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Journal: Reciprocal crosslink among MeCP2/BDNF /CREB signaling pinpointed in autism spectrum disorder. (Pubmed Central) - Jan 17, 2024
NQ and LNQ displayed improvement in DNA damage in almost all brain regions after EFA alterations; even better results were noticed post-LNQ therapy. Therefore, it may be concluded that neuquinon and liposomal-loaded neuquinon have a therapeutic index versus EFA-induced autism in a rat model.
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Trial completion, Trial completion date: Comparative Single-dose Bioavailability Study of Different CoQ10 Formulations (clinicaltrials.gov) - Dec 14, 2022
P=N/A, N=30, Completed,
Therefore, it may be concluded that neuquinon and liposomal-loaded neuquinon have a therapeutic index versus EFA-induced autism in a rat model. Recruiting --> Completed | Trial completion date: Dec 2021 --> Dec 2022
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Journal: Synthesis of Oxidant Functionalised Cationic Polymer Hydrogel for Enhanced Removal of Arsenic (III). (Pubmed Central) - Nov 30, 2021
A cationic polymer gel (N-[3-(dimethylamino)propyl]acrylamide, methyl chloride quaternary)(DMAPAA-Q gel)-supported oxidising agent (KMnO or KCrO) was proposed to remove As from water...The removal of As is influenced by the co-existing high-valence anions. Based on these results, the gels were found to be efficient for the As(III) adsorption and could be employed for the As(III) removal from the industrial wastewater.
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Preclinical, Journal: A fully defined 3D matrix for ex vivo expansion of human colonic organoids from biopsy tissue. (Pubmed Central) - May 15, 2021
In order to overcome these limitations, and to enable clinical translation, we tested the use of a fully defined hydrogel matrix, QGel CN99, to establish and expand intestinal organoids directly from human colonic biopsies...All data proved comparable to organoids cultured in the BME-benchmark Matrigel. The application of a fully defined hydrogel, completely bypassing the use of BMEs, will drastically improve the reproducibility and scalability of organoid studies, but also advance translational applications in personalized medicine and stem cell-based regenerative therapies.
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ESTABLISHING HUMAN COLONIC ORGANOIDS FROM TISSUE BIOPSIES IN A FULLY-DEFINED HYDROGEL () - May 4, 2020 - Abstract #DDW2020DDW_6719;
We have identified a fully-defined matrix that efficiently supports primary human colonic organoids long-term, completely by-passing the use of BME. We expect this novel fully-defined matrix to drastically improve the reproducibility of organoid studies and to advance the translational use of stem cell-based therapies in clinical settings.
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