carbetocin / Generic mfg. 
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  • ||||||||||  intranasal carbetocin (LV-101) / Levo Therap
    P3 data, Journal:  Intranasal Carbetocin Reduces Hyperphagia, Anxiousness and Distress in Prader-Willi Syndrome: CARE-PWS Phase 3 Trial. (Pubmed Central) -  Jun 19, 2023   
    P3
    We did not find a difference in effects between HSC and oxytocin for PPH among women who were neither induced nor augmented or among those who were induced or augmented. Carbetocin was well tolerated, and the 3.2-mg dose was associated with clinically meaningful improvements in hyperphagia and anxiousness and distress behaviors in participants with PWS.
  • ||||||||||  carbetocin / Generic mfg.
    Enrollment open, Trial completion date, Trial primary completion date:  Carbetocin Versus Syntocinon for Prevention of Postpartum Hemorrhage in Cardiac Patients Undergoing Caesarean Section (clinicaltrials.gov) -  Jun 6, 2023   
    P4,  N=38, Enrolling by invitation, 
    Carbetocin was well tolerated, and the 3.2-mg dose was associated with clinically meaningful improvements in hyperphagia and anxiousness and distress behaviors in participants with PWS. Not yet recruiting --> Enrolling by invitation | Trial completion date: Apr 2022 --> Jun 2023 | Trial primary completion date: Mar 2022 --> Jun 2023
  • ||||||||||  carbetocin / Generic mfg.
    Trial completion:  Oxytocin i.m./i.v. Versus Carbetocin i.v. in Elective Cesarean Sections (clinicaltrials.gov) -  May 24, 2023   
    P4,  N=550, Completed, 
    Not yet recruiting --> Enrolling by invitation | Trial completion date: Apr 2022 --> Jun 2023 | Trial primary completion date: Mar 2022 --> Jun 2023 Unknown status --> Completed
  • ||||||||||  epinephrine / Generic mfg., carbetocin / Generic mfg.
    New P4 trial:  Methods Decreasing Bleeding in Open Myomectomy (clinicaltrials.gov) -  Apr 10, 2023   
    P4,  N=105, Recruiting, 
  • ||||||||||  carbetocin / Generic mfg.
    Trial completion, Head-to-Head:  Oxytocin vs Carbetocin at Cesarean Delivery in Women With Morbid Obesity (clinicaltrials.gov) -  Feb 23, 2023   
    P=N/A,  N=48, Completed, 
    Although prophylactic carbetocin was associated with a reduction in the rate of PPH ??500 mL, carbotocin is non-inferiors to oxytocine at preventing severe post-partum hemorrhage due atony after vaginal delivery. Recruiting --> Completed
  • ||||||||||  carbetocin / Generic mfg.
    Journal:  Oxytocin: a new target for neuroprotection? (Pubmed Central) -  Feb 7, 2023   
    Using a rodent model of IUGR associated with developing white matter damage, we recently reported that carbetocin, a brain permeable OT receptor (OTR) agonist, induced a significant reduction of activated microglia, the primary immune cells of the brain...Further studies are needed to assess the protective role of OT in the developing brain through modulation of microglial activation, a key feature of brain injury observed in infants born preterm or growth-restricted. They are expected to have several impacts in the near future not only for improving knowledge of microglial cell physiology and reactivity during brain development, but also to design clinical trials testing interventions associated with endogenous OT release as a relevant strategy to alleviate neuroinflammation in neonates.
  • ||||||||||  tranexamic acid IV / Generic mfg., carbetocin / Generic mfg.
    Trial completion:  Efficacy of Four Different Treatment Regimes on Postpartum Hemorrhage (clinicaltrials.gov) -  Jan 26, 2023   
    P=N/A,  N=300, Completed, 
    They are expected to have several impacts in the near future not only for improving knowledge of microglial cell physiology and reactivity during brain development, but also to design clinical trials testing interventions associated with endogenous OT release as a relevant strategy to alleviate neuroinflammation in neonates. Recruiting --> Completed
  • ||||||||||  tranexamic acid oral / Generic mfg., carbetocin / Generic mfg.
    Review, Journal:  Prevention of postpartum hemorrhage in vaginal deliveries. (Pubmed Central) -  Dec 2, 2022   
    Individual risk factors, risk assessment tools and prediction models have been used for determining a patient's risk of PPH. Measures for the prevention of PPH include identification and management of iron deficiency anemia, unit readiness and preparedness through performing regular simulations and having a PPH cart or medication kit readily available, prophylactic uterotonic - carbetocin alone or dual agents such as oxytocin and misoprostol or oxytocin and methylergometrine or antifibrinolytic (oxytocin and tranexamic acid) use in the third stage of labor immediately after fetal head delivery, and controlled cord traction.
  • ||||||||||  carbetocin / Generic mfg.
    Trial completion date, Trial primary completion date:  Carbetocin at Elective Cesarean Deliveries: A Dose-finding Study in Women With Twin Pregnancy. (clinicaltrials.gov) -  Nov 21, 2022   
    P=N/A,  N=30, Recruiting, 
    We found significantly higher power density spectrum peak frequency two hours after oxytocin compared to carbetocin. Trial completion date: Dec 2022 --> Jun 2023 | Trial primary completion date: Dec 2022 --> Jun 2023
  • ||||||||||  carbetocin / Generic mfg.
    Journal:  Carbetocin Controls Intraoperative Blood Loss and Thickness of Myometrium in Scar Uterus Cases. (Pubmed Central) -  Oct 18, 2022   
    There were no significant differences in estradiol (E2), luteinizing hormone (LH), or follicle-stimulating hormone (FSH) between the two groups before the surgery (p=0.596, 0.840, and 0.940, respectively), but there were significant differences after the surgery (p=0.011, 0.001, and 0.005, respectively). The use of carbetocin in the cesarean section of a full-term scar uterus is significantly effective in shortening the operation time, reducing the amount of intraoperative blood loss, and promoting the recovery of the uterus.
  • ||||||||||  tranexamic acid IV / Generic mfg., carbetocin / Generic mfg.
    Review, Journal:  Evidence-based Labor Management: Third stage of labor (Part 5). (Pubmed Central) -  Sep 10, 2022   
    During the third stage of labor, oxytocin and tranexamic acid, oxytocin and misoprostol, oxytocin and methylergometrine, or carbetocin is recommended for the prevention of postpartum hemorrhage after vaginal delivery...If oxytocin and tranexamic acid combination is chosen, intravenous tranexamic acid (1 g) in addition to intravenous oxytocin (10 IU) immediately after delivery of the neonate and before placental delivery is recommended...There is insufficient evidence to support or refute routine cord blood gas sampling after delivery. Public cord blood banking is recommended.
  • ||||||||||  carbetocin / Generic mfg.
    Review, Journal:  Is there a role for carbetocin in the prophylaxis of postpartum obstetric haemorrhage? (Pubmed Central) -  Aug 31, 2022   
    A Cochrane review, published in 2018, ranked carbetocin in the top three drug regimens for preventing postpartum haemorrhage and an international consensus statement on uterotonic use for caesarean birth concluded that carbetocin may become the preferred drug for caesarean birth, by reducing the need for additional uterotonics. The higher cost of carbetocin when compared with oxytocin is a limiting factor, but the significant healthcare costs of a postpartum haemorrhage and the physiological impact of this event suggests it a reasonable alternative to consider, especially if ergometrine is contraindicated or in those who are undergoing a caesarean birth or are at high risk of bleeding.
  • ||||||||||  tranexamic acid oral / Generic mfg., carbetocin / Generic mfg.
    Review, Journal:  Preventing Postpartum Hemorrhage (PPH) with Combined Therapy Rather Than Oxytocin Alone Pharmacologic Therapy. (Pubmed Central) -  Aug 27, 2022   
    The WOMAN-2 Trial, designed to assess if tranexamic acid prevents PPH in women with moderate to severe anemia undergoing vaginal delivery, is currently recruiting participants. The additive, infra-additive or synergistic action of oxytocin in combination with other second-line therapies deserves further study.
  • ||||||||||  carbetocin / Generic mfg.
    Trial completion date, Trial primary completion date, Head-to-Head:  Oxytocin vs Carbetocin at Cesarean Delivery in Women With Morbid Obesity (clinicaltrials.gov) -  Aug 19, 2022   
    P=N/A,  N=48, Recruiting, 
    The additive, infra-additive or synergistic action of oxytocin in combination with other second-line therapies deserves further study. Trial completion date: May 2022 --> Dec 2022 | Trial primary completion date: May 2022 --> Dec 2022
  • ||||||||||  carbetocin / Generic mfg.
    Journal:  Oxytocin receptor behavioral effects and cell types in the bed nucleus of the stria terminalis. (Pubmed Central) -  Jul 9, 2022   
    We show that infusion of carbetocin, a biased OTR-Gq agonist, in the BNST reduced social approach in both female and male California mice...In the NAc, most Oxtr+ cells were D1 dopamine receptor-expressing neurons and interneurons. These differences in Oxtr cell type distribution may help explain how activation of OTR in BNST versus NAc can have different effects on social approach and social vigilance.