AZD1466 News - LARVOL Sigma

|||||||||| AZD1466 / AstraZeneca, Catalyst Biosci, anatabine (RCP-006) / Rock Creek Pharma
Preclinical, Journal: Nicotine-mediated effects in neuronal and mouse models of synucleinopathy. (Pubmed Central) - Sep 18, 2023
Moreover, when investigating the role of nicotinic acetylcholine receptor (nAChR) signaling in nicotine's neuroprotective effects in iPSC-derived dopaminergic neurons, we observed that while ?4-specific antagonists reduced the nicotine-induced calcium response, ?4 agonists (e.g., AZD1446 and anatabine) mediated similar neuroprotective responses against ?-Syn PFF-provoked neurodegeneration. Our results show that nicotine attenuates ?-Syn-provoked neuropathology in vivo and in a humanized neuronal model of synucleinopathy and that activation of ?4?2 nicotinic receptors might mediate these neuroprotective effects.

|||||||||| bradanicline (ATA-101) / CODA Biotherap
Journal: Evidence for alpha nicotinic receptor activation during the cough suppressing effects induced by nicotine and identification of ATA-101 as a potential novel therapy for the treatment of chronic cough. (Pubmed Central) - Feb 17, 2022
Significance Statement This study documents the antitussive actions of nicotine and identifies the α nicotinic receptor subtype as the target for nicotine during cough suppression described in humans. We additionally present evidence suggesting that ATA-101 and other α nicotinic receptor selective agonists may be promising candidates for the treatment of chronic refractory cough.

|||||||||| methylphenidate tablet / Generic mfg.
Journal: Cingulate impairments in ADHD: Comorbidities, connections, and treatment. (Pubmed Central) - Apr 14, 2020
Methylphenidate decreases hyperactivity in aMCC...AZD1446 (ɑ4β2 nAChR agonist) improves the Groton Maze task due to high nAChR in dPCC/RSC engaged in spatial orientation...Thus, ADHD children/adolescents respond impulsively to the significance of stimuli without having cortical inhibition. Finally, controls show negative relationships between aMCC and the default mode network, and ADHD compromises this relationship, showing decreased connectivity between ACC and precuneus/PCC.



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