- |||||||||| Vraylar (cariprazine) / Mitsubishi Tanabe, Recordati, Gedeon Richter, AbbVie, Rexulti (brexpiprazole) / Lundbeck, Otsuka
Journal: Comparison of the Metabolic Characteristics of Newer Second Generation Antipsychotics: Brexpiprazole, Lurasidone, Asenapine, Cariprazine, and Iloperidone With Olanzapine as a Comparator. (Pubmed Central) - Sep 9, 2021 Although some weight gain was seen with the newer SGAs, all demonstrated significantly favorable metabolic characteristics compared with olanzapine. Monitoring of weight and metabolic parameters remain important in patients treated with SGAs.
- |||||||||| Trintellix (vortioxetine) / Lundbeck, Takeda
Journal: Effects of Subchronic Administrations of Vortioxetine, Lurasidone, and Escitalopram on Thalamocortical Glutamatergic Transmission Associated with Serotonin 5-HT7 Receptor. (Pubmed Central) - Sep 9, 2021 Subchronic administration of effective doses of vortioxetine, lurasidone, and escitalopram downregulated the 5-HT7R expression of the plasma membrane in the MDTN; the 5-HT7R downregulation induced by vortioxetine and lurasidone was observed at 3 days, but that induced by escitalopram required a longer duration of 7 days. These results indicate that chronic administration of vortioxetine, escitalopram, and lurasidone generate downregulation of 5-HT7R in the thalamus; however, the direct inhibition of 5-HT7R associated with vortioxetine and lurasidone generates more rapid downregulation than the indirect elevation of the extracellular serotonin level via serotonin transporter inhibition by escitalopram.
- |||||||||| Cyclurad (cycloserine/lurasidone) / NeuroRx
Biomarker, Trial completion date, Trial primary completion date: NRX-GLX: NRX101 Glx Biomarker Validation Study (clinicaltrials.gov) - Sep 8, 2021 P2/3, N=24, Active, not recruiting, These results indicate that chronic administration of vortioxetine, escitalopram, and lurasidone generate downregulation of 5-HT7R in the thalamus; however, the direct inhibition of 5-HT7R associated with vortioxetine and lurasidone generates more rapid downregulation than the indirect elevation of the extracellular serotonin level via serotonin transporter inhibition by escitalopram. Trial completion date: Feb 2021 --> Feb 2022 | Trial primary completion date: Dec 2020 --> Dec 2021
- |||||||||| Cyclurad (cycloserine/lurasidone) / NeuroRx
Trial completion date, Trial primary completion date: MBD: NRX101 for Bipolar Depression and Sub-acute Suicidal Ideation and Behavior (clinicaltrials.gov) - Sep 8, 2021 P2/3, N=150, Not yet recruiting, Trial completion date: Dec 2021 --> Apr 2022 | Trial primary completion date: Aug 2021 --> Mar 2022 Trial completion date: Mar 2022 --> Jul 2022 | Trial primary completion date: Mar 2022 --> Jun 2022
- |||||||||| lurasidone / Generic mfg.
Clinical, Journal, Monotherapy: Double-Blind, Placebo-Controlled Study of Lurasidone Monotherapy for the Treatment of Bipolar I Depression. (Pubmed Central) - Sep 8, 2021 Monotherapy with once daily doses of lurasidone 20-60 mg, but not 80-120 mg, significantly reduced depressive symptoms and improved functioning in patients with bipolar I depression. Results overall were consistent with previous studies, suggesting that lurasidone 20-60 mg/day is effective and safe in diverse ethnic populations, including Japanese.
- |||||||||| risperidone / Generic mfg., lurasidone / Generic mfg.
Journal: Contrasting Typical and Atypical Antipsychotic Drugs. (Pubmed Central) - Sep 7, 2021 These advantages of the atypical APDs in efficacy and safety are due, in part, to initiation of synaptic plasticity via direct and indirect effects of the atypical APDs on a variety of proteins, especially G proteins, and release of neurotrophins (e.g., brain-derived neurotrophic factor). The typical APDs beneficial effects on psychosis are mainly the result of D receptor blockade, which can be associated with serious side effects and lack of tolerability.
- |||||||||| amisulpride / Generic mfg., lurasidone / Generic mfg., ziprasidone / Generic mfg.
Review, Journal: Amisulpride - is it as all other medicines or is it different? An update. (Pubmed Central) - Sep 1, 2021 In 2018, the Agency for Health Technology Assessment and Tariff System issued positive recommendation for lurasidone in schizophrenia (Recommendation 30/2018) facilitating its entry to the market...It might also be superior to haloperidol in inducing symptomatic remission in first episode schizophrenia...Therefore many patients accept treatment with amisulpride for its measurable clinical gains, such as improvement of positive symptoms and higher quality of life, compared to typical neuroleptics. Pharmacokinetics of amisulpride also encourage its wider use, especially when there is either a need for combined psychopharmacotherapy or comorbidity with general medical condition rises a need for somatic parallel treatment.
- |||||||||| lurasidone / Generic mfg.
Clinical, Clinical data, Journal: Lurasidone in lactation: A case study with laboratory and clinical outcomes. (Pubmed Central) - Aug 20, 2021 Treatment with lurasidone 40 or 80 mg once daily (flexibly dosed) continued to be well tolerated with patients demonstrating further improvement in symptoms over the course of a 12-week open-label extension study in patients with schizophrenia. No abstract available
- |||||||||| lurasidone / Generic mfg.
Journal: Stable Solid Dispersion of Lurasidone HCl with Augmented Physiochemical Properties for the treatment of schizophrenia and bipolar disorder. (Pubmed Central) - Aug 11, 2021 The in vitro dissolution results showed that maximum dissolution rate with LH-GSH SD (97.85 ± 2.40 %) compared to plain drug (50.5 ± 3.02 %) at 15 minutes(t min, %) and thus, satisfying criteria of immediate release dosage form.DSC and FTIR data confirmed the stability of LH-GSH SD for 3 months at accelerated stability condition (40 ± 2°C and 75 ± 5 % RH).The prepared LH-GSH SD can be used as a tool to target dual problems i.e., enhanced physicochemical properties along with possible management of disorder which could be due to synergism with co-administered GSH. This approach is thought to be efficiently providing the relief to the psychological patients.
- |||||||||| lurasidone / Generic mfg.
Clinical, Journal: Lurasidone in the long-term treatment of Japanese patients with bipolar I disorder: a 52 week open label study. (Pubmed Central) - Aug 4, 2021 P3 Long-term treatment with lurasidone 20-120 mg/day for Japanese patients with bipolar disorder maintained improvements in depressive symptoms for depressed patients who were treated in a prior 6 week trial and led to improvements in manic symptoms among a newly recruited subgroup of patients with a recent/current manic, hypomanic, or mixed episode. Few changes in weight or metabolic parameters were evident.
- |||||||||| Rexulti (brexpiprazole) / Lundbeck, Otsuka
Clinical, Review, Journal: Pharmacological Management of Glucose Dysregulation in Patients Treated with Second-Generation Antipsychotics. (Pubmed Central) - Jul 28, 2021 The outcome of lifestyle-changing interventions has been disappointing. Switching from clozapine, olanzapine, or quetiapine to lower cardiometabolic-risk SGAPs, like aripiprazole, brexpiprazole, cariprazine, lurasidone, or ziprasidone, has been recommended.
- |||||||||| risperidone / Generic mfg., lurasidone / Generic mfg.
Review, Journal: Modulation of Serotonin Receptors in Neurodevelopmental Disorders: Focus on 5-HT7 Receptor. (Pubmed Central) - Jul 14, 2021 5-HTR modulators improved altered behaviors in animal models and also affected neuronal morphology via the 5-HTR/G signaling pathway. Through the investigation of recent studies, it is suggested that 5-HTR could be a potential therapeutic target for the treatment of NDDs.
- |||||||||| lithium carbonate ER / Generic mfg., lurasidone / Generic mfg.
Clinical, Review, Journal: Old Age Bipolar Disorder-Epidemiology, Aetiology and Treatment. (Pubmed Central) - Jul 11, 2021 Lamotrigine and lurasidone could be considered in bipolar depression...Combined psychosocial and pharmacological treatments also appear to be a treatment of choice for OABD. More research is needed on the optimal pharmacological and psychosocial approaches to OABD, as well as their combination and ranking in an evidence-based therapy algorithm.
- |||||||||| lithium carbonate ER / Generic mfg., lurasidone / Generic mfg.
Clinical, Review, Journal: The Challenges of Children with Bipolar Disorder. (Pubmed Central) - Jul 11, 2021 Lithium and atypical antipsychotics are effective in mania, but treatment of depression remains obscure, with the exception of lurasidone, for children ages 10-17...Cognitive dysfunction after a first manic hospitalization improves over the next year only on the condition that no further episodes occur. Yet comprehensive expert treatment after an initial manic hospitalization results in many fewer relapses than traditional treatment as usual, emphasizing the need for combined pharmacological, psychosocial, and psycho-educational approaches to this difficult and highly recurrent illness.
- |||||||||| lurasidone / Generic mfg.
Clinical, Journal: A Case of Hypersexuality Probably Associated With Lurasidone. (Pubmed Central) - Jul 9, 2021 Yet comprehensive expert treatment after an initial manic hospitalization results in many fewer relapses than traditional treatment as usual, emphasizing the need for combined pharmacological, psychosocial, and psycho-educational approaches to this difficult and highly recurrent illness. No abstract available
- |||||||||| lurasidone / Generic mfg.
Journal: Coamorphization combined with complexation enhances dissolution of lurasidone hydrochloride and puerarin with synchronized release. (Pubmed Central) - Jun 22, 2021 In comparison to crystalline/amorphous LH and PUE, the coamorphous system exhibited significantly enhanced dissolution with synchronized release behavior of LH and PUE, which was mainly due to the complexation formation between LH and PUE in solution proved by fluorescence quenching test and phase-solubility diagram. In addition, coamorphous LH-PUE showed superior physical stability over pure amorphous LH and PUE under both long-term and accelerated storage conditions.
- |||||||||| lurasidone / Generic mfg.
Clinical, Journal: Risk analysis of lurasidone in patients with schizophrenia and bipolar depression. (Pubmed Central) - Jun 16, 2021 In addition, coamorphous LH-PUE showed superior physical stability over pure amorphous LH and PUE under both long-term and accelerated storage conditions. In conclusion, Marketing Authorization Holder (MAH) and Regulatory Authorities (RA) should monitor these adverse drug reactions.
- |||||||||| lurasidone / Generic mfg.
Preclinical, Journal: Novel inhibitors of the main protease enzyme of SARS-CoV-2 identified via molecular dynamics simulation-guided in vitro assay. (Pubmed Central) - Jun 9, 2021 Among these are corilagin, a gallotannin, and lurasidone, an antipsychotic drug, which emerged as the most promising natural product and drug, respectively, and might thus be candidates for drug repurposing for the treatment of COVID-19. In addition, we also tested the inhibitory activity of testosterone, and our results reveal testosterone as possessing moderate inhibitory potency against the 3CL enzyme, which may thus provide an explanation why older men are more severely affected by COVID-19.
- |||||||||| lurasidone / Generic mfg.
Journal: Chemical puzzles in the search for new, flexible derivatives of lurasidone as antipsychotic drugs. (Pubmed Central) - Jun 2, 2021 Among the obtained compounds, N-(6-(4-(benzo[d]isothiazol-3-yl)piperazin-1-yl)hexyl)naphthalene-sulfonamides 1v and 1w were distinguished as multifunctional ligands showing increased affinity for 5-HTR, and 2-(6-(4-(benzo[d]isothiazol-3-yl)piperazin-1-yl)hexyl)-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one 1i - a multifunctional ligand showing moderate affinity for 5-HTR and threefold lower for 5-HTR. In the paper, we discuss some of the observed dependencies regarding 5-HT/5-HTR affinity using molecular docking methods.
- |||||||||| Rexulti (brexpiprazole) / Lundbeck, Otsuka
Journal: Antipsychotics with no dopamine receptor blockade; promise or hype? (Pubmed Central) - May 29, 2021 So far, all antipsychotics block the dopamine-2 (D2) receptor in the brain, including recently available antipsychotics such as lurasidone, cariprazine and brexpiprazole...Hitherto, the effects of molecules that do not block the D2 receptor for the treatment of psychotic disorders are either disappointing or equivocal, e.g. glutamate system modulators as the metabotropic mGLu2/3 agonist LY2140023...This is encouraging, although the duration of the RCT and relatively selected group of patients preclude firm conclusions on its efficacy. We may be hopeful that antipsychotics with a novel mechanism of action are investigated, but only the future will learn whether SEP-363856 will have true added value to improve the life of patients suffering from psychotic disorders.
- |||||||||| Botox (onabotulinumtoxin A) / GSK, AbbVie
[VIRTUAL] Right Arm Dystonia In A Former Baseball Pitcher () - May 29, 2021 - Abstract #ACSM2021ACSM_1396; Cervical spine x-rays: Multilevel degenerative changes of the cervical spine. MRI cervical spine: Multilevel degenerative changes with facet arthropathy, slight retrolisthesis from C3-C7, and loss of disc height from C4-C7.
- |||||||||| lurasidone / Generic mfg.
Journal: Is it depression or is it bipolar depression? (Pubmed Central) - May 27, 2021 Primary care providers who can differentiate presenting symptoms of bipolar depression from unipolar depression and offer appropriate treatment options will optimize patient care in clinical practice. Relevant information for this review was identified through a multistep literature search of PubMed using the terms bipolar depression/bipolar disorder plus other relevant terms.
- |||||||||| lurasidone / Generic mfg.
Clinical, Review, Journal: Identification of clinical phenotypes in schizophrenia: the role of lurasidone. (Pubmed Central) - May 25, 2021 The most frequent reason for switching to other therapies is the need for long-acting formulations, as in patients at risk of very low adherence or suicide. Lurasidone does not strongly impact metabolism or the cardiovascular system (QT interval), and does not influence the metabolism of other drugs, showing good efficacy and tolerability.
- |||||||||| lithium carbonate ER / Generic mfg., lurasidone / Generic mfg.
[VIRTUAL] A Case of Parasomnia Overlap Disorder in a Patient on Lithium () - May 17, 2021 - Abstract #SLEEP2021SLEEP_1074; His other medications included propranolol 40mg BID, lithium 900mg/1200mg, oxcarbazepine 600mg bid, lamictal 225mg bid, lurasidone 80mg qday, and benztropine 2mg bid...His workup and treatment is still ongoing, but he has continued on clonazepam 2mg but taken 2 hours earlier, and has started a new APAP. Because of the severity of his bipolar disorder (including severe suicidal ideation), he is not a candidate to tapering the lithium or to taking serotonergic antidepressants.
- |||||||||| risperidone / Generic mfg., trazodone ER / Generic mfg., lurasidone / Generic mfg.
Clinical, Journal: Psychotropic-Induced Priapism in a Treatment-Refractory Patient: A Case Report. (Pubmed Central) - May 15, 2021 While on clozapine, fluphenazine, haloperidol, lurasidone, and olanzapine at varying times, the patient did not appear to develop priapism...This is not the first case to describe this effect, but will give clinicians a timeline of events and medications that did and did not appear to elicit priapism in a patient with treatment-refractory schizoaffective disorder. Knowledge of which psychotropic medications may be more likely to induce priapism is crucial to preventing long-term penile damage.
- |||||||||| Clinical, Journal: Roux-en-Y Gastric Bypass and Antipsychotic Therapeutic Drug Monitoring: Two Cases. (Pubmed Central) - May 15, 2021
Her medications prior and following the procedure include bupropion, fluvoxamine, lurasidone, methylphenidate, oxcarbazepine, and verapamil...Medications on admission included phenytoin, oxcarbazepine, risperidone, and venlafaxine...We describe the contributions of drug-drug interactions, medication release mechanisms, and food coadministration that may have affected our therapeutic drug monitoring. Our therapeutic drug monitoring results need to be replicated prior to use in the general population but suggest that oral extended-release drug formulations are particularly poor choices and that nonoral antipsychotic formulations may be preferred in some patients who have undergone RYBG.
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