024 --> Sep 2025
- |||||||||| prednisolone / Generic mfg.
Journal: Resection of Gastric Cancer Remitted Anti-signal Recognition Particle Myopathy. (Pubmed Central) - Aug 24, 2022
Although the myopathy relapsed two times in two years under oral prednisolone and intravenous immunoglobulin therapy, the myopathy remained in remission for more than three years after resection of gastric cancer. Although the anti-SRP myopathy is not considered to be cancer-associated in general, we should note that some cases of anti-SRP myopathy may be ameliorated with appropriate cancer treatment.
- |||||||||| prednisolone / Generic mfg., ursodeoxycholic acid / Generic mfg.
Journal: Primary biliary cholangitis presenting with Fanconi syndrome: an important phenotype. (Pubmed Central) - Aug 24, 2022
Kidney function was stabilised, but a sustained improvement was not seen. This case acts as a reminder of the rare association of tubulointerstitial nephritis and Fanconi syndrome with primary biliary cholangitis, which may be an under-recognised phenotype.
- |||||||||| prednisolone / Generic mfg., minocycline / Generic mfg., azathioprine / Generic mfg.
Journal: Liquid Vitamin E Injection for Cosmetic Facial Rejuvenation: A Disaster report of Lipogranuloma. (Pubmed Central) - Aug 11, 2022
Herein, we report a case of liquid vitamin E injection for cosmetic facial rejuvenation and development of facial persistent erythema and induration, treated with oral prednisolone, azathioprine, and minocycline. Also, we review the reported cases of vitamin E injection for cosmetic facial rejuvenation.
- |||||||||| prednisolone / Generic mfg., valacyclovir / Generic mfg.
Journal: Case Report: Acute Retinal Necrosis after a Cervical Epidural Steroid Injection. (Pubmed Central) - Aug 11, 2022
The progressive nature of acute retinal necrosis is usually debilitating to vision, even when managed properly. Because prognosis is often poor, it is important to make proper diagnoses combined with a complete review of the patient's medical history and immune status to prevent further vision loss.
- |||||||||| prednisolone / Generic mfg.
Journal: A case of localized fasciitis with ulcerative colitis (Pubmed Central) - Aug 4, 2022
We administered 60 mg (1.0 mg/kg/day) of prednisolone orally on day 9 and the pain and swelling in both legs promptly resolved...Gastrocnemius myalgia syndrome, which causes pain and localized fasciitis, is often reported as a complication of Crohn's disease but is rare in conjunction with ulcerative colitis. It is important that clinicians are aware of this syndrome so it can be recognized early and successfully treated.
- |||||||||| ceftriaxone / Generic mfg., prednisolone / Generic mfg., trimethoprim/sulfamethoxazole / Generic mfg.
Journal: Whipple's disease with normal duodenal histology diagnosed by ileal biopsy using balloon endoscopy. (Pubmed Central) - Aug 3, 2022
The patient was treated with intravenous ceftriaxone and oral trimethoprim-sulfamethoxazole, and her symptoms improved one month after treatment. Balloon endoscopy performed 32 months later revealed complete improvement in lesions of the ileum.
- |||||||||| prednisolone / Generic mfg.
Enrollment change, Trial termination: NorPEPS: The Norwegian Prednisolone in Early Psychosis Study (clinicaltrials.gov) - Aug 1, 2022
P2, N=12, Terminated,
Balloon endoscopy performed 32 months later revealed complete improvement in lesions of the ileum. N=90 --> 12 | Recruiting --> Terminated; Stopped because of COVID 19 pandemic
- |||||||||| prednisolone / Generic mfg., cyclophosphamide / Generic mfg., mycophenolate mofetil / Generic mfg.
Journal: Anti-factor H antibody associated hemolytic uremic syndrome following SARS-CoV-2 infection. (Pubmed Central) - Jul 28, 2022
Increased vigilance is required during the pandemic, especially in patients with anti-FH associated aHUS, who might relapse despite quiescent disease for a prolonged period. A higher resolution version of the Graphical abstract is available as Supplementary information.
- |||||||||| prednisolone / Generic mfg.
Journal: Exogenous glucocorticoid treatment affects Sertoli cell load and epididymal sperm quality in domestic cats (Felis catus). (Pubmed Central) - Jul 28, 2022
Treatment cats were given 1 mg kg oral prednisolone daily for 50 days...Prednisolone treatment resulted in an increase in the proportion of abnormal sperm in the epididymis, which may be explained by an increased nurturing demand on a reduced Sertoli cell population. These findings provide novel evidence to support the hypothesis that elevated GC concentrations, such as those resulting from captivity-related stress, have the potential to impair testicular function and sperm quality in felids.
- |||||||||| cyclosporine / Generic mfg.
Journal: TAFRO syndrome with renal biopsy successfully treated with steroids and cyclosporine: a case report. (Pubmed Central) - Jul 27, 2022
These findings provide novel evidence to support the hypothesis that elevated GC concentrations, such as those resulting from captivity-related stress, have the potential to impair testicular function and sperm quality in felids. Given that only few reports of improvement in the systemic symptoms of TAFRO syndrome using steroids and cyclosporine exist, our study investigating the relationship between the pathogenesis of TAFRO syndrome and renal disorders, as well as treatment methods, provides valuable insights.
- |||||||||| zilovertamab vedotin (MK-2140) / Merck (MSD)
Enrollment open, Combination therapy: waveLINE-007: A Study of Zilovertamab Vedotin (MK-2140) in Combination With Cyclophosphamide, Doxorubicin, and Prednisone Plus Rituximab or Rituximab Biosimilar (Truxima) (R-CHP) in Participants With Diffuse Large B-Cell Lymphoma (DLBCL) (MK-2140-007) (clinicaltrials.gov) - Jul 26, 2022
P2, N=60, Recruiting,
Given that only few reports of improvement in the systemic symptoms of TAFRO syndrome using steroids and cyclosporine exist, our study investigating the relationship between the pathogenesis of TAFRO syndrome and renal disorders, as well as treatment methods, provides valuable insights. Not yet recruiting --> Recruiting
- |||||||||| prednisolone / Generic mfg., aspirin / Generic mfg.
Journal: Paracentral Acute Middle Maculopathy After COVID-19 Disease: Multimodal Evaluation. (Pubmed Central) - Jul 23, 2022
SARS-CoV-2 infection increases the risk of vascular thrombotic events with possible involvement of the retinal circulation, and PAMM may present as a possible complication. Ophthalmologists should be able to recognize it promptly through multimodal imaging findings.
- |||||||||| prednisolone / Generic mfg.
Journal: Palmar Fasciitis and Polyarthritis Syndrome Associated with Lung Adenocarcinoma. (Pubmed Central) - Jul 23, 2022
Salazosulfapyridine was not effective, but 15 mg/day of oral prednisolone improved his symptoms. Physicians should consider PFPAS and rule out malignancy in patients with arthritis in the extremities and flexion contractures associated with palmar fascial thickening.
- |||||||||| Cosentyx (secukinumab) / Novartis
SECUKINUMAB INDUCED ULCERATIVE COLITIS IN A PATIENT WITH PSORIASIS AND SUBSEQUENT MANAGEMENT (Science Lounge) - Jul 20, 2022 - Abstract #UEGW2022UEGW_2694;
The patient was treated with oral plus rectal mesalazine and a reducing course of oral prednisolone, without significant improvement...In conjunction with the dermatologist, the decision was made to stop secukinumab and treat her with infliximab without a washout period...Additionally, co-trimoxazole was initiated for Pneumocystis pneumonia prophylaxis...In January 2020, azathioprine was added to the treatment and she reported significant improvement with bowels opening 4-5 times per day and resolution of blood/mucus in the stool. Faecal calprotectin levels dropped to 21 and psoriasis was reported to be well controlled.
- |||||||||| prednisolone / Generic mfg.
Journal: Punctate inner choroidopathy immediately after COVID-19 infection: a case report. (Pubmed Central) - Jul 16, 2022
Further studies should include larger cohorts of patients to elucidate the utility of MOG-Abs testing in PN. We experienced an extremely rare case of PIC immediately after COVID-19 infection and showed the potential safety and effectiveness of oral prednisolone in treating PIC in the active phase after the disappearance of the general COVID-19 infection symptoms.
- |||||||||| Opdivo (nivolumab) / Ono Pharma, BMS, Yervoy (ipilimumab) / Ono Pharma, BMS
Journal, PD(L)-1 Biomarker, IO biomarker: Ipilimumab- and nivolumab-induced myocarditis in a patient with metastatic cholangiocarcinoma: a case report. (Pubmed Central) - Jul 16, 2022
Moreover, the emerging combination of immune checkpoint inhibitors with non-immune checkpoint inhibitor therapies with potential synergistic cardiotoxic side effects (for example, tyrosine kinase inhibitors) will further complicate the diagnosis of immune-related cardiotoxicity. This case highlights the urgent need for predictive biomarkers to stratify patients at risk and to develop a standardized and multidisciplinary management approach for early diagnosis and treatment of this severe immune-related adverse event.
- |||||||||| Erleada (apalutamide) / J&J, Airui'en (rezvilutamide) / Jiangsu Hengrui Pharma
Enrollment open, Trial initiation date, Trial primary completion date: Neoadjuvant Intense Endocrine Therapy for High Risk and Locally Advanced Prostate Cancer (clinicaltrials.gov) - Jul 14, 2022
P2, N=900, Recruiting,
Our experience suggests the efficacy of early multimodal treatment, including SGL, in treating ocular symptoms associated with HZO. Not yet recruiting --> Recruiting | Initiation date: Jul 2022 --> Feb 2020 | Trial primary completion date: Dec 2029 --> Dec 2026
- |||||||||| prednisolone / Generic mfg.
Trial completion date, Trial primary completion date: High-TeC: Nasal High-Flow in COPD (clinicaltrials.gov) - Jul 13, 2022
P=N/A, N=136, Recruiting,
Not yet recruiting --> Recruiting | Initiation date: Jul 2022 --> Feb 2020 | Trial primary completion date: Dec 2029 --> Dec 2026 Trial completion date: Apr 2023 --> Jul 2023 | Trial primary completion date: Jan 2023 --> May 2023
- |||||||||| prednisolone / Generic mfg.
Clinical, Review, Journal: Idiopathic Lipogranulomatous Orbital Inflammation: A Case Report and Literature Review. (Pubmed Central) - Jul 6, 2022
The patient was managed with a tapering course of oral prednisolone and two 40 mg intraorbital triamcinolone injections resulting in complete resolution of her presenting symptoms. This represents a rare case of idiopathic lipogranulomatous orbital inflammation.
- |||||||||| prednisolone / Generic mfg.
Journal: Short-time ventricular tachycardia ablation for cardiac sarcoidosis using coherent map. (Pubmed Central) - Jul 6, 2022
A 69-year-old woman with isolated cardiac sarcoidosis was hospitalized for frequent appropriate implantable converter defibrillator therapies for ventricular tachycardia (VT) despite of favorably controlled condition with oral prednisolone...The patient has been free from any cardiovascular events after the procedure. Coherent map might be feasible for revealing the critical isthmus of hemodynamically stable VTs without using electrophysiological techniques, including entrainment, pacing study, and voltage map during own beats, and would enable us to achieve successful VT ablation in a short time.
- |||||||||| vigabatrin / Generic mfg.
Journal: Treatment with high dose prednisolone in vigabatrin-refractory infantile spasms. (Pubmed Central) - Jul 2, 2022
High-dose (8 mg/kg/day) oral prednisolone resulted in sustained complete ECR (at 6 weeks) in two-thirds of the children with hypsarrhythmia or hypsarrhythmia variant on EEG with/without parentally reported IS. It was generally well tolerated and found to be safe.
- |||||||||| prednisolone / Generic mfg., cyclophosphamide / Generic mfg., azathioprine / Generic mfg.
Journal: Rare Case of Renal Limited Dual Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis: Double Trouble! (Pubmed Central) - Jul 2, 2022
It was generally well tolerated and found to be safe. Dual anti-neutrophil cytoplasmic antibody-associated vasculitis characterized by both PR3-ANCA and MPO-ANCA antibodies is a rare clinical entity.Prior to treating with immunosuppression, we need to rule out secondary aetiologies such as drugs, certain infections, autoimmune diseases and haematological malignancies.Atypical presentations such as hypocomplementemia, other serological abnormalities like positive ANA, cryoglobulins, anti-histone antibody and histology showing mesangial hypercellularity, interstitial inflammation and lack of pauci-immunity, may create a diagnostic dilemma.
- |||||||||| prednisolone / Generic mfg.
Journal: T cell responses to Mycobacterium indicus pranii immunotherapy and adjunctive glucocorticoid therapy in tuberculous pericarditis. (Pubmed Central) - Jun 28, 2022
Participants with definite or probable TBP were randomly assigned to receive five injections of MIP or placebo at 2-week intervals and either 6 weeks of oral prednisolone or placebo...Despite the positive effect of prednisolone on hospitalizations and constrictive pericarditis in the IMPI trial, prednisolone did not significantly reduce pro-inflammatory T cell responses in this sub-study. The modest improvement of mycobacteria-specific T cell upon combinatorial therapy with MIP and prednisolone requires further investigation.
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