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13 Diseases |  |
25 Trials |
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25 Trials |  |
318 News |  |
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- | tranexamic acid oral / Generic mfg., carbetocin / Generic mfg.
Journal: Integrating Heat-Stable Carbetocin and Tranexamic Acid for Prevention and Management of Postpartum Hemorrhage in Sub-Saharan Africa: A Five-Country Pilot Implementation Study. (Pubmed Central) - Dec 4, 2024
Dedicated training is required to improve the documentation of patient charts on PPH care. Introducing these medicines holds promise for improving PPH care in low- and middle-income countries, including by addressing suboptimal efficacy due to cold chain system challenges.
- | tranexamic acid oral / Generic mfg., carbetocin / Generic mfg.
Journal: Special Collection: Implementation Research Evidence for Prevention and Treatment of Postpartum Hemorrhage in High-Burden Low- and Middle-Income Countries. (Pubmed Central) - Dec 4, 2024
The burden of mortality from PPH is predominantly in low- and middle-income countries and demands coordinated accelerated efforts from the global maternal health community to meet the Sustainable Development 3 maternal health target by 2030. The International Journal of Maternal and Child Health and AIDS and the Concept Foundation are proud to present this Special Collection demonstrating the evidence for introducing heat-stable carbetocin and tranexamic acid, showcasing the feasibility and acceptability of their utilization for PPH prevention and management in resource-limited high-burden settings.
- | tranexamic acid oral / Generic mfg., carbetocin / Generic mfg.
Journal: Empowering Midwives in Humanitarian Settings: Integrating Heat-Stable Carbetocin and Tranexamic Acid into Postpartum Hemorrhage Training. (Pubmed Central) - Dec 4, 2024
Findings can guide future training in similar fragile, low-resource, and humanitarian settings. Strengthening midwifery leadership, fostering interdisciplinary collaboration, and using the LDHF training approach can contribute to resilient health systems and taskforce, aligning with global efforts to reduce maternal mortality.
- | carbetocin / Generic mfg.
Licensing / partnership, Retrospective data, Journal: Introduction of Heat-Stable Carbetocin through a Public-Private Partnership Model in India: A Retrospective Study to Determine Feasibility and Its Optimal Use in Public Health Settings. (Pubmed Central) - Dec 4, 2024
The PPH incidence and case referral rates noted in this study were 0.7% and 16.7%, respectively, with no reported adverse drug events or deaths. Our study suggests the safe and appropriate use of HSC within India's public health system.
- | tranexamic acid oral / Generic mfg., carbetocin / Generic mfg.
Journal: A Tale of Two Medicines: The Need for Ownership, End-to-End Planning and Execution for Development and Introduction of Maternal Health Medicines. (Pubmed Central) - Dec 4, 2024
We describe distinct access challenges between the two drugs, both having compelling safety and efficacy data and normative recommendations around the same time; one patent protected and owned by a pharmaceutical company and another with multiple generic manufacturers. We highlight the need for coordinated action to facilitate access to evidence-based maternal health commodities.
- | tranexamic acid oral / Generic mfg., carbetocin / Generic mfg.
Journal: Feasibility, Acceptability, and Appropriate Use of Novel and Lesser-Used Medicines for Prevention and Treatment of Postpartum Hemorrhage: Evidence from Implementation Research. (Pubmed Central) - Dec 4, 2024
Assessing the feasibility and acceptability of implementing these medicines in different resource settings can help bridge the gap between research and development to policy and practice, in an effort to reduce the significant health inequities facing women accessing the public health sector for quality care during labor and delivery. In this Special Collection, we explore the findings from mixed-methods implementation research studies in nine LMICs which support the acceptability and feasibility of HSC and TXA administration by healthcare providers, generating evidence to help inform the introduction and scale-up of these new and lesser-utilized PPH medicines.
- | carbetocin / Generic mfg.
Journal: An Implementation Research Study on Uterotonics Use Patterns and Heat-stable Carbetocin Acceptability and Safety for Prevention of Postpartum Hemorrhage in Nigeria. (Pubmed Central) - Dec 4, 2024
HSC is non-inferior to oxytocin in preventing PPH, has few side effects compared to misoprostol or oxytocin-misoprostol combination, and more cost-effective when compared with the other three uterotonics. Although the geographical scope of our study is only three states in Nigeria, the preponderance of suboptimal uterotonics across the country makes our findings applicable to the whole country and other low- and middle-income countries with similar challenges.
- | carbetocin / Generic mfg.
Journal: Introduction of Heat-Stable Carbetocin for Postpartum Hemorrhage Prevention in Public Sector Hospitals in Kenya: Provider Experience and Policy Insights. (Pubmed Central) - Dec 4, 2024
Policymakers find value in introducing HSC as it alleviates challenges with the fragile cold chain systems. This study contributes to the global body of knowledge on the introduction of lifesaving commodities, which is anticipated to potentially improve PPH prevention and management, and hence reduce maternal mortality.
- | tranexamic acid oral / Generic mfg., carbetocin / Generic mfg.
Journal: Postpartum Hemorrhage in Humanitarian Settings: Implementation Insights from Using Heat-Stable Carbetocin and Tranexamic Acid. (Pubmed Central) - Dec 4, 2024
Addressing challenges like medication confusion underscores the need for ongoing education and clear guidelines for the use of HSC, TXA, oxytocin, and other drugs for PPH prevention and treatment. Our findings stress the importance of a comprehensive strategy to overcome health system barriers in PPH management, potentially improving maternal health outcomes in resource-limited and fragile contexts, with broader global implications.
- | tranexamic acid oral / Generic mfg., carbetocin / Generic mfg.
Journal: Postpartum Hemorrhage in Humanitarian Settings: Heat-Stable Carbetocin and Tranexamic Acid Implementation Study in Uganda. (Pubmed Central) - Dec 4, 2024
It could be scaled up with continuous capacity development and supportive supervision to mitigate confusion between existing and new medications, such as the decreased use of oxytocin for PPH treatment. Maintaining investments in cold-chain strengthening remains critical to ensure the quality of oxytocin.
- | tranexamic acid oral / Generic mfg., carbetocin / Generic mfg.
Journal: Postpartum Hemorrhage in Humanitarian Settings: Heat-Stable Carbetocin and Tranexamic Acid Implementation Study in South Sudan. (Pubmed Central) - Dec 4, 2024
It could be scaled up in similar contexts with ongoing supervision to mitigate confusion between the existing and new medications, such as the reduced use of oxytocin for PPH treatment. Sustaining cold chain investments remain vital to ensure oxytocin quality.
- | carbetocin / Generic mfg.
New trial: Effects of Carbetocin and Oxytocin Used in Cesarean Sections on Postoperative Pain (clinicaltrials.gov) - Nov 18, 2024
P=N/A, N=120, Recruiting, Sponsor: Ankara City Hospital Bilkent
- | tranexamic acid oral / Generic mfg., carbetocin / Generic mfg.
Journal: Cross-Sectional Survey to Assess Hospital System Readiness for Hemorrhage During and After Cesarean Delivery in Africa. (Pubmed Central) - Nov 6, 2024
It is likely that the lack of a combination of factors leads to failure to rescue mothers in Africa from postoperative complications. These findings should facilitate codesign of quality improvement initiatives to reduce hemorrhage related to CD.
- carbetocin / Generic mfg.
Carbetocin for the Prevention of Postpartum Hemorrhage Due to Uterine Atony Following Vaginal Delivery: A Retrospective Cost-Benefit Analysis Based on Clinical Experience from Polish Medical Centers () - Nov 4, 2024 - Abstract #ISPOREU2024ISPOR_EU_2838;
These findings should facilitate codesign of quality improvement initiatives to reduce hemorrhage related to CD. Widespread use of effective PPH prevention by Carbetocin, can potentially have a positive impact on saving hospital resources (personnel and budget) in Poland.
- | carbetocin / Generic mfg.
Journal: A randomized controlled trial on the comparison of two doses of carbetocin with oxytocin for the prevention of postpartum hemorrhage (concert trial). (Pubmed Central) - Nov 3, 2024
Patients that had 100??g of carbetocin had a better adequate uterine tone at the fifth minute compared to those who had 50??g and 10?IU of oxytocin. Generally, carbetocin use was less likely associated with risk of PPH and use of additional intervention.
- || carbetocin / Generic mfg.
Clinical, Review, Journal: Uterotonics for management of retained placenta. (Pubmed Central) - Oct 28, 2024
Further large-scale studies are necessary to evaluate uterotonics versus placebo, compare different uterotonic agents, or assess combined uterotonic regimens. Additional research should focus on identifying specific adverse effects, maternal satisfaction and well-being, breastfeeding rates at discharge, and postpartum anaemia.
- || carbetocin / Generic mfg.
Clinical, Review, Journal: Expression of Concern: Carbetocin versus sublingual misoprostol plus oxytocin infusion for prevention of postpartum hemorrhage at cesarean section in patients with risk factors: a randomized, open trail study. (Pubmed Central) - Sep 2, 2024
Additional research should focus on identifying specific adverse effects, maternal satisfaction and well-being, breastfeeding rates at discharge, and postpartum anaemia. No abstract available
- | carbetocin / Generic mfg.
Enrollment open, Trial completion date, Trial initiation date, Trial primary completion date: Comparative Efficacy of Carbetocin and Oxytocin in Parturients at Risk of Atonic Postpartum Hemorrhage Undergoing Elective Cesarean Delivery (clinicaltrials.gov) - Aug 26, 2024
P=N/A, N=160, Recruiting, Sponsor: Samuel Lunenfeld Research Institute, Mount Sinai Hospital
No abstract available Not yet recruiting --> Recruiting | Trial completion date: Mar 2025 --> Jul 2025 | Initiation date: May 2024 --> Sep 2024 | Trial primary completion date: Mar 2025 --> Jul 2025
- carbetocin / Generic mfg.
Observational data, Retrospective data, Journal: Shenghua decoction for postpartum hemorrhage attributed to uterine atony: An observational study. (Pubmed Central) - Aug 26, 2024
The findings of this study suggest that the preventive effects of SHD combined with carbetocin were superior to those of carbetocin alone for preventing postpartum hemorrhage. However, high-quality prospective studies are needed to validate and confirm these results.
- carbetocin / Generic mfg.
INTRAMYOMETRIAL INJECTION OF TERLIPRESSIN, CARBETOCIN, AND PLACEBO: IMPACT ON HEMOGLOBIN AND BLOOD LOSS IN OPEN MYOMECTOMY WITH HEMOSTATIC TOURNIQUETSA DOUBLE-BLIND RANDOMIZED CONTROLLED TRIAL (Mile High Poster Hall, 1a-1e, Station 14 (Colorado Convention Center)) - Jul 25, 2024 - Abstract #ASRM2024ASRM_1394;
- | tranexamic acid oral / Generic mfg.
Trial completion: Comparing Tranexamic Acid Versus Ecbolics in Preventing Hemorrhage During and After Cesarean Section (clinicaltrials.gov) - Jul 22, 2024
P=N/A, N=440, Completed, Sponsor: Cairo University
However, high-quality prospective studies are needed to validate and confirm these results. Not yet recruiting --> Completed
- | carbetocin / Generic mfg.
New P1 trial: Clinical study of electroacupuncture for treatment cardiovascular response induced by oxytocin during cesarean section. (EUDRACT) - Jul 15, 2024
P1, N=120, Recruiting, Sponsor: Jiangsu Provincial Hospital of Traditional Chinese Medicine; Jiangsu Provincial Hospital of Traditional Chinese Medicine
- | progesterone / Generic mfg., carbetocin / Generic mfg.
Journal: In mares resistant to endometrial infection, periovulatory treatment with ecbolic drugs does not influence uterine clearance or luteal development. (Pubmed Central) - Jul 10, 2024
In conclusion, treatment with clenbuterol does not impair uterine clearance in estrous mares resistant to endometritis. Repeated injection of the oxytocin analogue carbetocin during the early postovulatory period is not detrimental to corpus luteum function and can be recommended to enhance uterine clearance.
- | carbetocin / Generic mfg.
Journal: Rational Design of Cyanine-Based Fluorogenic Dimers to Reduce Nonspecific Interactions with Albumin and Lipid Bilayers: Application to Highly Sensitive Imaging of GPCRs in Living Cells. (Pubmed Central) - Jul 10, 2024
Moreover, the resulting original dimeric probes enabled a significant reduction of the nonspecific interactions with bovine serum albumin and lipid bilayers compared with the first generation of cyanine 5.5 dimers. Finally, the optimized asymmetric fluorogenic dimer was grafted to carbetocin for the specific imaging of the oxytocin receptor under no-wash conditions directly in cell culture media, notably improving the signal-to-background ratio compared with the previous generation of cyanine 5.5 dimers.
- || carbetocin / Generic mfg.
P4 data, Journal, Head-to-Head: Intramyometrial and intravenous oxytocin compared to intravenous carbetocin for prevention of postpartum hemorrhage in elective cesarean section-A quasi-randomized controlled phase IV non-inferiority interventional trial. (Pubmed Central) - Jul 2, 2024
Combined (IM/IV) oxytocin is not non-inferior to carbetocin regarding severe postpartum blood loss defined as postpartum Hb decrease ?30?g/L in elective cesarean sections. We recommend carbetocin for use in clinical practice for elective cesarean sections.
- || carbetocin / Generic mfg.
Review, Journal: Uterotonics, magnesium sulphate and antibiotics during childbirth and peripartum: important obstetric drugs for the anaesthesiologist. (Pubmed Central) - Jun 19, 2024
We also discuss the use of carbetocin as an effective alternative that has a therapeutic advantage in certain clinical circumstances...We describe the precautions to be taken during magnesium administration. Finally, we discuss the importance of understanding microbiology and the pharmacology of antibiotics in the management of obstetric infection and endometritis, and draw attention to the latest trends in antibiotic regimens in labour and caesarean section.
- | carbetocin / Generic mfg.
Enrollment open, Trial initiation date: Heat-stable carbetocin for the treatment of postpartum haemorrhage (EUDRACT) - May 24, 2024
P3, N=6200, Recruiting, Sponsor: WHO
Finally, we discuss the importance of understanding microbiology and the pharmacology of antibiotics in the management of obstetric infection and endometritis, and draw attention to the latest trends in antibiotic regimens in labour and caesarean section. Not yet recruiting --> Recruiting
- |||||||| intranasal carbetocin (ACP-101) / Acadia Pharma
New P3 trial: OLE Study of Carbetocin Nasal Spray for the Treatment of Hyperphagia in Prader-Willi Syndrome (clinicaltrials.gov) - May 20, 2024
P3, N=160, Enrolling by invitation, Sponsor: ACADIA Pharmaceuticals Inc.
- | carbetocin / Generic mfg.
Preclinical, Journal: Environmental Enrichment Enhances Ethanol Preference Over Social Reward in Male Swiss Mice: involvement of oxytocin-dopamine interactions. (Pubmed Central) - May 18, 2024
Nonetheless, they suggest that mechanisms other than the prosocial effect of EE may contribute to the ethanol pro-rewarding effect of EE and Carbetocin. They also point towards an OT-dopamine interaction potentially underlying some of these effects.
- || Review, Journal: A narrative review of the literature relevant to obstetric anesthesiologists: the 2023 Gerard W. Ostheimer lecture. (Pubmed Central) - May 5, 2024
They also point towards an OT-dopamine interaction potentially underlying some of these effects. Neonatal morbidity is reduced with antenatal maternal buprenorphine compared with methadone for treatment of opioid use disorder...The ED90 of 3% chloroprocaine (with IT fentanyl 10?
- | carbetocin / Generic mfg.
Journal: A single administration of carbetocin before electroejaculation increases the insemination doses produced from each ejaculate in rams. (Pubmed Central) - Apr 9, 2024
Carbetocin administration before EE of rams improved the quantitative and qualitative characteristics of the ejaculate, duplicating the number of insemination doses collected. It can be a promising treatment to obtain a greater quantity of doses to inseminate with a lower frequency of semen collections, reducing the negative impacts of EE on animal welfare.
- | carbetocin / Generic mfg.
New trial: Comparative Efficacy of Carbetocin and Oxytocin in Parturients at Risk of Atonic Postpartum Hemorrhage Undergoing Elective Cesarean Delivery (clinicaltrials.gov) - Mar 27, 2024
P=N/A, N=160, Not yet recruiting, Sponsor: Samuel Lunenfeld Research Institute, Mount Sinai Hospital
- | carbetocin / Generic mfg.
Preclinical, Journal: Postpartum Oxytocin Treatment via the Mother Reprograms Long-Term Behavioral Disorders Induced by Early Life Stress on the Plasma and Brain Metabolome in the Rat. (Pubmed Central) - Mar 17, 2024
We also investigated the reversal effect of postpartum carbetocin (Cbt) on these signatures, along with its impact on deficits in cognitive, social, and exploratory behavior...Our findings represent the first evidence of how early life stress may alter the metabolomic profile in aged individuals, thereby increasing vulnerability to CNS disorders. This raises the intriguing prospect that the pharmacological activation of oxytocin receptors soon after delivery through the mother may rectify these alterations.
- | carbetocin / Generic mfg.
Enrollment open: Comparing the Dose-response Profiles of Uterotonics After Initial Carbetocin Administration - an Ex-vivo Study in Desensitized Human Myometrium (clinicaltrials.gov) - Mar 12, 2024
P=N/A, N=32, Recruiting, Sponsor: Samuel Lunenfeld Research Institute, Mount Sinai Hospital
This raises the intriguing prospect that the pharmacological activation of oxytocin receptors soon after delivery through the mother may rectify these alterations. Not yet recruiting --> Recruiting
- | carbetocin / Generic mfg.
New trial: Comparing the Dose-response Profiles of Uterotonics After Initial Carbetocin Administration - an Ex-vivo Study in Desensitized Human Myometrium (clinicaltrials.gov) - Feb 29, 2024
P=N/A, N=32, Not yet recruiting, Sponsor: Samuel Lunenfeld Research Institute, Mount Sinai Hospital
- | carbetocin / Generic mfg.
Journal: The influence of parity, body condition, litter size and carbetocin administration on colostrum production and immunoglobulin levels in highly productive sows within a tropical environment. (Pubmed Central) - Feb 10, 2024
Not yet recruiting --> Recruiting In conclusion, during the initial 6
- ||| intranasal carbetocin (ACP-101) / Acadia Pharma
Enrollment status: Study of Carbetocin Nasal Spray for the Treatment of Hyperphagia in Prader-Willi Syndrome (clinicaltrials.gov) - Jan 25, 2024
P3, N=170, Recruiting, Sponsor: ACADIA Pharmaceuticals Inc.
In conclusion, during the initial 6 Enrolling by invitation --> Recruiting
- | carbetocin / Generic mfg.
New P1/2 trial: Efficacy of Carbetocin in Prevention of Postpartum Hemorrhage in Obese Versus Non Obese Women (clinicaltrials.gov) - Jan 21, 2024
P1/2, N=150, Completed, Sponsor: Cairo University
- | Journal, BRCA Biomarker: Epigenomic Profiling Advises Therapeutic Potential of Leukotriene Receptor Inhibitors for a Subset of Triple-Negative Breast Tumors. (Pubmed Central) - Dec 27, 2023
Finally, our results suggest that the epigenetic status of leukotriene B4 receptors is a novel, potential, predictive, and prognostic biomarker for TNBC. These findings might improve individualized therapy for TNBC patients by introducing new therapeutic adjuncts as anticancer agents.
- | carbetocin / Generic mfg.
New P3 trial, Head-to-Head: Heat-stable carbetocin for the treatment of postpartum haemorrhage (EUDRACT) - Dec 22, 2023
P3, N=6200, Not yet recruiting, Sponsor: WHO
- |||||||| intranasal carbetocin (ACP-101) / Acadia Pharma
New P3 trial: Study of Carbetocin Nasal Spray for the Treatment of Hyperphagia in Prader-Willi Syndrome (clinicaltrials.gov) - Dec 15, 2023
P3, N=170, Enrolling by invitation, Sponsor: ACADIA Pharmaceuticals Inc.
- | carbetocin / Generic mfg.
New trial: Carbetocin in the Prevention of Primary Postpartum Haemorrhage (clinicaltrials.gov) - Dec 7, 2023
P=N/A, N=244, Completed, Sponsor: Ministry of Health and Population, Egypt
- | carbetocin / Generic mfg.
Preclinical, Journal: Carbetocin Inhibits Behavioral Sensitization to Ethanol in Male and Female Mice, Independent of Corticosterone Levels. (Pubmed Central) - Nov 24, 2023
We also found a reduction in their ethanol consumption due to the CBT treatment. In conclusion, carbetocin emerges as a promising and effective intervention for mitigating ethanol-induced behavioral sensitization and reducing ethanol intake, highlighting its potential significance in alcohol addiction treatment.
- ||| carbetocin / Generic mfg.
Trial completion: Evaluating Efficacy of Intravenous Carbetocin Versus Intramyometrial Injection of Adrenaline in Reducing Blood Loss (clinicaltrials.gov) - Oct 16, 2023
P1, N=62, Completed, Sponsor: Egymedicalpedia
In conclusion, carbetocin emerges as a promising and effective intervention for mitigating ethanol-induced behavioral sensitization and reducing ethanol intake, highlighting its potential significance in alcohol addiction treatment. Recruiting --> Completed
- | tranexamic acid oral / Generic mfg.
New trial: Comparing Tranexamic Acid Versus Ecbolics in Preventing Hemorrhage During and After Cesarean Section (clinicaltrials.gov) - Sep 29, 2023
P=N/A, N=444, Not yet recruiting, Sponsor: Cairo University
- || carbetocin / Generic mfg.
Trial completion: A Study to Evaluate the Effect of Carbetocin on the QT/QTc Interval in Healthy Subjects (clinicaltrials.gov) - Sep 26, 2023
P1, N=40, Completed, Sponsor: Ferring Pharmaceuticals
Recruiting --> Completed Active, not recruiting --> Completed
- | carbetocin / Generic mfg.
Journal: Carbetocin vs. oxytocin at elective caesarean delivery: a reply. (Pubmed Central) - Sep 7, 2023
Active, not recruiting --> Completed No abstract available
- | carbetocin / Generic mfg.
Journal, Head-to-Head: Carbetocin vs. oxytocin at elective caesarean delivery: challenges and complexities in performing and interpreting a non-inferiority trial. (Pubmed Central) - Sep 7, 2023
No abstract available No abstract available
- || carbetocin / Generic mfg.
Enrollment closed: A Study to Evaluate the Effect of Carbetocin on the QT/QTc Interval in Healthy Subjects (clinicaltrials.gov) - Sep 5, 2023
P1, N=40, Active, not recruiting, Sponsor: Ferring Pharmaceuticals
No abstract available Recruiting --> Active, not recruiting
- || carbetocin / Generic mfg.
Clinical, Journal: The efficacy of three regimes of uterotonic agents for prevention of postpartum blood loss at undergoing cesarean section: a prospective randomized clinical trial. (Pubmed Central) - Aug 29, 2023
P=N/A
Our results demonstrate that carbetocin shows no superiority in the prevention of PPH in women undergoing cesarean section. Oxytocin still seems to be a highly effective alternative to prevent PPH.