lurasidone / Generic mfg. 
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  • ||||||||||  lurasidone / Generic mfg.
    Trial completion:  ELICE_BD: Study of the Efficacy of Lurasidone in Cognitive Functioning in Bipolar Patients (clinicaltrials.gov) -  Feb 14, 2025   
    P3,  N=100, Completed, 
    The developed method is simple, robust, precise, accurate and sensitive which can be utilized for the regular analysis of LURA-H in quality control laboratories of bulk drug substance and PLGA containing formulations of LURA-H. Recruiting --> Completed
  • ||||||||||  Trintellix (vortioxetine) / Lundbeck, Takeda
    Clinical, Journal:  Clinical efficacy and safety of vortioxetine as an adjuvant drug for patients with bipolar depression. (Pubmed Central) -  Jan 16, 2025   
    Overall, the designed lyophilizates containing L-histidine and L-arginine, hold promise as orodispersible platforms for improved performance of lurasidone hydrochloride. This study suggested that lurasidone combination with vortioxetine might have potential benefits to bipolar II depression in the early stage, while disease progression should be monitored closely for the risk of switching to mania.
  • ||||||||||  lurasidone / Generic mfg.
    Journal:  Unveiling Cathepsin B inhibition with repurposed drugs for anticancer and anti-Alzheimer's drug discovery. (Pubmed Central) -  Dec 19, 2024   
    The results revealed that CatB and Lurasidone, as well as Paliperidone, form stable complexes throughout the simulation. Taken together, the findings suggest that Lurasidone and Paliperidone can act as repurposed CatB inhibitors with potential applications in the development of therapeutics against AD and other CatB-associated diseases after further validation.
  • ||||||||||  lurasidone / Generic mfg.
    Journal:  Nanomolar detection of lurasidone hydrochloride in pharmaceutical formulations (Serodopamoun (Pubmed Central) -  Dec 19, 2024   
    The optimized sensor possessed significantly enhanced accuracy, providing a cost-effective alternative to traditional methods. The accuracy, selectivity, precision, stability, and sensitivity of these potentiometric sensors make them valuable for detecting LSH in urine samples spiked with the pharmaceutical formulation Serodopamoun
  • ||||||||||  lurasidone / Generic mfg.
    PK/PD data, Journal:  Changes in the pharmacokinetics of lurasidone in a pregnant woman with schizophrenia. (Pubmed Central) -  Dec 11, 2024   
    Decreased serum lurasidone levels during pregnancy may increase the risk of symptom worsening in patients with schizophrenia. Hence, clinicians should be knowledgeable about the risk of decreased drug levels and the need for therapeutic monitoring and dosage adjustments during pregnancy to maintain treatment efficacy and maternal and fetal health.
  • ||||||||||  lurasidone / Generic mfg.
    Journal:  The antipsychotic drug lurasidone inhibits coronaviruses by affecting multiple targets. (Pubmed Central) -  Dec 10, 2024   
    In this study, our investigations on the mechanism of action of lurasidone suggested that the drug exhibits antiviral activity by targeting the papain-like protease (PL-Pro) of both viruses, and the Spike protein of SARS-CoV-2, thereby hampering both the entry and the viral replication. In vitro assays demonstrate that lurasidone significantly reduces viral load in infected cells, showing that the drug is a promising candidate for further development as a dual-action antiviral, offering a potential new strategy in the fight against COVID-19 and other coronavirus-related diseases.
  • ||||||||||  lurasidone / Generic mfg.
    Journal:  Mood stabilizers for treatment of bipolar disorder in pregnancy and impact on neonatal outcomes. (Pubmed Central) -  Dec 9, 2024   
    In vitro assays demonstrate that lurasidone significantly reduces viral load in infected cells, showing that the drug is a promising candidate for further development as a dual-action antiviral, offering a potential new strategy in the fight against COVID-19 and other coronavirus-related diseases. This study suggests that the use of lurasidone, other atypical antipsychotics, and lamotrigine have better neonatal outcomes than untreated bipolar disorder in pregnancy.
  • ||||||||||  lurasidone / Generic mfg.
    Journal:  The potential of supramolecular synthon to develop coamorphous systems with tailored physical stability: Mechanistic insights integrating kinetics and thermodynamics. (Pubmed Central) -  Nov 23, 2024   
    Herein, a supramolecular synthon approach based on the interaction between functional groups, was exploited to design coamorphous systems (CMs) consisting of lurasidone hydrochloride (LH) and three coformers, saccharin (SAC), L-tryptophan (TRP), and L-cysteine hydrochloride (CYS)...Importantly, the relationship between supramolecular synthon and kinetic/thermodynamic mechanisms was also discussed, and the positive correlation between configurational entropy and intermolecular interactions was proposed in this paper. Our findings demonstrated the great potential of supramolecular synthon in designing coamorphous systems with tailored physical stability, and further provided a deeper insight into the mechanisms of physical stability of coamorphous systems.
  • ||||||||||  Promacta (eltrombopag) / Novartis
    Journal:  Discovering Lassa virus nucleoprotein inhibitors via in silico drug repositioning approach. (Pubmed Central) -  Nov 14, 2024   
    The study underscores the importance of further experimental and clinical validation of these in silico findings. The identified drugs present promising candidates for potential treatments for Lassa fever, addressing the current gap in approved therapeutics for this life-threatening infectious disease.
  • ||||||||||  lithium carbonate ER / Generic mfg.
    Lithium-Induced Nephrotic Syndrome: A Rare Complication of a Known Kidney Offender () -  Oct 12, 2024 - Abstract #KIDNEYWEEK2024KIDNEY_WEEK_5259;    
    She was started on Lithium Carbonate 4 months prior...However, if the symptoms persist beyond 6 weeks, a kidney biopsy to exclude other causes and treatment with prednisone have been done in the case reports. Kidney biopsy usually shows minimal change disease.This case provides an example of a rare renal side effect of Lithium that occurs after relative short duration of treatment..
  • ||||||||||  fluoxetine / Generic mfg., lurasidone / Generic mfg.
    Dialysis for Lamotrigine Intoxication in a Teenager () -  Oct 12, 2024 - Abstract #KIDNEYWEEK2024KIDNEY_WEEK_5047;    
    A rebound in LTG level was seen the next day off dialysis; however, patient already had recovery from AMS.Due to the severity of clinical presentation and delay in LTG levels resulting, we performed dialysis for 3 consecutive days in this patient w clinical improvement.. . Lamotrigine intoxication.
  • ||||||||||  lurasidone / Generic mfg.
    PK/PD data, Journal:  Contrasting the pharmacokinetic performance and gut microbiota effects of an amorphous solid dispersion and lipid nanoemulsion for a poorly water-soluble anti-psychotic. (Pubmed Central) -  Sep 12, 2024   
    The poorly soluble antipsychotic, lurasidone, was formulated with ASD and LNE due to its rate-limiting dissolution, poor oral bioavailability, and significant food effect...In contrast, the ASD exerted a 'gut neutral' effect, whereby a mild enrichment of alpha diversity and OTUs was observed. Importantly, this suggests that ASDs are effective solubility-enhancing formulations that can be used without comprising the integrity of the gut microbiota - an integral consideration in the treatment of mental health disorders, such as schizophrenia, due to the role of the gut microbiota in regulating mood and cognition.
  • ||||||||||  Vraylar (cariprazine) / Mitsubishi Tanabe, Recordati, Gedeon Richter, AbbVie, Rexulti (brexpiprazole) / Lundbeck, Otsuka, Caplyta (lumateperone) - Intra / Cellular Therapies
    Review, Journal:  Advances in Mood Disorder Pharmacotherapy: Evaluating New Antipsychotics and Mood Stabilizers for Bipolar Disorder and Schizophrenia. (Pubmed Central) -  Sep 7, 2024   
    The potential of new mood stabilizer candidates lumateperone and brexpiprazole is also presented...The results underscore the importance of ongoing and future research to better understand the action and efficacy of these mood stabilizers and their implications in the treatment of mood disorders, aiming to achieve euthymia and improve the quality of life of affected patients. In this article, we aim to review current drug treatments for the management of mood disorders, including bipolar disorder and schizophrenia.
  • ||||||||||  quetiapine extended-release / Generic mfg., lurasidone / Generic mfg.
    Retrospective data, Journal:  Discontinuation Rate of Lurasidone and Quetiapine Extended Release in Bipolar Depression. (Pubmed Central) -  Sep 3, 2024   
    The acceptability of both antipsychotics to bipolar depression in clinical practice may be similar. However, specific AEs for each antipsychotic (LUR: akathisia and QUE-ER: somnolence) were associated with high treatment discontinuation.
  • ||||||||||  lurasidone / Generic mfg.
    Review, Journal:  Towards full recovery with lurasidone: effective doses in the treatment of agitation, affective, positive, and cognitive symptoms in schizophrenia and of dual psychosis. (Pubmed Central) -  Aug 12, 2024   
    Moreover, practical insights into lurasidone usage encompass swift dose escalation within a 1-5-day span and recommended combination strategies with other medications such as benzodiazepines for insomnia or agitation, beta-blockers for akathisia, and antihistamines or antimuscarinic drugs for patients transitioning rapidly from antipsychotics with substantial antihistamine and/or anticholinergic effects. Finally, a series of clinical cases is presented, highlighting benefits of lurasidone in terms of cognitive function, functional recovery and other therapeutic aspects for the management of schizophrenia.
  • ||||||||||  lurasidone / Generic mfg.
    Preclinical, Journal:  Computational Screening of Repurposed Drugs for HMG-CoA Synthase 2 in Alzheimer's Disease. (Pubmed Central) -  Jul 20, 2024   
    The study revealed that HMGCS2 forms stable protein-ligand complexes with Penfluridol and Lurasidone. Our findings indicate that Penfluridol and Lurasidone competitively bind to HMGCS2 and warrant their further exploration as potential repurposed molecules for anti-Alzheimer's drug development.
  • ||||||||||  lithium carbonate ER / Generic mfg., iloperidone / Generic mfg.
    Journal:  Iloperidone (Fanapt) - a new indication for bipolar disorder. (Pubmed Central) -  Jul 15, 2024   
    Our findings indicate that Penfluridol and Lurasidone competitively bind to HMGCS2 and warrant their further exploration as potential repurposed molecules for anti-Alzheimer's drug development. No abstract available
  • ||||||||||  asenapine / Generic mfg., iloperidone / Generic mfg., lurasidone / Generic mfg.
    Preclinical, Journal:  The effect of new atypical antipsychotic drugs on the expression of transcription factors regulating cytochrome P450 enzymes in rat liver. (Pubmed Central) -  Jun 15, 2024   
    The changes in the expression of AhR, CAR, and PXR mostly correlate with alterations in the expression and activity of respective CYP enzymes found in our previous studies. Since these transcription factors are also engaged in the expression of phase II drug metabolism and drug transporters, changes in their expression may affect the metabolism of endogenous substrates and pharmacokinetics of concomitantly used drugs.
  • ||||||||||  Cyclurad (cycloserine/lurasidone) / NRx Pharma, Alvogen
    Trial completion:  MBD: NRX-101 for Bipolar Depression With Subacute Suicidal Ideation (clinicaltrials.gov) -  May 7, 2024   
    P2/3,  N=74, Completed, 
    Vortioxetine presents as a promising therapeutic alternative that is worth considering for patients with escitalopram-induced jitteriness/anxiety syndrome. Active, not recruiting --> Completed
  • ||||||||||  olanzapine / Generic mfg., lurasidone / Generic mfg.
    Enrollment change, Trial termination:  The Safety and Efficacy of Lurasidone In Subjects With Schizophrenia Switched From Olanzapine (clinicaltrials.gov) -  Apr 19, 2024   
    P4,  N=13, Terminated, 
    These findings emphasize the need for tailored, comprehensive treatment strategies in managing the complexities of this patient population. N=162 --> 13 | Active, not recruiting --> Terminated; Company's business decision
  • ||||||||||  lurasidone / Generic mfg.
    Trial completion, Trial completion date:  The Safety and Effectiveness of Latuda (clinicaltrials.gov) -  Apr 18, 2024   
    P=N/A,  N=3192, Completed, 
    N=162 --> 13 | Active, not recruiting --> Terminated; Company's business decision Enrolling by invitation --> Completed | Trial completion date: Jun 2024 --> Jun 2023