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Journal: Epigenetic activation of O-linked β-N-acetylglucosamine transferase overrides the differentiation blockage in acute leukemia. (Pubmed Central) - Jan 26, 2021 Our novel methodology helps meet demands for reliable cultivar characterization in the context of an ever-growing market for medicinal and recreational cannabis. In conclusion, we provide evidence for overcoming the differentiation blockage in acute leukemia in subentities beyond promyelocytic and IDH1/2-mutated leukemia and thereby identify O-GlcNAcylation as a novel (drugable) field for future leukemia research.
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Journal: Labeling of Cannabidiol Products: A Public Health Perspective. (Pubmed Central) - Jan 1, 2021 Manufacturers of these products may reasonably be expected to understand and adhere to FDA regulations for labeling and marketing of food, dietary supplements and drugs, both over-the-counter (OTC) and prescription, even though FDA has interpreted federal law as excluding them from these categories. As manufacturers prepare for forthcoming regulations, a better understanding of the basic framework for FDA labeling and marketing regulations for food, dietary supplements and drugs is warranted.
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Journal: Chronic adolescent exposure to ∆9-tetrahydrocannabinol decreases NMDA current and extrasynaptic plasmalemmal density of NMDA GluN1 subunits in the prelimbic cortex of adult male mice. (Pubmed Central) - Dec 30, 2020 Adolescence is a vulnerable period of development when limbic connection of the prefrontal cortex (PFC) involved in emotional processing may be rendered dysfunctional by chronic exposure to delta-9-tetrahydrocannabinol (∆9-THC), the major psychoactive compound in marijuana...Electron microscopic immunolabeling in the PL-PFC of adult mice that had received Δ9-THC only during adolescence showed a significant (1) decrease in the extrasynaptic plasmalemmal density of obligatory GluN1-NMDA subunits in dendrites of all sizes and (2) a shift from cytoplasmic to plasmalemmal distribution of GluN1 in large dendrites receiving mainly inhibitory-type synapses from CB1R-labeled terminals. From these results and concomitant behavioral studies, we conclude that social dysfunctions resulting from excessive intake of ∆9-THC in the increasingly available marijuana products used by male teens may largely reflect circuit defects in PL-PFC networks communicating through endocannabinoid-regulated NMDA receptors.
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[VIRTUAL] Evaluation of the appropriate use of dronabinol in the inpatient setting () - Dec 26, 2020 - Abstract #ASHP2020ASHP_871; The following data points have been collected using the electronic medication record, Epic: age, sex, creatinine clearance, history of intravenous drug use, utilization of a pain consult, ordering team or prescriber, indication, type of pain, prior pain medication use, home medication continuation, dose, frequency, number of doses administered, prescriptions for opioids and/or dronabinol at discharge, and whether the prescription had been picked up from the pharmacy. Descriptive statistics, including means with standard deviations and medians with interquartile ranges, will be utilized as appropriate.
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Clinical, Review, Journal: Medicinal cannabis for psychiatric disorders: a clinically-focused systematic review. (Pubmed Central) - Dec 23, 2020 There is currently encouraging, albeit embryonic, evidence for medicinal cannabis in the treatment of a range of psychiatric disorders. Supportive findings are emerging for some key isolates, however, clinicians need to be mindful of a range of prescriptive and occupational safety considerations, especially if initiating higher dose THC formulas.
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Journal: The effect of cannabis toxicity on a model microbiome bacterium epitomized by a panel of bioluminescent E. coli. (Pubmed Central) - Dec 22, 2020 From all the tested cannabinoids, only delta-9-tetrahydrocannabinol (THC) and delta-9-tetrahydrocannabinolic acid A (THCA) produced a genotoxic effect, while the other tested cannabinoids, demonstrated cytotoxic or oxidative damages...The results showed that despite the lack of cannabigerol (CBG), cannabidivarin (CBDV), cannabinol (CBN), and cannabichromene (CBC) in the artificial solution mimicking the CN6 cannabis variety, a similar response pattern to the cannabinoids standards mixture was obtained. This work contributes to the understanding of such correlations and may provide a realistic view of cannabinoid effects on the human microbiome.
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Journal: Is the Urine Cannabinoid Level Measured via a Commercial Point-of-Care Semiquantitative Immunoassay a Cannabis Withdrawal Syndrome Severity Predictor? (Pubmed Central) - Dec 22, 2020 Background: For cannabis-dependent subjects, the relationship between cannabis withdrawal syndrome (CWS) severity and the urine cannabinoid concentrations are unclear; we investigated this using a commercial point-of-care (POC) enzyme immunoassay detecting 11-nor-9-carboxy-Delta-9-tetrahydrocannabinol (THC-COOH)...In patients with MWC > 11 points upon admission, creatinine-adjusted THC-COOH ratios also significantly predicted CWS severity-again with moderate effect size. Females showed prolonged urinary THC-COOH elimination and cannabis withdrawal.
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Journal: Characterization of Cannabidiol in Alternative Biological Specimens and Urine, After Consumption of an Oral Capsule. (Pubmed Central) - Dec 19, 2020 Contrary to the hallucinogenic ingredient of the plant, delta-9-tetrahydrocannabinol, cannabidiol does not seem to have a sedative effect, which can increase its popularity among users...Cannabidiol produced a very low but significant chromatographic signal in beard hair, with concentrations lower than 1 pg/mg. Finally, cannabidiol tested positive in urine after enzymatic hydrolysis with a Cmax at 70 ng/mL, after 6 hours.
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Journal: Determining Risks for Cannabis Use Disorder in the Face of Changing Legal Policies. (Pubmed Central) - Dec 17, 2020 This includes: (1) higher rates of edible consumption and vaping, (2) higher delta-9-tetrahydrocannabinol (THC) potency and lower cannabidiol (CBD) levels, and, (3) younger age of initiation of use...There is currently a lack of empirical studies that evaluate this interaction. We propose that future research consider a bioecological framework for CUD to allow for a comprehensive understanding of the effects of legal climate that could inform policy and clinical practice.
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Journal: Selective Extraction of Cannabinoid Compounds from Cannabis Seed Using Pressurized Hot Water Extraction. (Pubmed Central) - Dec 17, 2020 Phytochemicals of Cannabis sativa mainly for the use in the different industries are that of delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD)...At this condition, the predicted and experimental ratio of THCt (THC + CBN)/CBDt (CBD + CBC+ CBG) was found to be 0.17 and 0.18, respectively. Therefore, PHWE can be seen as an alternative to the classic extraction approach as the efficiency is higher and it is environmentally friendly.
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Clinical, Review, Journal: Safety Considerations in Cannabinoid-Based Medicine. (Pubmed Central) - Dec 12, 2020 The available evidence shows that, as with any other class of pharmaceuticals, cannabinoid-based medicines are associated with safety risks which should be assessed in the context of potential therapeutic benefits. Each patient should be assessed on an individual basis and physicians must rely on informed, evidence-based decision-making when determining whether a cannabinoid-based medicine could be an appropriate treatment option.
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Preclinical, Journal: Vitamin C ameliorates tetrahydrocannabinol-induced spermatotoxicity in-vitro. (Pubmed Central) - Dec 10, 2020 Each patient should be assessed on an individual basis and physicians must rely on informed, evidence-based decision-making when determining whether a cannabinoid-based medicine could be an appropriate treatment option. Vitamin C ameliorates the THC-induced reduction in spermatozoa motility in-vitro by modulation of their kinematics.
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Clinical, Journal: Cannabinoids for Pain Control During Medical Abortion: A Randomized Controlled Trial. (Pubmed Central) - Nov 26, 2020 P4 This comprehensive single-cell transcriptomic profiling provides important insights into THC's acute effects on immune function that may have important medical implications. Dronabinol does not reduce the maximum level of pain experienced by women undergoing medical abortion.
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Review, Journal: Medical cannabis for chronic pain: can it make a difference in pain management? (Pubmed Central) - Nov 22, 2020 Evidences from clinical trials showed therapeutic benefits of cannabis, especially delta-9-tetrahydrocannabinol and cannabinoids reduced neuropathic pain intensity in various conditions...The pharmacokinetics and safety of medical cannabis need to be studied by conducting clinical research. The complex and variable chemically active contents of herbal cannabis and methodological limitations in the administration of cannabis to study participants, make the clinical research difficult.
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Although the numbers of cases were not high, the urban portion of the River Torrens had a much higher number of drowning events per kilometre compared to other inland waterways in South Australia such as the Murray River. This is most likely due to the vulnerability that exists for intoxicated individuals in the city from falls into the water and to the availability of the river as a means of suicide to members of the adjacent urban population.
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Review, Journal: Effects of Cannabis and Its Components on the Retina: A Systematic Review. (Pubmed Central) - Nov 7, 2020 This is most likely due to the vulnerability that exists for intoxicated individuals in the city from falls into the water and to the availability of the river as a means of suicide to members of the adjacent urban population. This review suggests that cannabinoids may have an important role in retinal processing and function.
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Journal: Investigation of chloroplast regions rps16 and clpP for determination of Cannabis sativa crop type and biogeographical origin. (Pubmed Central) - Nov 6, 2020 Cannabis sativa can be classified as either hemp (a legal crop containing less than 0.3% delta-9-tetrahydrocannabinol, THC) or marijuana (an illegal drug containing more than 0.3% THC)...Phylogenetic analysis and principal component analysis suggested a closer relationship among USA-Mexico marijuana, Chilean marijuana and medical marijuana, and USA hemp. Genotyping additional polymorphisms in future studies is expected to reveal further differences between these sample groups.
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Review, Journal: Taste disorder's management: a systematic review. (Pubmed Central) - Oct 30, 2020 The systematic review provided evidence about the clinical efficacy of oral procedures, zinc supplementation, and palliative cares in dysgeusic patients. Further research is needed to find effective treatments with low adverse effects.
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