Glycyron (ammoniated glycyrrhizin) News

|||||||||| Glycyron (ammoniated glycyrrhizin) / Eisai, Minophagen
May I ask what are the Glycyron tablets are called in Egypt and China (Twitter) - Apr 5, 2023

|||||||||| Glycyron (ammoniated glycyrrhizin oral) / Eisai, Minophagen
Journal: 18β-glycyrrhetyl-3-O-sulfate would be a causative agent of licorice-induced pseudoaldosteronism. (Pubmed Central) - Aug 20, 2020
Previously, we found 22α-hydroxy-18β-glycyrrhetyl-3-O-sulfate-30-glucuronide (1), one of the metabolites of glycyrrhizin (GL) in the urine of Eisai hyperbilirubinuria rats (EHBRs) treated with glycyrrhetinic acid (GA), and suggested that it is also a possible causative agent of pseudoaldosteronism...In the plasma of a patient suffering from pseudoaldosteronism with rhabdomyolysis due to licorice, we found 8.6 µM of 3, 1.3 µM of GA, and 87 nM of 2, but 1, GL, and 3MGA were not detected. These findings suggest that 18β-glycyrrhetyl-3-O-sulfate (3) is an alternative causative agent of pseudoaldosteronism, rather than 3MGA and 1.

|||||||||| methotrexate / Generic mfg.
Journal: A Previously Unknown Drug-Drug Interaction Is Suspected in Delayed Elimination of Plasma Methotrexate in High-Dose Methotrexate Therapy. (Pubmed Central) - Jul 5, 2020
Multiple logistic regression analysis revealed that the concomitant use of SNMC solely was a significant risk factor for delayed MTX (odds ratio = 12.20; 95% CI = 1.06-139.84). Conclusion and Relevance: Concomitant use of SNMC was shown to be related to delayed elimination of serum MTX, and our results suggested a previously unknown drug-drug interaction between MTX and SNMC.

|||||||||| Glycyron (ammoniated glycyrrhizin oral) / Eisai, Minophagen, Stronger Neo-Minophagen C (ammoniated glycyrrhizin intravenous) / Eisai, Minophagen
Clinical, Journal: Initial Clinical Experience of the Herbal Medicine Inchinkoto for Refractory Hyperbilirubinemia Following Open-heart Surgery (Pubmed Central) - Jan 2, 2020
Hyperbilirubinemia improved in all patients after the introduction of Inchinkoto:1 day after in 1 case, 2 days after in 2 cases, 3 days after in 2 cases, and 4 days after in 1 case. These results indicate the potential of Inchinkoto to attenuate refractory hyperbilirubinemia following cardiac surgery with cardiopulmonary bypass.

|||||||||| Glycyron (ammoniated glycyrrhizin oral) / Eisai, Minophagen
Biomarker, Journal: Isolation of a novel glycyrrhizin metabolite as a causal candidate compound for pseudoaldosteronism. (Pubmed Central) - Oct 18, 2019
Compound 1 was actively transported into cells via OAT1 and OAT3, whereas GA was not. Compound 1, when produced in Mrp2-deficiency, represents a potential causative agent of pseudoaldosteronism, and might be used as a biomarker to prevent the adverse effect.



	Diseases Companies Products Productz Mechanisms of Action Sites