- |||||||||| dronabinol oral / Generic mfg.
Clinical, Journal: Aberrant structural-functional coupling in adult cannabis users. (Pubmed Central) - Apr 10, 2020
Disruption of these processes by delta-9-tetrahydrocannabinol (THC) could produce alterations either in structural and functional brain connectivity or in their association in cannabis (CB) users...Notably, the hippocampus and caudate specifically showed aberrant structural and functional coupling. These structures have high CB1 receptor density and may also be associated with changes in learning and habit formation that occur with chronic cannabis use.
- |||||||||| dronabinol oral / Generic mfg.
Clinical, Journal: Streamlining Quality Review of Mass Spectrometry Data in the Clinical Laboratory by Use of Machine Learning. (Pubmed Central) - Apr 10, 2020
We obtained retrospective data from gas chromatography-MS analyses of 11-nor-9-carboxy-delta-9-tetrahydrocannabinol (THC-COOH) in 1267 urine samples...Automated data review identified all analytically unacceptable assays in the test dataset, while reducing the manual review requirement by about 87%. This automation strategy can focus manual review only on assays likely to be problematic, allowing improved throughput and turnaround time without reducing quality.
- |||||||||| dronabinol oral / Generic mfg.
Trial suspension: Effects of Dronabinol in Opioid Maintained Patients (clinicaltrials.gov) - Apr 9, 2020
P1, N=20, Suspended,
This automation strategy can focus manual review only on assays likely to be problematic, allowing improved throughput and turnaround time without reducing quality. Recruiting --> Suspended
- |||||||||| dronabinol oral / Generic mfg.
Dose-Response Relationship between Vaporised Cannabidiol and Increase in Serum Anandamide in Healthy Volunteers (Spadolini - Ground Floor) - Apr 4, 2020 - Abstract #SIRS2020SIRS_1354;
In addition, CBD has been shown to reduce psychomimetic effects of delta-9-tetrahydrocannabinol (THC) when delivered simultaneously...However, as the dose of THC remained consistent while the amount of CBD did not, the original hypothesis remains valid. These findings support the theory that CBD inhibits degradation of AEA in humans, even at low doses, and implicate the FAAH enzyme as a potential novel target for treatment of psychosis.
- |||||||||| dronabinol oral / Generic mfg.
Relationship between Schizophrenia Polygenic Risk Score and the Acute Psychotomimetic Effects of Cannabinoids. (Spadolini - Ground Floor) - Apr 4, 2020 - Abstract #SIRS2020SIRS_1204;
Using a well-validated human laboratory paradigm with delta-9-tetrahydrocannabinol (THC), the main psychotomimetic constituent of cannabis, healthy individuals receive intravenous THC or placebo in a double blind, placebo controlled, randomized manner...Discussion Preliminary evidence suggest that SCZ-PRS influences the psychosis-like effects of cannabinoids. Future studies will examine the impact of prior cannabis exposure, family history of psychosis and individual variability in the endocannabinoid system on the association between SCZ-PRS and cannabinoid related psychosis.
- |||||||||| dronabinol oral / Generic mfg.
Journal: Characterization of new chloroplast markers to determine biogeographical origin and crop type of Cannabis sativa. (Pubmed Central) - Apr 3, 2020
sativa crops can be classified as marijuana (a drug containing the psychoactive chemical delta-9-tetrahydrocannabinol) or hemp (the non-drug form of the plant)...Hemp samples from the USA and Canada, marijuana samples from Mexico and Chile, and medical marijuana samples from Chile were evaluated using two cpDNA hotspot regions, rpl32-trnL and trnS-trnG. Principal component analysis supported some differences between the groups based on their crop type and biogeographic origin.
- |||||||||| dronabinol oral / Generic mfg.
Effects of Delta-9-Tetrahydrocannabinol (THC) on Oocyte Competence and Early Embryonic Development (ENDOExpo) - Apr 1, 2020 - Abstract #ENDO2020ENDO_4167;
Differences seen exclusively at the low THC dose suggest a role of THC as partial agonist of CB1. This research aims to understand the effects of cannabis on fertility, as current knowledge during pre-implantation development is limited, making it difficult for physicians to properly advise patients undergoing IVF.
- |||||||||| dronabinol oral / Generic mfg.
Effects of Delta-9-Tetrahydrocannabinol (THC) on Oocyte Competence and Early Embryonic Development (Room 154) - Apr 1, 2020 - Abstract #ENDO2020ENDO_3612;
Differences seen exclusively at the low THC dose suggest a role of THC as partial agonist of CB1. This research aims to understand the effects of cannabis on fertility, as current knowledge during pre-implantation development is limited, making it difficult for physicians to properly advise patients undergoing IVF.
- |||||||||| dronabinol oral / Generic mfg.
Journal: Cannabis y los sistemas exocannabinoide y endocannabinoide. Su uso y controversias. (Pubmed Central) - Mar 31, 2020
The primary cannabinoids that have been studied to date include cannabidiol and delta-9-tetrahydrocannabinol, which is responsible for most cannabis physical and psychotropic effects...Some studies suggest cannabidiol has great potential for therapeutic use as an agent with antiepileptic, analgesic, anxiolytic, antipsychotic, anti-inflammatory and neuroprotective properties; however, the findings on cannabinoids efficacy and cannabis-based medications tolerability-safety for some conditions are inconsistent. More scientific evidence is required in order to generate recommendations on the use of medicinal cannabis.
- |||||||||| dronabinol oral / Generic mfg.
Review, Journal: Cannabis use and the sperm epigenome: a budding concern? (Pubmed Central) - Mar 28, 2020
This review summarizes cannabis use and potency in the USA, provides a brief overview of DNA methylation as an epigenetic mechanism that is vulnerable in sperm to environmental exposures including cannabis, and summarizes studies that have examined the effects of parental exposure to cannabis or delta-9 tetrahydrocannabinol (THC, the main psychoactive component of cannabis) on the epigenetic profile of the gametes and behavior of offspring...These data substantiate an urgent need for additional studies assessing the effects of cannabis exposure on childhood health and development. This is especially true given the current growing state of cannabis use in the USA.
- |||||||||| dronabinol oral / Generic mfg.
Clinical, Journal, Adverse events: Dronabinol Therapy: Central Nervous System Adverse Events in Adults With Primary Brain Tumors. (Pubmed Central) - Mar 24, 2020
This secondary analysis explored CNS adverse events reported by adults with primary brain tumors while receiving dronabinol during chemotherapy. The occurrence of CNS adverse events in this population was similar to that reported by patients in other oncology populations.
- |||||||||| dronabinol oral / Generic mfg.
Review, Journal: Cannabinoids, Blood-Brain Barrier, and Brain Disposition. (Pubmed Central) - Mar 19, 2020
Potential therapeutic actions of the cannabinoids delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) are based on their activity as analgesics, anti-emetics, anti-inflammatory agents, anti-seizure compounds...Delivery of these cannabinoids in the brain following different routes of administration (subcutaneous, oral, and pulmonary) is illustrated and commented. Finally, the potential role of cannabinoids in drug-resistance in the clinical management of neurological or psychiatric diseases such as epilepsy and schizophrenia is discussed on the light of their crossing the BBB.
- |||||||||| dexamethasone / Generic mfg., mirtazapine / Generic mfg., dronabinol oral / Generic mfg.
Trial completion date, Trial initiation date, HEOR: Nutrition and Pharmacological Algorithm for Oncology Patients Study (clinicaltrials.gov) - Mar 18, 2020
P4, N=30, Not yet recruiting,
Finally, the potential role of cannabinoids in drug-resistance in the clinical management of neurological or psychiatric diseases such as epilepsy and schizophrenia is discussed on the light of their crossing the BBB. Trial completion date: Jun 2020 --> Dec 2020 | Initiation date: Feb 2020 --> May 2020
- |||||||||| dronabinol oral / Generic mfg.
Blowing Bubbles: A Case of Pneumatoceles Due to Vaping (PENNSYLVANIA CONVENTION CENTER, Hall D-E (200 Level), Area A) - Mar 15, 2020 - Abstract #ATS2020ATS_9664;
Delta-9-tetrahydrocannabinol (THC) containing products have been implicated in the majority of cases, although the exact mechanism remains unidentified...CT scan confirmed extensive pneumomediastinum, diffuse bilateral ground glass opacities with mosaic attenuation, and a single air sac in the anterior basilar segment of the right lower lobe that was felt to represent a cyst or pneumatocele (Figure 1a).Methylprednisolone and antibiotics were initiated for vaping-related pneumonitis versus community acquired pneumonia...Finally, a toxic chemical within the vape product could result in direct alveolar wall destruction. Underlying asthma may have put this patient at higher risk for small airway inflammation and obstruction, possibly contributing to subacute development of extensive pneumatoceles unique to his case.
- |||||||||| dronabinol oral / Generic mfg.
Journal: Cannabis and Cannabinoid Biology in Stroke. (Pubmed Central) - Mar 13, 2020
Underlying asthma may have put this patient at higher risk for small airway inflammation and obstruction, possibly contributing to subacute development of extensive pneumatoceles unique to his case. No abstract available
- |||||||||| dronabinol oral / Generic mfg.
Journal: Marijuana Use in Pregnancy: A Review. (Pubmed Central) - Mar 4, 2020
The main active chemical of marijuana (delta-9-tetrahydrocannabinol [THC]) readily crosses the placenta, and cannabinoid receptors have been identified in fetal brain and placenta...There is a critical need for research on effects in pregnancy using present-day THC doses. Once the adverse perinatal effects of marijuana exposure are identified and well characterized, patient education and antenatal surveillance can be developed to predict and mitigate its impact on maternal and fetal health.
- |||||||||| dronabinol oral / Generic mfg.
Journal: Cannabis and Cognition: Connecting the Dots towards the Understanding of the Relationship. (Pubmed Central) - Mar 4, 2020
Cognitive impairments affect patients' daily functions, sociability, and long-term outcome, posing elevated economic, social, and clinical burdens. There is, thus, a compelling case for implementing behavioral and cognitive rehabilitation therapies for these patients, as well as investigating the endocannabinoid system in the development of new psychopharmacological treatments.
- |||||||||| dronabinol oral / Generic mfg.
Trial completion date, Trial primary completion date: Individual Differences in Drug Response (clinicaltrials.gov) - Mar 4, 2020
P1, N=60, Recruiting,
There is, thus, a compelling case for implementing behavioral and cognitive rehabilitation therapies for these patients, as well as investigating the endocannabinoid system in the development of new psychopharmacological treatments. Trial completion date: Jun 2020 --> Jun 2021 | Trial primary completion date: Jun 2020 --> Jun 2021
- |||||||||| dronabinol oral / Generic mfg.
Trial primary completion date: Tetrahydrocannabinol (THC) and Sleep (clinicaltrials.gov) - Mar 3, 2020
P1, N=14, Recruiting,
Trial completion date: Jun 2020 --> Jun 2021 | Trial primary completion date: Jun 2020 --> Jun 2021 Trial primary completion date: Feb 2020 --> Feb 2021
- |||||||||| dronabinol oral / Generic mfg.
Clinical, Journal: Efficacy and Safety of Appetite-Stimulating Medications in the Inpatient Setting. (Pubmed Central) - Mar 2, 2020
Conclusion and Relevance: In inpatients, there was no difference in change in meal intake or weight between dronabinol, megestrol, or mirtazapine, but they may show numerical improvements in meal intake. To our knowledge, this is the first study to evaluate the use of dronabinol, megestrol, and mirtazapine initiated in the inpatient setting.
- |||||||||| dronabinol oral / Generic mfg.
Review, Journal: A Review of Scientific Evidence for THC:CBD Oromucosal Spray (Nabiximols) in the Management of Chronic Pain. (Pubmed Central) - Mar 1, 2020
This review examines evidence for THC:CBD oromucosal spray (nabiximols) in the management of chronic pain conditions. Cumulative evidence from clinical trials and an exploratory analysis of the German Pain e-Registry suggests that add-on THC:CBD oromucosal spray (nabiximols) may have a role in managing chronic neuropathic pain, although further precise clinical trials are required to draw definitive conclusions.
- |||||||||| dronabinol oral / Generic mfg.
Clinical, Journal: Delta-9-THC exposure during zebra finch sensorimotor vocal learning increases cocaine reinforcement in adulthood. (Pubmed Central) - Feb 28, 2020
Use of this place conditioning method has allowed us to determine that, when administered during periods of sensorimotor vocal learning, delta-9-THC, but not nicotine persistently increases sensitivity to cocaine through adulthood. Establishment of this method significantly expands the songbird drug exposure model, and holds promise for better appreciation of mechanisms important to sensorimotor learning that is dependent upon successful progress through sensitive periods of CNS development.
- |||||||||| galantamine hydrobromide / Generic mfg., dronabinol oral / Generic mfg.
Journal: Feasibility and effects of galantamine on cognition in humans with cannabis use disorder. (Pubmed Central) - Feb 26, 2020
The findings of this pilot study support the feasibility of the administration of galantamine for individuals with CUD. Adequately powered, randomized, placebo-controlled trials are required to investigate the potential of galantamine to improve cognitive deficits associated with CUD.
- |||||||||| dronabinol oral / Generic mfg.
Trial completion date, Trial initiation date, Trial primary completion date: Effects of Delta9-tetrahydrocannabinol (THC) on Retention of Memory for Fear Extinction Learning in PTSD: R33 Study (clinicaltrials.gov) - Feb 23, 2020
P1, N=100, Not yet recruiting,
Adequately powered, randomized, placebo-controlled trials are required to investigate the potential of galantamine to improve cognitive deficits associated with CUD. Trial completion date: Dec 2022 --> Dec 2023 | Initiation date: Jan 2020 --> Jul 2020 | Trial primary completion date: Dec 2022 --> Dec 2023
- |||||||||| Relivar (dronabinol buccal) / Sumitomo Dainippon, dronabinol oral / Generic mfg.
Dronabinol prescribing at one hospital in a state with legalized recreational cannabis () - Feb 20, 2020 - Abstract #ASAM2020ASAM_229;
This analysis signals that inpatient prescribing of dronabinol at one institution in a state with high-potency, legalized cannabis occurs with some frequency and may be increasing. Furthermore, prescribing of dronabinol is highest on small surgical subspecialty services, suggesting that prescribing culture varies widely on the inpatient services.
- |||||||||| dronabinol oral / Generic mfg.
A Case of a Posterior Fossa Atypical Teratoid Rhabdoid Tumor in an Adult Female () - Feb 11, 2020 - Abstract #ISPRM2020ISPRM_326;
Given such limited cases reported in adults, overall prognosis and impact of resection and adjuvant therapy remains unclear.Conclusions : AT/RT is a rare, potentially devastating diagnosis which can produce an array of neurologic and functional deficits. These patients would benefit from early access to a multidisciplinary team including oncology, neurosurgery and rehabilitation medicine to assist with ongoing care.
- |||||||||| dronabinol oral / Generic mfg.
Journal: Gene copy number is associated with phytochemistry in Cannabis sativa. (Pubmed Central) - Feb 6, 2020
Two major cannabinoids-THCA (delta-9-tetrahydrocannabinolic acid) and CBDA (cannabidiolic acid)-are products of a three-step biochemical pathway...Our results demonstrate that biosynthetic genes found at multiple points in the pathway could be useful for breeding purposes, and suggest that natural and artificial selection have shaped CN variation. Truncations in specific paralogs are associated with lack of production of particular cannabinoids, showing how phytochemical diversity can evolve through a complex combination of processes.
- |||||||||| dronabinol oral / Generic mfg.
Clinical, Journal: Impact of Cannabinoids on Symptoms of Refractory Gastroparesis: A Single-center Experience. (Pubmed Central) - Jan 30, 2020
Conclusions Cannabinoids dramatically improve the symptoms of gastroparesis. Furthermore, an improvement in abdominal pain with cannabinoids represents a breakthrough for gastroparesis-associated abdominal pain treatment, for which there are currently no validated therapies.
- |||||||||| dronabinol oral / Generic mfg.
Clinical, Journal: Cannabinoid modulation of opioid analgesia and subjective drug effects in healthy humans. (Pubmed Central) - Jan 29, 2020
This study indicates that dronabinol did not enhance the analgesic effects of oxycodone and increased abuse- and impairment-related subjective effects. These data suggest that dronabinol may not be an effective or appropriate opioid adjuvant; it could potentially increase opioid dose requirements, while increasing psychoactive opioid effects.
- |||||||||| dronabinol oral / Generic mfg.
Clinical, PK/PD data, Journal: A patient-centric liquid chromatography-tandem mass spectrometry microsampling assay for analysis of cannabinoids in human whole blood: Application to pediatric pharmacokinetic study. (Pubmed Central) - Jan 28, 2020
Three major cannabinoids in cannabis are delta-9-tetrahydrocannabinol (THC), cannabidiol (CBD), and cannabinol (CBN)...Dried microsamples were stable for one week at 40 °C, two weeks (15 days) under different storage conditions (room temperature, 4, -20 and -78 °C), one month (29 days) at -20 and -78 °C and three months (68 days) at -78 °C. This assay provides an efficient quantitation of THC, CBD, and CBN in VAMS™ devices and is currently being implemented for pediatric clinical trials.
- |||||||||| dronabinol oral / Generic mfg.
Enrollment open, Enrollment change, Trial completion date, Trial initiation date, Trial primary completion date: Evaluation of Dronabinol For Acute Pain Following Traumatic Injury (clinicaltrials.gov) - Jan 27, 2020
P2, N=122, Enrolling by invitation,
This assay provides an efficient quantitation of THC, CBD, and CBN in VAMS™ devices and is currently being implemented for pediatric clinical trials. Not yet recruiting --> Enrolling by invitation | N=216 --> 122 | Trial completion date: Jun 2020 --> Jul 2021 | Initiation date: Apr 2019 --> Oct 2019 | Trial primary completion date: May 2020 --> May 2021
- |||||||||| hydromorphone hydrochloride / Generic mfg., dronabinol oral / Generic mfg.
Trial completion date, Trial primary completion date: Enhancing Medication-based Analgesia in Humans (clinicaltrials.gov) - Jan 22, 2020
P2, N=100, Recruiting,
Increased neural activation in PFC represents a potential biomarker for cannabis intoxication. Trial completion date: Jan 2020 --> Apr 2020 | Trial primary completion date: Jan 2020 --> Apr 2020
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