- |||||||||| dexamethasone / Generic mfg., mirtazapine / Generic mfg., dronabinol oral / Generic mfg.
Trial completion date, Trial initiation date, Trial primary completion date, HEOR: Nutrition and Pharmacological Algorithm for Oncology Patients Study (clinicaltrials.gov) - Oct 28, 2020
P4, N=30, Not yet recruiting,
Trial completion date: Sep 2021 --> Dec 2021 | Initiation date: Sep 2020 --> Jan 2021 | Trial primary completion date: Sep 2021 --> Dec 2021
- |||||||||| pregabalin / Generic mfg., dronabinol oral / Generic mfg.
[VIRTUAL] A Case Report Of Analgesia Alternative: Dronabinol () - Oct 17, 2020 - Abstract #ASA2020ASA_1342;
Initial pain regimen included acetaminophen, tramadol, methocarbamol, pregabalin, lidocaine patch and celecoxib, which did not control patient's pain. Decision was made to start patient on Dronabinol, which provided significant analgesia.
- |||||||||| Duragesic (fentanyl) / J&J
[VIRTUAL] A Case Report Of Alternative Analgesia: Dronabinol () - Oct 17, 2020 - Abstract #ASA2020ASA_1288;
Initial pain regimen included acetaminophen, tramadol, methocarbamol, pregabalin, lidocaine patch and ketorolac for two days before transitioning to celecoxib, which did not control patient's pain. Decision was made to start patient on Dronabinol, which provided significant analgesia.
- |||||||||| dronabinol oral / Generic mfg.
[VIRTUAL] Ganja Kidney: Acute Tubular Injury Associated with Synthetic Marijuana, A Rising Incidence (On-Demand) - Oct 11, 2020 - Abstract #KIDNEYWEEK2020KIDNEY_WEEK_668;
Discussion Cannabinoids are found in natural marijuana and contain many active compounds, but delta-9 tetrahydrocannabinol (THC) and cannabidiol (CBD) are of most interest...Compared to cannabis, synthetic cannabinoids have a greater risk for serious neuropsychiatric toxicity and severe acute kidney injury. We need more clinical research to identify the specific nephrotoxic agents.
- |||||||||| dronabinol oral / Generic mfg.
[VIRTUAL] Analysis of Medical Use of Cannabis in the World- State and Prospects () - Oct 3, 2020 - Abstract #ISPOREU2020ISPOR-EU_537;
The formulations of dronabinol are available in the US, Canada, and New Zealand by prescription...The medical indications for the treatment of various diseases have increased significantly, but medical cannabis is an expensive treatment. Therefore, evidence-based data on effectivenessn safety of medical marijuana, it’s dosage, treatment duration is needed and prospective for the rational use of cannabis products to prevent addiction among young people and patients.
- |||||||||| dronabinol oral / Generic mfg.
Journal: Vape shop owners'/managers' attitudes about CBD, THC, and marijuana legal markets. (Pubmed Central) - Oct 2, 2020
Over the past decade in the US there have been marked pivotal changes in the policy and retail environment regarding cannabinoids, particularly cannabidiol (CBD) and delta-9-tetrahydrocannabinol (THC)...Some chose to distance themselves from marijuana products, their use, and the possibility of entering marijuana retail if it were to evolve in their state, while some indicated high levels of enthusiasm for the growing retail marijuana market. Future research should examine how vape shops and other retailers of CBD and marijuana communicate with consumers about products and modes of using such products, as well as how various industry sectors (e.g., vape shops) adapt or evolve with increasing regulation of nicotine and increasing legalization of marijuana retail.
- |||||||||| dronabinol oral / Generic mfg.
[VIRTUAL] Sleep Disruption, and Other Behavioral Alterations, During Withdrawal Following Chronic THC Exposure in Mice () - Sep 30, 2020 - Abstract #ACNP2020ACNP_414;
However, because reliable, objective measures of withdrawal from delta-9-tetrahydrocannabinol (THC), the major psychoactive ingredient in cannabis, are generally difficult to observe in laboratory animal models, back-translational studies on the physiological mechanism of cannabis/THC withdrawal are lacking... These data open the door for pre-clinical research efforts to determine the neurobiological bases of, and potentially treat, a primary withdrawal symptom of cannabis use disorder.
- |||||||||| dronabinol oral / Generic mfg.
Journal: Potential of Cannabinoid Receptor Ligands as Treatment for Substance Use Disorders. (Pubmed Central) - Sep 23, 2020
As evidence continues to accumulate, neutral CB1R antagonists (such as AM4113), CB2R agonists (JWH133, Xie2-64), and nonselective phytocannabinoids (cannabidiol, β-caryophyllene, ∆-tetrahydrocannabivarin) have shown great therapeutic potential for SUDs, as shown in experimental animals. Several cannabinoid-based medications (e.g., dronabinol, nabilone, PF-04457845) that entered clinical trials have shown promising results in reducing withdrawal symptoms in cannabis and opioid users.
- |||||||||| dronabinol oral / Generic mfg.
[VIRTUAL] Master Class 03 - Cannabis in Cancer Care - Part 2 (T.J. Eichler Theater, Master Classes) - Sep 13, 2020 - Abstract #ASTRO2020ASTRO_1835;
Cannabidiol (CBD) has emerged as a most favored cannabinoid because, unlike delta-9-tetrahydrocannabinol (THC), it is not “psychoactive.” The current CBD knowledge base will be explained...To outline the potential therapeutic benefits of cannabis and cannabinoids in patients with cancer. To assess the data suggesting that cannabinoids have anti-cancer activity.
- |||||||||| dronabinol oral / Generic mfg.
[VIRTUAL] Master Class 03 - Cannabis in Cancer Care - Part 1 (T.J. Eichler Theater, Master Classes) - Sep 13, 2020 - Abstract #ASTRO2020ASTRO_1525;
Cannabidiol (CBD) has emerged as a most favored cannabinoid because, unlike delta-9-tetrahydrocannabinol (THC), it is not “psychoactive.” The current CBD knowledge base will be explained...To outline the potential therapeutic benefits of cannabis and cannabinoids in patients with cancer. To assess the data suggesting that cannabinoids have anti-cancer activity.
- |||||||||| dronabinol oral / Generic mfg.
Retrospective data, Review, Journal: A global systematic review and meta-analysis on illicit drug consumption rate through wastewater-based epidemiology. (Pubmed Central) - Sep 5, 2020
The heterogeneity within studies based on continents subgroup just decreased in America for drugs like 11-nor-9-carboxy-delta9-tetrahydrocannabinol (I = 24.4%) and benzoylecgonine (I = 94.1%). The outcome of this meta-analysis can be used for finding the illicit drugs with global serious problem in view of consumption rate (i.e., cannabis and cocaine) and helping authorities to combat them.
- |||||||||| dronabinol oral / Generic mfg.
[VIRTUAL] Cannabinoids show anti-tumor effectiveness in soft tissue sarcomas (Abstract video presentations) - Sep 3, 2020 - Abstract #DGHO2020DGHO_1751;
Our findings provide a rationale to clinically explore cannabinoids in STS subentities as agents with remarkable antitumor efficacy. In specific, cannabinoids may provide a tool to positively interact and slow down tumor progression and metastasis.
- |||||||||| dronabinol oral / Generic mfg.
[VIRTUAL] Cannabinoids show anti-tumor effectiveness in soft tissue sarcomas (Abstract video presentations) - Sep 3, 2020 - Abstract #DGHO2020DGHO_993;
Our findings provide a rationale to clinically explore cannabinoids in STS subentities as agents with remarkable antitumor efficacy. In specific, cannabinoids may provide a tool to positively interact and slow down tumor progression and metastasis.
- |||||||||| dronabinol oral / Generic mfg.
[VIRTUAL] Cannabinoids show anti-tumor effectiveness in soft tissue sarcomas (Abstract video presentations) - Sep 3, 2020 - Abstract #DGHO2020DGHO_153;
Our findings provide a rationale to clinically explore cannabinoids in STS subentities as agents with remarkable antitumor efficacy. In specific, cannabinoids may provide a tool to positively interact and slow down tumor progression and metastasis.
- |||||||||| dronabinol oral / Generic mfg.
Clinical, Journal: Use of cannabidiol oil in children (Pubmed Central) - Sep 2, 2020
If a patient presents with poorly-understood fever, diarrhoea, vomiting or drowsiness, then the side effects of CBD oil should be considered. Finally, CBD should be differentiated from delta-THC, a cannabis-derived chemical with a psychoactive effect, the use of which should be discouraged in children.
- |||||||||| dronabinol oral / Generic mfg.
Review, Journal: Should Oncologists Recommend Cannabis? (Pubmed Central) - Aug 27, 2020
However, delta-9-tetrahydrocannabinol (THC) has been developed as a stand-alone pharmaceutical initially approved for the treatment of chemotherapy-related nausea and vomiting in 1986...Although many healthcare providers advise against the inhalation of a botanical as a twenty-first century drug-delivery system, evidence for serious harmful effects of cannabis inhalation is scant and a variety of other methods of ingestion are currently available from dispensaries in locales where patients have access to medicinal cannabis. Oncologists and palliative care providers should recommend this botanical remedy to their patients to gain first-hand evidence of its therapeutic potential despite the paucity of results from randomized placebo-controlled clinical trials to appreciate that it is both safe and effective and really does not require a package insert.
- |||||||||| dronabinol oral / Generic mfg.
Clinical, Journal: Preinjury Use of Marijuana and Outcomes in Trauma Patients. (Pubmed Central) - Aug 22, 2020
Although preinjury use of marijuana does not improve survival in trauma patients, it may provide some improvement in outcomes in patients with traumatic brain injury and those that are more severely injured (Injury Severity Score ≥16). The mechanism behind this finding needs further evaluation.
- |||||||||| dronabinol oral / Generic mfg.
[VIRTUAL] Does “cannabis-derived” mean to the public what it does to a chemist? (On Demand Oral) - Aug 20, 2020 - Abstract #ACSFall2020ACS-Fall_3270;
Language in the Agricultural Improvement Act of 2018 (the “2018 Farm Bill”) and state adult-use cannabis statutes ostensibly permit a wide-range of compounds in hemp and cannabis products beyond garden variety delta-9 tetrahydrocannabinol (THC) and cannabidiol (CBD)...Waiting for official mandates to establish jurisdiction subsequent to legally-sanctioned and regulated cannabis systems shortchanges expertise and foresight that can be applied now. In the interim, Academia and Industry can assist by creating the tools necessary to impel this issue.
- |||||||||| dronabinol oral / Generic mfg.
[VIRTUAL] Synthesis and pharmacology of delta 8 THC (On Demand Oral) - Aug 20, 2020 - Abstract #ACSFall2020ACS-Fall_3243;
This presentation will introduce delta 8 THC though its synthesis and pharmacology. Additionally it will compare and contrast the differences and similarities to delta 9 THC.
- |||||||||| dronabinol oral / Generic mfg.
[VIRTUAL] Analytical testing to ensure regulatory compliance and safety of cannabis products (On Demand Oral) - Aug 20, 2020 - Abstract #ACSFall2020ACS-Fall_3233;
The marketplace for cannabis and cannabis-derived products, including delta-9-tetrahydrocannabinol (THC, the main psychoactive ingredient) and cannabidiol (CBD, an ingredient with purported health benefits) is growing rapidly...As the availability of cannabis products continues to expand, issues related to product safety should garner study and attention. Therefore, the presentation will conclude with recommendations for future research areas to understand cannabis adulteration and potential health risks and address related analytical challenges.
- |||||||||| dronabinol oral / Generic mfg.
[VIRTUAL] Does “cannabis-derived” mean to the public what it does to a chemist? (Broadcast) - Aug 20, 2020 - Abstract #ACSFall2020ACS-Fall_610;
Language in the Agricultural Improvement Act of 2018 (the “2018 Farm Bill”) and state adult-use cannabis statutes ostensibly permit a wide-range of compounds in hemp and cannabis products beyond garden variety delta-9 tetrahydrocannabinol (THC) and cannabidiol (CBD)...Waiting for official mandates to establish jurisdiction subsequent to legally-sanctioned and regulated cannabis systems shortchanges expertise and foresight that can be applied now. In the interim, Academia and Industry can assist by creating the tools necessary to impel this issue.
- |||||||||| dronabinol oral / Generic mfg.
[VIRTUAL] Effect of nabiximols cannabinoid oromucosal spray on depressive symptoms, suicidality, and cognition in patients with multiple sclerosis (MS) () - Aug 16, 2020 - Abstract #MSDC2020MSDC_1096;
Background Substantial evidence has shown nabiximols, a complex botanical mixture containing delta-9-tetrahydrocannabinol and cannabidiol as the principal cannabinoids, can reduce spasticity associated with MS...Treatment difference of the adjusted mean was -1.47 (-6.41, 3.48), indicating nabiximols does not adversely affect working memory/cognitive processing speed in MS patients over a 48-week period compared with placebo.Conclusions Nabiximols had no notable effects on depression, suicidality, or working memory/processing speed in patients with MS. Funding: Greenwich Biosciences, Inc.
- |||||||||| dronabinol oral / Generic mfg.
Journal: Developing a phone-based measure of impairment after acute oral ∆-tetrahydrocannabinol. (Pubmed Central) - Aug 13, 2020
The phone tasks were brief, to facilitate use in a non-laboratory setting, but it is likely that this made them less sensitive to the impairing effects of ∆-tetrahydrocannabinol. These findings confirm that ∆-tetrahydrocannabinol impairs performance on several tasks at two recreationally relevant doses, but raises question about the feasibility of designing a phone application as a sensitive field sobriety test for cannabis.
- |||||||||| dronabinol oral / Generic mfg.
Trial primary completion date: THC-PREG-I: Testing the Interactive Effects of Delta-9-Tetrahydrocannabinol and Pregnenolone: Sub-Study I (clinicaltrials.gov) - Aug 8, 2020
P1, N=19, Recruiting,
These findings confirm that ∆-tetrahydrocannabinol impairs performance on several tasks at two recreationally relevant doses, but raises question about the feasibility of designing a phone application as a sensitive field sobriety test for cannabis. Trial primary completion date: Aug 2020 --> Dec 2020
- |||||||||| dronabinol oral / Generic mfg.
Trial completion date, Trial primary completion date: Effects of Dronabinol in Opioid Maintained Patients (clinicaltrials.gov) - Aug 7, 2020
P1, N=20, Suspended,
This finding suggests that prefrontal dopamine levels are involved in the susceptibility to acute effects of cannabis. Trial completion date: Aug 2020 --> Jan 2021 | Trial primary completion date: May 2020 --> Dec 2020
- |||||||||| dronabinol oral / Generic mfg.
Trial completion date, Trial initiation date, Trial primary completion date: PrECEPT: Effects of Pregnancy-associated Hormones on THC Metabolism in Women (clinicaltrials.gov) - Aug 7, 2020
P4, N=12, Not yet recruiting,
Trial completion date: Aug 2020 --> Jan 2021 | Trial primary completion date: May 2020 --> Dec 2020 Trial completion date: Jun 2024 --> Dec 2023 | Initiation date: Jun 2020 --> Sep 2020 | Trial primary completion date: Jan 2024 --> May 2023
- |||||||||| dronabinol oral / Generic mfg.
Review, Journal: A Review of Human Studies Assessing Cannabidiol's (CBD) Therapeutic Actions and Potential. (Pubmed Central) - Aug 5, 2020
Numerous CBD products are available, ranging from a US Food and Drug Administration (FDA)-approved product called Epidiolex to products created for medical marijuana dispensaries and products sold in smoke shops, convenience stores, and over the Internet...CBD is not risk free, with adverse events (primarily somnolence and gastrointestinal in nature) and drug interactions. CBD has been shown to increase liver function tests and needs further study to assess its impact on suicidal ideation.
- |||||||||| dronabinol oral / Generic mfg.
[VIRTUAL] Cannabinoid CB1 and dopamine D2 receptors transcriptional dysregulation in perinatal delta-9-tetrahydrocannabinol exposed rats and in schizophrenic subjects (Poster Area) - Aug 5, 2020 - Abstract #ECNP2020ECNP_866;
In schizophrenic patients, DRD2 DNA methylation was significantly reduced at CpG site 1 (CNT: 3.57 ± 0.14; SCZ: 3.06 ± 0.11; p=0.0114), CpG 2 (CNT: 3.49 ± 0.14; SCZ: 2.81 ± 0.11; p=0.00079), CpG 3 (CNT: 3.16 ± 0.14; SCZ: 2.62 ± 0.12; p=0.0092) as well as in the average of the 3 CpG sites investigated (CNT: 3.40 ± 0.13; SCZ: 2.82 ± 0.10; p=0.0032). Conclusions The DRD2 and CNR1 dysregulation here reported further supports the hypothesis that the dopamine-cannabinoid interaction could underlie psychotic disorder and the CBD treatment effect highlighted suggest how this compound may normalize THC induced psychosis modulating Dopaminergic activity.
- |||||||||| dronabinol oral / Generic mfg.
[VIRTUAL] Frequency of anxious and depressive symptoms in a population of cannabidiol users (Poster Area) - Aug 5, 2020 - Abstract #ECNP2020ECNP_342;
Cannabidiol (CBD) and delta-9-tetrahydrocannabinol (THC) are the main active cannabinoids in cannabis...However, self-medication of subclinical withdrawal symptoms in subjects with cannabis use disorders cannot be ruled out, given their high frequency in this population. More studies should be perform in order to highlight the clinical characteristics of CBD users, that in some case could be take in charge by clinicians notably psychiatrists.
- |||||||||| dronabinol oral / Generic mfg.
Journal: Medical cannabis: What practitioners need to know. (Pubmed Central) - Aug 1, 2020
Cannabis contains varying amounts of the cannabinoids delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD), depending on various cultivation factors...Cannabis is associated with a greater risk of adverse effects than active and placebo controls, and may be involved in clinically significant drug-drug interactions. The evolving regulatory and legal landscape on the use of medical cannabis will guide prescription and recreational use in the coming years.
- |||||||||| dronabinol oral / Generic mfg.
Biomarker, Journal: Cannabis-induced altered states of consciousness are associated with specific dynamic brain connectivity states. (Pubmed Central) - Jul 31, 2020
Behavioural measures of the subjective experiences of changed perceptions and tetrahydrocannabinol plasma levels during intoxication were associated with this state. With the help of the dynamic connectivity approach we could elucidate neural correlates of the transitory perceptual changes induced by delta-9-tetrahydrocannabinol in cannabis users, and possibly identify a biomarker of cannabis intoxication.
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